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TEA domain transcription factor 1(TEAD1)induces cardiac fibroblasts cells remodeling through BRD4/Wnt4 pathway

Signal Transduction and Targeted Therapy 2024年第3期9卷 1209-1220页

作者： Shuai Song Xiaokai Zhang Zihang Huang Yongchao Zhao Shuyang Lu Linqi Zeng Fengze Cai Tongyao Wang Zhiqiang Pei Xinyu Weng Wei Luo Hao Lu Zilun Wei Jian Wu Peng Yu Li Shen Xiaochun Zhang Aijun Sun Junbo Ge Department of cardiology Zhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular DiseasesShanghaiChina State Key Laboratory of cardiology Zhongshan HospitalFudan UniversityShanghaiChina Key Laboratory of Viral Heart Diseases National Health CommissionShanghaiChina Key Laboratory of Viral Heart Diseases Chinese Academy of Medical SciencesShanghaiChina National Clinical Research Center for interventional Medicine ShanghaiChina Department of cardiac surgery Zhongshan HospitalFudan UniversityShanghaiChina Institutes of Biomedical Sciences Fudan UniversityShanghaiChina Shanghai Institute of Hypertension Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Cardiac fibroblasts(CFs)are the primary cells tasked with depositing and remodeling collagen and significantly associated with heart failure(HF).TEAD1 has been shown to be essential for heart development and ***,fibroblast endogenous TEAD1 in cardiac remodeling remains incompletely *** analyses revealed consistently upregulated cardiac TEAD1 expression in mice 4 weeks after transverse aortic constriction(TAC)and Ang-l *** investigation revealed that CFs were the primary cell type expressing elevated TEAD1 levels in response to pressure *** TEAD1 knockout was achieved by crossing TEAD1-floxed mice with CFs-and myofibroblasts-specific Cre *** and histological analyses demonstrated that CFs-and myofibroblasts-specific TEAD1 deficiency and treatment with TEAD1 inhibitor,VT103,ameliorated TAC-induced cardiac ***,RNA-seq and ChiP-seq analysis identified Wnt4 as a novel TEAD1 ***1 has been shown to promote the fibroblast-to-myofibroblast transition through the Wnt signalling pathway,and genetic Wnt4 knockdown inhibited the pro-transformation phenotype in CFs with TEAD1 ***,coimmunoprecipitation combined with mass spectrometry,chromatin immunoprecipitation,and luciferase assays demonstrated interaction between TEAD1 and BET protein BRD4,leading to the binding and activation of the Wnt4 *** conclusion,TEAD1 is an essential regulator of the pro-fibrotic CFs phenotype associated with pathological cardiac remodeling via the BRD4/Wnt4 signallingpathway.

关键词： TEAD1 expression Wnt4

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Pathologically successful conversion hepatectomy for advanced giant hepatocellular carcinoma after multidisciplinary therapy:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1647-1659页

作者： Ju-Hang Chu Lu-Yao Huang Ya-Ru Wang Jun Li Shi-Long Han Hao Xi Wen-Xue Gao Ying-Yu Cui Ming-Ping Qian Department of General surgery Shanghai Tenth People's HospitalSchool of MedicineTongji UniversityShanghai 200072China Department of interventional and Vascular surgery Shanghai Tenth People's HospitalSchool of MedicineTongji UniversityShanghai 200072China Department of Pathology Shanghai Tenth People's HospitalSchool of MedicineTongji UniversityShanghai 200072China Clinical Research Management Office Shanghai Tenth People’s HospitalShanghai 200072China Department of Cell Biology Institute of Medical GeneticsState Key Laboratory of CardiologyTongji University School of MedicineShanghai 200331China

