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Towards an actionable One Health approach

贫困所致传染病(英文) 2024年第2期13卷 1-6页

作者： Zhang Xiao-Xi Lederman Zohar Han Le-Fei Schurer Janna M. Xiao Li-Hua Zhang Zhi-Bing Chen Qiu-Lan Pfeiffer Dirk Ward Michael P. Sripa Banchob Gabri?l Sarah Dhama Kuldeep Acharya Krishna Prasad Robertson Lucy J. Deem Sharon L. Aenishaenslin Cécile Dantas-Torres Filipe Otranto Domenico Grace Delia Wang Yang Li Peng Fu Chao Poeta Patrícia Rahman Md. Tanvir Kassegne Kokouvi Zhu Yong-Zhang Yin Kun Liu Jiming Wang Zhao-Jun Guo Xiao-Kui Gong Wen-Feng Schwartl?nder Bernhard Ren Ming-Hui Zhou Xiao-Nong Sydney School of veterinary Science The University of Sydney Camden Australia Tropical Disease Research Center Department of Tropical Medicine Faculty of Medicine Khon Kaen University Khon Kaen Thailand laboratory of foodborne parasitic zoonoses Department of translational physiology infectiology and public health Chair Faculty Committee on Internationalisation Faculty of Veterinary Medicine Ghent University Merelbeke Belgium division of Pathology ICAR-Indian Veterinary Research Institute (IVRI) Bareilly Uttar Pradesh India Department of livestock Services Animal Quarantine Office-Kathmandu Budhanilkantha Kathmandu Nepal Parasitology Department of Paraclinical Sciences Faculty of Veterinary Medicine Norwegian University of Life Sciences ?s Norway One Government Drive Saint Louis Zoo Institute for Conservation Medicine St. Louis USA Groupe de Recherche en épidémiologie des Zoonoses et Santé Publique (GREZOSP) Faculté de médecine vétérinaire Université de Montréal Saint-Hyacinthe Québec Canada Centre de recherche en santé publique de l Université de Montréal et du CIUSSS du Centre-Sud-de-l’?le-de-Montréal Montréal Québec Canada Department of Immunology Aggeu Magalh?es Institute Oswaldo Cruz Foundation (Fiocruz) Recife Brazil School of Global Health Chinese Center for Tropical Diseases Research Shanghai Jiao Tong University School of Medicine Shanghai People’s Republic of China Department of veterinary Medicine University of Bari Valenzano Italy Department of Pathobiology Faculty of Veterinary Science Bu-Ali Sina University Hamedan Iran Natural Resources Institute University of Greenwich Chatham Maritime UK International livestock Research Institute Nairobi Kenya Director of key laboratory of Animal Antimicrobial Resistance Surveillance Ministry of Agriculture and Rural Affairs Beijing People’s Republic of China Institute of Animal Science Chinese Academy of Agricultural Sciences Beijing People’s Republic of China key laboratory of Ecosystem Network O

Background Despite the increasing focus on strengthening One Health capacity building on global level, challenges remain in devising and implementing real-world interventions particularly in the Asia-Pacific region. Recognizing these gaps, the One Health Action Commission (OHAC) was established as an academic community for One Health action with an emphasis on research agenda setting to identify actions for highest impact.Main text This viewpoint describes the agenda of, and motivation for, the recently formed OHAC. Recognizing the urgent need for evidence to support the formulation of necessary action plans, OHAC advocates the adoption of both bottom-up and top-down approaches to identify the current gaps in combating zoonoses, antimicrobial resistance, addressing food safety, and to enhance capacity building for context-sensitive One Health implementation.Conclusions By promoting broader engagement and connection of multidisciplinary stakeholders, OHAC envisions a collaborative global platform for the generation of innovative One Health knowledge, distilled practical experience and actionable policy advice, guided by strong ethical principles of One Health.

