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P50 auditory sensory gating in first onset schizophrenics and normal healthy adults

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Frontiers of Medicine 2007年第4期1卷 429-432页

作者： WANG Hongxing ZHANG Mingdao CHEN Xingshi LOU Feiying LIANG Jianhua CHEN Chong SHI Tiantao LU Qiulin Department of Psychiatry Ankang HospitalBeijing 101300China Teaching and Researching division of Mental Medicine Shanghai Second Medical UniversityShanghai 200030China division of Neurophysiology Shanghai Mental Health CenterShanghai 200030China Administration division Ankang HospitalBeijing 101300China

The aim of this research was to investigate the variations of P50 auditory sensory gating(P50)in normal healthy adults and the first onset *** using the American Nicolet Bravo electromyography/evoked potential(EMG/EP)system,P50 was measured with conditioning-testing paradigm(paired-click stimuli S1 and S2 were used)in 58 first onset schizophrenics and 108 healthy adults,and the Positive and Negative Syndrome Scale(PANSS)was *** following three conclusions have been reached.(1)In normal control(NC)group,measured from central,anterior and posterior zone(Cz,Fz and Pz respectively),there were no statistical differences(P>0.05)between S1 and S2 evoked P50 peak latencies(S1-P50 and S2-P50);the ampli-tudes of S2-P50[(2.2P1.4),(2.3P1.5)and(2.1P1.4)μV respectively]reduced significantly as compared with S1-P50[(5.6P3.3),(5.6P3.9)and(4.9P2.8)μV respectively](P0.05).(2)Compared with NC,the schizophrenic group significantly showed lower S1-P50 amplitudes(P0.05)in schizophrenic *** first onset schizophrenics had sensory gating deficits,which could be quantified by P50.

关键词： schizophrenia brain electrophysiology evoked potentials,auditory P50 sensory gating

Dyssynchronous pacing triggers endothelial-mesenchymal transition through heterogeneity of mechanical stretch in a canine model.

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Dyssynchronous pacing triggers endothelial-mesenchymal trans...

Smooth Muscle Hgs Deficiency Leads to Impaired Esophageal Motility

中国生理学会基质生物学专业委员会成立大会暨第一次全国基质生物学学术会议

作者： Mai J Hu Q Xie Y Su S Qiu Q Yuan W Yang Y Song E Chen Y Wang J Department of Cardiology Sun Yat-sen Memorial Hospital of Sun Yat-sen University Guangdong Province Key Laboratory of Arrhythmia and electrophysiology

BACKGROUND:Endothelial-mesenchymal transition(EndMT)plays a pivotal role in cardiac ***,it is unclear whether EndMT is involved in dyssynchronous heart failure(DHF).METHODS AND RESULTS:Twelve dogs received 3-week rapid right ventricular pacing(RVP)to develop DHF and then were randomly divided into a RVP group(n=6;RVP for another 3 weeks)and a biventricular pacing

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Smooth Muscle Hgs Deficiency Leads to Impaired Esophageal Mo...

Current Management Strategies in Patients with Heart Failure and Atrial Fibrillation:A Review of the Literature

2015中国遗传学会大会

作者： Jicheng Chen Ning Hou Chong Zhang Yan Teng Xuan Cheng Zhenhua Li Jie Ren Jian Zeng Rui Li Wei Wang Xiao Yang Yu Lan odel Organism division E-institutes of Shanghai UniversitiesShanghai Jiaotong University State Key Laboratory of Proteomics Collaborative Innovation Center for Cardiovascular DisordersGenetic Laboratory of Development and DiseaseInstitute of Biotechnology Department of Cardiovascular electrophysiology Research College of Basic MedicineCapital Medical University

As a master component of endosomal sorting complex required for transport proteins,hepato-cyte growth factor-regulated tyrosine kinase substrate(Hgs)participates multiple cellular ***,the physiological role of Hgs in smooth muscle cells(SMCs)is by far *** we explored the in vivo function of Hgs in SMCs by using a conditional gene knockout *** deficiency in SMCs uniquely led to a progressive dilatation of esophagus with a remarkable thinning muscle *** note,the mutant esophagus showed a decreased contractile responsiveness to potassium chloride and acetylcholine ***,an increase in the inhibitory neurites along with an intense infiltration of T lymphocytes in the mucosa and muscle layer were ***,Hgs deficiency in SMCs resulted in a disturbed expression of a set of genes involved in neurotrophin and inflammation,suggesting that defective SMC might be a novel source for excessive production of cytokines and chemokines which may trigger the neu-ronal dysplasia and ultimately contribute to the compromised esophageal *** data suggest potential implications in the pathogenesis of related diseases such as gastroesophageal reflux disease.