BACKGROUND Hepatocellular carcinoma(HCC)is one of the leading causes of death due to its complexity,heterogeneity,rapid metastasis and easy recurrence after surgical *** demonstrated that combination therapy with transcatheter arterial chemoembolization(TACE),hepatic arterial infusion chemotherapy(HAIC),Epclusa,Lenvatinib and Sintilimab is useful for patients with advanced *** SUMMARY A 69-year-old man who was infected with hepatitis C virus(HCV)30 years previously was admitted to the hospital with abdominal *** computed tomography(CT)revealed a low-density mass in the right lobe of the liver,with a volume of 12.9 cm×9.4 cm×15 cm,and the mass exhibited a“fast-in/fast-out”pattern,with extensive filling defect areas in the right branch of the portal vein and an alpha-fetoprotein level as high as 657 ng/***,he was judged to have advanced *** treatment,the patient received three months of Epclusa,three TACE treatments,two HAIC treatments,three courses of sintilimab,and twenty-one months of *** the third month of treatment,the patient developed severe side effects and had to stop immunotherapy,and the Lenvatinib dose had to be *** pathological diagnosis indicated a complete *** patient recovered well after the operation,and no tumor recurrence was *** Multidisciplinary conversion therapy for advanced enormous HCC caused by HCV infection has a significant *** drug adjustments should be made during any treatment according to the patient's tolerance to treatment.

关键词： Hepatocellular therapy Conversion hepatectomy interventional therapy Epclusa Lenvatinib Sintilimab Case report

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Treatment and Clinical Management of Chronic Thromboembolic Pulmonary Hypertension:An Update of Literature Review

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Congenital Heart Disease 2024年第2期19卷 157-176页

作者： Yuan Ren Yingxian Sun Zhiguang Yang Yanli Chen The Department of cardiology The First Affiliated Hospital of China Medical UniversityShenyang110000China The Radiology Department Shengjing Hospital of China Medical UniversityShenyang110020China

Chronic thromboembolic pulmonary hypertension(CTEPH)is a chronic,progressive,debilitating,and life-threa-tening complication of pulmonary embolism(PE).Recent technological advances have permitted various treat-ment options for the treatment of CTEPH,including surgery,angioplasty,and medical treatment,depending on the location and characteristics of *** endarterectomy(PEA)is the treatment of choice for CTEPH,as it offers excellent long-term outcomes and a high probability of ***,various medical and interventional therapies are currently being developed for patients with inoperable *** review mainly summarizes the current treatment approaches of CTEPH,offering more options for specialist physicians to,thus,better manage chronic thromboembolic syndromes.

关键词： Chronic thromboembolic pulmonary hypertension(CTEPH) chronic thromboembolic pulmonary disease(CTEPD) pulmonary endarterectomy(PEA) balloon pulmonary angioplasty(BPA) COVID-19

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Multi-Modality Imaging in a Hybrid Setting Facilitates Transcatheter Closure of a Traumatic Ventricular Septal Defect

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World Journal of Cardiovascular surgery 2013年第6期3卷 186-189页

作者： Tamim Nazif Rebecca T. Hahn Robert Sommer Susheel K. Kodali Mathew R. Williams Isaac George divisions of interventional cardiology and cardiothoracic surgery Columbia University College of Physicians and Surgeons New York USA

We present a case of transcatheter closure of a traumatic ventricular septal defect (VSD), in which simultaneous 3-dimensional (3D) transesophageal echocardiography (TEE) and angiography played a critical role in defe... 详细信息

关键词： Ventricular Septal Defect Transcatheter Percutaneous

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Institutional re-evolution of mitral valve procedures

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Journal of Geriatric cardiology 2022年第7期19卷 551-554页

作者： Matteo Ponzoni Alessandro Fiocco Raphael Caraffa Matteo Nadali Lorenzo Longinotti Nicola Pradegan Olimpia Bifulco Laura Besola Luca Nai Fovino Giuseppe Tarantini Andrea Colli Gino Gerosa Cardiac surgery Unit Department of CardiacThoracicVascular Sciences and Public HealthUniversity of PaduaItaly interventional cardiology Unit Department of CardiacThoracicVascular Sciences and Public HealthUniversity of PaduaItaly Cardiac surgery Unit Department of SurgicalMedical and Molecular Pathology and Critical Care MedicineUniversity of PisaItal

The introduction of transcatheter aortic va-lve replacement changed our approach for those patients with a high-to-prohibitive risk profile,and,more recently,for those with an in-termediate-to-low risk profile.[1]Similarly,patients with mitral valve regurgitation(MVR)can now be-nefit from various transcatheter technologies,whose indications and recommendations are the subject of intense clinical investigation.

