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Acta Pharmaceutica Sinica b 2012年第3期2卷 286-293页

作者： Yichen Hu Li Wan Jinming Zhang Fang Yang Jiliang cao pharmacy college Chengdu University of Traditional Chinese MedicineChengdu 611137China The Ministry of Education Key Laboratory of Standardization of chinese Herbal Medicine Chengdu 611137China State Key Laboratory breeding base of Systematic Research Development and Utilization of Chinese Medicine ResourcesChengdu 611137China Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100094China

Pesticide residue analysis plays an important role in the quality control of chinese materia *** paper reports the development and validation of an analytical method for the quantitative determination of the residues of 39 pesticides in 12 different matrices of chinese materia *** preparation utilized the QuEchERS method with acetonitrile:1% aqueous acetic acid(9:1,v/v)as extraction solvent followed by sample clean-up by dispersive solid phase extraction using primary secondary amine sorbent and graphitized carbon *** were then analysed by gas chromatography coupled with electron impact mass spectrometry in the selected ion monitoring *** of detection(LOD)and limit of quantitation(LOQ)values were in the ranges 0.5-50 ng/g and 1-100 ng/g,*** recoveries of the 39 pesticides were in the range 75-112% with precision(as relative standard deviation,RSD)chERS method allows rapid and sensitive analysis of multiple pesticide residues in chinese materia medica.

关键词： chinese materia medica Gas chromatographymass spectrometry Pesticide residues QuEchERS method

Synthesis and antitumor activity of novel substituted uracil-1’（N）-acetic acid ester derivatives of 20（S）-camptothecins

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Synthesis and antitumor activity of novel substituted uracil...

中国化学会第十届全国天然有机化学学术会议

作者： Di-Zao Li Xian-Dao Pan college of pharmacy State key Laboratory of Medicinal Chemical Biology State Key Laboratory of Elemento-Organic Chemistry and Tianjin Key Laboratory of Molecular Drug Research Nankai University State Key Laboratory of bioactive Substance and Function of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College

＜正＞camptothecin（cPT）and its related analogues represent an important class of agents useful in the treatment of ***-activity relationship（SAR）studies showed that the ring E lactone and the natural 20S-configuration of camptothecins are essential for antitumor *** structural modifications have concerned the A and b rings of cPTs,in which wide

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润肤剂引起的烧伤

英国医学杂志中文版 2022年第6期25卷 357-358页

作者： Matthew J Ridd Sarah Hall Majella E Lane Amanda Roberts Hywel c Williams 王誉涵(译) Population health sciences University of BristolBristolUK School of pharmacy De Montfort UniversityLeicesterUK School of pharmacy University College LondonLondonUK centre for Evidence based Dermatology School of MedicineUniversity of NottinghamNottinghamUK 首都儿科研究所皮肤科

一位72岁行动不便且患有帕金森病痴呆的男性,因上半身烧伤到急诊科就诊。该患者吸烟,而且他的看护者每天给他全身涂抹润肤剂长期维持治疗湿疹。主治医生证实,这名患者被烧伤是由于他的香烟接触到右臂的睡衣时迅速燃烧造成的。

关键词：急诊科看护者维持治疗帕金森病痴呆润肤剂烧伤

Adenosine triphosphate induced cell death: Mechanisms and implications in cancer biology and therapy

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World Journal of clinical Oncology 2023年第12期14卷 549-569页

作者： Hao-Ling Zhang Doblin Sandai Zhong-Wen Zhang Zhi-Jing Song Dinesh babu Yasser Tabana Sabbar Saad Dahham Mowaffaq Adam Ahmed Adam Yong Wang Wei Wang Hao-Long Zhang Rui Zhao Khaled barakat Mohammad Syamsul Reza Harun Siti Nurfatimah Mohd Shapudin bronwyn Lok Department of biomedical Science Advanced Medical and Dental InstituteUniversity Sains MalaysiaPenang 13200Malaysia School of Public health Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina clinical college of chinese Medicine Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Faculty of pharmacy and Pharmaceutical sciences University of AlbertaEdmonton AB T6G 2E1Canada Department of Science University of Technology and Applied Sciences RustaqRustaq 10 P.C.329Oman Department of chemistry and biochemistry San Diego State UniversitySan DiegoCA 92182United States Pathology center Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina college of Acupuncture-Moxibustion and Tuina Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina

Adenosine triphosphate(ATP)induced cell death(AIcD)is a critical cellular process that has garnered substantial scientific interest for its profound relevance to cancer biology and to therapeutic *** comprehensive review unveils the intricate web of AIcD mechanisms and their intricate connections with cancer *** review offers a comprehensive framework for comprehending the multifaceted role of AIcD in the context of *** is achieved by elucidating the dynamic interplay between systemic and cellular ATP homeostasis,deciphering the intricate mechanisms governing AIcD,elucidating its intricate involvement in cancer signaling pathways,and scrutinizing validated key ***,the exploration of AIcD as a potential avenue for cancer treatment underscores its essential role in shaping the future landscape of cancer therapeutics.

