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Transport mechanism in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organisms over a curved oscillatory surface

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 177-192页

作者： M.NAVEED M.IMRAN T.ASGHAR Z.ABBAS Department of Mathematics Division of Science and TechnologyUniversity of Education Department of Mathematics The Islamia University of Bahawalpur

This paper examines the transport analysis, including both heat transfer and mass transfer, in hybrid nanofluid flow containing gyrotactic microorganisms towards a curved oscillatory surface. The influence of magnetic fields is also inspected in terms of their physical characteristics. To depict the phenomena of transport, modified versions of both Fick's and Fourier's laws are used. Additionally, the characteristics of both heterogeneous and homogeneous chemical reactions are also incorporated. Utilizing a curvilinear coordinate system, the flow problem is formulated as partial differential equations(PDEs)for momentum, concentration, microorganism field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the homotopy analysis method(HAM).The effects of significant flow parameters on the pressure and microorganism fields, velocity, oscillation velocity, concentration, and temperature distributions are shown via graphs. Furthermore, the variations in skin friction, mass transfer rate, heat transfer rate, and local motile number due to different involved parameters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and temperature fields are enhanced as the values of the solid volume fraction variables *** is also verified that the concentration rate field decreases as the values of the homogeneous reaction strength parameter and the radius of curvature parameter increase, and it increases with the Schmidt number and the heterogeneous reaction strength *** outcomes show a favorable response of the motile number to advanced values of the Peclet number, the Schmidt number, the microorganism difference parameter, and the bio-convective Lewis number.

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Mechanism by which Rab5 promotes regeneration and functional recovery of zebrafish Mauthner axons

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Neural Regeneration Research 2025年第6期20卷 1816-1824页

作者： Jiantao Cui Yueru Shen Zheng Song Dinggang Fan Bing Hu Center for Advanced Interdisciplinary Science and Biomedicine of IHM Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina

Rab5 is a GTPase protein that is involved in intracellular membrane trafficking. It functions by binding to various effector proteins and regulating cellular responses, including the formation of transport vesicles and their fusion with the cellular membrane. Rab5 has been reported to play an important role in the development of the zebrafish embryo;however, its role in axonal regeneration in the central nervous system remains unclear. In this study, we established a zebrafish Mauthner cell model of axonal injury using single-cell electroporation and two-photon axotomy techniques. We found that overexpression of Rab5 in single Mauthner cells promoted marked axonal regeneration and increased the number of intra-axonal transport vesicles. In contrast, treatment of zebrafish larvae with the Rab kinase inhibitor CID-1067700markedly inhibited axonal regeneration in Mauthner cells. We also found that Rab5 activated phosphatidylinositol 3-kinase(PI3K) during axonal repair of Mauthner cells and promoted the recovery of zebrafish locomotor function. Additionally, rapamycin, an inhibitor of the mechanistic target of rapamycin downstream of PI3K, markedly hindered axonal regeneration. These findings suggest that Rab5 promotes the axonal regeneration of injured zebrafish Mauthner cells by activating the PI3K signaling pathway.

关键词： axonal regeneration Mauthner cell nerve regeneration Rab5 zebrafish

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Mechanistic insight into the synergy between nickel single atoms and nanoparticles on N-doped carbon for electroreduction of CO2

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Journal of Energy Chemistry 2025年第1期100卷 327-336页

作者： Mingdong Sun Wenwen Guan Cailing Chen Chao Wu Xiaoling Liu Biao Meng Tao Chen Yu Han Jun Wang Shibo Xi Yu Zhou State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University Advanced Membranes and Porous Materials Center Physical Sciences and Engineering Division King Abdullah University of Science and Technology Institute of Sustainability for Chemicals Energy and Environment A*STAR (Agency for Science Technology and Research) College of Materials Science and Engineering Sichuan University

The synergy of single atoms （SAs） and nanoparticles （NPs） has demonstrated great potential in promoting the electrocatalytic carbon dioxide reduction reaction （CO2RR）;however,the rationalization of the SAs/NPs proportion remains one challenge for the catalyst ***,a Ni2+-loaded porous poly（ionic liquids）(PIL) precursor synthesized through the free radical self-polymerization of the ionic liquid monomer,1-allyl-3-vinylimidazolium chloride,was pyrolyzed to prepare the Ni,N co-doped carbon materials,in which the proportion of Ni SAs and NPs could be facilely modulated by controlling the annealing *** catalyst Ni-NC-1000 with a moderate proportion of Ni SAs and NPs exhibited high efficiency in the electrocatalytic conversion of CO2into *** Ni K-edge X-ray absorption near-edge structure （XANES） spectra and theoretical calculations were conducted to gain insight into the synergy of Ni SAs and *** charge transfer from Ni NPs to the surrounding carbon layer and then to the Ni SAs resulted in the electron-enriched Ni SAs active *** the electroreduction of CO2,the coexistence of Ni SAs and NPs strengthened the CO2activation and the affinity towards the key intermediate of*COOH,lowering the free energy for the potential-determining*CO2→*COOH step,and therefore promoted the catalysis efficiency.