关键词： mitral patients transcatheter

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Early mortality and safety after transcatheter aortic valve replacement using the SAPIEN 3 in nonagenarians

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Journal of Geriatric cardiology 2018年第6期15卷 387-393页

作者： Eiji Ichimoto Adam Arnofsky Michael Wilderman Richard Goldweit Joseph De Gregorio Department of Invasive cardiology Englewood Hospital and Medical Center Englewood N J United States Department of cardiothoracic surgery Englewood Hospital and Medical Center Englewood N J United States Department of Vascular surgery Englewood Hospital and Medical Center Englewood N J United States Department of interventional cardiology Englewood Hospital and Medical Center Englewood NJ United States

BackgroundTranscatheter 大动脉的阀门代替(TAVR ) 与严重大动脉的狭窄为许多老病人被执行了(作为) 。智慧 3 是最近的汽球可扩充的修复术之一。试图用在 97 个连续病人全部的 *** 的 SAPIEN 3 在 TAVR 以后调查早临床的结果的这研究... 详细信息

BackgroundTranscatheter 大动脉的阀门代替(TAVR ) 与严重大动脉的狭窄为许多老病人被执行了(作为) 。智慧 3 是最近的汽球可扩充的修复术之一。试图用在 97 个连续病人全部的 *** 的 SAPIEN 3 在 TAVR 以后调查早临床的结果的这研究经历了 TAVR 为象在 2015 年 12 月和 2016 年 12 月之间严重。这些，用 SAPIEN 3 经历了 TAVR 的 85 个连续病人被包括。根据年龄，病人们被分类直到 90 年组织的年龄(17 个病人) 或年龄 < 90 年组(68 个病人) 。包括所有原因死亡和在 30 天的早安全的合成端点的临床的结果是在年龄 90 年组的胸的外科医生分数的 *** 社会比年龄高< 90 年组( 12.3 慳敧愠??敲楧湯污猠慣敬愠摮?湩瀠牡楴畣慬?映牯搠晩敦敲瑮氠湡?獵?祴数?渠敥?潭敲爠獥慥'??畯?景琠敨洠獯?楷敤祬搠獩牴扩瑵摥氠湡?獵?祴数?敷敲猠汥'陶?潴愠慮祬敺?湩汣摵湩?湩牴摯'讚硴城嬊Ｎ蹡P慲獳慬摮?獡眠汥?獡椠瑮潲畤散?湡?慮畴慲?桳畲汢湡?匠楯?慰瑲捩敬猠穩?猠楯?牯慧楮?慭瑴牥愠摮漠桴?

关键词：大动脉安全死亡阀门回归分析年龄修复术端点

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TBC1D15 deficiency protects against doxorubicin cardiotoxicity via inhibiting DNAPKcs cytosolic retention and DNA damage

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Acta Pharmaceutica Sinica B 2023年第12期13卷 4823-4839页

作者： Wenjun Yu Haixia Xu Zhe Sun Yuxin Du Shiqun Sun Miyesaier Abudureyimu Mengjiao Zhang Jun Tao Junbo Ge Jun Ren Yingmei Zhang Department of cardiology and Shanghai Institute of Cardiovascular Diseases Zhongshan HospitalFudan UniversityShanghai 200032China National Clinical Research Center for interventional Medicine Shanghai 200032China Department of Cardiovascular surgery Zhongnan Hospital of Wuhan UniversityWuhan 430071China Hubei Provincial Engineering Research Center of Minimally Invasive Cardiovascular surgery Wuhan 430071China Department of cardiology Affiliated Hospital of Nantong UniversityNantong 226001China Cardiovascular Department Shanghai Xuhui Central HospitalZhongshan-Xuhui HospitalFudan UniversityShanghai 200030China Department of Cardiovascular surgery Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510000China

