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Uptake of HIV Self-testing among Men Who have Sex with Men in Beijing, China： a Cross-sectional Study

Biomedical and Environmental Sciences 2017年第6期30卷 407-417页

作者： REN Xian Long WU Zun You MI Guo Dong MCGOOGAN Jennifer ROU Ke Ming ZHAO Yan division of prevention intervention National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing 102206 China National Center for AIDS/STD Control and prevention Chinese Center for Disease Control and Prevention Beijing 102206 China Office of the Director National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing 102206 China division of Treatment and Care National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing 102206 China

Objective To examine HIV self-testing uptake and its determinates among men who have sex with men （MSM） in Beijing, China. Methods A cross-sectional online survey was conducted in Beijing, China in 2016. Participants were users of a popular Chinese gay networking application and had an unknown or negative HIV status. Univariate and multivariate logistic regression analyses were conducted to examine factors associated with HIV self-testing based on adjusted odds ratio （AOR） and 95% confidence interval （CI）. Results Among the 5,996 MSM included in the study, 2,383 （39.7%） reported to have used HIV self-testing kits. Willingness to use an HIV self-test kit in the future was expressed by 92% of the participants. High monthly income （AOR = 1.49; CI = 1.10-2.02; P = 0.010）, large number of male sex partners （≥2： AOR = 1.24; CI = 2.09-1.43; P = 0.002）, sexual activity with commercial male sex partners （〉 2： AOR = 1.94; CI = 1.34 -2.82; P = 0.001）, long-term drug use （AOR = 1.42; CI = 1.23-1.62; P 〈 0.001）, and long-term HIV voluntary counseling and testing （VCT） attendance （AOR = 3.62; CI = 3.11-4.22; P 〈 0.001） were all associated with increased odds of HIV self-testing uptake. Conclusion The nearly 40% rate of HIV self-testing uptake among MSM in our sample was high. In addition, an over 90% willingness to use kits in the future was encouraging. HIV self-testing could be an important solution to help China achieve the global target of having 90% of all people living with HIV diagnosed by 2020.

关键词： Men who have sex with men HIV self-testing Associated factors Beijing

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New approaches for precise response evaluation in hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第12期20卷 3059-3068页

作者： Koichi Hayano Jorge M Fuentes-Orrego Dushyant V Sahani division of Abdominal Imaging and intervention Department of RadiologyMassachusetts General Hospital

With the increasing clinical use of cytostatic and novel biologic targeted agents,conventional morphologic tumor burden assessments,including World Health Organization criteria and Response Evaluation Criteria in Solid Tumors,are confronting limitations because of their difficulties in distinguishing viable tumor from necrotic or fibrotic ***,the investigation for reliable quantitative biomarkers of therapeutic response such as metabolic imaging or functional imaging has been *** this review,we will discuss the conventional and new approaches to assess tumor *** targeted therapy or locoregional therapies can induce biological changes much earlier than morphological changes,these functional tumor burden analyses are very ***,some of them have not gone thorough all steps for standardization and ***,these new techniques and criteria will play an important role in the cancer management,and provide each patient more tailored therapy.

关键词： Hepatocellular carcinoma World Health Organization criteria Response Evaluation Criteria in Solid Tumors European Association for the Study of Liver Computed tomography perfusion Dynamic contrast-enhanced-magnetic resonance imaging Diffusion-weighted imaging Positron emission tomography

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Association between autoimmune gastritis and gastric polyps:Clinical characteristics and risk factors

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 73-87页

作者： Jing-Zheng Jin Xiao Liang Shu-Peng Liu Rui-Lan Wang Qing-Wei Zhang Yu-Feng Shen Xiao-Bo Li division of Gastroenterology and Hepatology Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China division of Gastroenterology and Hepatology Shanghai Institute of Digestive DiseasesShanghai 200001China division of Gastroenterology and Hepatology Renji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China division of Gastroenterology and Hepatology Sichuan Armed Police Corps HospitalLeshan 610041Sichuan ProvinceChina division of Gastroenterology and Hepatology NHC Key Laboratory of Digestive DiseasesRenji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Gastroenterology Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai Institute of Digestive DiseasesShanghai 200127China

