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A qualitative study on the adverse reactions of mass treatment for lymphatic filariasis in Orissa,India

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Asian Pacific Journal of Tropical Medicine 2010年第1期3卷 55-58页

作者： Babu BV division of Epidemiology Regional Medical Research CentreIndian Council of Medical ResearchBhubaneswar-751 023India & Indian Council of Medical ResearchNew Delhi 110 029India

Objective:To describe the perceptions of community members and programme partners regarding severity,management and impact of adverse reactions on mass drug administration (MDA) ***:Based on various qualitative data collected from five districts of Orissa,India,where MDA had been implemented during 2002 and *** qualitative surveys included focus group discussions with community members and health workers,and semi-structured interviews with key informants in the community,medical officers at primary health centres,district level health officers and private ***:It showed that many people suffered from adverse reactions,though the reactions were not *** paper reported different ways of management of adverse reactions at the community *** impact of adverse reactions on MDA compliance was serious,as many people did not consume the drug due to fear of adverse *** rumours of adverse reactions and news in media deterred people from consuming the ***:All categories of respondents indicates the need of more information to address the problem of adverse reactions during *** present paper warrants incorporating the messages on adverse reactions during health communication and social mobilization campaigns of MDA.

关键词： Lymphatic filariasis Mass drug administration Adverse reactions Qualitative study Orissa India

Growth inhibition mediated by PSP94 or CRISP-3 is prostate cancer cell line specific

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Asian Journal of Andrology 2010年第5期12卷 677-689页

作者： Bhakti R. Pathak Ananya A. Breed Vaishali H. Nakhawa Dhanashree D. Jagtap Smita D. Mahale division of Structural Biology National Institute for Research in Reproductive Health Indian Council of Medical ResearchMumbai 400012 India

The prostate secretory protein of 94 amino acids （PSP94） has been shown to interact with cysteine-rich secretory protein 3 （CRISP-3） in human seminal plasma. Interestingly, PSP94 expression is redaced or lost in the majority of the prostate tumours, whereas CRISP-3 expression is upregulated in prostate cancer compared with normal prostate tissue. To obtain a better understanding of the individual roles these proteins have in prostate tumourigenesis and the functional relevance of their interaction, we ectopically expressed either PSP94 or CRISP-3 alone or PSP94 along with CRISP-3 in three prostate cell lines （PC3, WPE1-NB26 and LNCaP） and performed growth inhibition assays. Reverse transcription-polymerase chain reaction and Western blot analysis were used to screen prostate cell lines for PSP94 and CRISP-3 expression. Mammalian expression constructs for human PSP94 and CRISP-3 were also generated and the expression, localization and secretion of recombinant protein were assayed by transfection followed by Western blot analysis and immunofluorescence assay. The effect that ectopic expression of PSP94 or CRISP-3 had on cell growth was studied by clonogenic survival assay follokving transfection. To evaluate the effects of coexpression of the two proteins, stable clones of PC3 that expressed PSP94 were generated. They were subsequently transfected with a CRISP-3 expression construct and subjected to clonogenic survival assay. Our results showed that PSP94 and CRISP-3 could each induce growth inhibition in a cell line specific manner. Although the growth of CRISP-3-positive cell lines was inhibited by PSP94, growth inhibition mediated by CRISP-3 was not affected by the presence or absence of PSP94. This suggests that CRISP-3 may participate in PSP94-independent activities during prostate tumourigenesis.

关键词： β-microseminoprotein CRISP-3 clonogenic survival assay LNCaP PC3 WPE1-NB26

Prospecting microbial biofilms as climate smart strategies for improving plant and soil health: A review

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Pedosphere 2023年第1期33卷 129-152页

作者： Kulandaivelu VELMOUROUGANE Shobit THAPA Radha PRASANNA division of Crop Production Indian Council of Agricultural Research-Central Institute for Cotton Research(CICR)Nagpur 440010India indian council of Agricultural research-National Bureau of Agriculturally Important Microorganisms KushmaurMau Nath Bhanjan 275103India division of Microbiology Indian Council of Agricultural Research-Indian Agricultural Research InstituteNew Delhi 110012India

Microbes and their products play key roles in complementing chemical fertilizers and plant protection chemicals by eliciting defence mechanisms in crop plants,thereby providing immunity and resistance against diverse *** the different environmental technologies used to mitigate climate change,several microbiological interventions are promising,among which biofilms,both naturally-existing and laboratory-developed,and their application have gained momentum *** biofilms are aggregations of microbial cells in a self-generated polymeric matrix,which are produced by several genera of bacteria,yeasts,cyanobacteria,and fungi as a mode of reproductive fitness,thereby advantageous in successful proliferation,even in extreme *** propensity of microbial biofilms to grow in diverse niches and adapt to biotic and abiotic stresses illustrates their immense potential as biofertilizers and disease suppression options in various crops across diverse *** the inhospitable habitats of deserts and denudated land,biofilms play an important role in preventing soil erosion and sustaining vegetation,microflora,and *** represent a mode of growth for several microbes with plant growth-promoting and biocontrol potential,which are important in seed establishment and the facilitation of exchanging nutrients and metabolites from the *** this review,we discuss the prospects of microbial biofilms as a green option in agriculture in general and,more specifically,their potential in mitigating climate change.

