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Advances on ALV-J in China over the past two decades

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Journal of Integrative Agriculture 2025年第2期24卷 429-440页

作者： Wenrui Fan Yuntong Chen Mengmeng Yu Yongzhen Liu Yulong Gao Avian Immunosuppressive Diseases division State Key Laboratory for Animal Disease Control and PreventinonHarbin Veterinary Research InstituteChinese Academy of Agricultural Sciences Jiangsu Co-Innovation Center for the prevention and Control of Important Animal Infectious Disease and Zoonose Yangzhou University

Avian leukosis is an important tumorigenic disease caused by the avian leukosis virus(ALV) in poultry. ALVs belong to the retroviral family and are classified into 11 subgroups(ALV-A to ALV-K). Among them, ALV-J was first introduced into China in 1999, spreading widely and evolving from infecting meat-type chickens to layer chickens and Chinese local chickens. ALV-J typically induces myeloid leukosis in infected chickens, but also induces a high proportion of hemangiomas in infected layer chickens, posing a serious threat to poultry breeds in China. As a retrovirus, the genome of ALV-J has undergone significant mutations, which may be related to the expansion of the infection host range and increased pathogenicity of ALV-J. Over the last two decades, the introduction and spread of ALV-J in China have caused substantial losses to the poultry industry. Specialized detection assays have been developed to combat ALV-J infections in China. Additionally, ongoing research aims to employ gene-editing technology as a novel antiviral strategy to control the spread of ALV infections. This review highlights the importance of understanding the impact of ALV-J on the Chinese poultry industry and emphasizes the need for ongoing research and innovation to safeguard poultry health and promote sustainable poultry farming practices in China.

关键词： subgroup J avian leucosis epidemiology molecular variation pathogenicity prevention and control

Transport mechanism in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organisms over a curved oscillatory surface

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 177-192页

作者： M.NAVEED M.IMRAN T.ASGHAR Z.ABBAS Department of Mathematics Division of Science and TechnologyUniversity of Education Department of Mathematics The Islamia University of Bahawalpur

This paper examines the transport analysis, including both heat transfer and mass transfer, in hybrid nanofluid flow containing gyrotactic microorganisms towards a curved oscillatory surface. The influence of magnetic fields is also inspected in terms of their physical characteristics. To depict the phenomena of transport, modified versions of both Fick's and Fourier's laws are used. Additionally, the characteristics of both heterogeneous and homogeneous chemical reactions are also incorporated. Utilizing a curvilinear coordinate system, the flow problem is formulated as partial differential equations(PDEs)for momentum, concentration, microorganism field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the homotopy analysis method(HAM).The effects of significant flow parameters on the pressure and microorganism fields, velocity, oscillation velocity, concentration, and temperature distributions are shown via graphs. Furthermore, the variations in skin friction, mass transfer rate, heat transfer rate, and local motile number due to different involved parameters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and temperature fields are enhanced as the values of the solid volume fraction variables *** is also verified that the concentration rate field decreases as the values of the homogeneous reaction strength parameter and the radius of curvature parameter increase, and it increases with the Schmidt number and the heterogeneous reaction strength *** outcomes show a favorable response of the motile number to advanced values of the Peclet number, the Schmidt number, the microorganism difference parameter, and the bio-convective Lewis number.

关键词： analytical solution Cattaneo-Christov heat and mass flux chemical reaction gyrotactic microorganism hybrid nanofluid O368 oscillating curved stretchable sheet

Florfenicol can inhibit chick growth and lead to immunosuppression

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Journal of Integrative Agriculture 2025年第1期24卷 261-271页

作者： Fanliang Meng Kuihao Liu Yesheng Shen Peixun Li Tailong Wang Yiran Zhao Sidang Liu Mengda Liu Gang Wang Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and prevention College of Veterinary MedicineShandongAgricultural UniversityTai'an 271018China College of Veterinary Medicine Shanxi Agricultural UniversityTaigu 030801China division of Zoonoses Surveillance China Animal Health and Epidemiology CenterQingdao 266032China