关键词： One Health Global Health One Health Action Commission Research agenda

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Single amino acid substitution of VP1 N17D or VP2 H145Y confers acid-resistant phenotype of type Asia1 foot-and-mouth disease virus

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Virologica Sinica 2014年第2期29卷 103-111页

作者： Haiwei Wang Shanshan Song Jianxiong Zeng Guohui Zhou Decheng Yang Te Liang Li Yu division of livestock infectious diseases State Key Laboratory of Veterinary BiotechnologyHarbin Veterinary Research Institute Chinese Academy of Agricultural Sciences

Infection by foot-and-mouth disease virus(FMDV) is triggered by the acidic pH in endosomes after virus uptake by receptor-mediated endocytosis. However, dissociation of the FMDV 146S particle in mildly acidic conditions renders inactivated foot-and-mouth disease(FMD) vaccines much less effective. Type Asia1 FMDV mutants with increased resistance to acid inactivation were selected to study the molecular basis of viral resistance to acid-induced disassembly and improve the acid stability of FMDV. Sequencing of capsid-coding regions revealed four amino acid replacements(VP1 N17D, VP2 H145Y, VP2 G192D, and VP3 K153E) in the viral population of the acid-selected 10th passage. We performed single or combined mutagenesis using a reverse genetic system, and our results provide direct experimental evidence that VP2 H145Y or VP1 N17D substitution confers an acid-resistant phenotype to type Asia1 FMDV.

关键词：口蹄疫病毒氨基酸置换 VP2 VP1 抗性表型类型 FMDV

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Mycoplasma leachii causes polyarthritis in calves via the blood route but is not associated with pneumonia

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Journal of Integrative Agriculture 2018年第11期17卷 2536-2545页

作者： CHANG Ji-tao WANG Guan-bo ZHANG Yue WANG Fang JIANG Zhi-gang YU Li division of livestock infectious diseases/state key laboratory of veterinary biotechnology Harbin Veterinary Research InstituteChinese Academy of Agricultural Sciences

Mycoplasma leachiiwas initially isolated from arthritic calves in South Queensland, Australia, and its ability to cause clinical polyarthritis in calves was demonstrated by experimental infection. However, the source of M. leachii infection in calves and its means of spreading are not well known. In this study, one-month-old calves were inoculated with cultures of M. leachii or joint fluid （collected from M. leachii-infected calves） through the intraarticular, intravenous, intratracheal, intranasal or oral routes. Multidisciplinary procedures, including clinical assessment, etiology assessment, pathology and immunohistochemistry （IHC）, were used to evaluate the pathogenicity of M. leachfi in calves and to elucidate the transmission route of M. leachii infection in calves. The results showed that all calves inoculated intraarticularly with cultured GN407 or joint fluid and two-thirds of the calves inoculated intravenously with joint fluid developed severe polyarthritis, and the M. leachfi antigen was detected in the joints of all infected calves by IHC and PCR. In contrast, calves inoculated with cultured M. leachfi or joint fluid through the intratracheal, intranasal or oral routes did not show any M. leachfi infection in the clinical assessment, etiology assessment, or pathology and IHC results. These results indicated that polyarthritis caused by M. leachii in calves is transmitted via the blood route; however, this disease is not transmitted through the respiratory or digestive routes. In addition, the M. leachii antigen was not detected in the lungs of all the inoculated calves using IHC and PCR, indicating that M. leachfi is not associated with pneumonia, even in the calves inoculated through the respiratory duct. These findings are important information for the prevention and control of calf polyarthritis caused by M. leachfi.

关键词： Mycoplasma leachii calf polyarthritis transmission via blood

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Identification of two novel linear epitopes on the p30 protein of African swine fever virus

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Journal of Integrative Agriculture 2023年第6期22卷 1945-1949页

作者： YU Si-hui SHAN Zhao-meng YANG Jing-jing LIU Yi-ning WU Chang-de ZHANG Zhen-jiang ZHU Yuan-mao MENG Bo ZHAN Jia-xing WEN Xue-xia ZHANG Ying key laboratory of livestock infectious diseases of Ministry of Education College of Animal Science and Veterinary MedicineShenyang Agricultural UniversityShenyang 110866P.R.China state key laboratory of veterinary biotechnology National High Containment Facilities for Animal Diseases Control and PreventionHarbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150069P.R.China

