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Dihydromyricetin promotes apoptosis, suppresses proliferation and tumor necrosis factor-α-mediated nuclear factor kappa-B activation in nasopharyngeal carcinoma CNE-2 cells

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Journal of Traditional Chinese Medicine 2021年第3期41卷 367-375页

作者： LI Caihong SHI Jinlian HUANG Bo DING Hang LIN Hanguang ZENG Jincheng ZHAO Yang LUO Guoqing Institute of Biochemistry and molecular Biology Guangdong Medical UniversityZhanjiang 524023China dongguan key laboratory of medical bioactive molecular developmental and translational research Guangdong Provincial Key Laboratory of Medical Molecular DiagnosticsGuangdong Medical UniversityDongguan 523808China Department of Otolaryngology of Shenzhen Longhua New District Central Hospital Shenzhen 518109China Department of Otolaryngology of The Third People's Hospital of Longgang Shenzhen 518115China Faculty of Forensic Medicine of Guangdong medical University Dongguan 523808China Department of Otolaryngology of the Second Affiliated Hospital of Guangdong medical University Zhanjiang 524023China Department of Otolaryngology of the Affiliated Hospital of Guangdong medical University Zhanjiang 524023China

OBJECTIVE: To investigate the efficacy of dihydromyricetin(DMY) on nasopharyngeal carcinoma(NPC) cell proliferation, apoptosis and to reveal the underlying mechanism in vitro ***: The CNE-2 cell line was treated with different concentrations of DMY and the effects of DMY on cell viability and proliferation were evaluated using cell counting kit-8(CCK-8) assay and plate colony formation assay. Cellular apoptosis was detected by flow cytometry following Annexin V fluorescein isothiocyanate/propidine iodide *** morphology was observed under a fluorescence microscope following Hoechst 333258 staining. The expression of phosphorylated inhibitor of nuclear factor kappa-B kinase subunit beta(p-IKKβ), phosphorylated inhibitor of nuclear factor kappa-B kinase subunit alpha(p-IKKα), inhibitor of nuclear factor kappa-B alpha(IκB-α), nuclear factor kappa-B(NF-κB)/p65 was examined by Western blot analysis and the nuclear translocation of NF-κB/p65 was observed using a confocal laser scanning ***: DMY inhibited the proliferative capability and colony formation of NPC CNE-2 cells. Meanwhile, DMY induced apoptosis of CNE-2 cells in a dose and time-dependent manner via upregulating B-cell lymphoma-2 associated X, but downregulating B-cell lymphoma-2 and pro-caspase-3. Importantly, we found that DMY suppressed tumor necrosis factor alpha(TNF-α)-mediated NF-κB activation via inhibiting p-IKKβ, p-IKKα and blocking NF-κB subunit ***: Our experiments demonstrated that DMY had significant antiproliferative and apoptosisinducing effects on CNE-2 cells. Additionally, DMY promoted inactivation of p-IKKβ, p-IKKα,and blocked the nuclear translocation of NF-κB subunit p65. These results suggest that DMY may be an important therapeutic approach for NPC.

关键词： Dihydromyricetin Nasopharyngeal carcinoma Cell proliferation Apoptosis I-kappa B kinase NF-kappa B Signal transduction

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Diagnostic and Prognostic Value of Protein Post-translational Modifications in Hepatocellular Carcinoma

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Journal of Clinical and translational Hepatology 2023年第5期11卷 1192-1200页

作者： Jing Wang Fangfang Wang Ning Wang Mei-Yin Zhang Hui-Yun Wang Guo-Liang Huang Guangdong Provincial key laboratory of medical molecular Diagnostics The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdongChina China-America Cancer research Institute Key Laboratory for Epigenetics of Dongguan CityGuangdong Medical UniversityDongguanGuangdongChina State key laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhouGuangdongChina

Hepatocellular carcinoma(HCC)is a common malignant tumor with high incidence and cancer mortality ***-translational modifications(PTMs)of proteins have a great impact on protein *** all proteins can undergo PTMs,including phosphorylation,acetylation,methylation,glycosylation,ubiquitination,and so *** studies have shown that PTMs are related to the occurrence and development of *** findings provide novel therapeutic targets for cancers,such as glypican-3 and *** clinical implications are also found in the studies of *** or prognostic value,and response to therapy have been *** HCC,it has been shown that glycosylated alpha-fetoprotein(AFP)has a higher detection rate for early liver cancer than conventional *** this review,we mainly focused on the diagnostic and prognostic value of PTM,in order to provide new insights into the clinical implication of PTM in HCC.

