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The association of isocarbophos and isofenphos with different types of glucose metabolism:The role of inflammatory cells

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Journal of Environmental Sciences 2025年第1期147卷 322-331页

作者： Jintian Geng Dandan Wei Lulu Wang Qingqing Xu Juan Wang Jiayu Shi Cuicui Ma Mengzhen Zhao Wenqian Huo Tao Jing Chongjian Wang Zhenxing Mao Department of Epidemiology and Biostatistics College of Public HealthZhengzhou UniversityZhengzhou 450001China Department of Occupational and Environmental health Sciences College of Public HealthZhengzhou UniversityZhengzhou 450001China School of public health Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074China

To investigate the associations between isocarbophos and isofenphos with impaired fasting glucose(IFG)and type 2 diabetes mellitus(T2DM),and to assess the mediation roles of inflammation *** were 2701 participants in the case-control study,including 896 patients with T2DM,900 patients with IFG,905 subjects with *** isocarbophos and isofenphos concentrationsweremeasured using gas chromatography and triple quadrupole tandem mass *** linear models were used to calculate the relationships between plasma isofenphos and isocarbophos levels with inflammatory factor levels and *** cell was used as mediators to estimate the mediating effects on the above *** and isofenphos were positively related with T2DM after adjusting for other *** odds ratio(95%confidence interval)(OR(95%CI))for T2DM was 1.041(1.015,1.068)and for IFG was 1.066(1.009,1.127)per unit rise in *** prevalence of T2DM increased by 6.4%for every 1 unit more of ln-isofenphos(OR(95%CI):1.064(1.041,1.087)).Additionally,a 100%rise in ln-isocarbophos was linked to 3.3%higher ln-HOMA2IR and a 0.029 mmol/L higher glycosylated hemoglobin(HbA1c)(95%CI:0.007,0.051).While a 100%rise in ln-isofenphos was linked to increase in ln-HOMA2 and ln-HOMA2IR of 5.8%and 3.4%,***,white blood cell(WBC)and neutrophilic(NE)were found to be mediators in the relationship between isocarbophos and T2DM,and the corresponding proportions were 17.12%and 17.67%,*** and isocarbophos are associated with IFG and T2DM in the rural Chinese population,WBC and NE have a significant role in this relationship.

关键词： Isocarbophos Isofenphos Type 2 diabetes mellitus Inflammatory cells Mediation effect

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Efficacy of acupuncture plus Tuina in agriculturists with knee osteoarthrosis in Phayao,Thailand:a randomized controlled trial

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Journal of Acupuncture and Tuina Science 2025年第1期23卷 82-88页

作者： Poonyaphat SIRITEERATHITIKUL Monticha KUNYALUE Yaowasak YAOWAPANKUL Punyisa PUDPONG Namngern CHANTARAMANEE Sasivimol BOOTSIKEAW Taweewun SRISOOKKUM Department of Traditional Chinese Medicine School of Public HealthUniversity of PhayaoPhayao 56000Thailand Giwon Clinic Chonburi 20150Thailand Department of Occupational health and Safety School of Public HealthUniversity of PhayaoPhayao 56000Thailand doctor of public health program School of Public HealthUniversity of PhayaoPhayao 56000Thailand