BACKGROUND The relationship between autoimmune gastritis(AIG)and gastric polyps(GPs)is not well *** To explore the clinical characteristics and risk factors of AIG with GPs in *** This double center retrospective study included 530 patients diagnosed with AIG from July 2019 to July *** collected clinical,biochemical,serological,and demographic data were of each *** regression analyses,both multivariate and univariate,were conducted to pinpoint independent risk factors for GPs in patients with AIG *** operating characteristic curves were utilized to establish the optimal cutoff values,sensitivity,and specificity of these risk factors for predicting GPs in patients with *** Patients with GPs had a higher median age than those without GPs[61(52.25-69)years vs 58(47-66)years,P=0.006].The gastrin-17 levels were significantly elevated in patients with GPs compared with those without GPs[91.9(34.2-138.9)pmol/mL vs 60.9(12.6-98.4)pmol/mL,Pintervention in managing GPs in patients with AIG.

关键词： Autoimmune gastritis Gastric polyps Neuroendocrine tumor Risk factors Nomogram

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HIV care-seeking behaviour after HIV selftesting among men who have sex with men in Beijing,China:a cross-sectional study

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Infectious Diseases of Poverty 2017年第1期6卷 1001-1011页

作者： Xian-Long Ren Zun-You Wu Guo-Dong Mi Jennifer M.McGoogan Ke-Ming Rou Yan Zhao Nanci Zhang division of prevention intervention National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and Prevention155 Changbai RoadChangping DistrictBeijing 102206People’s Republic of China Office of the Director National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and Prevention155 Changbai RoadChangping DistrictBeijing 102206People’s Republic of China division of Treatment and Care National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and Prevention155 Changbai RoadChangping DistrictBeijing 102206People’s Republic of China

Background:Men who have sex with men(MSM)has become the group with the fastest growing HIV epidemic in *** many Chinese MSM are conducting HIV self-testing,we aimed to determine the rate of HIV care seeking after self-testing,examine characteristics of“seekers”compared to“non-seekers,”and explore factors associated with HIV care-seeking ***:A cross-sectional study design was used and an online survey was conducted in Beijing,China in 2016,among users of a popular Chinese gay networking smart phone ***-square test was used to compare characteristics of those who sought HIV care(“seekers”)and those who did not(“non-seekers”).Univariate and multivariate logistic regression analyses were conducted to assess factors associated with HIV care ***:Among 21,785 screened,2383 participants(10.9%)were included in the study.A total of 380 participants(15.9%)reported seeking HIV care after HIV self-testing while 2003(84.1%)did *** of knowledge of the“window period”(adjusted odds ratio[AOR]=0.68,95%confidence interval[95%CI]=0.47-0.97,P=0.04)was associated with reduced odds of seeking HIV care,while lower monthly income(AOR=1.29,95%CI=1.03-1.62,P=0.03)and obtaining HIV self-testing kits from health facilities(AOR=2.40,95%CI=1.81-3.17,Pinterventions aimed at improving linkage to care after HIV self-testing are urgently n

关键词： Men who have sex with men HIV self-testing HIV care Linkage to care Care cascade China

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Autoimmune pancreatitis in the context of IgG4-related disease:Review of imaging findings

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World Journal of Gastroenterology 2014年第41期20卷 15177-15189页

作者： Leslie K Lee Dushyant V Sahani division of Abdominal Imaging and intervention Department of RadiologyMassachusetts General HospitalHarvard Medical School