关键词： Diagnosis Hepatocellular carcinoma Post-translational modification Prognosis

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Modulation of IL-37 expression by triptolide and triptonide in THP-1 cells

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Cellular & molecular Immunology 2015年第4期12卷 515-518页

作者： Lingge He Zhuangyan Liang Fuqian Zhao Lifei Peng Zhangquan Chen key laboratory for medical molecular Diagnostic of Guangdong Province Guangdong Medical College Dongguan China Department of Clinical /m.munolo .gy. Guangdong Medical College Dongguan China These authors contributed equally to this work.''

IL-37 is an anti-inflammatory cytokine that was only recently identified, and it is highly expressed in tissues from patients with inflammatory and autoimmune diseases. Inflammatory cytokines and inflammatory stimuli can induce the upregulation of IL-37. However, it has not been reported whether anti-inflammatory medications induce the expression of IL-37. In this work, we uncovered, for the first time, that two main bioactive components, triptolide and triptonide, from the herb Tripterygium wilfordii Hook f. （TwHF）, which possess anti-inflammatory activity, upregulate the expression of IL-37, and this expression was suppressed by ERKI/2 and p38 MAPK inhibitors. Overall, our research demonstrated, for the first time, that anti-inflammatory active components （triptolide and triptonide） upregulated the expression of IL-37 most likely via activation of the ERKI/2 and p38 MAPK pathways.

关键词： IL-37 THP-1 cells Tripterygium wilfordii Hook F. triptolide triptonide

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molecular imaging of advanced atherosclerotic plaques with folate receptor-targeted 2D nanoprobes

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Nano research 2020年第1期13卷 173-182页

作者： Zhide Guo Liu Yang Mei Chen Xuejun Wen Huanhuan Liu Jingchao Li Duo Xu Yuanyuan An Changrong Shi Jindian Li Xinhui Su Zijing Li Ting Liu Rongqiang Zhuang Nanfeng Zheng Haibo Zhu Xianzhong Zhang State key laboratory of molecular Vaccinology and molecular Diagnostics&Center for molecular Imaging and translational Medicine School of Public HealthXiamen UniversityXiamen361102China State key laboratory for bioactive Substances and Functions of Natural Medicines Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation StudyInstitute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing100050China College of Materials Science and Engineering Hunan UniversityChangsha410082China The State key laboratory for Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy MaterialsDepartment of ChemistryXiamen UniversityXiamen361005China Zhongshan Hospital Affiliated to Xiamen University Xiamen361004China

Vulnerable atherosclerotic plaques are responsible for most cardiovascular diseases(CVDs).Folate receptor(FR)positive activated macrophages were thought to be a prominent component in the development of vulnerable *** objective of this study is to develop folate conjugated two-dimensional(2D)Pd@Au nanomaterials(Pd@Au-PEG-FA)for targeted multimodal imaging of the FRs in advanced atherosclerotic *** and imaging studies(single photon emission computed tomography(SPECT),computed tomography(CT)and photoacoustic(PA)imaging)were performed to confirm the prolonged blood half-life and enrichment of radioactivity in atherosclerotic *** signals were detected in vivo with SPECT,CT and PA imaging in heavy atherosclerotic plaques,which were significantly higher than those of the normal aortas after injection of Pd@*** studies with preinjection of excess FA could effectively reduce the targeting ability of Pd@Au-PEG-FA in atherosclerotic plaques,further demonstrating the specific binding of Pd@Au-PEG-FA for plaque *** characterization revealed that the signal of probe was in accordance with the high-risk *** summary,the Pd@Au-PEG-FA has favorable pharmacokinetic properties and provides a valuable approach for detecting high-risk plaques in the presence of FRs in atherosclerotic plaques.

