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Pressure-responsive pH-triggered layer-by-layer coating of paclitaxel-eluting balloon catheters for instant high-dose drug delivery for percutaneous coronary artery intervention

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Nano Research 2024年第10期17卷 9141-9151页

作者： Jeong Yu Lee Shonit Nair Sharma Sung-Yu Hong Young-Guk Ko Yangsoo Jang Minjae Do Michael Christopher Stark Qiwen Peng Benjamin Allen Mossburg Bo Chan Seo Yuhan Lee Department of Materials Science and Engineering Korea Advanced Institute of Science and TechnologyDaejeon 305-701Republic of Korea Department of Anesthesiology Perioperativeand Pain MedicineCenter for Accelerated Medical Innovation&Center for NanomedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA Department of Biological Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA Cardiovascular Product Evaluation Center Yonsei University College of MedicineSeoul 120-752Republic of Korea division of Cardiology Department of Internal MedicineSeverance Cardiovascular HospitalYonsei University College of MedicineSeoul 120-752Republic of Korea

Cardiovascular diseases remain the leading cause of mortality worldwide,with percutaneous coronary interventions(PCI)using drug-eluting stents(DES)as the standard treatment for coronary artery *** advancements in DES technology,challenges such as restenosis and stent thrombosis still necessitate further interventions and carry considerable risks,highlighting an urgent need for a novel therapeutic approach with lower restenosis rates and reduced reintervention *** balloons(DEBs)coated with anti-proliferative agents offer a novel method of local drug delivery for reducing restenosis by directly administering drugs to the lesion ***,efficient delivery of drugs within the brief procedural window while minimizing drug loss during maneuvering to the target site remains a ***,we developed a pressure-responsive and pH-triggered,paclitaxel(PTX)coated DEB catheter for rapid and high-dose delivery of paclitaxel to the lesion sites,overcoming the limitations of drug dispersion and inefficiencies associated with conventional *** the charge reversion of albumin around its isoelectric point,paclitaxel-loaded human serum albumin nanoparticles(PTX-HSA-NPs)and heparin were coated using a layer-by-layer deposition method at pH *** exposure to physiological pH(i.e.,7.4),the coating is rapidly released from the balloon *** with a protective shellac coating,the DEB achieved controlled release of high-dose paclitaxel to the arterial tissue in vivo(up to 400μg per gram tissue),exceeding current DEBs in the *** results suggest the pH-responsive,multi-layer coated DEB’s potential for superior procedural outcomes,addressing a critical unmet need in PCI.

关键词： drug-eluting balloon layer-by-layer coating coronary artery disease paclitaxel

Necrotic stercoral colitis:Importance of computed tomography findings

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World Journal of Gastroenterology 2011年第3期17卷 379-384页

作者： Cheng-Hsien Wu Li-Jen Wang Yon-Cheong Wong Chen-Chih Huang Chien-Cheng Chen Chao-Jan Wang Jen-Feng Fang Chuen Hsueh division of Emergency and Critical Care Radiology Department of Medical Imaging and InterventionChang Gung Memorial Hospital division of Trauma and Emergency Department of SurgeryChang Gung Memorial Hospital Chang Gung University Department of Pathology Chang Gung Memorial HospitalChang Gung University

AIM: To study the computed tomography (CT) signs in facilitating early diagnosis of necrotic stercoral colitis (NSC). METHODS: Ten patients with surgically and pathologically confirmed NSC were recruited from the Clinico-Pathologic-Radiologic conference at Chang Gung Memorial Hospital, Taoyuan, Taiwan. Their CT images and medical records were reviewed retrospectively to correlate CT findings with clinical presentation. RESULTS: All these ten elderly patients with a mean age of 77.1 years presented with acute abdomen at our Emergency Room. Nine of them were with systemic medical disease and 8 with chronic constipation. Seven were with leukocytosis, two with low-grade fever, two with peritoneal sign, and three with hypotensive shock. Only one patient was with radiographic detected abnormal gas. Except the crux of fecal impaction, the frequency of the CT signs of NSC were, proximal colon dilatation (20%), colon wall thickening (60%), dense mucosa (62.5%), mucosal sloughing (10%), perfusion defect (70%), pericolonic stranding (80%), abnormal gas (50%) with pneumo-mesocolon (40%) in them, pericolonic abscess (20%). The most sensitive signs in decreasing order were pericolonic stranding, perfusion defect, dense mucosal, detecting about 80%, 70%, and 62.5% of the cases, respectively. CONCLUSION: Awareness of NSC and familiarity with the CT diagnostic signs enable the differential diagnosis between NSC and benign stool impaction.

