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Fecal microbiota transplantation in allergic diseases

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World Journal of Methodology 2025年第2期15卷 83-91页

作者： Ece TüsüzÖnata ÖnerÖzdemir division of pediatric Allergy and Immunology Medical FacultySakarya UniversityAdapazarı54100SakaryaTürkiye

Microorganisms such as bacteria,fungi,viruses,parasites living in the human intestine constitute the human intestinal *** refers to composi-tional and quantitative changes that negatively affect healthy gut *** recent years,with the demonstration that many diseases are associated with dysbiosis,treatment strategies targeting the correction of dysbiosis in the treat-ment of these diseases have begun to be *** microbiota trans-plantation(FMT)is the process of transferring faeces from a healthy donor to another recipient in order to restore the gut microbiota and provide a therapeutic *** studies have gained popularity after probiotic,prebiotic,symbiotic studies in the treatment of dysbiosis and related *** has emerged as a potential new therapy in the treatment of allergic diseases as it is associated with the maintenance of intestinal microbiota and immunological balance(T helper 1/T helper 2 cells)and thus suppression of allergic *** this article,the definition,application,safety and use of FMT in allergic diseases will be discussed with current data.

关键词： Microbiota Dysbiosis Faecal microbiota transplantation Allergic diseases

Adnexal Sliding Hernia in an Infant: Clinical-Anatomical Case Report

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Open Journal of pediatrics 2025年第1期15卷 93-100页

作者： Ralf-Bodo Tröbs Grigore Cernaianu Matthias Nissen Department of General Visceral and Pediatric Surgery St. Vincenz Hopitals Paderborn Germany division of pediatric Surgery University Hospital Cologne Cologne Germany Department of pediatric Surgery St. Maries Hospital Witten Ruhr-University of Bochum Sankt Elisabeth Gruppe Germany

We present a case report of laparoscopic herniorrhaphy in an infant with ovarian prolapse. Using this case study, we demonstrate the role of the ovarian ligamentous apparatus. A structure appearing like the male gubernaculum was identified. The anatomical and functional role of this “gubernaculum” will be the subject of discussion. Further detailed laparoscopic examinations are indicated to better understand the ligamentous anatomy of ovarian prolapse.

关键词： Inguinal Hernia Ovarian Prolapse Ovarian Descensus Sliding Hernia Gubernaculum

Total estimated effective doses from radiologic imaging modalities of children with cancer:a single center experience

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World Journal of pediatrics 2017年第3期13卷 242-247页

作者： Derya Ozyorük Suna Emir HacιAhmet Demir Gülsah Bayram Kabacam Bahattin Tunc division of pediatric oncology Ankara Children's Hematology and Oncology Education and Research HospitalAnkaraTurkey division of Radiology Ankara Children's Hematology and Oncology Education and Research HospitalAnkaraTurkey

Background:Recently,awareness of the cumulative radiation exposure for pediatric oncology patients has been increasing,together with increased survival rates and longer life *** aim of our study was to quantify the amount of ionising radiation from imaging modalities of pediatric oncology ***:Eighty-eight patients who were diagnosed with childhood cancer and followed up for 5 years between 2004-2014 in our center were included in the ***' medical files were reviewed retrospectively for imaging history in the first 5 years after *** estimated effective doses from radiologic imaging modalities were ***,the basic demographic data,histologic type,stage,and outcomes of disease were collected for all ***:The individual total estimated effective doses ranged from 8.73 to 167 mSv,with a median of 62.92 *** tomography was the greatest contributor of total effective *** doses ranged 21.45-113.20 mSv (median:62.92 mSv) in Hodgkin lymphoma,12.53-167.10 mSv (median:52 mSv) in non-Hodgkin lymphoma,4.13-172.98 mSv (median:52 mSv) in neuroblastoma,31-149.89 mSv (median:63.10 mSv) in Wilms' tumor,11.50-73.72 mSv (median:36.90 mSv) in germ cell tumor,26.46-125.86 mSv (median:80.90 mSv) in other solid tumor and 0.02-13.31 mSv (5.25 mSv) in brain tumor ***-two children (25%) died with progressive disease during the 5-year follow-up ***:Similar to previous studies,the total estimated effective doses in children with cancer have been found various according to diagnosis,stage and clinical *** clarify the harmfull effects of radiation burden,prospective studies should be conducted in children with cancer.