关键词： Adenosine triphosphate induced cell death Adenosine triphosphate homeostasis Mechanism cancer signaling pathways Prognosis and clinical values cancer treatment

chemical constituents from Trichosanthes cucumeroides

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Journal of chinese Pharmaceutical sciences 2020年第6期29卷 431-438页

作者： Jing chen Li cheng Fuqian Wang Xuanbin Wang Yonghui Zhang Xincai Hao Deptment of Traditional chinese Medicine Renmin HospitalHubei University of MedicineShiyan 442008China Hubei Key Laboratory of Natural Medicinal chemistry and Resource Evaluation School of PharmacyTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of pharmacy Wuhan First HospitalWuhan 430022China

One new triterpenoid, 3β-[(E)-caffeoyloxy]-D:c-friedooleana-7,9(11)-dien-29-oic acid(1) and nine known triterpenoids identified as cucurbitacin b(2), 23,24-dihydrocucurbitacin b(3), 23,24-dihydrocu-curbitacin D(4), cucurbitacin D(5), cucurbalsaminol A(6), 3-epi-isocucurbitacin D(7), curbitacin G(8), cucurbitacin J(9) and cucurbitacin I(10) were purified from Trichosanthes cucumeroides. Their structures were confirmed by spectroscopic data analysis and comparison with previous literature. All compounds were obtained from T. cucumeroides for the first time.

关键词： Trichosanthes cucumeroides chemical constituents Triterpenoid Structural identification

Recent Progress in Structural Modification and Activities on Panax notoginseng Saponins

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Medicinal Plant 2022年第4期13卷 90-98页

作者： Jinna ZHOU Xiaorong ZHOU cheng ZOU Mu WANG Hong YU college of Science Tibet UniversityLhasa 850001China Department of pharmacy Sanming First HospitalAffiliated Hospital of Fujian Medical UniversitySanming 365000China School of Pharmaceutical Science&Yunnan Key Laboratory of Pharmacology for Natural Products Kunming Medical UniversityKunming 650500China Plant Science college Tibet Agriculture&Animal Husbandry UniversityNyingchi 851418China Yunnan Herbal Laboratory College of Ecology and Environmental SciencesYunnan UniversityKunming 650106China

This paper reviews recent progress in the structural modification and activities on Panax notoginseng saponins(PNS).PNS can not only improve the function of cardio-cerebral system,central nervous system and immune system,but also reveal anticancer,anti-aging and anti-oxidation *** order to solve the problem of low bioavailability and poor absorbability of PNS in vivo,usually,the researchers modified the structure of PNS with three methods:glycoside cleavage(including acid hydrolysis,sulfation,etc.),biotransformation method(including enzyme hydrolysis,microbial transformation)and combinatorial chemical *** was found that the structural modification sites of PNS were single,mainly aimed at c-3,c-6 and c-20,which provided a new perspective for the structural modification of ***,structural modification on PNS with high yield and ready availability are significant in the discovery of new active ingredients and *** of PNS are applied to research of structure-activity relationship,which is beneficial to the development of new medicines.

关键词： Panax notoginseng saponins Structural modification Activities

Altered mitochondria and bcl-2 expression in the hippocampal cA3 region in a rat model of acute epilepsy

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Neural Regeneration Research 2009年第4期4卷 276-280页

作者： Jiyan cheng Lina Wu Qiaozhi Wang Yanfeng Gan Guangyi Liu Hong Yu Electron Microscopy Laboratory Luzhou Medical College Luzhou 646000 Sichuan Province China Department of Histology and Embryology Luzhou Medical College Luzhou 646000 Sichuan Province China

bAcKGROUND： Previous studies have shown that the mitochondrial structure and function are damaged in animal models of epilepsy. In addition, the bcl-2 protein is capable of regulating mitochondrial stability. ObJEcTIVE： To observe and validate changes in mitochondrial structure and bcl-2 expression, and to analyze these characteristics in the hippocampal cA3 region of rat models of epilepsy. DESIGN, TIME AND SETTING： This randomized, controlled, animal experiment was performed at the Laboratory of Electron Microscopy and Department of Histology and Embryology, Luzhou Medical college between 2007 and 2008. MATERIALS： coriamyrtin was provided by the pharmacy Factory of West china University of Medical sciences. The primary and secondary antibodies were provided by Zhongshan Goldenbridge biotechnology, beijing. METHODS： A total of 44 adult, male, Sprague Dawley rats were randomly divided into control （n = 11） and epilepsy （n = 33） groups. Rats in the epilepsy group were induced by coriamyrtin （50 μ g/kg）, which was injected into the lateral ventricles. The rats were then observed at 3, 6, and 24 hours after epilepsy induction, with 11 rats at each time point. Epilepsy was not induced in rats from the control group. MAIN OUTcOME MEASURES： Pathological changes in the hippocampal cA3 region were observed by light microscopy; bcl-2 expression was analyzed by immunohistochemistry; and mitochondrial changes in the hippocampus were observed under transmission electron microscopy. RESULTS：（1） The control group displayed very little bcl-2 protein expression in the hippocampal cA3 region. However, after 3 hours of epilepsy, expression was visible. by 6 hours, expression peaked and then subsequently decreased after 24 hours, but remained higher than the control group （P 〈 0.05）. （2） Mitochondria were damaged to varying degrees in the epilepsy groups. For example, mitochondria edema, cristae space increase, and disappearance of mitochondria were apparent. Moreover, mitochondrial