关键词： Fecal impaction Dense mucosa Pericolonic stranding Stercoral colitis Computed tomography

HIV and syphilis infections among street-based female sex workers in China, 2010-2012

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Chinese Medical Journal 2014年第4期127卷 707-711页

作者： Li Dongmin Wang Lu Lin Wen Li Peilong Wang Lan Guo Wei Ge Lin Ding Zhengwei Cui Yan Wang Ning division of Epidemiology National Center for Acquired Immune Definciency Syndrome/Sexually Transmitted Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing 102206 China Santa Clara County Public Health Department California 95126USA

Background Female sex workers （FSW） were high-risk population for HIV and other sexually transmitted diseases （STD） earlier,and now are an important driver of the HIV/AIDS epidemic in *** surveillance for FSW was set up to monitor the trend of HIV prevalence and risk behavior-related HIV *** study collected the data on street-based FSW from HIV sentinel surveillance system to understand HIV and syphilis infections,risk behaviors,and intervention in China from 2010 to *** The study population was the street-based FSW who were recruited for the national HIV integrated biological and behavioral surveillance between 2010 and *** information,HIV-related risk behaviors,and HIV and syphilis testing results were described and trend analysis was *** Between 2010 and 2012,the number of street-based FSW surveyed was 3725,3425,and 3335,*** knowledge awareness rate significantly increased from 74.6% in 2010 to 76.8% in 2011 and 82.2% in 2012 （P 〈0.01）.More FSW consistently used condom in the last month （49.0% in 2010; 51.0% in 2011; and 59.0% in 2012） and in the last commercial sex （72.0% in 2010; 78.5% in 2011; and 80.0% in 2012） over *** proportions of individuals who received HIV testing in the last year were 31.2% （2010）,37.0% （2011）,and 36.9% （2012）（P-trend 〈0.01）.HIV prevalence rate changed from 1.5% in 2010 to 1.4% in 2011 and 2.3% in 2012 （P-trend=0.01）.Syphilis prevalence rate was 6.9%,7.2%,and 7.1% in the same *** top three provinces with the highest average HIV prevalence rates over the 3 years were Guangxi （5.9%）,Yunnan （4.2%）,and Sichuan （1.2%）.Conclusions Street-based FSW are at high risk of HIV and syphilis *** efforts need to target streetbased FSW who are of old age and minority,who use illicit drugs and have syphilis infection.

关键词： street-based female sex worker HIV syphilis prevalence risk behaviors

Impact of continuous care on cardiac function in patients with lung cancer complicated by coronary heart disease

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World Journal of Clinical Cases 2024年第2期12卷 314-321页

作者： Ting Gao Jin-Lan Luo Pan Guo Xi-Wen Hu Xiao-Yan Wei Yan Hu division of Cardiovascular First Ward Department of Internal MedicineLiyuan HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430077Hubei ProvinceChina Department of Cardiovascular Medicine Wuhan Wuchang HospitalWuhan 430063Hubei ProvinceChina Cardiovascular Clinical Medical Center Liyuan HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430077Hubei ProvinceChina Department of Second Thoracic Surgery Hubei Cancer HospitalWuhan 430079Hubei ProvinceChina