Clinical application of doxorubicin(DOX)is heavily hindered by DOX *** theories were postulated for DOX cardiotoxicity including DNA damage and DNA damage response(DDR),although the mechanism(s)involved remains to be *** study evaluated the potential role of TBC domain family member 15(TBC1D15)in DOX ***-induced cardiac-specific Tbcldi5 knockout(Tbcldi5^(CKO))or Tbcldi5 knockin(Tbcldi5^(CKI))male mice were challenged with a single dose of DOx prior to cardiac assessment 1 week or 4 weeks following DOX *** encoding TBC1D15 or containing shRNA targeting Tbcld15 were used for Tbcld15 overexpression or knockdown in isolated primary mouse *** results re-vealed that DOX evoked upregulation of TBC1D15 with compromised myocardial function and overt mortality,the effects of which were ameliorated and accentuated by Tbcldi5 deletion and Tbcld15 overexpression,*** overtly evoked apoptotic cell death,the effect of which was alleviated and exacerbated by Tbcld15 knockout and overexpression,***,DOX provoked mitochondrial membrane potential collapse,oxidative stress and DNA damage,the effects of which were mitigated and exacerbated by Tbcld15 knockdown and overexpression,*** scrutiny revealed that TBC1D15 fostered cytosolic accumulation of the cardinal DDR element DNA-dependent protein kinase catalytic subunit(DNA-PKcs).Liquid chromatography-tandem mass spectrometry and coimmunoprecipitation denoted an interaction between TBCID15 and DNA-PKcs at the segment 594-624 of ***,overexpression of TBC1D15 mutant(A594-624,deletion of segment 594-624)failed to elicit accentuation of DOX-induced cytosolic retention of DNA-PKcs,DNA damage and cardiomyocyte apoptosis by TBC1D15 wild ***,Tbcld15 deletion ameliorated DOXinduced cardiomyocyte contractile anomalies,apoptosis,mitochondrial anomalies,DNA damage and cytosolic DNA-PKcs accumulatio

关键词： Doxorubicin Cardiotoxicity DNA damage DNA damage response Mitochondrial anomalies Cardiomyocyte apoptosis TBC1D15 DNA-PKcS

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Left main coronary stenosis as a late complication of percutaneous angioplasty:an old problem,but still a problem

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Journal of Geriatric cardiology 2009年第1期6卷 26-30页

作者： Giuseppe Faggian Gianluca Rigatelli Francesco Santini Giuseppe Petrilli Paolo Cardaioli Loris Roncon Alessandro Mazzucco Division of Cardiac surgery University of Verona Medical School Verona Italy Interventional Cardiology Unit Division of Cardiology Rovigo General Hospital Rovigo Italy Division of Cardiac Surgery University of Verona Medical School Verona Italy Division of Cardiac Surgery University of Verona Medical School Verona Italy Interventional Cardiology Unit Division of Cardiology Rovigo General Hospital Rovigo Italy Interventional Cardiology Unit Division of Cardiology Rovigo General Hospital Rovigo Italy Division of Cardiac Surgery University of Verona Medical School Verona Italy

Objective Accelerated left main coronary stenosis (LMCS) is a known potential late complication of coronary artery catheter procedures. The aim of this study was to assess the current occurrence of LMCS as a delayed complication of percutaneous angioplasty (PTCA) of the left coronary branches in our institution. Methods The medical records of patients referred for coronary artery by-pass surgery from the same cardiology Unit in the January 2003 to December 2006 period and presenting a significant (> 50%) LMCS as a new finding following a PTCA of the left coronary artery branches, were reviewed. Patients with retrospective evidence of any LMCS at previous coronary angiographies preceding the percutaneous procedure were excluded. Results Thirty-seven patients (5 females, mean age 71.1±8.6 years) out of 944 (4%) having undergone a PTCA, fulfilled the inclusion criteria, 19 (51%) after a procedure also involving the LAD coronary artery. Extraback-up guiding catheters were used in most cases. Use of multiple wires or balloons was observed in 3 cases (8%). Rotablator and proximal occlusion device were used in one case respectively (3%). Twenty patients (54%) have had more than one percutaneous coronary intervention on the left coronary branches. The mean time elapsed from the first angioplasty and surgical intervention was 18.1±7.8 months. Conclusions The potential occurrence of LMCS following a percutaneous intervention procedure, especially when complicated and repeated, should not be underestimated in the current era. This evidence may offer the rationale to schedule non-invasive imaging tests to monitor left main coronary patency after the procedure as well as to fuel further research to develop less traumatic materials.

