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Innate immune responses in RNA viral infection

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Frontiers of Medicine 2021年第3期15卷 333-346页

作者： Qian Xu Yuting Tang Gang Huang divisions of Pathology and Experimental hematology and Cancer Biology Cincinnati Children’s Hospital Medical CenterCincinnatiOH 45229USA Department of hematology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

RNA viruses cause a multitude of human diseases,including several pandemic events in the past *** viral invasion,the innate immune system responds rapidly and plays a key role in activating the adaptive immune *** the innate immune system,the interactions between pathogen-associated molecular patterns and host pattern recognition receptors activate multiple signaling pathways in immune cells and induce the production of pro-inflammatory cytokines and interferons to elicit antiviral ***,dendritic cells,and natural killer cells are the principal innate immune components that exert antiviral *** this review,the current understanding of innate immunity contributing to the restriction of RNA viral infections was briefly *** the main role of immune cells in combating viral infection,the intercellular transfer of pathogen and host-derived materials and their epigenetic and metabolic interactions associated with innate immunity was *** knowledge provides an enhanced understanding of the innate immune response to RNA viral infections in general and aids in the preparation for the existing and next emerging viral infections.

关键词： innate immune viral infection intercellular signaling metabolic changes epigenetic changes

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World Journal of Gastroenterology 2015年第41期21卷 11793-11803页

作者： Giuseppe Aprile Karim Rihawi Elisa De Carlo Stephen T Sonis Department of Medical oncology University and General Hospital of Udine divisions of Oral Medicine Brigham and Women’s Hospital Boston the Dana-Farber Cancer Institute BiomodelsLLCWatertown

Gastrointestinal toxicities(GIT), including oral mucositis,nausea and vomiting, and diarrhea, are common side effects of chemotherapy and targeted agents in patients with advanced colorectal cancer and pancreatic cancer. Being often underreported, it is still difficult to precisely establish their burden in terms of both patient's quality of life and cancer care costs. Moreover, with the use of more intensive upfront combination regimens, the frequency of these toxicities is rapidly growing with a potential negative effect also on patient's outcome, as a result of dose reductions, delays or even discontinuation of active treatments. Thus, identifying patients at higher risk of developing GIT as well as an optimal management are paramount in order to improve patient's compliance and outcome. After the description of the main treatment-induced GIT, we discuss the current knowledge on the pathophysiology of these side effects and comment the scales commonly used to assess and grade them. We then provide a critical update on GIT incidence based on the results of key randomized trials conducted in patients with metastatic colorectal cancer and advanced pancreatic cancer.

关键词： Gastrointestinal toxicities Oral mucositis Diarrhe

New Metrics from a Fractional Gravitational Field

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Communications in Theoretical Physics 2017年第9期67卷 309-312页

作者： Rami Ahmad El-Nabulsi Athens Institute for Education and Research Mathematics and Physics Divisions

Agop et al. proved in Commun. Theor. Phys. （2008） that, a Reissner-Nordstrom type metric is obtained, if gauge gravitational field in a fractal spacetime is constructed by means of concepts of scale relativity. We prove in this short communication that similar result is obtained if gravity in D-spacetime dimensions is fractionalized by means of the Glaeske-Kilbaz Saigo fractional. Besides, non-singular gravitational fields are obtained without using extra-dimensions. We present few examples to show that these gravitational fields hold a number of motivating features in spacetime physics.

关键词： D-spacetime dimensions fractional gravitational field

Targeted therapy in advanced metastatic colorectal cancer: Current concepts and perspectives

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World Journal of Gastroenterology 2014年第20期20卷 6102-6112页

作者： Florian Hohla Thomas Winder Richard Greil Ferenc G Rick Norman L Block rew V Schally Ⅲrd Medical Department with hematology Medical Oncology Hemostasis Rheumatology and Infectious Diseases Oncologic Center Center for Clinical Cancer and Immunology Trials Laboratory of Immunological and Molecular Cancer Research Paracelsus Medical University of Salzburg A-5020 Salzburg Austria Department of oncology Medical University of Zurich 8091 Zurich Switzerland Endocrine Polypeptide and Cancer Institute Veterans Affairs Medical Center and South Florida Veterans Affairs Foundation for Research and Education Miami FL 33125 United States Department of Urology Florida International University Herbert Wertheim College of Medicine Miami FL 33199 United States divisions of hematology/oncology and Endocrinology Department of Pathology and Department of Medicine Miller School of Medicine University of Miami Miami FL 33136 United States

The introduction of new cytotoxic substances as well as agents that target vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) signaling has improved clinical outcome of patients with metastatic colorectal cancer (mCRC). In this review we summarize the most relevant clinical data on VEGF and EGFR targeting regimens in mCRC. The effects of available treatment strategies for mCRC are often temporary, with resistance and disease progression developing in most patients. Thus, new treatment strategies are urgently needed. Some GI peptides including gastrin and gastrin releasing peptide, certain growth factors such as insulin-like growth factor-I and II and neuropeptides such as growth hormone releasing hormone (GHRH) are implicated in the growth of CRC. Experimental investigations in CRC with antagonistic analogs of bombesin/gastrin-releasing peptide, GHRH, and with cytotoxic peptides that can be targeted to peptide receptors on tumors, are summarized in the second part of the review.

