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Asian Pacific Journal of Tropical Biomedicine 2011年第1期1卷 43-48页

作者： Govindarajan M Mathivanan T Elumalai K Krishnappa K Anandan A division of Vector Biology and phytochemistry Department of ZoologyAnnamalai University Unit of Entomotoxicity Department of ZoologyGovernment Thirumagal Mills College

Objective:To determine the ovicidal and repellent activities of methanol leaf extract of Ervatamia coronaria(***) and Caeslpinia pulckerrima(***) against Culex quinquefasciatus(***),Aedes aegypti(***) and Anopheles stephensi(An. stephensi).Methods:The ovicidal activity was determined against three mosquito species at various concentrations ranging from 50-450 ppm under the laboratory *** hatch rates were assessed 48 h after *** repellent efficacy was determined against three mosquito species at three concentrations viz.,1.0,2.5 and 5.0 mg/cm under the laboratory conditions. Results:The crude extract of *** exerted zero hatchability(100%mortality) at 250.200 and 150 ppm for ***,*** and ***,*** crude extract of *** exerted zero hatchability(100%mortality) at 375.300 and 225 ppm for ***,*** and ***,*** methanol extract of E. coronaria found to be more repellenct than *** extract.A higher concentration of 5.0 mg/cm^2 provided 100%protection up to 150.180 and 210 min against ***,Ae. aegypti and ***,*** results clearly showed that repellent activity was dose ***:From the results it can be concluded the crude extracts of *** and *** are an excellent potential for controlling ***,*** and *** mosquitoes.

关键词： Ervatamia coronaria Caesalpinia pulcherrima Ovicidal activity Repellent activity Culex quinquefasciatus Aedes aegypti Anopheles stephensi Mosquito Leaf extract Mortality

Inhibition of Mahkota Dewa(Phaleria macrocarpa) bioactive fraction on proliferation of human retinoblastoma tumor cells Y-79 through suppression of mRNA level of cyclin E

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Asian Pacific Journal of Tropical Biomedicine 2017年第4期7卷 280-287页

作者： Nugroho Trilaksana Ignatius Riwanto Raymond Rubianto Tjandrawinata Reki Winarto Department of Ophthalmology Faculty of MedicineDiponegoro University Department of Surgery Faculty of MedicineDiponegoro University division of Molecular Pharmacology and phytochemistry Dexa Laboratories of Biomolecular SciencesDexa Medica Group

Objective: To prove the molecular mechanisms of Mahkota Dewa(Phaleria macrocarpa) in suppressing proliferation of human retinoblastoma cells through suppression of cell cycle's gene-regulators ***: In this study, the molecular mechanism of anti-tumor effect of fractioned extract of Phaleria macrocarpa(DLBS1425) in human retinoblastoma cells Y-79 was investigated by measuring the tumor cells viability, the assessment of population profiles of tumor cells in the cell cycle, and the mRNA concentration of p16, p21, p53, cyclin D,cyclin E, and E2 ***: DLBS1425 showed an inhibition effects towards proliferation of Y-79 cell *** of proliferation was shown by suppression of cell cycle ***1425 downregulated cyclin E, a G1 phase regulator gene of cell cycle, in dosedependent manner without affecting p53–p21 *** the other word, DLBS1425 inhibits cell proliferation through suppression of cyclin E independently towards conventional proliferation ***: Our results suggest that DLBS1425 is a potential anticancer agent which targets genes involved in cell proliferation in human retinoblastoma cells which make it pharmacologically ideal for the prevention and/or treatment of retinoblastoma cancer.

关键词： Phaleria macrocarpa Mahkota Dewa DLBS1425 Retinoblastoma Cyclin E Cell cycle

Central nervous system activity of Illicium verum fruit extracts

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Asian Pacific Journal of Tropical Medicine 2013年第11期6卷 869-875页

作者： Divya Chouksey Neeraj Upmanyu RS Pawar phytochemistry and Pharmacognosy division VNS Institute of PharmacyNeelbudBHOPALM.P.India R.K.D.F.College of Pharmacy Hoshangabad RoadBhopalM.P.-462047.India