BACKGROUND Despite sharing similar pathogenic factors,cancer and coronary heart disease(CHD)occur in comparable populations at similar ages and possess similar susceptibility ***,it is increasingly commonplace for patients to experience the simultaneous occurrence of cancer and CHD,a trend that is steadily *** To determine the impacts of continuing care on lung cancer patients with CHD following percutaneous coronary intervention(PCI).METHODS There were 94 lung cancer patients with CHD following PCI who were randomly assigned to the intervention group(n=38)and the control group(n=41).In the intervention group,continuing care was provided,while in the control group,routine care was *** evaluation of cardiac and pulmonary function,medication compliance,a 6-min walk test,and patient quality of life was *** Differences between the two groups were significant in left ventricular ejection fraction,6-min walk test,oxygen uptake,quality of life and medication compliance(Pintervention group was more *** intervention group had more patients with high medication compliance than the control group,with a statistically significant difference(P<0.05).CONCLUSION After undergoing PCI,lung patients with CHD could benefit from continued care in terms of cardiac and pulmonary function,medications compliance,and quality of life.

关键词： Lung cancer Continuing care Coronary heart disease Percutaneous coronary intervention

Alternative approaches to target Myc for cancer treatment

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Signal Transduction and Targeted Therapy 2021年第4期6卷 1157-1170页

作者： Chen Wang Jiawei Zhang Jie Yin Yichao Gan Senlin Xu Ying Gu Wendong Huang division of Medical Genomics and Cancer Institute(Key Laboratory of Cancer prevention and intervention Ministry of Education)the Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina Institute of Genetics Zhejiang University and Department of GeneticsSchool of MedicineZhejiang UniversityHangzhouChina Zhejiang Provincial Key Lab of Genetic and Developmental Disorder HangzhouZhejiang 310058China Molecular and Cellular Biology of Cancer Program&Department of Diabetes Complications and Metabolism Beckman Research InstituteCity of HopeDuarteCAUSA Irell&Manella Graduate School of Biological Sciences Beckman Research InstituteCity of HopeDuarteCAUSA Zhejiang Laboratory for Systems&Precision Medicine Zhejiang University Medical CenterHangzhou 311121China

The Myc proto-oncogene family consists of three members,C-MYC,MYCN,and MYCL,which encodes the transcription factor c-Myc(hereafter Myc),N-Myc,and L-Myc,*** protein orchestrates diverse physiological processes,including cell proliferation,differentiation,survival,and *** modulates about 15%of the global transcriptome,and its deregulation rewires the cellular signaling modules inside tumor cells,thereby acquiring selective *** deregulation of Myc occurs in>70%of human cancers,and is related to poor prognosis;hence,hyperactivated Myc oncoprotein has been proposed as an ideal drug target for ***,no specific drug is currently available to directly target Myc,mainly because of its"undruggable"properties:lack of enzymatic pocket for conventional small molecules to bind;inaccessibility for antibody due to the predominant nucleus localization of *** the topic of targeting Myc has actively been reviewed in the past decades,exciting new progresses in this field keep *** this review,after a comprehensive summarization of valuable sources for potential druggable targets of Myc-driven cancer,we also peer into the promising future of utilizing macropinocytosis to deliver peptides like Omomyc or antibody agents to intracellular compartment for cancer treatment.

关键词： treatment utilizing thereby

Colovesical fistula caused by glucocorticoid therapy for IgG4-related intrapelvic mass

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World Journal of Clinical Cases 2015年第12期3卷 1000-1004页

作者： Yohei Yabuuchi Hiroyuki Matsubayashi Masato Matsuzaki Akio Shiomi Michihisa Moriguchi Ichiro Kawamura Ichiro Ito Hiroyuki Ono division of Endoscopy Shizuoka Cancer Center division of Urology Shizuoka Cancer Center division of Colon Surgery Shizuoka Cancer Center division of intervention Radiology Shizuoka Cancer Center division of Infectious Diseases Shizuoka Cancer Center division of Pathology Shizuoka Cancer Center