African swine fever(ASF) is a hemorrhagic disease caused by African swine fever virus(ASFV), which belongs to the Asfarviridae family. ASF has become prevalent in Africa since it was first reported in Kenya in 1921(Rowlands et al. 2008;Costard et al. 2009). In 1957, it was introduced to Portugal in Europe, after which ASFV rapidly spread to other European countries and has already been eradicated in several countries except Sardinia(Mur et al. 2016). In 2007, ASF was introduced to Georgia and has continued its spread to other countries in Europe(Smietanka et al. 2016;Kolbasov et al. 2018;Garigliany et al. 2019;Linden et al. 2019). In China, an ASF outbreak was first reported on August 3, 2018 in a pig farm in Shenyang, Liaoning Province(Zhou et al. 2018). Since then, the dramatic spread of ASF throughout China has caused huge economic losses to the swine industry(Jiang et al. 2021).

关键词： African continued spread

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Rapid Recovery of Classical Swine Fever Virus Directly from Cloned cDNA

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Journal of Integrative Agriculture 2013年第5期12卷 877-883页

作者： HUANG Jun-hua LI Yong-feng HE Fan LI Dan SUN Yuan HAN Wen QIU Hua-ji division of Swine infectious diseases State Key Laboratory of Veterinary BiotechnologyHarbin Veterinary Research InstituteChinese Academy of Agricultural Sciences

The reverse genetics for classical swine fever virus （CSFV） is currently based on the transfection of in vitro transcribed RNA from a viral genomic cDNA clone, which is inefficient and time-consuming. This study was aimed to develop an improved method for rapid recovery of CSFV directly from cloned cDNA. Full-length genomic cDNA from the CSFV Shimen strain, which was flanked by a T7 promoter, the hepatitis delta virus ribozyme and T7 terminator sequences, was cloned into the low- copy vector pOK12, producing pOKShimen-RzTФ. Direct transfection of pOKShimen-RzTqb into PK/T7 cells, a PK-15- derived cell line stably expressing bacteriophage T7 RNA polymerase, allowed CSFV to be rescued rapidly and efficiently, i.e., at least 12 h faster and 31.6-fold greater viral titer when compared with the in vitro transcription-based rescue system. Furthermore, the progeny virus rescued from PK/T7 cells was indistinguishable, both in vitro and in vivo, from its parent virus and the virus rescued from classical reverse genetics. The reverse genetics based on intracellular transcription is efficient, convenient and cost-effective. The PK/T7 cell line can be used to rescue CSFV directly from cloned cDNA and it can also be used as an intracellular transcription and expression system for studying the structure and function of viral genes.

关键词： classical swine fever virus reverse genetics T7 RNA polymerase stable cell line

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Discovery of Kaempferol,a Novel ADAM10 Inhibitor,as a Potential Treatment for Staphylococcus aureus Infection

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Engineering 2023年第9期28卷 206-221页

作者： Tingting Wang Jianfeng Wang Xiangzhu Xu Fan Jiang Hongfa Lv Qinghui Qi Can Zhang Qianghua Lv Xuming Deng Department of Respiratory Medicine Center for Pathogen Biology and Infectious Diseases&Key Laboratory of Organ Regeneration and Transplantation of the Ministry of EducationState Key Laboratory for Zoonotic DiseasesThe First Hospital of Jilin UniversityChangchun 130021China state key laboratory for Diagnosis and Treatment of Severe Zoonotic infectious diseases&key laboratory of Zoonosis Research Ministry of EducationInstitute of ZoonosisCollege of Veterinary MedicineJilin UniversityChangchun 130062China key laboratory for Molecular Enzymology and Engineering of Ministry of Education School of Life SciencesJilin UniversityChangchun 130012China key laboratory of livestock and Poultry Multi-omics of MARA&Shandong key laboratory of Animal Disease Control and Breeding Institute of Animal Science and Veterinary MedicineShandong Academy of Agricultural SciencesJinan 250100China

Host-directed therapy(HDT)is an emerging novel approach for treating multidrug-resistant Staphylococcus aureus(S.aureus)infection.Functioning as the indispensable specific cellular receptor for a-toxin(Hla),a-disintegrin and metalloproteinase 10(ADAM10)is exploited to accelerate S.aureus infection through diverse mechanisms.The extraordinary contribution of ADAM10 to S.aureus pathogenesis renders it an attractive HDT target for combating S.aureus infection.Our study is the first to demonstrate the indispensable role of ADAM10 in S.aureus-induced necroptosis,and it enhances our knowledge of the role of ADAM10 in S.aureus infection.Using a fluorogenic substrate assay,we further identified kaempferol as a potent ADAM10 inhibitor that effectively protected mice from S.aureus infection by suppressing Hla-mediated barrier disruption and necroptosis.Collectively,our work presents a novel hostdirected therapeutic strategy for using the promising candidate kaempferol to treat S.aureus infection and other diseases relevant to the disordered upregulation of ADAM10.

