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Nano-revolution in hepatocellular carcinoma:A multidisciplinary odyssey-Are we there yet?

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World Journal of Hepatology 2024年第5期16卷 684-687页

作者： Howard D Lee Li-Yun Yuan Department of Medicine Division of Gastrointestinal and Liver DiseasesKeck School of Medicine of University of Southern CaliforniaLos AngelesCA 90033United States

In this editorial we comment on the review by Zhou et al reviewing the landscape of nanomedicine in the treatment of hepatocellular carcinoma(HCC).We focus on the immense potential of nanotechnology,particularly ligand-receptor mediated nanotherapy,in revolutionizing the treatment landscape of *** advan-cements in multidisciplinary treatment,HCC remains a significant global health ***-mediated nanotherapy offers the opportunity for precise drug delivery to tumor sites,targeting specific receptors overexpressed in HCC cells,thereby enhancing efficacy and minimizing side *** drug resistance and aggressive tumor biology is facilitated by nanomedicine,bypassing traditional hurdles encountered in *** include targeting glypican-3,asialoglycoprotein,transferrin receptor or folic acid receptors,capitalizing on their over-expression in tumor *** ability for multi-receptor targeting through dual-ligand nanoparticle modification holds the prospect of further enhancement in specificity and efficacy of directed ***,challenges including immune responses,reproducibility in nanoparticle synthesis,and production scalability *** directions involve refining targeting strategies,improving drug release mechanisms,and streamlining production processes to enable personalized and multifunctional ***,the integration of nanotherapy in HCC treatment holds immense promise,but continued partnership and effort are needed in offering hope for more effective,precise,and accessible clinical care in the management of HCC.

关键词： Hepatocellular carcinoma nanomedicine Ligand-receptor mediated nanotherapy Precision medicine Personalized medicine Targeting

Nanowire-mediated miR NA delivery

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Science China Life Sciences 2024年

作者： Yuan Wang Bing Chen Laboratory for Biomaterials and Drug Delivery Department of Anesthesiology Division of Critical Care Medicine Boston Children's Hospital Harvard Medical School College of Electronic and Optical Engineering and College of Flexible Electronics (Future Technology) Nanjing University of Posts and Telecommunications

In the ever-evolving nanomedicine and biotechnology, the pursuit of advanced drug delivery systems that induce precise positioning and targeting in the complex biological landscape for personalized and efficient therapies has become a paramount endeavor (Vargason et al., 2021).Central to this trend is the delivery of functional microRNAs (miRNAs), which play crucial roles in regulating gene expression (Li et al., 2021).

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Near-infrared fluorescent aptamer-templated silver nanoclusters facilely synthesized for cellular imaging applications

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Chinese Science Bulletin 2014年第16期59卷 1868-1872页

作者： Shengliang Li Weipeng Cao Shubin Jin Chunqiu Zhang Juan Liu Guozhang Zou Feng Li Xing-Jie Liang Department of Neurobiology and Anatomy Zhongshan School of MedicineSun Yat-sen University Laboratory of nanomedicine and Nanosafety Division of Nanomedicine and NanobiologyNational Center for Nanoscience and Technology of China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Chinese Academy of Sciences

Fluorescent metal nanoclusters(NCs)have received extensive attention for their potential uses in ***,we develop a facile strategy to synthesize near-infrared fluorescent silver nanoclusters(Ag NCs)stabilized by MUC1 *** MUC1-Ag NCs are characterized by UV–Vis absorption spectroscopy,fluorescence spectroscopy,transmission electron microscopy,and fluorescence *** results indicated that the MUC1-Ag NCs possess bright near-infrared luminescence,high stability,and excellent *** cellular imaging of MUC1-Ag NCs by confocal laser microscopy demonstrated them to be promising candidates as novel fluorescent probes for biomedical application.

