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Chinese Journal of Polymer Science 2024年第10期42卷 1505-1513页

作者： Bin-Bo Wang Rong Huang Xin Wang Tao Jiang Yi Wang Shuai Du Fa-Lin Li Jin Zhu Song-Qi Ma Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan University Key Laboratory of Bio-based Polymeric Materials Technology and Application of Zhejiang Province Divisions of Polymers and CompositesNingbo Institute of Materials Technology and EngineeringChinese Academy of Sciences University of Chinese Academy of Sciences

Poly(butylene adipate-co-terephthalate)(PBAT), a widely studied biodegradable material, has not effectively addressed the problem of plastic waste. Taking into consideration the cost-effectiveness, upcycling PBAT should take precedence over direct composting degradation. The present work adopts a chain breaking-crosslinking strategy, upcycling PBAT into dual covalent adaptable networks(CANs). During the chainbreaking stage, the ammonolysis between PBAT and polyethyleneimine(PEI) established the primary crosslinked network. Subsequently, styrene maleic anhydride copolymer(SMA) reacted with the hydroxyl group, culminating in the formation of dual covalent adaptable networks. In contrast to PBAT, the PBAT-dual-CANs exhibited a notable Young's modulus of 239 MPa, alongside an inherent resistance to creep and solvents. Owing to catalysis from neighboring carboxyl group and excess hydroxyl groups, the PBAT-dual-CANs exhibited fast stress relaxation. Additionally,they could be recycled through extrusion and hot-press reprocessing, while retaining their biodegradability. This straightforward strategy offers a solution for dealing with plastic waste.

关键词： Chain breaking-crosslinking strategy Dynamic crosslinked networks Poly(butylene adipate-co-terephthalate) Recycle Upcycle

Activity of Angiogenesis Inhibitors in Metastatic Epithelioid Hemangioendothelioma:A Case Report

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Clinical oncology and cancer researeh 2012年第2期9卷 133-136页

作者： Sumit Gaur Alireza Torabi Thomas I O'Neill divisions of hematology-oncology Texas Tech University Health Science Center divisions of Pathology Texas Tech University Health Science Center divisions of Radiology Texas Tech University Health Science Center

This report describes a patient with metastatic epithelioid hemangioendothelioma treated with bevacizumab and nanoparticle albumin-bound *** treatment was well tolerated and led to the stabilization of an aggressive variant of the disease. This case report is the first one that describes the activity of the combination of chemotherapy and bevacizumab in epithelioid *** describing the activity of bevacizumab and other agents(thalidomide,lenalidomide,and interferon) believed to possess anti-angiogenic activities is also reviewed.

关键词： hemangioendothelioma angiogenesis inhibitors nab-paclitaxel bevacizumab

Respiratory Mechanics, Respiratory Muscle Strength, Control of Ventilation and Gas Exchange in Patients with Autoimmune Liver Disease

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Open Journal of Respiratory Diseases 2024年第2期14卷 25-38页

作者： Ahmet Baydur Jacob Korula divisions of Pulmonary Critical Care and Sleep Medicine Los Angeles USA Keck School of Medicine University of Southern California Los Angeles California USA Liver Diseases Rancho Los Amigos National Rehabilitation Center Downey California USA

Objectives: To assess respiratory elastance and resistive properties in patients with autoimmune liver disorders using the passive relaxation expiration technique and compare findings to a group of patients with non-autoimmune liver disease and control subjects. These findings were then related to control of ventilation and gas exchange. A secondary objective was to assess respiratory muscle strength and gas exchange and their relation to respiratory mechanics. Methods: Measurements included respiratory elastance and resistance using the passive relaxation method. Pulmonary function, gas exchange and control of ventilation were assessed using standard methods. Results: a) Compared to control subjects, Ers in patients with liver disease was on average 50% greater than in controls;b) mean respiratory resistance, expressed as the respiratory constants, K1 and K2 in the Rohrer relationship, Pao/V’ = K1 + K2V’, was not different from control resistance;c) mean maximal inspiratory and maximal expiratory pressures averaged 36% and 55% of their respective control values;d) inspiratory occlusion pressure in 0.1 sec (P0.1) was increased and negatively associated with FVC;and e) increases in P0.1, mean inspiratory flow (Vt/Ti) and presence of respiratory alkalosis confirmed the increase in ventilatory drive. Despite inspiratory muscle weakness in patients, P0.1/Pimax averaged 5-fold higher than in control subjects. Conclusions: Despite inspiratory muscle weakness and a V’E similar to that in normal subjects, central drive is increased in patients with chronic liver disease. The increase in ventilatory drive is related to smaller lung volumes and weakly associated with increase in respiratory elastance. Findings confirm that P0.1 is a reliable measure of central drive and is an approach that can be used in the evaluation of control of ventilation in patients with chronic liver dis

关键词： Autoimmune Liver Disease Control of Ventilation Occlusion Pressure Passive Relaxation Method Primary Biliary Cirrhosis Respiratory Elastance Respiratory Resistance