关键词： 2D material folate receptor multifunctional imaging activated macrophages atherosclerosis

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Tailoring therapeutics via a systematic beneficial elements comparison between photosynthetic bacteria-derived OMVs and extruded nanovesicles

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bioactive Materials 2024年第6期36卷 48-61页

作者： Tingshan Xiao Yichuan Ma Ziyang Zhang Yixin Zhang Yu Zhao Xiaohan Zhou Xueyi Wang Kun Ge Junshu Guo Jinchao Zhang Zhenhua Li Huifang Liu College of Pharmaceutical Science Key Laboratory of Pharmaceutical Quality Control of Hebei ProvinceHebei UniversityBaoding071002China The Tenth Affiliated Hospital Southern Medical University(Dongguan People’s Hospital)Guangdong Provincial Key Laboratory of Cardiac Function and MicrocirculationDongguan 523000China State key laboratory of New Pharmaceutical Preparations and Excipients Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of EducationChemical Biology Key Laboratory of Hebei ProvinceHebei UniversityBaoding071002China College of Chemistry&Materials Science Hebei UniversityBaoding071002China

Photosynthetic bacteria(PSB)has shown significant potential as a drug or drug delivery system owing to their photothermal capabilities and antioxidant ***,the actualization of their potential is impeded by inherent constraints,including their considerable size,heightened immunogenicity and compromised *** these obstacles and pursuing more effective solutions remains a top *** to extracellular vesicles,bacterial outer membrane vesicles(OMVs)have demonstrated a great potential in biomedical *** from PSB encapsulate a rich array of bioactive constituents,including proteins,nucleic acids,and lipids inherited from their parent ***,they emerge as a promising and practical ***,OMVs have suffered from low yield and inconsistent particle *** response,bacteria-derived nanovesicles(BNVs),created through controlled extrusion,adeptly overcome the challenges associated with ***,the differences,both in composition and subsequent biological effects,between OMVs and BNVs remain *** a groundbreaking endeavor,our study meticulously cultivates PSB-derived OMVs and BNVs,dissecting their *** minimal differences in morphology and size between PSB-derived OMVs and BNVs,the latter contains a higher concentration of active ingredients and *** noteworthy is the elevated levels of lysophosphatidylcholine(LPC)found in BNVs,known for its ability to enhance cell proliferation and initiate downstream signaling pathways that promote angiogenesis and ***,our results indicate that BNVs can accelerate wound closure more effectively by orchestrating a harmonious balance of cell proliferation and migration within NIH-3T3 cells,while also activating the EGFR/AKT/PI3K *** contrast,OMVs have a pronounced aptitude in anti-cancer efforts,driving macrophages toward the M1 phenotype and promoting the release of inflammatory

关键词： Photosynthetic bacteria Outer membrane vesicles Bacteria-derived nanovesicles Antitumor Lysophosphatidylcholine

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NIR-II light triggered burst-release cascade nanoreactor for precise cancer chemotherapy

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bioactive Materials 2024年第3期33卷 311-323页

作者： Yu-Jing Pan Yang Zhang Biao-Qi Chen Yi Zhao Jin-Yang Wang Chang-Yong Li Da-Gui Zhang Ranjith Kumar Kankala Shi-Bin Wang Gang Liu Ai-Zheng Chen Fujian Provincial key laboratory of Biochemical Technology&Institute of Biomaterials and Tissue Engineering Huaqiao UniversityXiamen361021China Center for Nanomedicine and Department of Anesthesiology Perioperative and Pain MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA02115USA State key laboratory of Vaccines for Infectious Diseases Xiang An Biomedicine LaboratoryNational Innovation Platform for Industry-Education Integration in Vaccine ResearchState Key Laboratory of Molecular Vaccinology and Molecular DiagnosticsCenter for Molecular Imaging and Translational MedicineSchool of Public HealthXiamen UniversityXiamen361102China