关键词： children effective dose ionizing radiation

Effect of tandem autologous stem cell transplantation on survival in pediatric patients with high-risk solid tumors in South China

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World Journal of Stem Cells 2025年第2期17卷 42-52页

作者： Zi-Yan Luo Li-Qun Fan Wen-Ling Guo Jian-Ping Yang Zhuo-Yan Li Yong-Xian Huang Hua Jiang Xiao-Hong Zhang division of hematology and oncology Department of PediatricsGuangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou 510000Guangdong ProvinceChina Department of pediatric hematology oncology Guangdong Women and Children HospitalGuangzhou 510000Guangdong ProvinceChina

BACKGROUND Despite advances in treatment,the prognosis for patients with high-risk pediatric solid tumors remains *** autologous stem cell transplantation(ASCT)offers promise for improving outcomes in these *** study aimed to examine the efficacy and prognostic factors of tandem ASCT in pediatric patients with high-risk solid *** To determine the survival outcomes and prognostic factors in pediatric patients with high-risk solid tumors undergoing tandem *** A total of 40 pediatric patients with high-risk solid tumors treated from March 2015 to August 2022 were included in this retrospective *** diagnoses of the patients included neuroblastoma,germ cell tumors,atypical teratoid/rhabdoid tumor,medulloblastoma,and *** induction chemotherapy,all patients received tandem ASCT and were allocated into two groups(group A and group B)based on high-dose chemotherapy *** relevance was evaluated by examining patient characteristics,such as sex,age,lactate dehydrogenase levels,primary site,the number of metastatic sites,and bone marrow *** The median follow-up duration since the first ASCT was 24 months(range:1-91 months),with 5-year overall survival(OS)and event-free survival(EFS)rates of 73%and 70%,respectively,for the entire *** 3-year OS rates were 67%for group A and 87%for group B(P=0.29),with corresponding 3-year EFS rates of 67%and 79%(P=0.57).Among neuroblastoma patients,the 5-year OS and EFS were 69%and 63%(P=0.23).Univariable analysis revealed a notable association of age≥36 months and elevated lactate dehydrogenase level at diagnosis with poorer *** acute adverse effects,all patients demonstrated good tolerance to the treatment,with no occurrences of transplant-related *** Tandem ASCT demonstrates promising survival outcomes for patients with high-risk solid tumors,particularly neuroblastoma,with manageable toxicity and no transplant-related mortali

关键词： Autologous stem cell transplantation pediatric solid tumors Neuroblastoma Survival outcomes Prognostic factors

Deciphering the role of hedgehog signaling in pancreatic cancer

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The Journal of Biomedical Research 2016年第5期30卷 353-360页

作者： Dongsheng Gu Kelly E Schlotman Jingwu Xie Wells Center for pediatric Research Division of Hematology and OncologyDepartment of PediatricsIndiana University Simon Cancer CenterIndiana University

Pancreatic cancer, mostly pancreatic ductal adenocarcinoma （PDAC）, is a leading cause of cancer-related death in the US, with a dismal median survival of 6 months. Thus, there is an urgent unmet need to identify ways to diagnose and to treat this deadly cancer. Although a number of genetic changes have been identified in pancreatic cancer, their mechanisms of action in tumor development, progression and metastasis are not completely understood. Hedgehog signaling, which plays a major role in embryonic development and stem cell regulation, is known to be activated in pancreatic cancer; however, specific inhibitors targeting the smoothened molecule failed to improve the condition of pancreatic cancer patients in clinical trials. Furthermore, results regarding the role of Hh signaling in pancreatic cancer are controversial with some reporting tumor promoting activities whereas others tumor suppressive actions. In this review, we will summarize what we know about hedgehog signaling in pancreatic cancer, and try to explain the contradicting roles of hedgehog signaling as well as the reason（s） behind the failed clinical trials. In addition to the canonical hedgehog signaling, we will also discuss several non-canonical hedgehog signaling mechanisms.