关键词： Colorectal cancer Targeted treatment Vascular endothelial growth factor Epidermal growth factor receptor Peptide receptors Gastrin-releasing peptide Growth hormone releasing hormone Luteinizing hormone-releasing hormone Cytotoxic analogs

Electrochemical performance of all-solid lithium ion batteries with a polyaniline film cathode

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Journal of Energy Chemistry 2016年第1期25卷 93-100页

作者： Ji-Woo Oh Rye-Gyeong Oh Yongku Kang Kwang-Sun Ryu Department of Chemistry University of Ulsan Advanced Materials divisions Korea Research Institute of Chemical Technology

We have prepared a high-density polyaniline（PANI） paste（50 mg/m L）, with similar physical properties to those of paints or pigments. The synthesis of PANI is confirmed by Fourier transform infrared（FT-IR） spectroscopy. The morphologies of PANI, doped PANI, and doped PANI paste are confirmed by scanning electron microscopy（SEM）. Particles of doped PANI paste are approximately 40–50 nm in diameter, with a uniform and cubic shape. The electrochemical performances of doped PANI paste using both liquid and solid polymer electrolytes have been measured by galvanostatic charge and discharge process. The cell fabricated with doped PANI paste and the solid polymer electrolyte exhibits a discharge capacity of ～87 μAh/cm2（64.0 m Ah/g） at the second cycle and～67 μAh/cm2（50.1 m Ah/g） at the 100 th cycle.

关键词： Lithium ion batteries Cathode Conducting polymer Polyaniline Flexible battery

VISUALIZATION OF DYNAMIC ORGANIZATION OF CYTOSKELETON GELS IN LIVING CELLS BY HYBRID-SPM

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Chinese Journal of Polymer Science 2003年第2期21卷 169-174页

作者： K.Kawabata Y.Sado M.Nagayama T.Nitta K.Nemoto Y.Koyama H.Haga divisions of Biological Sciences Graduate School of Science Hokkaido University 060-0810 SapporoDivisions of Physics Graduate School of Science. Hokkaido University 060-0810 SapporoDivisions of Physics Graduate School of Science. Hokkaido University 060-0810 SapporoDivisions of Physics Graduate School of Science. Hokkaido University 060-0810 SapporoDivisions of Physics Graduate School of Science. Hokkaido University 060-0810 SapporoDepartment of Biochemistry Hokkaido University Graduate School of Medicine Sapporo 060-8638 JapanDivisions of Physics Graduate School of Science Hokkaido University 060-0810 Sapporo

We succeeded in performing of hybrid Scanning Probe Microscopy (hybrid-SPM) in which mechanical-SPM andfluorescence microscopy are combined. This technique is able to measure simultaneously mechanical properties anddistribution of cytoskeletons of living cells by using green fluorescent protein. We measured evolution of both local elasticityand distributions of actin stress fibers in an identical fibroblast living in physiological conditions. The SPM experimentsrevealed that stiffer lines develop in living cells, which correspond to actin stress fibers. The elasticity of the actin stressfibers is as high as 100 kPa. We discuss mechanical effects on the development of actin filament networks.

关键词： Scanning probe microscopy Green fluorescent protein Fibroblast Cell migration, Cytoskeleton Elasticity

Clinical management of advanced gastric cancer: The role of new molecular drugs

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World Journal of Gastroenterology 2014年第40期20卷 14537-14558页

作者： Ferdinando De Vita Natale Di Martino Alessio Fabozzi Maria Maddalena Laterza Jole Ventriglia Beatrice Savastano Angelica Petrillo Valentina Gambardella Vincenzo Sforza Luigi Marano Annamaria Auricchio Gennaro Galizia Fortunato Ciardiello Michele Orditura Division of Medical oncology Department of Clinical and Experimental Medicine and Surgery Second University of Naples School of Medicine 80131 Naples Italy Ⅷ General and Gastrointestinal Surgery School of Medicine Second University of Naples School of Medicine 80138 Naples Italy divisions of Surgical oncology Department of Clinical and Experimental Medicine and Surgery Second University of Naples School of Medicine 80131 Naples Italy