The current strategy of co-delivering copper ions and disulfiram(DSF)to generate cytotoxic CuET faces limitations in achieving rapid and substantial CuET production,specifically in tumor *** overcome this challenge,we introduce a novel burst-release cascade reactor composed of phase change materials(PCMs)encapsulating ultrasmall Cu_(2-x)Se nanoparticles(NPs)and DSF(DSF/Cu_(2-x)Se@PCM).Once triggered by second near-infrared(NIR-II)light irradiation,the reactor swiftly releases Cu_(2-x)Se NPs and DSF,enabling catalytic reactions that lead to the rapid and massive production of Cu_(2-x)Se-ET complexes,thereby achieving in situ *** mechanism of the burst reaction is due to the unique properties of ultrasmall Cu_(2-x)Se NPs,including their small size,multiple defects,and high surface *** characteristics allow DSF to be directly reduced and chelated on the surface defect sites of Cu_(2-x)Se,forming Cu_(2-x)Se-ET complexes without the need for copper ion ***,Cu_(2-x)Se-ET has demonstrated a similar(to CuET)anti-tumor activity through increased autophagy,but with even greater potency due to its unique two-dimensional-like *** light-triggered cascade of interlocking reactions,coupled with in situ explosive generation of tumor-suppressive substances mediated by the size and valence of Cu_(2-x)Se,presents a promising approach for the development of innovative nanoplatforms in the field of precise tumor chemotherapy.

关键词： Ultrasmall Cu_(2-x)Se nanoparticles High surface activity Nanoreactor Phase change materials Precise chemotherapy

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Double crosslinked biomimetic composite hydrogels containing topographical cues and WAY-316606 induce neural tissue regeneration and functional recovery after spinal cord injury

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bioactive Materials 2023年第6期24卷 331-345页

作者： Xingchang Zhao Xianzhe Lu Kai Li Shiqiang Song Zhaohui Luo Chuanchuan Zheng Chengliang Yang Xiumei Wang Liqiang Wang Yujin Tang Chong Wang Jia Liu Department of Orthopaedics Affiliated Hospital of Youjiang Medical University for NationalitiesBaiseGuangxiChina Guangxi key laboratory of Basic and translational research of Bone and Joint Degenerative Diseases Guangxi Biomedical Materials Engineering Research Center for Bone and Joint Degenerative DiseasesBaiseGuangxiChina Academy of Orthopedics Guangdong ProvinceGuangdong Provincial Key Laboratory of Bone and Joint Degeneration DiseasesThe Third Affiliated Hospital of Southern Medical UniversityGuangzhouChina Youjiang medical University for Nationalities BaiseGuangxiChina School of Mechanical Engineering Dongguan University of TechnologySongshan LakeDongguanGuangdongChina State key laboratory of New Ceramics and Fine Processing Key Laboratory of Advanced Materials of Ministry of EducationSchool of Materials Science and EngineeringTsinghua UniversityBeijingChina State key laboratory of Metal Matrix Composites School of Material Science and EngineeringShanghai Jiao Tong UniversityShanghaiChina

Spinal cord injury(SCI)is an overwhelming and incurable disabling condition,for which increasing forms of multifunctional biomaterials are being tested,but with limited *** promising material should be able to fill SCI-induced cavities and direct the growth of new neurons,with effective drug loading to improve the local micro-organism environment and promote neural tissue *** this study,a double crosslinked biomimetic composite hydrogel comprised of acellularized spinal cord matrix(ASCM)and gelatin-acrylated-β-cyclodextrin-polyethene glycol diacrylate(designated G-CD-PEGDA)hydrogel,loaded with WAY-316606 to activate canonical Wnt/β-catenin signaling,and reinforced by a bundle of three-dimensionally printed aligned polycaprolactone(PCL)microfibers,was *** G-CD-PEGDA component endowed the composite hydrogel with a dynamic structure with a self-healing capability which enabled cell migration,while the ASCM component promoted neural cell affinity and *** diffusion of WAY-316606 could recruit endogenous neural stem cells and improve neuronal *** aligned PCL microfibers guided neurite elongation in the longitudinal *** behavior studies further showed that the composite hydrogel could significantly recover the motor function of rats after *** study provides a proficient approach to produce a multifunctional system with desirable physiological,chemical,and topographical cues for treating patients with SCI.