IgG4-related disease(IgG4-RD) is an immune-mediated fibroinflammatory disorder that can occur in almost all systemic organs and generally responds to corticosteroid treatment. We report a rare case of an IgG4-related intrapelvic mass lesion that responded to steroid therapy but caused a fistula between the sigmoid colon and bladder. A 71-year-old man was followed after treatment for hepatocellular carcinoma. Follow-up computed tomography(CT) incidentally depicted left hydronephrosis with an ill-demarcated intrapelvic mass lesion. This lesion was histologically diagnosed as IgG4-RD by open biopsy, and peroral steroid therapy was initiated. One month after starting steroids, a colovesical fistula was detected by follow-up CT. A colostomy and urethral catheterization were emergently performed. The patient recovered and the mass lesion was drastically minimized by the initiation of glucocorticoids; however, he still needs urethral catheterization. IgG4-RD develops in various systemic organs and generally responds well to steroids. Clinicians must be watchful for the complications of responses to corticosteroids, such as fistulization, when the mass lesion of IgG4-RD is adjacent to multiple luminal organs.

关键词： IgG4-related disease Intrapelvic mass Steroid therapy Colovesical fistula Colostomy Urethral catheterization

Effect of Sex Composition of Children on the Gender of Next Birth in the Context of Low Fertility in Rural China

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China Population and Development Studies 2017年第1期1卷 83-97页

作者： Ying LI Quanbao JIANG Stuart GIETEL-BASTEN Shuzhuo LI Institute for Population and Development Studies Xi'an Jiaotong University(China) Department of Social Policy and intervention University of Oxford and Division of Social ScienceHong Kong University of Science and Technology

China currently has the world's most skewed national sex ratio at *** this paper,we use data from China's 2001 National Family Planning and Reproductive Health Survey and employ hierarchical logistic models to study how macro factors(mainly fertility policy and economic indicators,as represented by per capita GDP of the village units sampled in this research)and micro factors(mainly fertility intention and sex composition of children)affect the gender of the next *** find that the effect of fertility policies is intertwined with the sex composition of children already *** those couples who have had a son(or sons),fertility policy exerts no effect;but for those with only daughters,the effect is ***,fertility intention,independent from fertility policy,has a significant effect on the gender of the next birth.

关键词： sex ratio at birth hierarchical logistic model fertility policy fertility intention sex composition of children

Oral anti-coagulants use in Chinese hospitalized patients with atrial fibrillation

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Chinese Medical Journal 2024年第2期137卷 172-180页

作者： Jing Lin Deyong Long Chenxi Jiang Caihua Sang Ribo Tang Songnan Li Wei Wang Xueyuan Guo Man Ning Zhaoqing Sun Na Yang Yongchen Hao Jun Liu Jing Liu Xin Du Louise Morgan Gregg C.Fonarow Sidney C.Smith Jr Gregory Y.H.Lip Dong Zhao Jianzeng Dong Changsheng Ma On behalf of CCC-AF investigators Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China National Clinical Research Center for Cardiovascular Diseases Beijing 100029 China Department of Epidemiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of HeartLung and Blood Vessel DiseasesBeijing 100029China International Quality Improvement Department American Heart AssociationDallasTX 07076USA division of Cardiology Geffen School of Medicine at University of CaliforniaLos Angeles CA 90024USA division of Cardiology University of North CarolinaChapel HillNC 27599USA Department of Cardiology Liverpool Centre for Cardiovascular ScienceUniversity of Liverpool and Liverpool Heart&Chest HospitalLiverpool L143PEUK Department of Clinical Medicine Aalborg UniversityAalborg 9000Denmark 不详