Objective:To study the efficacy of acupuncture combined with Tuina(Chinese therapeutic massage)compared to acupuncture alone and sham acupuncture in aspects of symptom control and mobility functions in farmers suffering from knee osteoarthrosis(KOA).Methods:Individuals enrolled at a community hospital in Thailand were extended invitations to take part in the research *** who volunteered provided informed consent and were then randomly assigned to one of three groups,namely the combined group,the acupuncture group,and the control ***-four cases in the combined group received acupuncture and Tuina treatments;32 cases in the acupuncture group received acupuncture alone;and 30 cases in the control group received sham acupuncture *** group underwent therapeutic sessions once daily for 10 *** the main outcome measured,the Western Ontario and McMaster Universities osteoarthritis index(WOMAC)was used to assess pain,stiffness,and *** secondary outcomes included movement angles measured with a goniometer and balance function evaluated by the timed up and go ***:A total of 96 patients were *** the intervention,WOMAC total score and pain,stiffness,and function scores were significantly reduced and the joint range of motion was improved in both the combined group and the acupuncture group when compared to the control group(P<0.05);there were no significant differences between the combined group and the acupuncture *** to the acupuncture group,a lowered balance score was observed in the combined group(P<0.05).Conclusion:After once-daily interventions for 10 consecutive days in KOA patients,both the combination of acupuncture and Tuina and acupuncture alone proved effective in alleviating pain and improving the range of motion compared to the control group.

关键词： Acupuncture Tuina Massage Alternative Medicine Osteoarthritis,Knee Randomized Controlled Trial

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Association between Per and Polyfluoroalkyl Substance and Abdominal Fat Distribution:A Trait Spectrum Exposure Pattern and Structure-Based Investigation

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Biomedical and Environmental Sciences 2025年第1期38卷 3-14页

作者： Zhi Li Shilin Shan Chenyang Song Chengzhe Tao Hong Qian Qin Yuan Yan Zhang Qiaoqiao Xu Yufeng Qin Yun Fan Chuncheng Lu State Key Laboratory of Reproductive Medicine Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjing 211166JiangsuChina Key Laboratory of Modern Toxicology of Ministry of Education School of Public HealthNanjing Medical UniversityNanjing 211166JiangsuChina Department of public health Kangda College of Nanjing Medical UniversityLianyungang 222000JiangsuChina Department of Microbes and Infection School of Public HealthNanjing Medical UniversityNanjing 211166JiangsuChina

Objective To investigate the associations between eight serum per-and polyfluoroalkyl substances(PFASs)and regional fat depots,we analyzed the data from the National health and Nutrition Examination Survey(NHANES)2011-2018 *** Multiple linear regression models were developed to explore the associations between serum PFAS concentrations and six fat compositions along with a fat distribution score created by summing the concentrations of the six fat *** associations between structurally grouped PFASs and fat distribution were assessed,and a prediction model was developed to estimate the ability of PFAS exposure to predict obesity *** Among females aged 39-59 years,trunk fat mass was positively associated with perfluorooctane sulfonate(PFOS).Higher concentrations of PFOS,perfluorohexane sulfonate(PFHxS),perfluorodecanoate(PFDeA),perfluorononanoate(PFNA),and n-perfluorooctanoate(n-PFOA)were linked to greater visceral adipose tissue in this *** men,exposure to total perfluoroalkane sulfonates(PFSAs)and long-chain PFSAs was associated with reductions in abdominal fat,while higher abdominal fat in women aged 39-59 years was associated with short-chain *** prediction model demonstrated high accuracy,with an area under the curve(AUC)of 0.9925 for predicting obesity *** PFAS exposure is associated with regional fat distribution,with varying effects based on age,sex,and PFAS *** findings highlight the potential role of PFAS exposure in influencing fat depots and obesity risk,with significant implications for public *** prediction model provides a highly accurate tool for assessing obesity risk related to PFAS exposure.

关键词： Per-and polyfluoroalkyl substances Regional fat depots Obesity Structure-based NHANES

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Real-world cost-effectiveness of targeted temperature management in out-of-hospital cardiac arrest survivors: results from an academic medical center

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World Journal of Emergency Medicine 2025年第1期16卷 28-34页

作者： Wachira Wongtanasarasin Daniel K.Nishijima Wanrudee Isaranuwatchai Jeff rey S.Hoch Department of Emergency Medicine Faculty of MedicineChiang Mai UniversityChiang Mai 50200Thailand Department of Emergency Medicine University of California Davis School of MedicineSacramento 95817USA health Intervention and Technology Assessment program Ministry of Public HealthBangkok 11000Thailand Institute of health Policy Management and EvaluationUniversity of TorontoToronto M5T 3M6Canada Division of health Policy and Management Department of Public Health SciencesUniversity of California Davis School of MedicineSacramento 95817USA Center for healthcare Policy and Research University of California Davis School of MedicineSacramento 95817USA