关键词： Spinal cord injury 3D printing PCL oriented fibers WAY-316606 Wnt/β-catenin signaling

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In situ immunomodulation of tumors with biosynthetic bacteria promote anti-tumor immunity

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bioactive Materials 2024年第2期32卷 12-27页

作者： Zhongda Lin Fanqiang Meng Yumeng Ma Chi Zhang Zhirang Zhang Zhaoxin Yang Yuan Li Linlin Hou Yuzhong Xu Xin Liang Xudong Zhang Shenzhen key laboratory for Systems Medicine in Inflammatory Diseases School of MedicineShenzhen Campus of Sun Yat-Sen UniversitySun Yat-Sen UniversityShenzhen518107GuangdongChina Guangdong Provincial key laboratory of medical molecular Diagnostics Key Laboratory of Stem Cell and Regenerative Tissue EngineeringSchool of Basic Medical SciencesGuangdong Medical UniversityDongguan523808China Department of Clinical laboratory Shenzhen Baoan HospitalThe Second Affiliated Hospital of Shenzhen UniversityShenzhen518101China

Immune checkpoint blockade(ICB)therapy potently revives T cell’s response to ***,patients suffered with tumors that had inadequate infiltrated immune cells only receive limited therapeutic benefits from ICB *** biology promotes the alternative strategy of harnessing tumor-targeting bacteria to synthesize therapeutics to modulate immunity in ***,we engineered attenuated Salmonella typhimurium VNP20009 with gene circuits to synthetize granulocyte-macrophage colony-stimulating factor(GM-CSF)and interleukin 7(IL-7)within tumors,which recruited dendritic cells(DCs)and enhanced T cell priming to elicit anti-tumor *** bacteria-produced GM-CSF stimulated the maturation of bone marrow-derived dendritic cells(BMDCs),while IL-7 promoted the proliferation of spleen isolated T cells and inhibited cytotoxicity T cell apoptosis in ***,engineered VNP20009 prefer to colonize in tumors,and inhibited tumor growth by enhancing DCs and T cell ***,the tumor-toxic GZMB^(+)CD8^(+)T cell and IFN-γ^(+)CD8^(+)T cell populations conspicuously increased with the treatment of engineered *** combination of GM-CSF-IL-7-VNP20009 with PD-1 antibody synergistically stunted the tumor progress and metastasis.

关键词： Salmonella GM-CSF IL-7 Synthetic biology Cancer immunotherapies

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Selection and identification of a novel ssDNA aptamer targeting human skeletal muscle

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bioactive Materials 2023年第2期20卷 166-178页

作者： Shuming Sun Han Liu Yan Hu Yanpeng Wang Mingri Zhao Yijun Yuan Yafei Han Yingying Jing Jin Cui Xiaoxiang Ren Xiao Chen Jiacan Su molecular Biology research Center Center for Medical GeneticsHunan Province Key Laboratory of Basic and Applied HematologySchool of Life SciencesCentral South UniversityChangsha410078China Institute of translational Medicine Shanghai UniversityShanghai200444China Center for medical Genetics&Hunan key laboratory of medical Genetics School of Life SciencesCentral South UniversityChangsh1Hunan410013China molecular Science and Biomedicine laboratory(MBL) State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of BiologyCollege of Chemistry and Chemical EngineeringAptamer Engineering Center of Hunan ProvinceHunan UniversityChangshaHunan410082China Department of Orthopedics Traum1 Shanghai Changhai HospitalNaval Medical UniversityShanghai200433China