关键词： Host-directed therapy Kaempferol ADAM10 inhibitor Staphylococcus aureus infection Barrier disruption Necroptosis

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A visual assay panel for the identification of monkeypox virus DNA belonging to the clades I and II

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Virologica Sinica 2023年第4期38卷 635-638页

作者： Pei Huang Zanheng Huang Meihui Liu Yujie Bai Hongli Jin Jingbo Huang Xingqi Liu Zhenhong Guan Ming Duan Haili Zhang Yuanyuan Li Sandra Chiu Hualei Wang state key laboratory for Diagnosis and Treatment of Severe Zoonotic infectious diseases Key Laboratory for Zoonosis Research of the Ministry of EducationInstitute of ZoonosisCollege of Veterinary MedicineJilin UniversityChangchun130062China division of Life Sciences and Medicine University of Science and Technology of ChinaHefei244199China

Dear Editor,Monkeypox virus(MPXV)is an enveloped double-stranded DNA virus belonging to the family Poxviridae,subfamily Chordopoxvirinae,and genus Orthopoxvirus(Hraib et al.,2022;Gong et al.,2022).MPXV forms Congo Basin clade(clade I)and West African clade(clade II)(Durski et al.,2018).Additionally,clade II consists of two subclades,clade IIa and clade IIb.

关键词： belong panel African

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Evaluation of an attenuated vaccine candidate based on the genotype C of bovine parainfluenza virus type 3 in albino guinea pigs

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Journal of Integrative Agriculture 2017年第9期16卷 2047-2054页

作者： MA Lei ZHU Yuan-mao YANG Ting XUE Fei division of livestock infectious diseases State Key Laboratory of Veterinary BiotechnologyHarbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150069P.R.China

Bovine parainfluenza virus type 3（BPIV3） is considered as one of the most important respiratory tract pathogens of both young and adult cattle, and widespread among cattle in the world. BPIV3 was first reported in China in 2008 and four strains of BPIV3 were isolated from Shandong Province, known as genotype C（BPIV3c）. Pathogen investigations had shown that BPIV3 c infection was very common among cattle in China. To date, BPIV3 can be classified into genotypes A, B and C based on genetic and phylogenetic analysis. Serological survey also demonstrates that BPIV3 infection is widespread in China, however, there is still no available vaccine for BPIV3 prevention in China nowadays. In the present study, the BPIV3 c strain SD0835 was continuously passaged on Madin-Darby bovine kidney（MDBK） cells for hundreds of times, and the pathogenicity of passage 209 was reduced in guinea pigs. The passage 209 of BPIV3 c strain SD0835 was used as a live vaccine candidate to immunize the guinea pigs. The vaccination results revealed that two vaccinations could induce excellent serum neutralizing antibody responses as well as proliferation of T lymphocytes. The vaccinated guinea pigs were well protected against challenge with a low passage of BPIV3 c strain SD0835. Additionally, the percentages of CD4~＋ and CD8~＋ T cell subsets of animals in vaccinated group increased after immunization; T cell subsets on day 2 after challenge in both groups decreased, and the decline of CD4~＋ and CD8~＋ T cell subsets levels of four guinea pigs in vaccinated group was relatively moderate, comparing with that of the control group. These data support further testing of the attenuated virus as an effective candidate vaccine.