关键词： hedgehog pancreatic cancer Glil non-canonical signaling cancer metastasis

Preclinical evaluation of cyclophosphamide and fludarabine combined with CD19 CAR-T in the treatment of B-cell hematologic malignancies in vivo

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oncology Research 2024年第6期32卷 1109-1118页

作者： ZHIGANG XIA MENGYAO TIAN YUCAI CHENG WENFANG YI ZEFAN DU TIANWEN LI YUCHEN WEN LINDI LI YONG LIU CHUN CHEN pediatric hematology Laboratory Division of Hematology/OncologyDepartment of PediatricsThe Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen518107China Scientific Research Center The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen518107China

Background:Chimeric antigen receptor T(CAR-T)cell therapy has achieved marked therapeutic success in ameliorating hematological ***,there is an extant void in the clinical guidelines concerning the most effective chemotherapy regimen prior to chimeric antigen receptor T(CAR-T)cell therapy,as well as the optimal timing for CAR-T cell infusion *** and Methods:We employed cell-derived tumor xenograft(CDX)murine models to delineate the optimal pre-conditioning chemotherapy regimen and timing for CAR-T cell ***,transcriptome sequencing was implemented to identify the therapeutic targets and elucidate the underlying mechanisms governing the treatment ***:Our preclinical in vivo evaluation determined that a combination of cyclophosphamide and fludarabine,followed by the infusion of CD19 CAR-T cells five days subsequent to the chemotherapy,exerts the most efficacious therapeutic effect in B-cell hematological ***,RNA-seq data indicated that the therapeutic efficacy predominantly perturbs tumor cell metabolism,primarily through the inhibition of key mitochondrial targets,such as C-Jun Kinase enzyme(C-JUN).Conclusion:In summary,the present study offers critical clinical guidance and serves as an authoritative reference for the deployment of CD19 CAR-T cell therapy in the treatment of B-cell hematological malignancies.

关键词： CD19 CAR-T B-cell hematologic malignancies Metabolism In vivo

Recurrent lymphoma presenting as painless, chronic intussusception: A case report

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World Journal of Clinical Cases 2020年第2期8卷 306-312页

作者： Parker Giroux Anderson Collier Michael Nowicki Department of pediatrics University of Mississippi Medical CenterJacksonMS 39216United States division of pediatric hematology and oncology University of Mississippi Medical CenterJacksonMS 39216United States division of pediatric Gastroenterology University of Mississippi Medical CenterJacksonMS 39216United States

BACKGROUND The clinical presentation of acute lymphoblastic lymphoma is highly *** prognosis is good, recurrence of disease can occur. Gastrointestinal relapse, including intussusception, is well-described but the absence of abdominal pain in this setting is *** SUMMARY We report a 13-year-old male with B-cell precursor acute lymphoblastic leukemia in remission presenting with anemia and weight loss. Examination was significant for absence of abdominal pain, but a stool sample was positive for occult blood. Pan-endoscopy was performed with colonoscopy revealing a mass filling the colonic lumen. Biopsy of the mass confirmed recurrence of recurrent Bcell lymphoma. Computed tomography scan revealed ileocolic intussusception resulting from the tumor. This case is unusual in that the patient had no abdominal pain despite the presence of *** While intestinal involvement with lymphoma has been well described in the literature, presentation as painless intussusception has not been reported. This case report highlights the wide spectrum of clinical manifestations of recurrent Bcell lymphoma involving the gastrointestinal tract, in particular the near absence of symptoms despite the finding of intussusception.

关键词： B-cell acute lymphoblastic leukemia Tumor relapse Intussusception Case report Anemia

Post-streptococcal acute glomerulonephritis in children:Association between proteinuria levels and renal outcomes

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World Journal of Clinical pediatrics 2025年第1期14卷 119-126页

作者： Randula Ranawaka Kavinda Dayasiri Udara Sandakelum Dulani Nelson Manoji Gamage Department of Paediatrics Faculty of MedicineUniversity of ColomboColombo 0094Sri Lanka University Paediatric Unit Lady Ridgeway Hospital for ChildrenColombo 0094WesternSri Lanka Department of Paediatrics Faculty of MedicineUniversity of KelaniyaRagama 0094Sri Lanka University pediatric Unit Lady Ridgeway Hospital for ChildrenColombo 0094WesternSri Lanka Nutrition division Ministry of HealthColombo 0094Sri Lanka