Gastric cancer is the fourth most common malignant neoplasm and the second leading cause of death for cancer in Western countries with more than 20000 new cases yearly diagnosed in the United States. Surgery represents the main approach for this disease but, notwithstanding the advances in surgical techniques, we observed a minimal improvement in terms of overall survival with a significant increasing of relapsing disease rates. Despite the development of new drugs has significantly improved the effectiveness of chemotherapy, the prognosis of patients with unresectable or metastatic gastric adenocarcinoma remains poor. Recently, several molecular target agents have been investigated; in particular, trastuzumab represents the first target molecule showing improvements in overall survival in human epithelial growth factor 2-positive gastric cancer patients. New molecules targeting vascular epithelial growth factor, mammalian target of rapamycin, and anti hepatocyte growth factor-c-Met pathway are also under investigation, with interesting results. Anyway, it seems necessary to select more accurately the population to treat with new agents by the identification of new biomarkers in order to optimize the results. In this paper we review the actual “scenario” of targeted treatments, also focusing on the new agents in development for gastric cancer and gastro-esophageal carcinoma, discussing their efficacy and potential applications in clinical practice.

关键词： Advanced gastric cancer Gastrointestinal cancer Targeted therapy Monoclonal antibodies Tyrosine-kinase inhibitor Gastric cancer

Outcomes in children with Clostridium difficile infection:results from a nationwide survey

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Gastroenterology Report 2016年第4期4卷 293-298,I0002页

作者： Arjun Gupta Darrell S Pardi Larry M Baddour Sahil Khanna divisions of Infectious Diseases Mayo ClinicRochesterMNUSA divisions of Gastroenterology and Hepatology Mayo ClinicRochesterMNUSA Department of Internal Medicine University of Texas Southwestern Medical CenterDallasTXUSA

Objective:Hospital-and population-based studies demonstrate an increasing incidence of Clostridium difficile infection(CDI)in adults and children;although pediatric CDI outcomes are incompletely *** analysed United States National Hospital Discharge Survey(NHDS)data to study CDI in hospitalized ***:NHDS data for 2005–2009(demographics,diagnoses and discharge status)were obtained;cases and comorbidities were identified using ICD-9 *** univariate and multivariate analyses were performed to ascertain incidence of CDI;associations between CDI and outcomes[length of stay(LOS),colectomy,all-cause in-hospital mortality and discharge to a care facility(DTCF)].Results:Of an estimated 13.8 million pediatric inpatients;46176 had CDI;median age was 3 years;overall incidence was 33.5/10000 *** annual frequency of CDI did not vary from 2005 to 2009(0.24–0.43%;P=0.64).On univariate analyses,children with CDI had a longer median LOS(6 vs 2 days),higher rates of colectomy[odds ratio(OR)2.0;95%confidence interval(CI)1.7–2.4],mortality(OR 2.5;95% CI 2.3–2.7),and DTCF(OR 1.6;95% CI 1.6–1.7)(all P<0.0001).After adjusting for age,sex and comorbidities,CDI was an independent and the strongest predictor of increased LOS(adjusted mean difference,6.4 days;95% CI 5.4–7.4),higher rates of colectomy(OR 2.1;95% CI 1.8–2.5),mortality(OR 2.3;95% CI 2.2–2.5),and DTCF(OR 1.7;95% CI 1.6–1.8)(all P<0.0001).On excluding infants from the analysis,children with CDI had higher rates of mortality,DTCF and longer LOS than children without ***:Despite increased awareness and advancements in management,CDI remains a significant problem and is associated with increased LOS,colectomy,in-hospital mortality and DTCF in hospitalized children.

关键词： Clostridium difficile infection children pediatric outcomes epidemiology

Scalar Tensor Cosmology With Kinetic, Gauss-Bonnet and Nonminimal Derivative Couplings and Supersymmetric Loop Corrected Potential

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Communications in Theoretical Physics 2019年第7期71卷 831-836页

作者： Rami Ahmad El-Nabulsi Athens Institute for Education and Research Mathematics and Physics Divisions8 Valaoritou StreetKolonaki 10671 AthensGreece

We discuss a particular four-dimensional cosmology based on non-minimal scalar tensor theories characterized by a supersymmetric loop corrected potential and a Hubble parameter defined as a function of the scalar ***-law solutions are obtained in the FRW background giving rise to acceleratedly expanding universe characterized by a scale factor and a scalar field depending both on the non-minimal coupling parameterξ.Based on SNeIa data and on Hubble data X-ray gas mass fraction measurements,we find 0.116<ξ<0.225 which results on a universe dominated by vacuum energy.

关键词： scalar tensor cosmology Gauss-Bonnet coupling non-minimal derivative coupling vacuum energy