关键词：生物医学应用近红外发光荧光光谱纳米团簇合成适体激光共聚焦显微镜透射电子显微镜

Targeted delivery of RNAi to cancer cells using RNA-ligand displaying exosome

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Acta Pharmaceutica Sinica B 2023年第4期13卷 1383-1399页

作者： Nasir Uddin Daniel WBinzel Dan Shu Tian-Min Fu Peixuan Guo Center for RNA Nanobiotechnology and nanomedicine Division of Pharmaceutics and PharmacologyCollege of Pharmacythe Ohio State UniversityColumbusOH 43210USA Dorothy M.Davis Heart and Lung Research Institute the Ohio State UniversityColumbusOH 43210USA James Comprehensive Cancer Center College of Medicinethe Ohio State UniversityColumbusOH 43210USA Department of Biological Chemistry&Pharmacology College of Medicinethe Ohio State UniversityColumbusOH 43210USA

Exosome is an excellent vesicle for in vivo delivery of therapeutics,including RNAi and chemical *** extremely high efficiency in cancer regression can partly be attributed to its fusion mechanism in delivering therapeutics to cytosol without endosome ***,being composed of a lipidbilayer membrane without specific recognition capacity for aimed-cells,the entry into nonspecific cells can lead to potential side-effects and *** engineering approaches for targeting-capacity to deliver therapeutics to specific cells is *** with chemical modification in vitro and genetic engineering in cells have been reported to decorate exosomes with targeting *** nanoparticles have been used to harbor tumor-specific ligands displayed on exosome *** negative charge reduces nonspecific binding to vital cells with negatively charged lipid-membrane due to the electrostatic repulsion,thus lowering the side-effect and *** this review,we focus on the uniqueness of RNA nanoparticles for exosome surface display of chemical ligands,small peptides or RNA aptamers,for specific cancer targeting to deliver anticancer therapeutics,highlighting recent advances in targeted delivery of siRNA and miRNA that overcomes the previous RNAi delivery *** understanding of exosome engineering with RNA nanotechnology promises efficient therapies for a wide range of cancer subtypes.

关键词： RNA interference RNA nanotechnology Endolysosome trapping Exosome engineering Targeted delivery Chemical drug delivery

NLRP3 inflammasome activation determines the fibrogenic potential of PM_(2.5) air pollution particles in the lung

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Journal of Environmental Sciences 2022年第1期34卷 429-441页

作者： Wei Cao Xiang Wang Jiulong Li Ming Yan Chong Hyun Chang Joshua Kim Jinhong Jiang Yu-Pei Liao Shannon Tseng Sydney Kusumoputro Candice Lau Marissa Huang Pengli Han Pengju Lu Tian Xia Translational Medical Center Zhengzhou Central Hospital Affiliated Zhengzhou UniversityZhengzhou 450007China division of nanomedicine Department of MedicineUniversity of CaliforniaLos Angeles 90095CAUnited States Basic Medical College Zhengzhou UniversityZhengzhou 450001China Department of Ecology and Evolutionary Biology University of CaliforniaLos Angeles 90095CAUnited States Department of Integrative Biology and Physiology University of CaliforniaLos Angeles 90095CAUnited States Department of Molecular Cell and Developmental BiologyUniversity of CaliforniaLos Angeles 90095CAUnited States

Airborne fine particulate matter(PM_(2.5))is known to cause respiratory inflammation such as chronic obstructive pulmonary disease and lung ***3 inflammasome activation has been implicated in these diseases;however,due to the complexity in PM_(2.5)compositions,it is difficult to differentiate the roles of the components in triggering this *** collected eight real-life PM_(2.5)samples for a comparative analysis of their effects on NLRP3 inflammasome activation and lung *** vitro assays showed that although the PM_(2.5)particles did not induce significant cytotoxicity at the dose range of 12.5to 100μg/m L,they induced potent TNF-αand IL-1βproduction in PMA differentiated THP-1 human macrophages and TGF-β1 production in BEAS-2B human bronchial epithelial *** the dose of 100μg/m L,PM_(2.5)induced NLRP3 inflammasome activation by inducing lysosomal damage and cathepsin B release,leading to IL-1β*** was confirmed by using NLRP3-and ASC-deficient cells as well as a cathepsin B inhibitor,ca-074 *** of PM_(2.5)via oropharyngeal aspiration at 2 mg/kg induced significant TGF-β1 production in the bronchoalveolar lavage fluid and collagen deposition in the lung at 21days post-exposure,suggesting PM_(2.5)has the potential to induce pulmonary *** ranking of in vitro IL-1βproduction correlates well with the in vivo total cell count,TGF-β1 production,and collagen *** summary,we demonstrate that the PM_(2.5)is capable of inducing NLRP3 inflammasome activation,which triggers a series of cellular responses in the lung to induce fibrosis.