BACKGROUND Post-streptococcal acute glomerular nephritis(PSAGN)is mostly a benign *** usual sequelae of PSAGN include hypertension,its complications,and acute kidney *** PSAGN is associated with significant long-term morbidity,and histological abnormalities such as crescentic glomerulonephritis are infrequently *** has also been linked to late-onset chronic kidney disease in some populations due to high levels of *** This prospective observational study was conducted at Lady Ridgeway Hospital(Colombo,Sri Lanka)over 15 *** with PSAGN were enrolled based on clinical and laboratory *** proteinuria≥2+for 2 weeks and serum creatinine>100μmol/L warranted renal biopsy,assessed via light microscopy and *** of complement 3(C3)within 6 to 8 weeks was required for *** on clinical features,urine protein levels,and renal function were collected from patient records,and potential associations were analysed using Statistical Package for the Social Sciences and R language for statistical *** approval was obtained from the Ethical Review Committee,Lady Ridgeway Hospital for Children(Ref No:LRH/ERC/2021/60).RESULTS Forty-four patients were *** were 27(61.4%)male patients and 17(38.6%)female ***-seven(84%)of them were above 5 years of ***(45%)patients had a history of skin sepsis,and eighteen(41%)had a history of throat *** patients with proteinuria≥2+,53%had serum creatinine>100µmol/L,while among those with proteinuria100µmol/*** association of high-degree proteinuria with elevated serum creatinine was significant(χ²=7.8,P=0.005)in *** odds ratio of the logistic regression model was 1.049(95%confidence interval:1.003-1.098),indicating a positive direction with statistically significant association(P=0.037).There was no significant association between proteinuria and the degree of

关键词： Proteinuria Post-streptococcal acute glomerulonephritis Renal outcome Renal biopsy Crescents Serum creatinine

Kaposiform hemangioendothelioma in children: a benign vascular tumor with multiple treatment options

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World Journal of pediatrics 2018年第4期14卷 322-329页

作者： Irene Schmid Anne K.Klenk Monika Sparber-Sauer Ewa Koscielniak Rebecca Maxwell Beate Haberle division of pediatric hematology and oncology Dr.von Hauner Children’s HospitalLudwig-Maximilians University of MunichLMULindwurmstr.480337 MunichGermany Klinikum Stuttgart-Olgahospital Stuttgart Cancer CenterZentrum fur Kinder-Jugend-und FrauenmedizinPediatrics 5(OncologyHematologyImmunology)StuttgartGermany Department of P ediatric hematology and oncology Children’s HospitalTubingenGermany pediatric Surgery Dr.von Hauner Childen’s HospitalLudwig-Maximilians University of Munic hMunichGermany

Background Kaposiform hemangioendothelioma (KHE) is a rare vascular tumor affecting infants and young children. Although benign, it can be associated with an aggressive locally growing tumor and/or a life-threatening Kasabach–Merritt phenomenon (KMP). To date, only reviews of limited cases have been performed. We, therefore, conducted a comprehensive literature search to collect relevant data and make recommendations for future treatment trials. Methods Review of the available literature between 1993 and 2017 revealed a total of 105 publications involving 215 patients of less than 21 years of age. To this, we added 12 from our department and 4 from the Cooperative Weichteilsarkomstudie database. Results We found that KMP was present in 79% of the infants, in 47% of the 1–5-year olds, in 43% of the 6–12-year olds, and in 10% of the 13–21-year-old patients. KMP was present in nearly all (94%) patients with retroperitoneal tumors and in all patients with extra-regional tumors. The median size of a KHE without KMP was 12 cm2 as compared to 49 cm2 when associated with a KMP. With complete (not further classifiable if R0 or R1) resection, all patients were cured. If inoperable, response regarding KMP/regression of tumor size was seen in 29/28% with steroid-, 47/39% with vincristine-, 44/43% with interferon alpha-, 65/61% with anti-platelet agents-, and in 97/100% with sirolimus-containing therapies. Conclusions Patients with progressive KHE should undergo resection whenever it is considered a safe option. If inoperable, sirolimus should be the first choice for treating KMP and reducing tumor size.

关键词： Kaposiform hemangioendothelioma Kasabach–Merritt phenomenon pediatric