Innate immune responses in RNA viral infection

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Frontiers of Medicine 2021年第3期15卷 333-346页

作者： Qian Xu Yuting Tang Gang Huang divisions of Pathology and Experimental hematology and Cancer Biology Cincinnati Children’s Hospital Medical CenterCincinnatiOH 45229USA Department of hematology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

RNA viruses cause a multitude of human diseases,including several pandemic events in the past *** viral invasion,the innate immune system responds rapidly and plays a key role in activating the adaptive immune *** the innate immune system,the interactions between pathogen-associated molecular patterns and host pattern recognition receptors activate multiple signaling pathways in immune cells and induce the production of pro-inflammatory cytokines and interferons to elicit antiviral ***,dendritic cells,and natural killer cells are the principal innate immune components that exert antiviral *** this review,the current understanding of innate immunity contributing to the restriction of RNA viral infections was briefly *** the main role of immune cells in combating viral infection,the intercellular transfer of pathogen and host-derived materials and their epigenetic and metabolic interactions associated with innate immunity was *** knowledge provides an enhanced understanding of the innate immune response to RNA viral infections in general and aids in the preparation for the existing and next emerging viral infections.

关键词： innate immune viral infection intercellular signaling metabolic changes epigenetic changes

Accuracy of three diagnostic tests used alone and in combination for detecting Helicobacter pylori infection in patients with bleeding gastric ulcers

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Chinese Medical Journal 2003年第12期116卷 1821-1826页

作者：廖健仲李嘉龙赖永智黄世鸿李瑞成吴启华涂天健陈振宽白其卉 divisions of Gastroenterology Cathay General Hospital divisions of Gastroenterology and Pathology Cathay General Hospital Department of Epidemiology

Objective Accuracy of diagnostic methods for detecting Helicobacter pylori (H. pylori) infection among patients with bleeding peptic ulcers has not been thoroughly investigated. The aim of this study was to compare the diagnostic tests and their combined usage in detection of H. pylori infection in patients with bleeding gastric ulcers and without the use of nonsteroidal anti-inflammatory *** A total of 57 patients who presented with bleeding gastric ulcers by endoscopy were enrolled. The status of H. pylori was identified by performing the rapid urease test (RUT), histology and 13C-labeled urea breath test (UBT). The criteria for having H. pylori infection was a minimum of two positive *** The prevalence of H. pylori infection in our patient group was 80.7%. Among the three tests used: RUT, histology, and UBT, sensitivities were 56.5%, 97.8% and 100%, while specificities were 100%, 45.5% and 81.8%, respectively. The overall accuracies of the tests were 78.3%, 71.6% and 90.9%, respectively. Although UBT obtained significantly higher accuracy than histology (P=0.02) as opposed to RUT (P=0.11), UBT had significantly higher sensitivity than RUT (P<0.001). In terms of combining any two of the three tests, more accuracy (98.9%) was achieved when both UBT and histology were used to confirm the diagnosis of the other. Conversely, failure to use combined tests generated the potential of missing a proper H. pylori *** UBT is superior to the other two tests in bleeding gastric ulcers. RUT lacks sensitivity for detection of H. pylori infection. However, the concomitant use of UBT and histology seems to be more accurate when gastric ulcers present with bleeding.

关键词： diagnostic test Helicobacter pylori breath test gastric ulcer

Development of China's biofuel industry and policy making in comparison with international practices

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Science Bulletin 2015年第11期60卷 1049-1054,I0008页

作者：赵军 Bureau of Academic divisions Chinese Academy of Sciences

Bioethanol and biodiesel are the main biofuels produced in the industrial scale. Research into bioethanol in China began around 1930, whereas biodiesel was not investigated as a biofuel until 1980. The Renewable Energy Law of the People＇s Republic of China, which took effect on 1 January 2006, was perhaps the most important decree aimed at promoting the development and utilization of renewable energy.

关键词：生物燃料中国可再生能源法中华人民共和国国际产业生物柴油生物乙醇

New Metrics from a Fractional Gravitational Field

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Communications in Theoretical Physics 2017年第9期67卷 309-312页

作者： Rami Ahmad El-Nabulsi Athens Institute for Education and Research Mathematics and Physics Divisions

Agop et al. proved in Commun. Theor. Phys. （2008） that, a Reissner-Nordstrom type metric is obtained, if gauge gravitational field in a fractal spacetime is constructed by means of concepts of scale relativity. We prove in this short communication that similar result is obtained if gravity in D-spacetime dimensions is fractionalized by means of the Glaeske-Kilbaz Saigo fractional. Besides, non-singular gravitational fields are obtained without using extra-dimensions. We present few examples to show that these gravitational fields hold a number of motivating features in spacetime physics.