关键词： Particulate matter Predictive toxicology NLRP3 inflammasome IL-1β Lung fibrosis Lung inflammation

Dynamic changes of protein corona compositions on the surface of zinc oxide nanoparticle in cell culture media

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Frontiers of Chemical Science and Engineering 2019年第1期13卷 90-97页

作者： Vo-Van Giau Yoon-Hee Park Kyu-Hwan Shim Sang-Wook Son Seong-Soo A. An Department of Bionanotechnology and Gachon Medical Research Institute Gachon University and Gachon Medical Research Institute Seongnam Korea Laboratory of Cell Signaling and nanomedicine Department of Dermatology and Division of Brain Korea 21 Project for Biomedical Science Korea University College of Medicine Seoul Korea

The potential applications of nanomaterials used in nanomedicine as ingredients in drug delivery systems and in other products continue to expand. When nanomaterials are introduced into physiological environments and driven by energetics, they readily associate proteins forming a protein corona (PC) on their surface. This PC could result in an alteration of the nanomatcrial's surface characteristics, affecting their interaction with cells due to conformational changes in adsorbed protein molecules. However, our current understanding of nanobiological interactions is still very limited. Utilizing a liquid chromatography-mass spectroscopy/mass spectroscopy technology and a Cytoscape plugin (ClueGO) approach, we examined the composition of the PC for a set of zinc oxide nanoparticles (ZnONP) from cell culture media typically and further analyzed the biological interaction of identified proteins, respectively. In total, 36 and 33 common proteins were investigated as being bound to ZnONP at 5 min and 60 min, respectively. These proteins were further analyzed with ClueGO, a Cytoscape plugin, which provided gene ontology and the biological interaction processes of identified proteins. Proteins bound to the surface of nanoparticles that may modify the structure, therefore the function of the adsorbed protein could be consequently affect the complicated biological processes.

关键词： ZnONPs nanoparticles protein corona ClueGO

Supercritical fluid technology:A game-changer for biomacromolecular nanomedicine preparation and biomedical application

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Chinese Chemical Letters 2024年第7期35卷 89-99页

作者： Yating Zheng Yulan Huang Jing Luo Xuqi Peng Xiran Gui Gang Liu Yang Zhang State Key Laboratory of Vaccines for Infectious Diseases Xiang An Biomedicine LaboratoryNational Innovation Platform for Industry-Education Integration in Vaccine ResearchState Key Laboratory of Molecular Vaccinology and Molecular DiagnosticsCenter for Molecular Imaging and Translational MedicineSchool of Public HealthXiamen UniversityXiamen 361102China Shen Zhen Research Institute of Xiamen University Shenzhen 518057China division of Urology and Department of Surgery Brigham and Women's HospitalHarvard Medical SchoolBostonMA 02115United States Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361102China

Biomacromolecules are attractive in biomedical applications as therapeutic agents and potential drug carriers due to their natural active components,good biocompatibility,and high ***,their large relative molecular weight,complex structure,susceptibility to degradation,and poor stability limit their *** can address these issues by improving the therapeutic value,bioavailability,permeability,and absorption of biomacromolecules while regulating their retention time in the ***,compelling evidence has been reported that supercritical fluid(SCF)technology has emerged as an alternative that maintains the integrity of biomacromolecules and reduces environmental *** this review,we highlight a set of unique nanosizing strategies based on SCF technology for biomacromolecular nanomedicine,and extensively discuss their characteristics and *** particular,the protein-based,nucleic acid-based,and polysaccharide-based nanomedicine preparations via SCF technology and their biomedical applications are summarized,and the potential for industrial production of biomacromolecular drugs is also *** further provide perspectives on the opportunities and challenges in this excellent field of biomacromolecular drugs nanotechnology.