BACKGROUND: Targeted temperature management(TTM) is a common therapeutic intervention, yet its cost-effectiveness remains uncertain. This study aimed to evaluate the real-world cost-effectiveness of TTM compared with that of conventional care in adult out-of-hospital cardiac arrest(OHCA) survivors using clinical patient-level ***: We conducted a retrospective cohort study at an academic medical center in the USA to assess the cost-effectiveness of TTM in adult non-traumatic OHCA survivors between 1 January, 2019 and 30 June, 2023. The primary outcome was survival to hospital discharge. Incremental cost-effectiveness ratios(ICERs) were calculated and compared with various decision makers' willingness to pay. Cost-effectiveness acceptability curves were utilized to evaluate the economic attractiveness of TTM. Uncertainty about the incremental cost and effect was explored with a 95% confidence ***: Among 925 non-traumatic OHCA survivors, only 30(3%) received TTM. After adjusting for potential confounders, the TTM group did not demonstrate a significantly lower cost(delta cost-$5,141, 95% confidence interval [95% CI]: $-35,347 to $25,065, P=0.79) and higher survival to hospital discharge(delta effect 6%, 95% CI:-11% to 23%, P=0.41). Additionally, a 95% confidence ellipse indicated uncertainty reflected by evidence that the true value of the ICER could be in any of the quadrants of the cost-effectiveness ***: Although TTM did not demonstrate a clear survival benefit in this study, its potential cost-effectiveness warrants further investigation with larger sample sizes. These findings highlight the need for additional research to optimize TTM use in OHCA care and inform resource allocation decisions.

关键词： Out-of-hospital cardiac arrest Targeted temperature management Cost-effectiveness Survival Real-world data

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Water Quality,Influential Factors,and Management Strategies from 2016 to 2020 in the Yangtze River Economic Belt,China

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Chinese Geographical Science 2025年第1期35卷 175-186页

作者： LIN Lanyu GUO Congrong CHEN Yanan HE Lihuan YAN Luyu FANG Dekun MA Guangwen ZHANG Fengying LI Mingsheng China National Environmental Monitoring Centre Beijing 100012China Department of health Ethics&SocietyCare and Public Health Research InstituteFaculty of HealthMedicine and Life SciencesMaastricht UniversityMaastricht 6200the Netherlands

The Yangtze River economic belt(YREB),China is important to the Chinese economy and for supporting sustainable *** the relationship between water quality indices and socioeconomic indicators could help improve aquatic environment management in the YREB and our understanding of the causes and effects of water quality variations in other large river *** this study,river water quality,factors affecting water quality,and management strategies,and correlations between water quality indices and socioeconomic indicators in the YREB during the 13th Five-Year Plan period(2016-2020)were *** single-factor evaluation method,constant price for GDP,and correlation analyses were *** results showed that:1)water quality in the YREB improved during the 13th Five-Year Plan *** number of aquatic environment sections meeting GradeⅠ-Ⅲwater quality standards increased by 13.1%and the number below Grade V decreased by 2.9%.2)The values of 12 indicators in the YREB exceeded relevant *** indicators with highest concentreation were the total phosphorus,chemical oxygen demand,ammonia nitrogen,and permanganate index,which were relatively high in downstream regions in Anhui Province,Jiangsu Province,and Shanghai Municipality.3)Ammonia nitrogen,chemical oxygen demand,and total phosphorus emissions per unit area and water extraction per unit area are relatively high in the three downstream regions mentioned above.4)Increased domestic sewage discharges have increased total wastewater discharges in the YREB.5)River water quality in the YREB strongly correlated with population,economic,and water resource indices and less strongly correlated with government investment,agriculture,meteorology,energy,and forestry *** confirmed the need to decrease wastewater discharges and non-point-source pollutant *** aquatic environment could be improved by taking reasonable measures to control population growth,adjusting the industrial str