Background:Oral anti-coagulants(OAC)are the intervention for the prevention of stroke,which consistently improve clinical outcomes and survival among patients with atrial fibrillation(AF).The main purpose of this study is to identify problems in OAC utilization among hospitalized patients with AF in ***:Using data from the Improving Care for Cardiovascular Disease in China-Atrial Fibrillation(CCC-AF)registry,guideline-recommended OAC use in eligible patients was ***:A total of 52,530 patients with non-valvular AF were enrolled from February 2015 to December 2019,of whom 38,203 were at a high risk of stroke,9717 were at a moderate risk,and 4610 were at a low *** admission,only 20.0%(6075/30,420)of patients with a diagnosed AF and a high risk of stroke were taking *** use of pre-hospital OAC on admission was associated with a lower risk of new-onset ischemic stroke/transient ischemic attack among the diagnosed AF population(adjusted odds ratio:0.54,95%confidence interval:0.43-0.68;P70%of AF patients were at a high risk of *** poor performance on guideline-recommended OAC use was found in this study,over time the CCC-AF project has made progress in stroke prevention in the Chinese AF ***

关键词： Atrial fibrillation Oral anti-coagulants OAC Stroke prevention Contraindication

Impact of alcohol consumption on treatment outcome of hepatocellular carcinoma patients with viral hepatitis who underwent transarterial chemoembolization

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World Journal of Hepatology 2022年第6期14卷 1162-1172页

作者： Attapon Rattanasupar Arunchai Chang Tanaporn Prateepchaiboon Nuttanit Pungpipattrakul Keerati Akarapatima Apiradee Songjamrat Songklod Pakdeejit Varayu Prachayakul Teerha Piratvisuth division of Gastroenterology Department of Internal MedicineHatyai HospitalHatyai 90110SongkhlaThailand Department of Internal Medicine Hatyai HospitalHatyai 90110SongkhlaThailand division of intervention Radiology Department of RadiologyHatyai HospitalHatyai 90110SongkhlaThailand Siriraj Gastrointestinal Endoscopy Center Division of GastroenterologyDepartment of Internal MedicineFaculty of MedicineSiriraj HospitalMahidol UniversityBangkoknoi 10700BangkokThailand NKC Institute of Gastroenterology and Hepatology Songklanagarind HospitalFaculty of MedicinePrince of Songkla UniversityHatyai 90110SongkhlaThailand

BACKGROUND Alcohol consumption increases the risk of hepatocellular carcinoma(HCC)in patients with pre-existing liver disease,including viral ***,studies on the impact of alcohol consumption on the outcomes of HCC are *** hypothesized that alcohol had an additional effect with chronic viral hepatitis infection on treatment outcomes after transarterial chemoembolization(TACE)in patients with intermediate-stage HCC(Barcelona Clinical Liver Cancer[BCLC]-B).AIM To evaluate the additional effect of alcohol on treatment outcomes of TACE among HCC patients with viral *** This study,conducted at Hatyai Hospital in Thailand,included HCC patients over 18 years of age with chronic viral *** of HCC patients with viral hepatitis classified as BCLC-B who underwent TACE as the first treatment modality between 2014 and 2019 were retrospectively *** with chronic viral hepatitis only were categorized under group A,and those with chronic viral hepatitis and concurrent alcohol consumption were categorized under group *** groups were compared,and the Cox proportional-hazards model was used to identify the survival-influencing *** Of the 69 patients,53 were categorized in group A and 16 in group *** were no statistically significant differences in tumor characteristics between the two patient ***,Group A had a statistically significantly higher proportion of complete response(24.5%vs 0%,P=0.030)and a higher median survival rate(26.2 mo vs 8.4 mo;log-rank P=0.012)compared to group *** associated with decreased survival in the proportional-hazards model included alcohol consumption(hazards ratio[HR],2.377;95%confidence interval[CI],1.109-5.095;P=0.026),presence of portal hypertension(HR,2.578;95%CI,1.320–5.037;P=0.006),largest tumor size>5 cm(HR,3.558;95%CI,1.824-6.939;P100 ng/mL(HR,2.536;95%CI,1.377-4.670;P=0.003).CONCLUSION In HCC BCLC B patients

关键词： Alcohol misuse Chronic viral hepatitis Hepatocellular carcinoma Risk factor Survival Transarterial chemoembolization