关键词： hepatocyte growth factor-regulated tyrosine kinase substrate smooth muscle cell esophageal motility inhibitory nenrite inflammation

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Cardiovascular Innovations and Applications 2020年第4期5卷 73-80页

作者： Alex M.Parker Juan R.Vilaro Mustafa M.Ahmed Juan M.Aranda division of Cardiology Department of MedicineUniversity of FloridaGainesvilleFL 32611USA

Heart Failure(HF)and Atrial Fibrillation(AF)are common diseases which lead to signifi cant morbidity and *** disease can be a challenge to treat clinically,especially when they present *** performed a review of the literature including clinical trials,metanalyses,and guidelines regarding the management of patients with HF and *** review describes the pathophysiologic mechanisms behind each disease state,their associated prognosis,and epidemiologic *** for prevention of stroke in patients with AF,including use of novel oral anticoagulants as well as prevention of the development of AF are *** review the medical and catheter-based therapies for AF and present an original algorithm for the management of AF in patients with HF.

关键词： heart failure atrial fibrillation cardiology electrophysiology

VAMP2 was involved in the translocation of atrial SK2 channels to plasma membrane in atrial fibrillation

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VAMP2 was involved in the translocation of atrial SK2 channe...

Intra-procedural arrhythmia during cardiac catheterization: A systematic review of literature

2019年中国生理学会心血管生理学术研讨会

作者： Tao Li Xuehui Fan Yiyan Yu Miaoling Li Ming Lei Xiaorong Zeng Xiaoqiu Tan Key Laboratory of Medical electrophysiology Ministry of EducationCollaborative Innovation Center for Prevention and Treatment of Cardiovascular DiseaseInstitute of Cardiovascular ResearchSouthwest Medical University

Background:Small conductance Caactivated potassium channel type 2(SK2 channels) were specially expressed in atrial tissues compared with ventricle,which may attribute to atrial arrythemia,such as atrial fibrillation(AF).We previous researches showed that SK2 currents in patients with chronic AF were increased,while,the encoded mRNA and protein of SK2 channels were ***,the underlying mechanism kept *** 2(VAMP2),a kind of trafficking proteins,plays a key role in vesicle fusion,which may contribute to the trafficking of ion channels ***:Here,we aim to investigate the role of VAMP2 on the translocation of SK2 channels and explore the underlying mechanism of the inconsistent change of SK2 channels in ***:human atrial tissues,cultured newborn rat atrial myocytes(NRAMs) and HEK293 cells were used in this *** mRNA and protein levels of SK2 and VAMP2 were detected with Real-time PCR and Western *** SK2 currents were recorded with patch-clamp *** trafficking of SK2 channels protein was investigated with confocal microscopy,flow cytometry and total internal reflection fluorescence(TIRF).Results:the mRNA and protein levels of VAMP2 were increased in patients with chronic AF(P pacing increased the SK2 currents and accelerated the surface expression of SK2 channel protein in ***-down of VAMP2 with RNA interference(RNAi) decreased the expression of SK2 channel *** HEK293 cells,VAMP2 increased the SK2 currents under whole-cell configuration(P <0.01 at V=-120 mV,n=10).VAMP2 can co-locate with SK2 channels in cardiomyocytes and in expressing HEK293 *** HEK293 cells,VAMP2 increased the expression of SK2 and accelerated the trafficking of SK2 channels protein to cell ***2 also stabilized SK2 channels protein in cell membrane with inhibiting the internalization of SK2 channels ***:VAMP2 was up-regulated

关键词： SK2 channels VAMP2 SNAREs trafficking atrial fibrillation

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World Journal of Cardiology 2020年第6期12卷 269-284页

作者： Fatima A Shaik David J Slotwiner Gregory M Gustafson Xuming Dai division of Cardiology New York Presbyterian Queens HospitalFlushingNY 11355United States

BACKGROUND Cardiac catheterization is among the most performed medical procedures in the modern *** were sporadic reports indicating that cardiac arrhythmias are common during cardiac catheterization,and there are risks of developing serious and potentially life-threatening arrhythmias,such as sustained ventricular tachycardia(VT),ventricular fibrillation(VF)and high-grade conduction disturbances such as complete heart block(CHB),requiring immediate ***,there is lack of systematic overview of these *** To systematically review existing literature and gain better understanding of the incidence of cardiac arrhythmias during cardiac catheterization,and their impact on outcomes,as well as potential approaches to minimize this *** We applied a combination of terms potentially used in reports describing various cardiac arrhythmias during common cardiac catheterization procedures to systematically search PubMed,EMBASE and Cochrane databases,as well as references of full-length *** During right heart catheterization(RHC),the incidence of atrial arrhythmias(premature atrial complexes,atrial fibrillation and flutter)was low(pacing due to transient *** premature ventricular complexes or non-sustained VT are common during RHC(up to 20%of cases).Sustained ventricular arrhythmias(VT and/or VF)requiring either withdrawal of catheter or cardioversion occurred infrequently(1%-1.3%).During left heart catheterizations(LHC),the incidence of ventricular arrhythmias has declined significantly over the last few decades,from 1.1%historically to 0.1%*** overall reported rate of VT/VF in diagnostic LHC and coronary angiography is 0.8

