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Methylenetetrahydrofolate Reductase Genotypes, Dietary Habits and Susceptibility to Stomach Cancer

Chinese Journal of Clinical Oncology 2004年第3期1卷 162-166页

作者： ChangmingGao TakezakiToshiro JianzhongWu JianhuoDing YantingLiu SupingLi PingSu XuHu TianliongXu HamajimaNobuyuki TajimaKazuo divisionofepidemiology JiangsuProvinceInstituteofCancerResearchNanjing210009China. divisionofepidemiologyandPrevention AichiCancerCenterResearchInstituteNagoya464-8681Japan. PublicHealthCenterofChuzhouDistrict Huaian221300China.

OBJECTIVE To study the relation among methylenetetrahydrofolate reductase (MTHFR) C677T genotypes, dietary habits and the risk of stomach cancer (SC).METHODS A case-control study was conducted with 107 cases of SC and 200 population-based controls in Chuzhou district, Huaian, Jiangsu province, China. The epidemiological data were collected, and DNA of peripheral blood leukocytes was obtained from all of the subjects..MTHFR genotypes were detected by PCR-RFLP. RESULTS (1) The prevalence of the MTHFR C/T or T/T genotypes was found to be significantly different between controls (68.5%) and SC cases (79.4%,P=0.0416), the increased risk had an adjusted OR of 1.79 (95%C1:1.01-3.19). (2) Among subjects who had a low intake of garlic or Chinese onion, MTHFR C/T or T/T genotypes significantly increased the risk of developing SC. Among non-tea drinkers or among subjects who had a frequent intakeof meat, the carriers of the MTHFR C/T or T/T genotypes had a higher risk of SC than individuals with the C/C type MTHFR. CONCLUSION The polymorphism of MTHFR C677T was associated with increased risk of developing SC, and that individuals with differing genotypes may have different susceptibilities to SC, based on their exposure level to environmental factors.

关键词：亚甲基四氢叶酸还原酶基因型饮食习惯易感性胃癌肿瘤

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Linkage of the cholesterol 7α-hydroxylase gene and low-density lipoprotein cholesterol conditional on apolipoprotein E association: the National Heart, Lung, and Blood Institute Family Heart Study

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Chinese Medical Journal 2005年第5期118卷 362-369页

作者： Jing-PingLin RichardH.Myers LauraAlmasy HilaryH.Coon DonnaK.Arnett YulingHong StevenC.Hunt OfficeofBiostatisticsResearch NationalHeartLungandBloodInstituteNationalInstitutesofHealthSahLakeCityUT84108-3528USA SectionofPreventiveMedicine BostonUniversitvSchoolofMedicineBostonMA02118USA DepartmentofGenetics SouthwestFoundationofBiomedicalResearchSanAntonioTX78245-0549USA DepartmentofPsychiatry UniversityofUtahUSA divisionofepidemiology UniversityofAlabamaBirminghanAL35294-0022USA AmerieanHeartAssociation NationalCenterDallas.TX75231-5129USA DepartmentofInternalMedicine UniversityofUtahSaltLakeCityUT84108USA

Background Genetic factors account for approximately 50% of the individual variation in plasma low-density lipoprotein cholesterol (LDL-C) concentrations in the general population. Several candidate genes have been proposed but their relative contributions to the variance in LDL-C are not known, except for apolipoprotein E (apoE). We report here an investigation of the relationship between LDL-C and cholesterol 7α-hydroxylase (CYP7), as well as apoE and low-density lipoprotein receptor (LDLR), three pivotal genes in LDL metabolism. Methods Our study population included more than 200 nuclear families with increased coronary heart disease (CHD) risk from the National Heart, Lung, and Blood Institute (NHLBI) Family Heart Study. Variance-component linkage methods, a measured genotype approach, and a variance-component linkage analysis conditional on a measured genotype association were used. Results The results showed significant linkage between a genetic determinant of plasma LDL-C concentrations and a polymorphism near CYP7 with its allelic variation accounting for 27% of the total LDL-C variation. There is significant association between plasma LDL-C concentrations and apoE genotypes. Conditional on the apoE association, the total LDL-C variation accounted by allelic variation of a polymorphism near CYP7 was increased *** Our results suggest the apoE and CYP7 may be two important genes accounting for the genetic variation of plasma LDL-C concentrations in a population with cardiovascular diseases.

关键词： linkage analysis CYP7 gene apoE gene low-density lipoprotein cholesterol

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