Objective:To research the acute toxicity of Illicium verum(***)fruit extracts and its action on central nervous ***:The TLC and HPTLC techniques were used as fingerprints to determine the chemical components present in *** albino rats and mice were utilized for *** powdered material was successively extracted with n-hexane,ethyl acetate and methanol using a Soxhlet *** toxicity studies were performed as per OECD *** CNS activity was evaluated on parameters of general behavior,sleeping pattern,locomotor activity,anxicty and myocoordination *** animals were trained for seven days prior to experiments and the divided into five groups with six animals in *** drug was administered by intraperitoneal route according to body *** dosing was done as prescribed in each ***:Toxicity studies reported 2 000 mg/kg as toxicological dose and 1/10 of the same dose was taken as therapeutic dose Intraperitoneal injection of all extracts at dose of 200 mg prolonged phenobarbitone induced sleeping time,produced alteration in general behavior pattern,reduced locomotor activity and produced anxiolytic effects but the extracts do not significantly alter muscles coordination *** three extracts of *** at the dose of 200 mg,methanol extract was found to produce more prominent effects,then hexane and ethylacetate ***:The observation suggested that the extracts of I. verum possess potent CNS depressant action and anxiolytic effect without interfering with motor coordination.

关键词： Illicium verum TLC HPTLC Anxiolytic CNS depressant

Comparative assessment for removal of anionic dye from water by different waste-derived biochar vis a vis reusability of generated sludge

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Biochar 2022年第1期4卷 986-1002页

作者： Mayank Singh MohdAhsan Versha Pandey Anupama Singh Disha Mishra Neerja Tiwari Pooja Singh Tanmoy Karak Puja Khare Crop Production and Protection DivisionCSIR-Central Institute of Medicinal and Aromatic PlantsLucknow 226015India phytochemistry division CSIR-Central Institute of Medicinal and Aromatic PlantsLucknow 226015India Upper Assam Advisory Centre Tea Research AssociationDikomDibrugarh 786101AssamIndia Academy of Scientific and Innovative Research(AcSIR) GaziabadIndia Biotechnology division Central Institute of Medicinal and Aromatic PlantsLucknow 226015India

In this study,four biochars prepared from different crop residue waste *** bagasse(SBB),coconut shell(CNB),paddy straw(PDB),and distilled waste of lemongrass(LGB)were evaluated for removal of Remazol Brilliant Blue R from the aqueous *** RBBR adsorption capacities of biochar were 97-79%for SBB,99.9-99.47%for CNB,66.1-48%for PDB,and 78-68%for LGB,dominantly controlled by their aromaticity and mineral *** Langmuir and Freundlich isotherms and pseudo-second-order kinetic models have described the chemisorption of RBBR on biochar *** thermodynamic data suggested that adsorption was spontaneous and *** biochars demonstrated excellent reusability(till four cycles with 50-61%regeneration).The purified water and biochar dye sludge demonstrated no *** findings obtained in this study may provide supports for the potential of biochars for anionic dye removal from water and utilization of generated sludge for zero waste-producing technologies in the future.

关键词： Biochar Remazol Brilliant Blue R Dye Adsorption Biochar dye sludge

Mosquito larvicidal and ovicidal properties of Pithecellobium dulce(Roxb.)Benth.(Fabaceae)against Culex quinquefasciatus Say(Diptera:Culicidae)

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Journal of Coastal Life Medicine 2014年第4期 308-312页

作者： Govindarajan Marimuthu Rajeswary Mohan division of Vector Biology and phytochemistry Department of ZoologyAnnamalai UniversityAnnamalainagar-608002TamilnaduIndia

Objective:To assess the larvicidal and ovicidal potential of the crude hexane,benzene,chloroform,ethyl acetate and methanol solvent extracts from the medicinal plant,Pithecellobium dulce(***)against filariasis vector mosquito,Culex quinquefasciatus(***).Methods:Twenty five early third instar larvae of *** were exposed to various concentrations and were assayed in the laboratory by using the protocol of W HO(2005).The larval mortality was observed after 24 h of *** ovicidal activity was determined against *** mosquito eggs to various concentrations ranging from 100-750 mg/L under the laboratory ***:The methanol extract of the leaves and seed of *** was the most effective against the larvae with LCs0 and LCgo values 164.12 mg/L,214.29 mg/L,289.34 mg/L and 410.18 mg/L being observed after 24 h of *** efficacy of methanol was followed by that of the ethyl acetate,chloroform,benzene and hexane *** mean percent hatchability of the egg rafts were observed after 48 h of *** 100%mortality was observed at 500 mg/L for leaf and 750 mg/L for seed methanol extracts of ***:From the results,it can be concluded that the larvicidal and ovicidal effect of *** against *** make this plant product promising as an alternative to synthetic insecticide in mosquito control programs.