关键词： biocontrol bioremediation climate change environmental stress nutrient sequestration plant growth promotion

Mass scale screening of common arboviral infections by an affordable,cost effective RT-PCR method

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Asian Pacific Journal of Tropical Biomedicine 2012年第2期2卷 97-101页

作者： Debjani Taraphdar Arindam Sarkar Shyamalendu Chatterjee indian council of medical research Virus Unit

Objective:To develop a rapid,cost effective RT-PCR method for the mass scale diagnosis of such diseases at the vireraia stage to find out the actual disease burden in that ***:For this purpose,cases with the history of only short febrile illness were *** 157 samples with the history of dengue/chikungunya like illness and only 58 samples with a history of acute encephalitis syndrome(AES)were ***:Out of 157 samples,42 and 74 were detected as dengue and chikungunya,respectively and out of 58 AES cases only 23 could be detected as Japanese encephalitis by this RT-PCR ***:This cost effective RT-PCR method can detect the total positive cases that remain undetected by EL1SA ***,this method is capable to detect the viral RNA from patients'sera even after the appearance of IgM antibody at one fifth costs as compared with the other commercially available kits.

关键词： Cost effective RT-PCR method Mass screening Arbovirus

CCR5A32 mutation does not influence the susceptibility to HCV infection, severity of liver disease and response to therapy in patients with chronic hepatitis C

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World Journal of Gastroenterology 2006年第29期12卷 4721-4726页

作者： Ankur Goyal PV Suneetha GT Kumar Deepak K Shukla Naveen Arora Shiv K Sarin Department of Gastroenterology G.B.Pant Hospital New DelhiInstitute of Genomic and Integrative Biology(Formerly CBT)Mall RoadDelhiDr.Ambedkar Center for Biomedical ResearchUniversity of DelhiIndia Department of Gastroenterology G.B.Pant Hospital New DelhiIndia division of non-communicable disease indian council of medical research Ansari NagarNew DelhiIndia Institute of Genomic and Integrative Biology (Formerly CBT) Mall RoadDelhiIndia

AIM： To study whether CCR5△32 mutation was associated with viral infection and severity of liver disease. METHODS： Two hundred and fifty two histologically proven, chronic HCV patients （mean age： 41±14 years; M/F： 164/88） were genotyped. PCR based genotyping of 32 bp deletion at the CCR5 locus was done. Fourhundred and eight matched healthy controls were studied to assess susceptibility to HCV infection. To assess correlation of immune gene polymorphism with severity of HCV related liver disease, patients with chronic HCV infection were divided into those with a fibrosis score of ≤ 2 （mild） or 〉 2 （severe） and histological activity index （HAI） of ≤ 5 or 〉 5. For correlation between CCR5△32 mutations and response to therapy, 129 patients who completed therapy were evaluated. RESULTS： The majority （89.4%） of the patients were infected with genotype 3. The frequency of homozygous CCR5△32 mutants was comparable to HCV patients as compared to the healthy controls （0.7% vs 0%, P = 0.1）. Further more, the frequency of CCR5△32 mutation was comparable in patients with mild or severe liver disease.（P = NS）. There was also no association observed with response to therapy and CCR5△32 mutation. CONCLUSION： CCR5△32 mutation does not have a role in disease susceptibility, severity or response to therapy in patients with chronic hepatitis C infection.

关键词： β-chemokine receptor 32 bp deletion CCchemokine ligand Human leukocyte antigen Histologicalactivity index

GeDiPNet: Online resource of curated gene-disease associations for polypharmacological targets discovery

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Genes & diseases 2023年第3期10卷 647-649页

作者： Indra Kundu Mridula Sharma Ram Shankar Barai Khushal Pokar Susan Idicula-Thomas Biomedical Informatics Centre Indian Council of Medical Research-National Institute for Research in Reproductive and Child HealthMumbai 400012India

There are numerous online databases dedicated to genes associated with human *** redundancy and lack of consistency of disease terms in these databases pose a significant impediment in high throughput data *** address this,we developed GeDiPNet by compiling data available on gene-disease associations from six popular open access sources namely DisGeNET,1 ClinGen.

关键词： databases online analysis.