关键词： water quality factors coping strategies Yangtze River economic belt(YREB),China

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Association between Fish Consumption and Stroke Incidence Across Different Predicted Risk Populations:A Prospective Cohort Study from China

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Biomedical and Environmental Sciences 2025年第1期38卷 15-26页

作者： Hongyue Hu Fangchao Liu Keyong Huang Chong Shen Jian Liao Jianxin Li Chenxi Yuan Ying Li Xueli Yang Jichun Chen Jie Cao Shufeng Chen Dongsheng Hu Jianfeng Huang Xiangfeng Lu Dongfeng Gu Department of Epidemiology Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjing 211166JiangsuChina Department of Epidemiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Key Laboratory of Cardiovascular Epidemiology Chinese Academy of Medical SciencesBeijing 100037China Research Units of Cohort Study on Cardiovascular Diseases and Cancers Chinese Academy of Medical SciencesBeijing 100730China School of public health and Emergency Management Southern University of Science and TechnologyShenzhen 518055GuangdongChina Department of Occupational and Environmental health School of Public HealthTianjin Medical UniversityTianjin 300070China Department of Epidemiology and health Statistics College of Public HealthZhengzhou UniversityZhengzhou 450001HenanChina Department of Epidemiology and health Statistics School of Public HealthShenzhen University Health Science CenterShenzhen 518071GuangdongChina

Objective The relationship between fish consumption and stroke is inconsistent,and it is uncertain whether this association varies across predicted stroke *** A cohort study comprising 95,800 participants from the Prediction for Atherosclerotic Cardiovascular Disease Risk in China project was conducted.A standardized questionnaire was used to collect data on fish *** were stratified into low-and moderate-to-high-risk categories based on their 10-year stroke risk prediction *** ratios(HRs)and 95%confidence intervals(CIs)were estimated using Cox proportional hazard models and additive interaction by relative excess risk due to interaction(RERI),attributable proportion(AP),and synergy index(SI).Results During 703,869 person-years of follow-up,2,773 incident stroke events were *** fish consumption was associated with a lower risk of stroke,particularly among moderate-to-high-risk individuals(HR=0.53,95%CI:0.47-0.60)than among low-risk individuals(HR=0.64,95%CI:0.49-0.85).A significant additive interaction between fish consumption and predicted stroke risk was observed(RERI=4.08,95%CI:2.80-5.36;SI=1.64,95%CI:1.42-1.89;AP=0.36,95%CI:0.28-0.43).Conclusion Higher fish consumption was associated with a lower risk of stroke,and this beneficial association was more pronounced in individuals with moderate-to-high stroke risk.

关键词： Fish consumption Stroke Predicted stroke risk Cohort study Interaction

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Genetic variants and mRNA expression levels of KLF4 and KLF5 with hypertension:A combination of case-control study and cohort study

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Journal of Biomedical Research 2025年第1期39卷 103-113页

作者： Xu Han Wen Li Changying Chen Jiahui Liu Junxiang Sun Feifan Wang Chao Wang Jialing Mu Xincheng Gu Fangyuan Liu Hankun Xie Song Yang Chong Shen Department of Epidemiology Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Cardiology the Affiliated Yixing People's Hospital of Jiangsu UniversityPeople's Hospital of Yixing CityWuxiJiangsu 214200China Department of Environmental Genomics School of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China