关键词： Biomacromolecules Supercritical fluid technology Therapeutic proteins Gene therapy nanomedicine

Bioengineering Functional Copolymers. XVII. Interaction of Organoboron Amide-Ester Branched Derivatives of Poly(Acrylic Acid) with Cancer Cells

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Journal of Cancer Therapy 2011年第2期2卷 266-275页

作者： Mustafa Türk Gülten Kahraman Sevda A. Khalilova Zakir M. O. Rzayev Serpil Oguztüzün Institute of Science & Engineering Division of Nanoscience and Nanomedicine Hacettepe University Ankara Turkey.

Novel bioengineering functional organoboron polymers were synthesized by 1) amidolysis of poly(acrcylic acid) (PAA) with 2-aminoethyldiphenyl borinate (2-AEPB), 2) esterification of organoboron PAA polymer (PAA-B) with a-hydroxy-methoxypoly(ethylene oxide) (PEO) as a compatibilizer and 3) conjugation of organoboron PEO branches (PAA-B-PEO) with folic acid (FA) as a targeting agent. Structure and composition of the synthesized polymers were characterized by FTIR-ATR and 1H (13C) NMR spectroscopy, chemical and physical analysis methods. Anti-tumor activity of organoboron functional polymer and its complex with FA (PAA-B-PEO-F) against cancer and normal cells were evaluated by using different biochemical methods such as cytotoxicity, statistical, apoptotic and necrotic cell indexes, double staining and caspase-3 immune staining, light and fluorescence inverted microscope analyses. It was found that citotoxicity and apoptotic/necrotic effects of polymers significantly depend on the structure and composition of studied polymers, and increase the following raw: PAA << PAA-B < PAA-B-PEO < PAA-B-PEO-F. Among them, PAA-B-PEO-F complex at 400 mg mL–1 concentration as a therapeutic drug exhibits minimal toxicity toward the nor-mal cells, but influential for HeLa cancer cells.

关键词： Synthesis Amidolysis Organoboron Polymers Conjugation Citotoxicity Apoptotic and Necrotic Effects

Natural okra-based hydrogel for chronic diabetic wound healing

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中国化学快报:英文版 2023年第8期34卷 248-253页

作者： Peikun Xin Shuyan Han Jun Huang Conglai Zhou Jiayuan Zhang Xinru You Jun Wu School of Biomedical Engineering Sun Yat-sen UniversityShenzhen 518107China Center for nanomedicine and Department of Anesthesiology Brigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115United States Institute of Biological and Medical Engineering Guangdong Academy of SciencesGuangzhou 510316China Guizhou University of Chinese Traditional Medicine Guiyang 550025China School of Life Science Jilin UniversityChangchun 130012China Bioscience and Biomedical Engineering Thrust The Hong Kong University of Science and Technology(Guangzhou)Guangzhou 511400China division of Life Science The Hong Kong University of Science and TechnologyHong Kong SARChina

As a representative of chronic wounds,the long-term high levels of oxidative stress and blood sugar in chronic diabetic wounds lead to serious complications,making them the biggest challenge in the research on wound *** edible natural biomaterials rich in terpenes,phenols,and flavonoids can act as efficient *** this study,okra extract was selected as the main component of a wound *** okra extracts obtained via different methods comprehensively maintained the bioactivity of multiple *** robust antioxidant properties of okra significantly reduced intracellular reactive oxygen species production,thereby accelerating the wound healing *** results showed that okra extracts and their hydrogel dressings increased cell migration,angiogenesis,and re-epithelization of the chronic wound area,considerably promoting wound remodeling in diabetic ***,okra-based hydrogels are promising candidates for skin regeneration and wider tissue engineering applications.

关键词： Okra Antioxidant Angiogenesis Wound healing Tissue engineering