关键词： coriamyrtin epilepsy hippocampus immunohistochemistry mitochondrion rats

作为一种新的心肌细胞代谢改变和焦亡调节剂,cPAL可调节小鼠心肌梗死损伤（英文）

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Engineering 2023年第1期 49-62页

作者：李佳敏薛宏儒徐宁龚丽玲李鸣李思佳黄迪张庆伟李鹏宇李青穗于航刘伊宁薛亚东陈海鑫刘佳丽张万玉刘明彬常思雨郎宪治赵星淼杜伟杰蔡本志王宁杨宝峰 State-Province Key Laboratories of biomedicine-Pharmaceutics of china & Key Laboratory of cardiovascular Medicine Research (Ministry of Education of the People's Republic of china) Department of Pharmacology College of Pharmacy Harbin Medical University Research Unit of Noninfectious chronic Diseases in Frigid Zones (2019RU070) Chinese Academy of Medical Sciences Northern Translational Medicine Research and cooperation center Heilongjiang Academy of Medical Sciences Harbin Medical University Institute of clinical pharmacy The University Key Laboratory of Drug Research Heilongjiang Higher Education Institutions Department of Pharmacy the Second Affiliated Hospital of Harbin Medical University

心肌梗死（Myocardial Infarction, MI）是一种严重的缺血性心脏病疾病，常伴有心肌代谢紊乱和心肌细胞死亡。越来越多的证据表明，长链非编码RNA(lnc RNA)参与癌症及心血管疾病（cardiovascular diseases, cVD）等多种疾病的病理过程...

心肌梗死（Myocardial Infarction, MI）是一种严重的缺血性心脏病疾病，常伴有心肌代谢紊乱和心肌细胞死亡。越来越多的证据表明，长链非编码RNA(lnc RNA)参与癌症及心血管疾病（cardiovascular diseases, cVD）等多种疾病的病理过程，并逐渐成为这些疾病的一种新的生物标志物。本研究旨在探究lnc RNA在调节心肌梗死后心肌重构中的作用及机制。研究发现三磷酸腺苷（ATP）在急性心肌梗死边缘区心肌组织中含量减少，糖脂代谢相关基因如分化抗原簇36(cD36)、己糖激酶（HK）和葡萄糖转运蛋白4(GLUT4)的表达水平也明显异常，并伴有心肌细胞焦亡的发生。随后发现一种此前未知的保守的lnc RNA AK009126(cardiomyocyte pyroptosis-associated lnc RNA, cPAL)。q RT-PcR结果显示，cPAL在心肌梗死小鼠的心脏梗死边缘区组织中显著上调，此外，腺相关病毒9(AAV9)通过其短发夹RNA(sh RNA)介导的内源性cPAL沉默，可以部分消除缺血小鼠的心肌代谢紊乱，并抑制心肌细胞焦亡。研究结果显示cPAL具有直接结合核因子kappa b(NFκb)的能力，并作为NFκb的激活剂诱导心肌细胞NFκb磷酸化，活化后的NFκb在转录水平促进caspase-1的转录，进而促进其翻译。同时，cPAL增加了心肌细胞中白细胞介素（Interleukin, IL）-18和IL-1β的释放。总的来说，本研究揭示了lnc RNA cPAL可能是心肌梗死后诱导心脏代谢异常和心肌细胞焦亡的一种新调节因子，并提示cPAL可能成为治疗心肌细胞缺血损伤的新靶点。

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Synergistic effect of α-mangostin on antibacterial activity of tetracycline, erythromycin, and clindamycin against acne involved bacteria

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chinese Herbal Medicines 2019年第4期11卷 412-416页