Florfenicol(FLO)is a chemically synthesized broad-spectrum antimicrobial agent of amide alcohols for animals,which is one of the most widely used antimicrobials in livestock,poultry,and *** the use of FLo,more and more attention has been paid to its hematopoietic toxicity,immunotoxicity,genotoxicity,and *** this study,SPF *** the age of 3 d began to drink water with the FLO at a dose of 100 mg L^(-1)for 6 consecutive days,and the growth performance of chicks was monitored,the effect of FLO on immune organs was detected by pathological examination and TdT-mediated dUTP nick-end labeling(TUNEL)apoptosis *** order to evaluate the level of organism immunity,the level of Newcastle disease virus antibody in serum was detected by hemagglutination inhibition test,the content of cytokines(IL-1,IL-2,IL-6,TNF-α,IFN-γ)in serum was detected by enzyme linked immunosorbent assay(ELISA),and the transcription of interferon-related genes(IRF-7,2′-5′OAS,Mx1)and cytokine genes(IL-6,TNF-α,IFN-γ)in immune organs were detected by real time fluorescence quantitative *** results showed that the early application of FLO could inhibit the growth and development of chicks,and the body weight and immune organ index of the treatment group were lower than those of the control *** examination showed that there was a decrease in the number of lymphocytes in the bursa of Fabricius in the treatment group in the early stage of drug withdrawal,and the results of TUNEL apoptosis staining in the bursa of Fabricius showed that obvious lymphocyte apoptosis occurred in the FLO treatment *** with the control group,the transcription levels of interferon-related genes IRF-7,2′-5′OAS,and cytokine genes IL-6,TNF-αand IFN-γin FLO treatment group decreased to a certain extent,while the transcription level of Mx1 gene had no significant difference at all time *** level of serum Newcastle disease virus(NDV)antibody and the contents of

关键词： Florfenicol chick growth immunosuppression interferon-related genes cytokines

Decoding complexity: the need to enhance precision and streamline spatial understanding in neuroscience

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Neural Regeneration Research 2025年第3期20卷 801-802页

作者： Sameehan Mahajani Armita Salahi Brenda Gonzalez Charlotte Nelson Frank Hsiung Biology&Applications division NodexusSan JoseCAUSA

Neuroscience is the ultimate frontier in our quest for a comprehensive understanding of human behavior. Since its launch in 2009, the Human Connectome Project has emerged as a pioneering force, making heroic strides i... 详细信息

关键词： behavior frontier dating

Vagus nerve stimulation in intracerebral hemorrhage:the need for further research

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Neural Regeneration Research 2025年第11期20卷 3213-3214页

作者： Sheharyar S.Baig Ali N.Ali Arshad Majid Sheffield Institute for Translational Neuroscience Division of NeuroscienceThe University of SheffieldSheffieldUK

Vagus nerve stimulation(VNS)and stroke:Stroke is the second leading cause of death and the third leading cause of disability worldwide(Baig et al.,2023).There have been significant paradigm shifts in the management of acute ischemic stroke through mechanical *** chronic ischemic stroke,invasive VNS paired with rehabilitation is associated with a significant increase in upper limb motor recovery and is FDA-approved(Baig et al.,2023).There are no treatments of similar efficacy in acute intracerebral hemorrhage(ICH)where several promising trials,e.g.,TICH-2,STOP-AUST,and TRAIGE did not show improvements in functional outcomes(Puy et al.,2023).

关键词： stimulation acute

Optimization of an Artificial Intelligence Database and Camera Installation for Recognition of Risky Passenger Behavior in Railway Vehicles

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Computers, Materials & Continua 2025年第1期82卷 1277-1293页

作者： Min-kyeong Kim Yeong Geol Lee Won-Hee Park Su-hwan Yun Tae-Soon Kwon Duckhee Lee Railroad Test&Certification division Korea Railroad Research Institute(KRRI)Cheoldo BangmulgwanroUiwang-si16105Republic of Korea Railroad Safety division Korea Railroad Research Institute(KRRI)Cheoldo BangmulgwanroUiwang-si16105Republic of Korea

Urban railways are vital means of public transportation in *** than 30%of metropolitan residents use the railways,and this proportion is expected to *** enhance safety,the government has mandated the installation of closed-circuit televisions in all carriages by ***,cameras still monitored *** address this limitation,we developed a dataset of risk factors and a smart detection system that enables an immediate response to any abnormal behavior and intensive monitoring *** created an innovative learning dataset that takes into account seven unique risk factors specific to Korean railway *** data collection was conducted across the Shinbundang Line of the Incheon Transportation Corporation,and the Ui-Shinseol *** observed several behavioral characteristics and assigned unique annotations to *** also considered carriage *** performance was evaluated by camera placement and *** the camera installation plan was *** dataset will find immediate applications in domestic railway *** artificial intelligence algorithms will be verified shortly.