关键词： Culex quinquefasciatus Pithecellobium dulce Larvicidal activity Ovicidal activity Leaf and seed

Chemical Components of Dendrobium chrysotoxum

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Chinese Journal of Chemistry 2012年第6期30卷 1327-1330页

作者：胡江苗范卫卫董发武缪泽鸿周俊 State Key Laboratory of phytochemistry and Plant Resource in West China Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650204China Graduate School of Chinese Academy of Sciences Beijing 100039China division of Anti-Tumor Pharmacology Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China

Two new phenanthrenes, named chrysotoxols A and B （1, 2） and 24 known compounds were isolated from the stems of the accession species in 2010 Chinese Pharmacopoeia of＂Shihu＂, Dendrobium chrysotoxum. All structures were elucidated by spectroscopic （NMR, MS, UV and IR） methods and the comparison with reported data in the literatures. Compound 2 and six known phenols were assessed for cytotoxic activity against two human tumor cell lines （A549 and HL-60）. The results indicated that erianin may have cytotoxic activity and the other six compounds lost activity at the concentration down to 10^-5 mol·L^-1.

关键词： Orchidaceae Dendrobium chrysotoxum chrysotoxol phenanthrene cytotoxic activity

Acortatarin A inhibits high glucose-induced extracellular matrix production in mesangial cells

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Chinese Medical Journal 2013年第7期126卷 1230-1235页

作者： ZHAO Zhi-fang ZHOU Li-li CHEN Xia CHENG Yong-xian HOU Fan-fan NIE Jing division of Neph-rology Nanfang Hospital Southern Medical University Research Institute ofNephrology Guangdong Province Key Laboratory for Organ Failure Research Ministry of Education Guangzhou Guangdong 510515 China State Key Laboratory of phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences Kunming Yunnan 650204 China

Background Diabetic nephropathy （DN） is the leading cause of end-stage renal disease. Various treatment regimens and combinations of therapies provide only partial renoprotection. Therefore new approaches are needed to retard the progression of DN. The aim of the present study was to evaluate the role of a novel spiroalkaloid from Acorus tatarinowii named acortatarin A （AcorA） in inhibiting high glucose-induced extracellular matrix accumulation in mesangial cells （MCs）. Methods The cytotoxity of AcorA on MCs was examined by 3-（4,5-dimethylthiazol-2-yl）-2.5-diphenyltetrazolium bromide （MTT） assay. The expression of fibronectin and collagen IV was examined by real time PCR and western blotting. The expression of p22phox and p47phox was detected by western blot. The interaction between p22phox and p47phox was examined by co-immunoprecipitation. The phosphorylation of p47phox was examined by immunoprecipitation. The phosphorylation of protein kinase C （PKC） α, PKCβ, phospholiase C gamma （PLCγ1）, and the p85 subunit of PI3K was determined by Western blotting. Results AcorA significantly inhibited high glucose-induced activation of NADPH oxidase, a ROS-generating enzyme, by increasing phosphorylation of p47phox and enhancing interaction between p22phox and p47phox. Preincubation of AcorA with MCs inhibited high glucose-induced collagen IV and fibronectin production in a dose-dependent manner. Moreover, AcorA attenuated high glucose enhanced phosphorylation of PKCα, PKCβ, PLCγ1, and the p85 subunit of PI3K. Conclusion AcorA inhibits high glucose-induced extracellular matrix production via blockinq NADPH oxidase activation.

关键词： acortatarin A high glucose mesangial cells extracellular matrix

Voacanga grandifolia(Miq.)Rolfe protects against alcohol-induced liver toxicity in rats

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Asian Pacific Journal of Tropical Biomedicine 2022年第12期12卷 504-511页

作者： Lal Chand Pal Shivankar Agrawal Arti Gautam Pharmacology division CSIR-National Botanical Research InstituteLucknow 226001Uttar PradeshIndia Department of phytochemistry ICMR-National Institute of Traditional MedicineNehru NagarBelagavi 590010KarnatakaIndia Department of Pharmaceutical Sciences Sam Higginbottom University of AgricultureTechnology&SciencesNainiPrayagraj 211007Uttar PradeshIndia