Assessment of public perspectives and barriers towards dengue preventive practices using the Health Belief Model in Puducherry,India:A cross-sectional study

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Asian Pacific Journal of Tropical Medicine 2024年第8期17卷 358-368,I0001页

作者： Dharani Govindasamy Gnanasekaran Vijalakashmi Balakrishnan Vijayakumar Arya Rahul indian council of medical research-Vector Control research Centre Deapartment of Health ResearchMinistry of Health and Family WelfareGovernment of IndiaPuducherryIndia

Objective:To assess the perspectives and barriers towards dengue preventive practices among the residents of Puducherry,***:A cross-sectional survey was conducted in 300 households in Puducherry,using a population-proportionate(7:3)distribution from urban and rural areas by grid *** adult interview per household was conducted and the participants were selected using a KISH grid.A semi-structured questionnaire based on the Health Belief Model(HBM)with additional questions on knowledge assessment was *** was assessed based on the correctness of answers and the HBM scores were calculated on a 5-point Likert *** were categorized based on the median score under each *** regression was used for adjusted analysis and models were built to predict the performances in each ***:Four percent of the participants lacked basic knowledge regarding dengue *** 208(69.3%)participants did not consider themselves at risk of contracting dengue within the next year,majority perceived dengue as a disease with low *** 49.3%(148)were skeptical about the benefit of time and money spent on dengue *** government efforts were stated as the major barrier(47.0%)and frequent reminders(142,47.3%)as the major cue to *** above 50 years(aOR 1.78,95%CI 1.04-3.06,P=0.037)and rural locality(aOR 2.68,95%CI 1.52-4.71,P=0.001)were found to be significantly associated with poor knowledge *** participants had a significantly higher chance to perceive low susceptibility as compared to the rural counterparts(aOR 1.74,95%CI 1.05-2.9,P=0.03).Participants with less than a high school education had low perceived benefits(aOR 2.46,95%CI 1.52-3.96,Pdisease perception,limited knowledge of breeding sites,and overrelian

关键词： Dengue Public perspectives Prevention Barriers Health belief model

Longitudinally extensive transverse myelitis associated with scrub typhus:A case report

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Asian Pacific Journal of Tropical Medicine 2024年第8期17卷 375-378页

作者： Amit Kumar Rajesh Chetiwal Shweta Tanwar Department of Medicine ESIC Postgraduate Institute of Medical Sciences and ResearchBasaidarapurNew DelhiIndia indian council of medical research New DelhiIndia

Rationale:Longitudinally extensive transverse myelitis(LETM)is a rare inflammatory demyelinating disease predominantly associated with autoimmune and inflammatory *** typhus can cause a variety of neurological complications,which may result in poor recovery and long-term *** report reveals a rare linkage between LETM and scrub *** concerns:A 24-year-old female presented with a history of fever for 10 days associated with progressive *** examination revealed bilateral lower limb weakness(grade 0/5)and bilateral upper limb weakness(grade 2/5)with reduced sensation below the T3 ***:Scrub typhus presenting with longitudinally extensive transverse ***:Steroid pulse therapy with antibiotics supported by early intensive ***:Complete recovery was ***:This case report highlights the importance of considering scrub typhus as a potential cause of LETM in endemic regions,particularly in patients presenting with febrile illness and neurological symptoms.

关键词： Longitudinally extensive transverse myelitis Scrub typhus Orientia tsutsugamushi Case report

Surveillance of Chikungunya virus activity in some North-eastern states of India

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Asian Pacific Journal of Tropical Medicine 2019年第1期12卷 19-25页

作者： Prafulla Dutta Siraj A.Khan Anil C.Phukan Sarat Hazarika Naba K.Hazarika Sumi Chetry Abdul M.Khan Harpreet Kaur ICMR-Regional medical research Center North Eastern Indira Gandhi Regional Institute of Health & medical Sciences Jorhat medical College & Hospital Gauhati medical College & Hospital indian council of medical research

Objective: To detect the prevalence pattern of Chikungunya virus in three states of Northeast India. Methods: A total of 1 510 samples were collected from different private and government hospitals of Assam, Arunachal Pradesh and Meghalaya. Serum was tested for the presence of IgM antibodies against Chikungunya virus followed by RT-PCR for amplification of Chikungunya E1 gene region using specific primers. Results: Overall, 11.83%(172/1 454) clinical samples were positive by MAC-ELISA and/or RT-PCR assay. Asymptomatic infection was seen in 17.86%. Males were more affected than females and age group 16-30 years was mostly affected. Fever(100.00%) was the primary symptom followed by headache(72.03%) and arthralgia(41.53%). Only 118 Chikungunya positive cases could be traced, of which 25.42% complained about sequelae of infection. In entomological investigation, Aedes aegypti was more predominant(92.10%) than Aedes albopictus(7.90%). No mosquito pools could be incriminated for Chikungunya virus. Conclusions: In this study, Chikungunya was observed to be prevalent in Assam, Arunachal Pradesh and Meghalaya. Though Chikungunya is a selflimiting infection, increasing morbidity by CHIKV infection is affecting social and economic status of individual. Thus, a community empowerment to effectively control mosquito population by employing different mosquito control measures along with personal protection is mandatory to tackle future outbreak of the disease.

关键词： Chikungunya Northeast India Aedes aegypti Aedes albopictus