Hypertension(HT)is a major risk factor for cardiovascular ***üppel-like factors(KLFs)are important transcription factors in *** have reported that KLF4 and KLF5 are correlated with several cardiovascular diseases,but population-based studies on associations between HT and KLF4 or KLF5 have rarely been ***,the current study investigated the associations of genetic variants and m RNA expression levels of KLF4 and KLF5 with HT,as well as the effects of antihypertensive drugs on the expression levels of these *** associations of one single-nucleotide polymorphism(SNP)in KLF4 and three SNPs in KLF5with HT were analyzed using a combination of case-control and cohort *** study populations were selected from a community-based cohort in four regions of Jiangsu *** risks of HT were estimated through logistic and Cox regression *** addition,m RNA expression levels of KLF4 and KLF5 were detected in 246 controls and 385 HT cases selected from the aforementioned *** the HT cases,263were not taking antihypertensive drugs[AHD(-)]and 122 were taking antihypertensive drugs[AHD(+)].In the case-control study,SNP rs9573096(C>T)in KLF5 was significantly associated with an increased risk of HT in the additive model(adjusted odds ratio[OR],1.106;95%confidence interval[CI],1.009 to 1.212).In the cohort study of the normotensive population,rs9573096 in KLF5 was also significantly associated with an increased risk of HT in the additive model(adjusted hazards ratio[HR],1.199;95%CI,1.070 to 1.344).KLF4 and KLF5m RNA expression levels were significantly higher in the AHD(-)group than in the control group(P<0.05),but lower in the AHD(+)group than in the AHD(-)group(P<0.05).The current study demonstrated the associations of KLF4 and KLF5 genetic variants with hypertension,as well as the association of the indicative variations in m RNA expression levels of KLF4 and KLF5 with the risk of hypertension and antihypertensive

关键词： hypertension KLF4 KLF5 single-nucleotide polymorphism mRNA expression antihypertensive drugs

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Clinical characteristics of patients with hepatitis and cirrhosis and the construction of a prediction model

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World Journal of Hepatology 2025年第2期17卷 54-64页

作者： Yu-Shuang Huang Wei Gao Ai-Jun Sun Chun-Wen Pu Shuang-Shuang Xu Department of Infectious Diseases Dalian Public Health Clinical CenterDalian 116031Liaoning ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Dalian Medical UniversityDalian 116011Liaoning ProvinceChina Dalian public health Clinical Center Dalian Municipal Research Institute for Public HealthDalian 116031Liaoning ProvinceChina

BACKGROUND Hepatitis B-associated cirrhosis is an important disease burden in ***,there is a lack of effective predictors in clinical practice to drive delivery and enable early treatment to delay disease *** To analyzing the clinical characteristics of patients with hepatitis and cirrhosis,the nomogram model was established and *** The clinical data of 1070 patients with hepatitis B who were treated in our hospital from October 2015 to July 2022 were *** a 7:3 ratio,749 cases were divided into training cohorts and 321 cases were divided into validation *** addition,the training cohort and validation cohort were further divided into hepatitis group and hepatitis B-related cirrhosis group based on whether the patient progressed to *** logistic regression was used to analyze the influencing factors of hepatitis progression to cirrhosis.A roadmap prediction model was established,and the predictive effect of the model was evaluated by patientsubject receiver operating characteristic curve(ROC),and the effectiveness of the model was evaluated by decision curve *** Binary logistic regression analysis was performed using hepatitis B-related cirrhosis=1 and hepatitis=0 as dependent variables,and univariate analysis of serological indicators was used as *** results showed that glutamic oxaloacetate aminotransferase/glutamate acetone aminotransferase levels,prothrombin time activity,and hepatitis B e antigen levels were all contributing factors to the progression of hepatitis to *** area under the ROC curve was 0.693[95%confidence interval(CI):0.631 to 0.756]for the training cohort and 0.675(95%CI:0.561 to 0.790)for the validation *** addition,the decision analysis curves of the prediction models of both the training cohort and the validation cohort confirmed the effectiveness of the nomogram prediction *** Three independent factors influencing the progression

关键词： Hepatitis Hepatitis B-related cirrhosis Clinical features Influencing factors Nomogram

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Physiology and health assessment,risk balance,and model for endstage liver disease scores:Postoperative outcome of liver transplantation