关键词： Single atom catalyst Synergy effect Carbon catalyst Electrocatalysis

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Tree Age Affects postharvest Attributes and Mineral Content in Amrapali Mango(Mangifera indica) Fruits

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Horticultural Plant Journal 2018年第2期4卷 55-61页

作者： MEENA Nirmal Kumar ASREY Ram division of Food Science and postharvest technology ICAR-Indian Agriculture Research Institute

The study was carried out to investigate the effect of tree age on postharvest attributes and mineral content of Amrapali mango fruits. Effect of 3 different tree ages(6, 18 and 30 years) on functional components, including the antioxidant activity(AOX), total phenols, total carotenoids,ascorbic acid and minerals like Ca, K, Mg, Fe, Zn, Cu, Mn and B along with total sugars, total soluble solids(TSS) and titratable acidity(TA),respiration rate, polygalacturonase(PG) and pectin methylesterase(PME) activities in Amrapali cultivar were studied. With tree ageing total phenols, ascorbic acid and antioxidant activity decreased whereas total carotenoids increased. Ca diminished and K elevated with the tree age progression while, B, Fe, Cu, Zn, and Mn showed an indefinite pattern. Total soluble solids and total sugars were recorded higher in 18 year old tree fruits. Fruit respiration rate, polygalacturonase and pectin methylesterase activities showed an upward trend with tree ageing. The study indicates that fruit produced from middle age group mango orchard(18 year old) suits to the requirement of consumers as well as industry.

关键词： mango(Mangifera indica) tree age functional parameter mineral

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The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan Sun Lingyun Nie Jing Zhang Xue Fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

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Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian Ding Chun Chen Heng Zhao Bin Dai Lei Ye Tao Song Shuai Huang Jia Wang Tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

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Harvest and postharvest Factors Affecting Bruise Damage of Fresh Fruits

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Horticultural Plant Journal 2020年第1期6卷 1-13页

作者： Zaharan Hussein Olaniyi AFawole Umezuruike Linus Opara postharvest technology Research Laboratory South African Research Chair in Postharvest TechnologyDepartment of Food ScienceFaculty of AgriSciencesStellenbosch UniversityStellenbosch 7602South Africa postharvest technology Research Laboratory South African Research Chair in Postharvest TechnologyDepartment of Horticultural ScienceFaculty of AgriSciencesStellenbosch UniversityStellenbosch 7602South Africa

Fresh fruits are susceptible to bruising, a common type of mechanical damage during harvest and at all stages of postharvest handling. In quest of developing and adoption of strategies to reduce bruise damage, it is of utmost importance to understand major factors influencing bruise susceptibility of fresh produce at these stages. This review presents a critical discussion of factors affecting bruising during harvest and postharvest handling of fresh fruits. Excessive compression forces during harvesting by handpicking or machines, and a series of impacts during harvesting, transport and packhouse operations can cause severe bruise damage. The review has further revealed that bruising is dependent on a number of other factors such as produce maturity, ripening, harvest time(during the day or season) and time lapse after harvest. The susceptibility to bruising is partly dependent on how these factors alter the produce physiological and biochemical properties, and the environmental conditions such as temperature, humidity and several other postharvest treatments. Hence, the successful applications of harvesting techniques by use of trained personnel and proper harvesting equipment are essential to reduce both the incidence and severity of ***, the careful selection of postharvest handling temperature and other treatments can increase resistance of fresh produce to bruise damage.

关键词： bruise damage harvest postharvest fruit quality

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Cross-linked alginate edible coatings incorporated with hexyl acetate: Film characteristics and its application on fresh-cut rose apple

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Food Bioscience 2023年第2期52卷 759-767页

作者： Nhung Thi Cam Duong Apiradee Uthairatanakij Natta Laohakunjit Pongphen Jitareerat Nattapon Kaisangsri division of postharvest technology School of Bioresources and TechnologyKing Mongkut’s University of TechnologyThonburiThailand division of Biochemical technology School of Bioresources and TechnologyKing Mongkut’s University of TechnologyThonburiThailand Pilot Plant Development and Training Institute King Mongkut’s University of TechnologyThonburiThailand