关键词： bovine parainfluenza virus type 3 attenuated vaccine genotype C guinea pig

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FoxJ1 inhibits African swine fever virus replication and viral S273R protein decreases the expression of FoxJ1 to impair its antiviral effect

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Virologica Sinica 2022年第3期37卷 445-454页

作者： Caina Ma Shasha Li Fan Yang Weijun Cao Huisheng Liu Tao Feng Keshan Zhang Zixiang Zhu Xiangtao Liu Yonghao Hu Haixue Zheng College of veterinary Medicine Gansu Agricultural UniversityLanzhou730070China state key laboratory of veterinary Etiological Biology National Foot and Mouth Diseases Reference LaboratoryKey Laboratory of Animal Virology of Ministry of AgricultureLanzhou Veterinary Research InstituteChinese Academy of Agricultural SciencesLanzhou730046China

African swine fever(ASF)is a highly pathogenic swine infectious disease that affects domestic pigs and wild boar,which is caused by the African swine fever virus(ASFV).ASF has caused huge economic losses to the pig industry and seriously threatens global food security and livestock health.To date,there is no safe and effective commercial vaccine against ASF.Unveiling the underlying mechanisms of ASFV-host interplay is critical for developing effective vaccines and drugs against ASFV.In the present study,RNA-sequencing,RT-qPCR and Western blotting analysis revealed that the transcriptional and protein levels of the host factor FoxJ1 were significantly down-regulated in primary porcine alveolar macrophages(PAMs)infected by ASFV.RT-qPCR analysis showed that overexpression of FoxJ1 upregulated the transcription of type I interferon and interferon stimulating genes(ISGs)induced by poly(dA:dT).FoxJ1 revealed a function to positively regulate innate immune response,therefore,suppressing the replication of ASFV.In addition,Western blotting analysis indicated that FoxJ1 degraded ASFV MGF505-2R and E165R proteins through autophagy pathway.Meanwhile,RT-qPCR and Western blotting analysis showed that ASFV S273R inhibited the expression of FoxJ1.Altogether,we determined that FoxJ1 plays an antiviral role against ASFV replication,and ASFV protein impairs FoxJ1-mediated antiviral effect by degradation of FoxJ1.Our findings provide new insights into the antiviral function of FoxJ1,which might help design antiviral drugs or vaccines against ASFV infection.

关键词： African swine fever virus(ASFV) FoxJ1 ISGs MGF505-2R E165R S273R

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The RING finger protein family in health and disease

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Signal Transduction and Targeted Therapy 2022年第9期7卷 3436-3458页

作者： Chunmei Cai Yan-Dong Tang Jingbo Zhai Chunfu Zheng Research Center for High Altitude Medicine School of MedicalQinghai UniversityXiningChina state key laboratory of veterinary biotechnology Harbin Veterinary Research Institute of Chinese Academy of Agricultural SciencesHarbinChina Medical College Inner Mongolia Minzu UniversityTongliao 028000China key laboratory of Zoonose Prevention and Control at Universities of Inner Mongolia Autonomous Region Tongliao 028000China The state key laboratory of Reproductive Regulation and Breeding of Grassland livestock School of Life SciencesInner Mongolia UniversityHohhotChina Department of Immunology School of Basic Medical SciencesFujian Medical UniversityFuzhouChina Department of Microbiology Immunology and Infectious DiseasesUniversity of CalgaryCalgaryAlbertaCanada

Ubiquitination is a highly conserved and fundamental posttranslational modification(PTM)in all eukaryotes regulating thousands of proteins.The RING(really interesting new gene)finger(RNF)protein,containing the RING domain,exerts E3 ubiquitin ligase that mediates the covalent attachment of ubiquitin(Ub)to target proteins.Multiple reviews have summarized the critical roles of the tripartite-motif(TRIM)protein family,a subgroup of RNF proteins,in various diseases,including cancer,inflammatory,infectious,and neuropsychiatric disorders.Except for TRIMs,since numerous studies over the past decades have delineated that other RNF proteins also exert widespread involvement in several diseases,their importance should not be underestimated.This review summarizes the potential contribution of dysregulated RNF proteins,except for TRIMs,to the pathogenesis of some diseases,including cancer,autoimmune diseases,and neurodegenerative disorder.Since viral infection is broadly involved in the induction and development of those diseases,this manuscript also highlights the regulatory roles of RNF proteins,excluding TRIMs,in the antiviral immune responses.In addition,we further discuss the potential intervention strategies targeting other RNF proteins for the prevention and therapeutics of those human diseases.

关键词： prevention involvement summarized

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