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World Journal of Transplantation 2025年第1期15卷 86-94页

作者： Raquel Hohenreuther Andresa ThoméSilveira Edison Moraes Rodrigues Filho Anderson Garcez Bruna Goularth Lacerda Sabrina Alves Fernandes Claudio Augusto Marroni Postgraduate program in Hepatology Universidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90050-170Brazil Department of Intensive Medicine Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Brazil Department of public health University of Vale do Rio dos SinosSao Leopoldo 93022-750Brazil

BACKGROUND Liver transplantation aims to increase the survival of patients with end-stage liver diseases and improve their quality of *** number of organs available for transplantation is lower than the *** provide fair organ distribution,predictive mortality scores have been *** To compare the Acute Physiology and Chronic health Evaluation IV(APACHE IV),balance of risk(BAR),and model for end-stage liver disease(MELD)scores as predictors of *** Retrospective cohort study,which included 283 adult patients in the postoperative period of deceased donor liver transplantation from 2014 to *** The transplant recipients were mainly male,with a mean age of 58.1 *** were mostly male,with a mean age of 41.6 *** median cold ischemia time was 3.1 hours,and the median intensive care unit stay was 5 *** APACHE IV,a mean of 59.6 was found,BAR 10.7,and MELD *** 28-day mortality rate was 9.5%,and at 90 days,it was 3.5%.The 28-day mortality prediction for APACHE IV was very good[area under the curve(AUC):0.85,P<0.001,95%CI:0.76-0.94],P<0.001,BAR(AUC:0.70,P<0.001,95%CI:0.58–0.81),and MELD(AUC:0.66,P<0.006,95%CI:0.55-0.78),P<*** 90 days,the data for APACHE IV were very good(AUC:0.80,P<0.001,95%CI:0.71–0.90)and moderate for BAR and MELD,respectively,(AUC:0.66,P<0.004,95%CI:0.55–0.77),(AUC:0.62,P<0.026,95%CI:0.51–0.72).All showed good discrimination between deaths and *** for the best value for liver transplantation,it was significant only for APACHE IV(P<0.001).CONCLUSION The APACHE IV assessment score was more accurate than BAR and MELD in predicting mortality in deceased donor liver transplant recipients.

关键词： Liver transplantation Acute physiology and chronic health evaluation IV Balance of risk Model for end-stage liver disease Mortality Intensive care unit

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A Feature Transformation and Selection Method to Acquire an Interpretable Model Incorporating Nonlinear Effects

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Acta Mathematica Sinica,English Series 2025年第2期41卷 703-732页

作者： Yu Zheng Jin Zhu Junxian Zhu Xueqin Wang International Institute of Finance School of ManagementUniversity of Science and Technology of China Department of Statistical Science School of Mathematics Sun Yat-Sen University Saw Swee Hock School of public health National University of Singapore

Finding a highly interpretable nonlinear model has been an important yet challenging problem, and related research is relatively scarce in the current literature. To tackle this issue, we propose a new algorithm called Feat-ABESS based on a framework that utilizes feature transformation and selection for re-interpreting many machine learning algorithms. The core idea behind Feat-ABESS is to parameterize interpretable feature transformation within this framework and construct an objective function based on these parameters. This approach enables us to identify a proper interpretable feature transformation from the optimization perspective. By leveraging a recently advanced optimization technique, Feat-ABESS can obtain a concise and interpretable model. Moreover, Feat-ABESS can perform nonlinear variable selection. Our extensive experiments on 205 benchmark datasets and case studies on two datasets have demonstrated that Feat-ABESS can achieve powerful prediction accuracy while maintaining a high level of interpretability. The comparison with existing nonlinear variable selection methods exhibits Feat-ABESS has a higher true positive rate and a lower false discovery rate.

关键词： Interpretable machine learning Bayesian optimization Adaptive best subset selection Nonlinear variable selection Feature transformation

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