Current understanding of autoimmune pancreatitis (AIP) recognizes a histopathological subtype of the disease to fall within the spectrum of IgG4-related disease. Along with clinical, laboratory, and histopathological data, imaging plays an important role in the diagnosis and management of AIP, and more broadly, within the spectrum of IgG4-related disease. In addition to the defined role of imaging in consensus diagnostic protocols, an array of imaging modalities can provide complementary data to address specific clinical concerns. These include contrast-enhanced computed tomography (CT) and magnetic resonance (MR) imaging for pancreatic parenchymal lesion localization and characterization, endoscopic retrograde and magnetic resonance cholangiopancreatography (ERCP and MRCP) to assess for duct involvement, and more recently, positron emission tomography (PET) imaging to assess for extra-pancreatic sites of involvement. While the imaging appearance of AIP varies widely, certain imaging features are more likely to represent AIP than alternate diagnoses, such as pancreatic cancer. While nonspecific, imaging findings which favor a diagnosis of AIP rather than pancreatic cancer include: delayed enhancement of affected pancreas, mild dilatation of the main pancreatic duct over a long segment, the “capsule” and “penetrating duct” signs, and responsiveness to corticosteroid therapy. Systemic, extra-pancreatic sites of involvement are also often seen in AIP and IgG4-related disease, and typically respond to corticosteroid therapy. Imaging by CT, MR, and PET also play a role in the diagnosis and monitoring after treatment of involved sites.

关键词： Autoimmune pancreatitis IgG4-related disease Pancreatic cancer Imaging Computed tomography Magnetic resonance Positron emission tomography Review

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Understanding cost data collection tools to improve economic evaluations of health interventions

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Stroke & Vascular Neurology 2019年第4期4卷 214-222页

作者： John M Chapel Guijing Wang division for Heart Disease and Stroke prevention CDCAtlantaGeorgiaUSA

Micro-costing data collection tools often used in literature include standardized comprehensive templates,targeted questionnaires,activity logs,on-site administrative databases,and direct *** tools are not mutually exclusive and are often used in *** tool has unique merits and limitations,and some may be more applicable than others under different *** application of micro-costing tools can produce quality cost estimates and enhance the usefulness of economic evaluations to inform resource allocation decisions.A common method to derive both fixed and variable costs of an intervention involves collecting data from the bottom up for each resource consumed(micro-costing).We scanned economic evaluation literature published in 2008-2018 and identified micro-costing data collection tools *** categorized the identified tools and discuss their practical applications in an example study of health interventions,including their potential strengths and *** economic evaluations of health interventions provide valuable information for justifying resource allocation decisions,planning for implementation,and enhancing the sustainability of the ***,the quality of intervention cost estimates is seldom addressed in the *** cost data forms the foundation of economic evaluations,and without reliable estimates,evaluation results,such as cost-effectiveness measures,could be *** this project,we identified data collection tools often used to obtain reliable data for estimating costs of interventions that prevent and manage chronic conditions and considered practical applications to promote their use.

关键词： estimates mutually cost

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Improving China＇s antiretroviral treatment program： assessing current and future performance using the principals of ethics

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Chinese Medical Journal 2009年第11期122卷 1346-1351页

作者： YIN Wen-yuan ZHANG Fu-jiet Naomi Juniper WU Zun-you division of Health Education and Behavioral intervention National Centre for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing 100050 China division of Treatment and Care National Centre for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing 100050 China

The global commitment to providing antiretroviral therapy （ART） to people living with human immunodeficiency virus/acquired immunodeficiency syndrome （HIV/AIDS） in low-income countries has raised hope that the increasing momentum in the fight against the worldwide HIV/AIDS pandemic will be sufficient to control it. However, improved availability of subsidized antiretroviral （ARV） treatments in low-income .countries raises complex ethical issues. In many resource-constrained countries the number of individuals infected with HIV in need of treatment far exceeds the supply of ARV medication. Resource allocation decisions can be made on the basis of many epidemiological, ethical, or preferential treatment priority criteria. Healthcare systems and funding in low-income countries are limited, requiring a step-by-step approach to scaling- up programs to reach their stated aims.