Objective:To evaluate the ethanol extract of Voacanga grandifolia for hepatoprotective and antioxidant potential against ethanol-induced liver toxicity in ***:Sprague-Dawley rats were administered ethanol(7 g/kg)and then treated with 100 and 200 mg/kg of Voacanga grandifolia *** phytochemical constituents and antioxidant potential of Voacanga grandifolia extract were evaluated by GC-MS and in vitro antioxidant *** indicators for liver damage and pro-apoptotic and antiapoptotic gene expression were determined using biochemical kits,ELISA,and qRT-PCR,***,histopathological study of the liver was ***:GC-MS identified propanoic acid,meso-erythritol,D-pinitol,myo-inositol,and hexadecanoic acid in Voacanga grandifolia *** grandifolia extract(100 and 200 mg/kg)increased the concentration of enzymatic antioxidants while diminishing the levels of inflammatory cytokines and biochemical ***-PCR assay showed that Voacanga grandifolia extracts upregulated antiapoptotic gene expression while downregulating pro-apoptotic gene ***,the plant extract improved the hepatic architecture of ethanol-intoxicated ***:Voacanga grandifolia extract demonstrates hepatoprotective activity against alcohol-induced liver injury in rats and could be a potential hepatoprotective agent.

关键词： Antioxidant Ethanol-induced toxicity Hepatoprotective Hepatic markers Voacanga grandifolia

Fatty Acid Compositional Studies of Lesser Known <i>Acacia tortilis</i>Seed Oil

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Food and Nutrition Sciences 2013年第9期4卷 59-62页

作者： Manjoosha Srivastava Shailesh Kumar Dayanand Dinanath College Institute of Pharmacy Kanpur India. phytochemistry division CSIR-National Botanical Research Institute Lucknow India

A. tortilis is commonly known as “Israeli babool”. The species is exposed to the world for its pods, gum and other aerial parts as fodder &feed for cattles. The plant was used as antidiabetic, antidiarrhoeal, antiasthmatic and also had several other medicinal benefits but the seed oil was not explored to the extent of its real potential. Hence the study was carried out to characterize the seed for oil and analysis of fatty acid composition through GC for quality control and maintenance. Commercial indices of oil were also estimated. Extracted oil is rich in Linolenic acid (50.43%) and Linoleic acid (36.74%). Beside this palmitic, stearic and oleic acid are other fatty acids identified. MUFA, PUFA, SFA and omega-6/ omega-3 ratio were also found to be promising for its potentiality in edible and clinical uses. The investigation thus scopes the utility of oil and prospects the lesser known plant seed as alternative oil source of nutritional and therapeutic importance.

关键词： A. tortilis Seed Oil Fatty Acid Cholesterol Fat

Multi-targeting cytotoxic drug leads from mushrooms

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Asian Pacific Journal of Tropical Medicine 2019年第12期12卷 531-536页

作者： MVNL Chaitanya Asha Jose P Ramalingam SC Mandal P Narendra Kumar Phytomedicine&phytochemistry division Raghavendra Institute of Pharmaceutical Education&Research(RIPER)(AUTONOMOUS)campusAnantapuramuAPIndia Department of Pharmacology Karpagam College of PharmacyOthakkalmadapamCoimbatore 32TamilnaduIndia RERDS-CPR Raghavendra Institute of Pharmaceutical Education&Research(RIPER)(AUTONOMOUS)AnantapuramuAPIndia Pharmacognosy and Phytotherapy Research Laboratory Division of PharmacognosyDepartment of Pharmaceutical TechnologyJadavpur UniversityKolkata 700032India School of Crop Production Technology Suranaree University of TechnologyThailand

Due to genetic and epigenetic mechanisms, cancer have become a resistant disease and there is a need for new molecules having multiple targeting action that promotes apoptosis. Phytomolecules having multiple targeting anticancer activity are in high demand and there is less documentation or information available on these metabolites. It is evident that mushrooms are became the store houses of new anticancer molecules and mushrooms like Agaricus blazei, Antrodia camphorate, Albatrellus confluens, Bolteus badius, Cordyceps militaris, Clitocybe maxima, Funalia trogii, Grifola frondosa, and Inocybe umbrinella, are some of the medicinal mushrooms reported for their cytotoxic activity. Cytotoxic molecules like lentinan, grifolin, illudin-S, psilocybin, ganoderic acid, theanine, and hispolon, have been isolated from various mushroom species. However, studies have been limited only to in vitro cytotoxic mechanisms and very few trials have been conducted to prove the clinical efficacy of these drug leads. Hence, the current review focuses on new anticancer metabolites isolated from various mushrooms having multiple targeting mechanisms in cancer. However, an extensive research is needed to define the biosynthesis and clinical mechanism of these multiple acting metabolites. This review provides a platform for researchers new anticancer drugs and to bring out potent multiple acting anticancer newer drugs.

关键词： Cancer Phytomolecules Multiple targeting Anticancer Drugs Leads