关键词： Catheterization Coronary angiography Percutaneous coronary intervention Ventricular fibrillation Ventricular tachycardia

Novel approaches for the treatment of ventricular tachycardia

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World Journal of Cardiology 2018年第7期10卷 52-59页

作者： Michael Spartalis Eleftherios Spartalis Eleni Tzatzaki Diamantis I Tsilimigras Demetrios Moris Christos Kontogiannis Efthimios Livanis Dimitrios C Iliopoulos Vassilis Voudris George N Theodorakis ESC Working Group on Cardiac Cellular electrophysiology Sophia Antipolis Cedex 06903France division of Cardiology Onassis Cardiac Surgery CenterAthens 17674Greece Laboratory of Experimental Surgery and Surgical Research University of Athens Medical SchoolAthens 11527Greece Department of Surgery Duke UniversityDurhamNC 27710United States Department of Clinical Therapeutics “Alexandra”HospitalUniversity of AthensAthens 11528Greece

Ventricular tachycardia(VT) is a crucial cause of sudden cardiac death(SCD) and a primary cause of mortality and morbidity in patients with structural cardiac disease. VT includes clinical disorders varying from benign to lifethreatening. Most life-threatening episodes are correlated with coronary artery disease, but the risk of SCD varies in certain populations, with various underlying heart conditions, specific family history, and genetic variants. The targets of VT management are symptom alleviation, improved quality of life, reduced implantable cardioverter defibrillator shocks, prevention of reduction of left ventricular function, reduced risk of SCD, and improved overall survival. Antiarrhythmic drug therapy and endocardial catheter ablation remains the cornerstone of guideline-endorsed VT treatment strategies in patients with structural cardiac abnormalities. Novel strategies such as epicardial ablation, surgical cryoablation, transcoronary alcohol ablation, pre-procedural imaging, and stereotactic ablative radiotherapy are an appealing area of res-earch. In this review, we gathered all recent advances in innovative therapies as well as experimental evidence focusing on different aspects of VT treatment that could be significant for future favorable clinical applications.

关键词： Ventricular tachycardia Catheter ablation Epicardial Sudden cardiac death Novel techniques Substrate

electrophysiology and heart rhythm disorders in older adults

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Journal of Geriatric Cardiology 2016年第8期13卷 645-651页

作者： Parag Goyal Michael W Rich division of Cardiology Weill Cornell Medical College New York USA Cardiovascular division Washington University School of Medicine St. Louis USA

1 Introduction Heart rhythm disorders, including bradyarrhythmias, atrial fibrillation （AF）, and ventricular arrhythmias, become increasingly common with aging and represent important causes of morbidity and mortality among older adults.[1-3] Older adults are particularly predisposed to these conditions due to the high prevalence of cardiovascular disease in con- junction with age-related changes that occur in the heart and cardiac conduction system.

关键词： Arrhythmia Atrial fibrillation Bradycardia The aged Ventricular tachycardia

有或无心脏外科手术史患者肺静脉窦隔离术后心房扑动消融的必要性

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世界核心医学期刊文摘（心脏病学分册） 2005年第8期1卷 53-53页

作者： Kilicaslan F. Verma A. Yamaji H. A. Natale Sect 腾增辉 pacing and electrophysiology Cleveland Clinic Foundation 9500 Euclid Avenue Cleveland OH 44195 United States

Objectives: The aim of this study was to assess the incidence of atrial flutter(AFL) after pulmonary vein antrum isolation(PVAI) in patients with previous cardiac surgery(PCS) in comparison to patients without PCS and to assess the need for AFL ablation in both groups. Background: Atrial fibrillation(AF) and AFL often co- exist. Pulmonary vein antrum isolation may be sufficient to control both arrhythmias. However, in patients with PCS, atrial incisions, cannulations, and scar areas may cause AFL recurrence despite elimination of pulmonary vein triggers. Methods: Data from 1,345 patients who had PVAI were analyzed. Patients with a history of AFL ablation and patients who had concomitant AFL ablation during PVAI were excluded from analysis. Sixty- three patients constituted the PCS group(Group 1, age 57± 13 years, 12 female) and 1,062 patients constituted the non- PCS group(Group 2, age 55± 12 years, 212 female). Patients in Group 1 had larger left atria, higher incidence of AFL pre- PVAI, and lower ejection fraction. Results: There was no significant difference in post- PVAI AF recurrence between Groups 1 and 2, but AFL incidence after PVAI was higher in Group 1(33% vs. 4% , p< 0.0001). Ablation of AFL in Group 1 patients resulted in an 86% acute success rate and 11% recurrence over a mean follow- up of 357± 201 days. Conclusions: In patients with PCS, post- PVAI AF recurrence is similar to patients without PCS. However, history of PCS is associated with a higher recurrence of AFL after PVAI. In a significant number of patients with PCS, AFL ablation is required to achieve a cure.

关键词：心房扑动心脏外科手术窦隔心房颤动复发率射血分数插管术左心房