关键词： acquired immunodeficiency syndrome antiretroviral treatment program ethics

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Improved cryopreservation of human hepatocytes using a new xeno free cryoprotectant solution

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World Journal of Hepatology 2012年第5期4卷 176-183页

作者： Mohammed Saliem Frida Holm Rosita Bergstrm Tengzelius Carl Jorns Lisa-Mari Nilsson Bo-Gran Ericzon Ewa Ellis Outi Hovatta division of Obstetrics and Gynecology Department of Clinical ScienceIntervention and TechnologyKarolinska Institute141 86 StockholmSweden division of Transplantation Surgery Department of Clinical ScienceIntervention and TechnologyKarolinska Institute141 86 StockholmSweden division of Pediatrics Department of Clinical ScienceIntervention and TechnologyKarolinska Institute141 86 StockholmSweden

AIM:To optimize a xeno-free cryopreservation protocol for primary human ***:The demand for cryopreserved hepatocytes is increasing for both clinical and research *** several hepatocyte cryopreservation protocols being available,improvements are urgently *** first compared controlled rate freezing to polystyrene box freezing and did not find any significant change between the *** the polystyrene box freezing,we compared two xeno-free freezing solutions for freezing of primary human hepatocytes:a new medium(STEM-CELLBANKER,CB),which contains dimethylsulphoxide(DMSO) and anhydrous dextrose,both permeating and non-permeating cryoprotectants,and the frequently used DMSO-University of Wisconsin(DMSOUW) *** viability of the hepatocytes was assessed by the trypan blue exclusion method as well as a calcein-esterase based live-dead assay before and after *** function of the hepatocytes was evaluated before and after cryopreservation by assessing enzymatic activity of 6 major cytochrome P450 isoforms(CYPs):CYP1A2,CYP2C9,CYP2C19,CYP2D6,CYP3A4 and ***:The new cryoprotectant combination preserved hepatocyte viability significantly better than the standard DMSO-UW protocol(P < 0.01).There was no significant difference in viability estimation between both the trypan blue(TB) and the Live-Dead Assay *** was a correlation between viability of fresh hepatocytes and the difference in cell viability between CB and DMSO protocols(r 2 = 0.69) using the TB ***,due to high within-group variability in the activities of the major CYPs,any statistical between-group differences were *** of human hepatocytes using the cryoprotectant combination was a simple and xeno-free procedure yielding better hepatocyte ***,it may be a better alternative to the standard DMSO-UW *** CYP activities did not seem to be a relevant way to compare hepatocyte function

关键词： Human hepatocytes Viability Cytochrome P540 Dimethylsulphoxide Cryoprotectant Cryopreservation

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Morphological alterations and redox changes associated with hepatic warm ischemia-reperfusion injury

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World Journal of Hepatology 2017年第34期9卷 1261-1269页

作者： Rim Jawad Melroy D'souza Lisa Arodin Selenius Marita Wallenberg Lundgren Olof Danielsson Greg Nowak Mikael Bjornstedt Bengt Isaksson division of Pathology Department of Laboratory Medicine Karolinska Institutet Department of Clinical Science Intervention and Technology (CLINTEC) Division of Surgery Karolinska Institutet Karolinska University Hospital Department of Clinical Science Intervention and Technology (CLINTEC) Division of Transplantation Surgery Karolinska Institutet Karolinska University Hospital