作者： Md Iftekhar Ahmad James E Keach Tapan behl Pharkphoom Panichayupakaranant Phytomedicine and Pharmaceutical biotechnology Excellence center Faculty of Pharmaceutical SciencesPrince of Songkla UniversityHat-Yai 90112Thailand Department of Tropical Plant and Soil sciences University of Hawai'i at MānoaKomohana Research and Extension CenterHiloHawai'i 96822USA Department of Pharmacology Chitkara College of PharmacyChitkara UniversityPunjab 140401India Department of Pharmacognosy and Pharmaceutical botany Faculty of Pharmaceutical SciencesPrince of Songkla UniversityHat-Yai 90112Thailand

Objective:To evaluate the synergistic effect ofα-mangostin with tetracycline,erythromycin,and clindamycin against bacteria involved in acne ***:A broth microdilution method was used to determine the minimum inhibitory concentration(MIc)ofα-mangostin and a range of *** effects on antibacterial activity were determined based on their own MIc,and then using a checkerboard method and a time-kill assay at 37°c for24 ***:α-Mangostin exhibited antibacterial activity against Propionibacterium acnes,Staphylococcus aureus,*** and *** with MIc values of 0.78,3.13,0.78,and 6.25μg/m L,*** results of the checkerboard assay showed thatα-mangostin produced synergistic effects with tetracycline,erythromycin,and clindamycin against all tested bacteria,with a fractional inhibitory concentration index(FIcI)between 0.09 and ***,time-kill curve data indicated thatα-mangostin increased the antibacterial activity of tetracycline,erythromycin,and ***:These findings suggested thatα-mangostin may be used to enhance the antibacterial activity of some antibiotics against bacteria involved in acne production.

关键词： α-Mangostin acne clindamycin erythromycin synergistic tetracycline

Gold nanoparticle-directed autophagy intervention for antitumor immunotherapy via inhibiting tumor-associated macrophage M2 polarization

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Acta Pharmaceutica Sinica b 2022年第7期12卷 3124-3138页

作者： Siyue Zhang Fangyuan Xie Kaichun Li He Zhang You Yin Yuan Yu Guangzhao Lu Shihao Zhang Yan Wei Ke Xu Yan Wu Hong Jin Lan Xiao Leilei bao can Xu Yulin Li Ying Lu Jie Gao Department of pharmacy Naval Medical UniversityShanghai 200433China changhai clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghai 200433China Institute of Translational Medicine Shanghai UniversityShanghai 200444China Department of pharmacy Shanghai Eastern Hepatobiliary Surgery HospitalNaval Medical UniversityShanghai 200433China Department of Oncology Shanghai Fourth People’s HospitalSchool of MedicineTongji UniversityShanghai 200434China Unit for drug and Instrument Supervision and Inspection of Wuxi Joint Logistic Support center Nanjing 210000China Key Laboratory for Ultrafine Materials of Ministry of Education Engineering Research Center for Biomedical Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China Department of Gastroenterology Shanghai Changhai HospitalNaval Medical UniversityShanghai 200433China Department of Neurology Changzheng HospitalNaval Medical UniversityShanghai 200003China Department of biomaterial College of Life SciencesMudanjiang Medical UniversityMudanjiang 157011China Department of Laboratory Medicine Hongqi HospitalMudanjiang Medical CollegeMudanjiang 157011China centre for biomedical Technologies Queensland University of TechnologyBrisbane QLD 4000Australia mWenzhou Institute of Shanghai UniversityWenzhou 325000China

Tumor-associated macrophages(TAMs),one of the dominating constituents of tumor microenvironment,are important contributors to cancer progression and treatment ***,regulation of TAMs polarization from M2 phenotype towards M1 phenotype has emerged as a new strategy for tumor ***,we successfully initiated antitumor immunotherapy by inhibiting TAMs M2 polarization via autophagy intervention with polyethylene glycol-conjugated gold nanoparticles(PEG-Au NPs).PEG-Au NPs suppressed TAMs M2 polarization in both in vitro and in vivo models,elicited antitumor immunotherapy and inhibited subcutaneous tumor growth in *** demonstrated by the m RFP-GFP-Lc3 assay and analyzing the autophagy-related proteins(Lc3,beclin1 and P62),PEGAu NPs induced autophagic flux inhibition in TAMs,which is attributed to the PEG-Au NPs induced lysosome alkalization and membrane ***,TAMs were prone to polarize towards M2phenotype following autophagy activation,whereas inhibition of autophagic flux could reduce the M2polarization of *** results revealed a mechanism underlying PEG-Au NPs induced antitumor immunotherapy,where PEG-Au NPs reduce TAMs M2 polarization via induction of lysosome dysfunction and autophagic flux *** study elucidated the biological effects of nanomaterials on TAMs polarization and provided insight into harnessing the intrinsic immunomodulation capacity of nanomaterials for effective cancer treatment.

关键词： Macrophage polarization Tumor-associated macrophages Nanomaterials Autophagy flux Lysosomal damage Gold nanoparticles M2 macrophage cancer therapy