Edible coatings,as carriers of antimicrobial compounds,have been proposed as an alternative method to preserve fresh-cut *** research focused to improve the shelf life of fresh-cut rose apples by applying an edible coating based on alginate cross-linked with calcium chloride(SAC)-enriched hexyl acetate(HA)as a natural antimicrobial *** SAC with HA in 0.01,0.03,and 0.05%(v/v)(SAC-HA)solution was evaluated for its film properties and applied to fresh-cut rose apples,and compared with the unmodified SAC *** quality and microbial contamination were determined every 2 days during 10 days of storage at 4℃.The film thickness,tensile strength,and elongation at break increased with the high concentrations of HA *** containing 0.03%HA had lower oxygen permeability(from 1.57 to 0.04×10^(-7) cm^(3)μm m^(-2) day^(-1) kPa^(-1)),as well as water vapor permeability(from 0.03 to 0.01 g mm m^(-2) day^(-1) kPa^(-1)),compared to the unmodified SAC ***,the greater coating uniformity and thickness were supported by scanning electron microscopy and Fourier transform infrared *** developed edible SAC coatings with 0.03%HA successfully preserved the physicochemical quality and extended the shelf life of fresh-cut rose apples for 10 days at 4℃ by retarding the respiration rate,inhibiting browning,and preventing microbial ***,the using of SAC-HA in fresh-cut products is a promising and safe preservation technique to extend shelf life.

关键词： Film properties Browning Antimicrobial Rose apple postharvest quality

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postharvest physiological responses of pomegranate fruit (cv. Wonderful) to exogenous putrescine treatment and effects on physico-chemical and phytochemical properties

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Food Science and Human Wellness 2020年第2期9卷 146-161页

作者： Olaniyi Amos Fawole Julian Atukuri Ebrahiema Arendse Umezuruike Obia Opara postharvest technology Research Laboratory South African Research Chair in Postharvest TechnologyDepartment of Horticultural ScienceFaculty of AgriSciencesStellenbosch UniversityPrivate Bag X1Stellenbosch7602South Africa postharvest technology Research Laboratory South African Research Chair in Postharvest TechnologyDepartment of Food ScienceFaculty of AgriSciencesStellenbosch UniversityPrivate Bag X1Stellenbosch7602South Africa Department of Botany and Plant Biotechnology University of JohannesburgP.O.Box 524Auckland Park 2006JohannesburgSouth Africa

Pomegranate fruit(***)were treated with putrescine(1,2 and 3 mmol/L)before storage for 4 months at 5℃ and 95%RH and the effects on postharvest life and quality attributes were *** showed that incidence of physiological disorders such as external decay,husk scald,chilling injury and aril browning increased with progressive storage but treating pomegranate fruit with putrescine reduced incidence of most *** fruit had higher levels of external decay(1.72%–33.26%),chilling injury(10.53%–38.77%)and scalding(15.04%–100%)with less attractive color during 4 month *** were observed on other fruit quality parameters although treatment with putrescine at 2 and 3 mmol/L concentration reduced changes in color,total soluble solid,Titratable acidity and ascorbic *** parameters were best preserved in fruit treated with 2 mmol/L concentration of putrescine with respect to juiciness and *** of pomegranate fruit with putrescine resulted in improved storability and fruit quality during ***,for short term storage,2 mmol/L concentration of putrescine could be recommended for maintaining fruit quality especially in the first two months of ***,for longer storage period,a higher concentration is recommended,as 3 mmol/L concentration was the most effective in alleviating disorders and maintaining physico-chemical parameters and sensory attributes during storage in this study.

关键词： Decay Chilling injury Phytochemical Sensory properties Principal component analysis

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Occurrence of ionization instability associated with plasma bubble in glow discharge magnetized plasma

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Plasma Science and technology 2019年第11期21卷 29-37页

作者： Mariammal MEGALINGAM Bornali SARMA division of Physics Vellore Institute of Technology

Floating potential fluctuations of glow discharge magnetized plasma are found to expose mixed mode oscillations(MMOs)in the existence of plasma *** bubble has been formed by emerging density gradient in the form of a sheath around a cylindrical and spherical grid to a critical value of applied *** Langmuir probes,LP1 and LP2,are retained in the ambient plasma to collect the plasma floating potential fluctuations at two different locations of the plasma *** perceived instability pattern shows regular-irregular-regular MMOs under various imposed ***,various nonlinear techniques such as phase space plot,recurrence plot and Hurst exponent have been executed to understand the underlying dynamical behavior of the ***-frequency(~200–1200 Hz)oscillations are also supposed and are inferred as ion-acoustic waves excited by ionization *** observed results are then validated with the theory of the instability based on a fluid hydrodynamic approach.

关键词： plasma bubble floating potential fluctuations MMO instability

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