AIM To study the effects of warm ischemia-reperfusion(I/R) injury on hepatic morphology at the ultrastructural level and to analyze the expression of the thioredoxin(TRX)and glutaredoxin(GRX) *** Eleven patients undergoing liver resection were subjected to portal triad clamping(PTC). Liver biopsies were collected at three time points; first prior to PTC(baseline), 20 min after PTC(post-ischemia) and 20 min after reperfusion(post-reperfusion). Electron microscopy and morphometry were used to study and quantify ultrastructural changes, respectively. Additionally, gene expression analysis of TRX and GRX isoforms was performed by quantitative PCR. For further validation of redox protein status, immunogold staining was performed for the isoforms GRX1 and *** Post-ischemia, a significant loss of the liver sinusoidal endothelial cell(LSEC) lining was observed(P = 0.0003) accompanied by a decrease of hepatocyte microvilli in the space of Disse. Hepatocellular morphology was well preserved apart from the appearance of crystalline mitochondrial inclusions in 7 out of 11 patients. Postreperfusion biopsies had similar features as post-ischemia with the exception of signs of a reactivation of the LSECs. No changes in the expression of redox-regulatory genes could be observed at mR NA level of the isoforms of the TRX family but immunoelectron microscopy indicated a redistribution of TRX1 within the *** At the ultrastructural level, the major impact of hepatic warm I/R injury after PTC was borne by the LSECs with detachment and reactivation at ischemia and reperfusion, respectively. Hepatocytes morphology were well preserved. Crystalline inclusions in mitochondria were observed in the hepatocyte after ischemia.

关键词： Hepatic ischemia-reperfusion injury Ischemia reperfusion injury Warm ischemia-reperfusion injury Glutaredoxins Thioredoxins Electron microscopy Oxidative stress Portal triad clamping

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Exploration for the Priority of HIV intervention:Modelling Health Impact and Cost-Effectiveness—Six Cities,Eastern China,2019-2028

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China CDC weekly 2024年第20期6卷 463-468,I0008-I0014页

作者： Youran Zhang Lili Wang Zhen Jiang Hongjing Yan Xiaoxia Liu Jing Gu Guoyong Wang Xiaosong Cheng Qiyan Leng Qisui Long Zimian Liang Jing Wang Liang Liang Yanchao Qiu Lin Chen Hang Hong School of Health Service Management Anhui Medical UniversityHefei CityAnhui ProvinceChina division of prevention and intervention National Center for AIDS and STD Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Jiangsu Provincial Center for Disease Control and prevention Nanjing CityJiangsu ProvinceChina Zhenjiang Center for Disease Control and prevention Zhenjiang CityJiangsu ProvinceChina Wuxi Center for Disease Control and prevention Wuxi CityJiangsu ProvinceChina Shandong Provincial Center for Disease Control and prevention Jinan CityShandong ProvinceChina Yantai Center for Disease Control and prevention Yantai CityShandong ProvinceChina Guangdong Provincial Center for Disease Control and prevention Guangzhou CityGuangdong ProvinceChina Foshan Center for Disease Control and prevention Foshan CityGuangdong ProvinceChina Hebei Provincial Center for Disease Control and prevention Shijiazhuang CityHebei ProvinceChina Shijiazhuang Center for Disease Control and prevention Shijiazhuang CityChina Zhejiang Provincial Center for Disease Control and prevention Hangzhou CityZhejiang ProvinceChina Ningbo Center for Disease Control and prevention Ningbo CityZhejiang ProvinceChina

Introduction:In order to enhance the effectiveness of resource allocation,regions must tailor their responses to their specific epidemiological and economic ***:Utilizing Spectrum software,we projected the cost-effectiveness of 10 chosen HIV interventions in six cities in eastern China from 2019 to *** assessed three scenarios—Base,Achievable,and Idealized—for each *** analysis included the projected number of HIV infections and deaths averted,as well as the incremental costeffectiveness ratios for each intervention in the six ***:In Shijiazhuang,Wuxi,Yantai,and Zhenjiang,cities with initially low antiretroviral therapy(ART)coverage,ART showed significant effectiveness,especially for ***,in Foshan and Ningbo,where ART coverage was notably high,oral pre-exposure prophylaxis(PrEP)for men who have sex with men(MSM)proved effective in the Idealized *** outreach,ART for males,and ART for females demonstrated cost-effectiveness across all six cities in both Achievable and Idealized scenarios at the predefined thresholds for each ***:Maintaining an appropriate coverage rate for outreach to MSM can lead to *** cities with low ART coverage,scaling up ART remains a crucial *** regions with high ART coverage,consideration may be given to the utilization of oral PrEP for MSM individuals,requiring budget allocation.

关键词： Eastern Ningbo Impact

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