关键词： D-spacetime dimensions fractional gravitational field

Targeted therapy in advanced metastatic colorectal cancer: Current concepts and perspectives

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World Journal of Gastroenterology 2014年第20期20卷 6102-6112页

作者： Florian Hohla Thomas Winder Richard Greil Ferenc G Rick Norman L Block rew V Schally Ⅲrd Medical Department with hematology Medical Oncology Hemostasis Rheumatology and Infectious Diseases Oncologic Center Center for Clinical Cancer and Immunology Trials Laboratory of Immunological and Molecular Cancer Research Paracelsus Medical University of Salzburg A-5020 Salzburg Austria Department of oncology Medical University of Zurich 8091 Zurich Switzerland Endocrine Polypeptide and Cancer Institute Veterans Affairs Medical Center and South Florida Veterans Affairs Foundation for Research and Education Miami FL 33125 United States Department of Urology Florida International University Herbert Wertheim College of Medicine Miami FL 33199 United States divisions of hematology/oncology and Endocrinology Department of Pathology and Department of Medicine Miller School of Medicine University of Miami Miami FL 33136 United States

The introduction of new cytotoxic substances as well as agents that target vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) signaling has improved clinical outcome of patients with metastatic colorectal cancer (mCRC). In this review we summarize the most relevant clinical data on VEGF and EGFR targeting regimens in mCRC. The effects of available treatment strategies for mCRC are often temporary, with resistance and disease progression developing in most patients. Thus, new treatment strategies are urgently needed. Some GI peptides including gastrin and gastrin releasing peptide, certain growth factors such as insulin-like growth factor-I and II and neuropeptides such as growth hormone releasing hormone (GHRH) are implicated in the growth of CRC. Experimental investigations in CRC with antagonistic analogs of bombesin/gastrin-releasing peptide, GHRH, and with cytotoxic peptides that can be targeted to peptide receptors on tumors, are summarized in the second part of the review.

关键词： Colorectal cancer Targeted treatment Vascular endothelial growth factor Epidermal growth factor receptor Peptide receptors Gastrin-releasing peptide Growth hormone releasing hormone Luteinizing hormone-releasing hormone Cytotoxic analogs

Electrochemical performance of all-solid lithium ion batteries with a polyaniline film cathode

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Journal of Energy Chemistry 2016年第1期25卷 93-100页

作者： Ji-Woo Oh Rye-Gyeong Oh Yongku Kang Kwang-Sun Ryu Department of Chemistry University of Ulsan Advanced Materials divisions Korea Research Institute of Chemical Technology

We have prepared a high-density polyaniline（PANI） paste（50 mg/m L）, with similar physical properties to those of paints or pigments. The synthesis of PANI is confirmed by Fourier transform infrared（FT-IR） spectroscopy. The morphologies of PANI, doped PANI, and doped PANI paste are confirmed by scanning electron microscopy（SEM）. Particles of doped PANI paste are approximately 40–50 nm in diameter, with a uniform and cubic shape. The electrochemical performances of doped PANI paste using both liquid and solid polymer electrolytes have been measured by galvanostatic charge and discharge process. The cell fabricated with doped PANI paste and the solid polymer electrolyte exhibits a discharge capacity of ～87 μAh/cm2（64.0 m Ah/g） at the second cycle and～67 μAh/cm2（50.1 m Ah/g） at the 100 th cycle.

关键词： Lithium ion batteries Cathode Conducting polymer Polyaniline Flexible battery

VISUALIZATION OF DYNAMIC ORGANIZATION OF CYTOSKELETON GELS IN LIVING CELLS BY HYBRID-SPM

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Chinese Journal of Polymer Science 2003年第2期21卷 169-174页

作者： K.Kawabata Y.Sado M.Nagayama T.Nitta K.Nemoto Y.Koyama H.Haga divisions of Biological Sciences Graduate School of Science Hokkaido University 060-0810 SapporoDivisions of Physics Graduate School of Science. Hokkaido University 060-0810 SapporoDivisions of Physics Graduate School of Science. Hokkaido University 060-0810 SapporoDivisions of Physics Graduate School of Science. Hokkaido University 060-0810 SapporoDivisions of Physics Graduate School of Science. Hokkaido University 060-0810 SapporoDepartment of Biochemistry Hokkaido University Graduate School of Medicine Sapporo 060-8638 JapanDivisions of Physics Graduate School of Science Hokkaido University 060-0810 Sapporo

We succeeded in performing of hybrid Scanning Probe Microscopy (hybrid-SPM) in which mechanical-SPM andfluorescence microscopy are combined. This technique is able to measure simultaneously mechanical properties anddistribution of cytoskeletons of living cells by using green fluorescent protein. We measured evolution of both local elasticityand distributions of actin stress fibers in an identical fibroblast living in physiological conditions. The SPM experimentsrevealed that stiffer lines develop in living cells, which correspond to actin stress fibers. The elasticity of the actin stressfibers is as high as 100 kPa. We discuss mechanical effects on the development of actin filament networks.

关键词： Scanning probe microscopy Green fluorescent protein Fibroblast Cell migration, Cytoskeleton Elasticity