Skeletal muscle disorders have posed great threats to *** delivery of drugs and oligonucleotides to skeletal muscle is *** can improve targeting *** this study,for the first time,the human skeletal muscle-specific ssDNA aptamers(HSM01,etc.)were selected and identified with Systematic Evolution of Ligands by Exponential Enrichment(SELEX).The HSM01 ssDNA aptamer preferentially interacted with human skeletal muscle cells in *** in vivo study using tree shrews showed that the HSM01 ssDNA aptamer specifically targeted human skeletal muscle ***,the ability of HSM01 ssDNA aptamer to target skeletal muscle cells was not affected by the formation of a disulfide bond with nanoliposomes in vitro or in vivo,suggesting a potential new approach for targeted drug delivery to skeletal muscles via ***,this newly identified ssDNA aptamer and nanoliposome modification could be used for the treatment of human skeletal muscle diseases.

关键词： Aptamer SELEX Human skeletal muscle Target delivery Nanoliposomes

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Astragalus Polysaccharide Enhances Voriconazole Metabolism under Inflammatory Conditions through the Gut Microbiota

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Journal of Clinical and translational Hepatology 2024年第5期12卷 481-495页

作者： Xiaokang Wang Xianjing Hu Chunxiao Ye Jingqian Zhao Shing Cheng Tan Liangbin Zhou Chenyu Zhao Kit Hang Wu Xixiao Yang Jinbin Wei Maoxun Yang The Marine Biomedical research Institute of Guangdong Zhanjiang ZhanjiangGuangdongChina Guangdong Provincial key laboratory of research and Development of Natural Drugs Guangdong Medical UniversityDongguanGuangdongChina Department of Pharmacy Shenzhen Longhua District Central HospitalShenzhenGuangdongChina dongguan key laboratory of Chronic Inflammatory Diseases The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdongChina Department of Pharmacy The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdongChina Department of Pharmacy Shenzhen Hospital of Southern Medical UniversityShenzhenGuangdongChina UKM medical molecular Biology Institute Universiti Kebangsaan MalaysiaKuala LumpurMalaysia Department of Biomedical Engineering Faculty of EngineeringThe Chinese University of Hong KongHong Kong SARChina Department of Pharmacy Nossa Senhora do Carmo-Lago Health CentreHealth BureauMacaoChina Pharmaceutical College Guangxi Medical UniversityNanningGuangxiChina

Background and Aims:Voriconazole(VRC),a widely used antifungal drug,often causes hepatotoxicity,which presents a significant clinical *** studies demonstrated that Astragalus polysaccharide(APS)can regulate VRC metabolism,thereby potentially mitigating its hepatotoxic *** this study,we aimed to explore the mechanism by which APS regulates VRC ***:First,we assessed the association of abnormal VRC metabolism with hepatotoxicity using the Roussel Uclaf Causality Assessment Method ***,we conducted a series of basic experiments to verify the promotive effect of APS on VRC *** in vitro and in vivo assays,including cytokine profiling,immunohistochemistry,quantitative polymerase chain reaction,metabolite analysis,and drug concentration measurements,were performed using a lipopolysaccharideinduced rat inflammation ***,experiments such as intestinal biodiversity analysis,intestinal clearance assessments,and Bifidobacterium bifidum replenishment were performed to examine the ability of *** to regulate the expression of the VRC-metabolizing enzyme CYP2C19 through the gut–liver ***:The results indicated that APS does not have a direct effect on ***,the assessment of gut microbiota function revealed that APS significantly increases the abundance of ***,which could lead to an anti-inflammatory response in the liver and indirectly enhance VRC *** dual-luciferase reporter gene assay revealed that APS can hinder the secretion of pro-inflammatory mediators and reduce the inhibitory effect on CYP2C19 transcription through the nuclear factor-κB signaling ***:The study offers valuable insights into the mechanism by which APS alleviates VRC-induced liver damage,highlighting its immunomodulatory influence on hepatic tissues and its indirect regulatory control of VRC-metabolizing enzymes within hepatocytes.

关键词： Astragalus polysaccharide Voriconazole Metabolism RUCAM Bifidobacterium bifidum Anti-inflammatory responses Gut Microbiota Hepatotoxicity

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