关键词： angioplasty coronary angiography surgery interventional coronary artery disease

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Transcatheter mitral valve repair in nonagenarians

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Journal of Geriatric cardiology 2022年第1期19卷 90-94页

作者： Pedro Luis Cepas-Guillén Isaac Pascual Eulogio Garcia Pilar Jimenez-Quevedo Alfonso Jurado-Roman Tomás Benito-González Rodrigo Estevez-Loureiro Pedro Li Dabit Arzamendi Bruno Melica Eduardo Infante de Oliveira Pedro Martín Lorenzo Felipe Fernández-Vázquez Guillermo Galeote Luis Nombela-Franco Leire Unzue Pablo Avanzas Manel Sabate Xavier Freixa cardiology Department Cardiovascular Institute(ICCV)Hospital ClinicIDIBAPSUniversity of BarcelonaBarcelonaSpain interventional cardiology Unit Hospital Universitario Central de AsturiasDepartment of MedicineUniversity of OviedoOviedoSpain Servicio de Hemodinámica y Cardiología Intervencionista HM CIEC-Centro Integral de Enfermedades CardiovascularesHospital Universitario HM MontepríncipeHM HospitalesMadridSpain Facultad de Medicina Universidad CEU San PabloMadridSpain cardiology Department Cardiovascular InstituteHospital Clínico San CarlosIdISSCMadridSpain Division of interventional cardiology University Hospital La PazIdiPAZCIBER-CVMadridSpain Department of cardiology University Hospital of LeónLeónSpain interventional cardiology Unit HospitalÁlvaro CunqueiroVigoSpain interventional cardiology Unit Hospital Sant Pau i Santa CreuBarcelonaSpain Serviço de Cardiologia Centro Hospitalar de Vila Nova de Gaia/Espinho-EPEVila Nova de GaiaPortugal Serviço de Cardiologia Hospital de Santa MariaCentro Hospitalar Lisboa NorteCentro Académico Médico de LisboaLisboaPortugal Servicio de Cardiología Hospital Universitario de Gran Canaria Dr.NegrínLas Palmas de Gran CanariaSpain

Given the increase in life expectancy indeveloped countries,nonagenarian population will become clinically and numerically relevant in our daily routine practice in the near *** has been observed to exert a profound influence on the prevalence of severe mitral regurgitation (MR) in the population.[1]Mitral valve surgery remains the gold standard of care for patients with symptomatic severe MR.

关键词： mitral routine surgery

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Surgical resection of a solitary para-aortic lymph node metastasis from hepatocellular carcinoma

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World Journal of Gastroenterology 2012年第23期18卷 3027-3031页

作者： Junji Ueda Hiroshi Yoshida Yasuhiro Mamada Nobuhiko Taniai Sho Mineta Masato Yoshioka Youichi Kawano Tetsuya Shimizu Etsuko Hara Chiaki Kawamoto Keiko Kaneko Eiji Uchida Department of surgery Nippon Medical School Tokyo 113-8603 Japan divisions of cardiology Hepatology Geriatrics and Integrated Medicine Department of Internal Medicine Nippon Medical School Tokyo 113-8603 Japan

Lymph node (LN) metastases from hepatocellular carcinoma (HCC) are considered uncommon. We describe the surgical resection of a solitary para-aortic LN metastasis from HCC. A 65-year-old Japanese man with B-type liver cirrhosis was admitted for the evaluation of a liver tumor. He had already undergone radiofrequency ablation, transcatheter arterial chemoembolization, and percutaneous ethanol injection therapy for HCC. Despite treatment, viable regions remained in segments 4 and 8. We performed a right paramedian sectionectomy with partial resection of the left paramedian section of the liver. Six months later, serum concentrations of alpha-fetoprotein (189 ng/mL) and PIVKA-2 (507 mAU/mL) increased. Enhanced com- puted tomography of the abdomen revealed a tumor (20 mm in diameter) on the right side of the abdominal aorta. Fluorine-18 fluorodeoxyglucose positron emission tomography revealed an increased standard uptake value. There was no evidence of recurrence in other regions. Esophagogastroduodenoscopy and colonoscopy revealed no malignant tumor in the gastrointestinal tract. Para-aortic LN metastasis from HCC was thus diagnosed. We performed lymphadenectomy. Histopathological examination revealed that the tumor was largely necrotic, with poorly differentiated HCC on its surface, which confirmed the suspected diagnosis. After 6 mo tumor marker levels were normal, with no evidence of recurrence. Our experience suggests that a solitary para-aortic LN metastasis from HCC can be treated surgically.

关键词：腹主动脉手术切除淋巴结肝癌孤立正电子发射断层扫描注射治疗无水酒精

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