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Correlation of abnormal histology with endoscopic findings among mycophenolate mofetil treated patients

World Journal of Gastrointestinal Endoscopy 2017年第8期9卷 405-410页

作者： Mitchell A Izower Merajur Rahman Ernesto P Molmenti Madhu C Bhaskaran Viren G Amin Sundas Khan Keith Sultan Department of Medicine North Shore University Hospital Division of Gastroenterology Department of MedicineNorth Shore University Hospital Department of Surgery North Shore University Hospital divison of nephrology Department of MedicineNorth Shore University Hospital the Feinstein Institute for Biomedical Research

AIM To describe all abnormal histological findings and their associated endoscopic presentation in patients using mycophenolate mofetil(MMF).METHODS A retrospective review of all individuals prescribed MMF within 6 mo of a colonoscopy or flexible sigmoidoscopy between 07/2009 and 09/2015 was performed within Northwell Health *** were analyzed for age,gender,procedure indication,MMF indication,and both gross and microscopic *** reports with abnormal histology were *** One hundred and eighty-four procedures from 170 patients were found,of which 39 met inclusion ***-one point three percent were *** was used for solid organ transplant in 71.8%.Diarrhea was the indication for 71.8% of *** percent of reports revealed gross and microscopic abnormalities while 41.0% had only microscopic *** 11 patients' reports(28.2%) indicated a specific histopathology of MMF *** the entire group,only 23.1% of abnormal histology was isolated proximal to the splenic *** Our results demonstrate a high rate of left sided disease and microscopic findings without gross mucosal abnormalities among patients using ***,a broader definition of MMF-colonopathy may be appropriate,with a majority of our abnormal histology falling outside of the more narrowly defined MMF-colitis *** the high frequency of isolated microscopic abnormalities and distal disease,sigmoidoscopy with random biopsies may be an appropriate,less invasive initial endoscopic examination in selected MMF patients.

关键词： Mycophenolate mofetil 大肠炎 Colonoscopy 腹泻

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