关键词： AI railway vehicle risk factor smart detection AI training data

Geochemistry of shales of middle Permian Barren Measures Formation,West Bokaro Basin,India:Implications on provenance,paleodepositional and paleoclimatic conditions

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Journal of Palaeogeography 2025年第01期14卷 40-65页

作者： Mritunjoy Banerjee Biplab Bhattacharya Arnab Bhattacharya Aniruddha Pathak Partha Pratim Banerjee Department of Earth Sciences Indian Institute of Technology Natural Resource division Tata Steel Limited

Geochemical analyses of fine-grained clastic sedimentary rocks,such as shales,are significant since they portray the nature of the control factors from source to sink in a sedimentary basin,and help characterizing the heterogeneity in potential source and/or reservoir *** rock geochemistry（including major element oxides,trace elements and rare earth elements） of 20 shale samples from the Permian Barren Measures Formation,West Bokaro Basin,Peninsular India,is presented to decipher the provenance,paleoweathering,paleotectonic,paleodepositional and paleoredox conditions of the basin within the Lower Gondwana paleogeographic framework.X-ray diffraction（XRD） peaks and scanning electron microscopy（SEM）reveal an abundance of quartz,muscovite and clay minerals,viz.,illite,kaolinite,etc.,with less abundant feldspar and *** concentrations of major element oxides,trace elements and rare earth elements（REEs） of the shale samples are compared with predefined standards such as PAAS and *** CIA（chemical index of alteration） and the A-CN-K values,based on the ratios of the major element oxides,signify intense chemical *** ratios of Sr/Cu versus Rb/Sr and K2O/Al2O3versus Ga/Rb,and high ∑REE values indicate a temperate *** of the major element oxides（e.g.,K2O/Na2O versus SiO2） suggest a passive tectonic *** Eu/Eu*and（Gd/Yb）_n values depict predominantly post-Archean granitic and gneissic source *** ratios of trace elements,viz.,Th/Sc,Th/Co,Th/Cr,La/Sc and Eu/Eu*,and the distribution pattern of the REEs（higher LREE in comparison to HREE） attest to a felsic-intermediate source from a nearby *** redox-sensitive trace elements,such as V and Ni,indicate a dysoxic condition that prevailed during *** ratios of Fe2O3versus MgO and Log（MgO/Al2O3） versus Log（K2O/Al2O3）,and the ternary plots of Fe2O3-MgO-SiO2/Al2O3suggest a non-marine to deltaic transitional *** evidence of marine influences during

关键词： Guadalupian Lower Gondwana Passive margin rift basin Fluvial–marine transition Anoxic condition West Bokaro Basin

Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru C.Guo division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British Columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science Core Collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P GC-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

Silk damping in scalar-induced gravitational waves:a novel probe for new physics

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Science China(Physics,Mechanics & Astronomy) 2025年第1期68卷 75-81页

作者： Yan-Heng Yu Sai Wang Theoretical Physics division Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China School of Physics University of Chinese Academy of SciencesBeijing 100049China

Silk damping is well known in the study of cosmic microwave background(CMB)and accounts for suppression of the angular power spectrum of CMB on large angular *** this article,we study the effect of Silk damping on the scalar-induced gravitational waves(SIGWs).Resulting from the dissipation of cosmic fluid,the Silk damping notably suppresses the energy-density spectrum of SIGWs on scales comparable to a diffusion scale at the decoupling time of weakly-interacting *** effect offers a novel observable for probing the underlying particle interaction,especially for those mediated by heavy gauge bosons beyond the standard model of *** anticipate that pulsar timing arrays are sensitive to gauge bosons with mass∼10^(3)-10^(4)GeV,while space-and ground-based interferometers to those with mass∼10^(7)-10^(12)GeV,leading to essential comple-ments to on-going and future experiments of high-energy physics.

关键词： scalar-induced gravitational waves Silk damping new physics