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Synthetic data as an investigative tool in hypertension and renal diseases research

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World Journal of Methodology 2025年第1期15卷 9-13页

作者： Aleena Jamal Som Singh Fawad Qureshi Sidney Kimmel Medical College Thomas Jefferson UniversityPhiladelphiaPA 19107United States School of Medicine University of Missouri Kansas CityKansasMO 64106United States division of Nephrology and hypertension Mayo ClinicRochesterMN 55905United States

There is a growing body of clinical research on the utility of synthetic data derivatives,an emerging research tool in *** nephrology,clinicians can use machine learning and artificial intelligence as powerful aids in their clinical decision-making while also preserving patient *** is especially important given the epidemiology of chronic kidney disease,renal oncology,and hypertension ***,there remains a need to create a framework for guidance regarding how to better utilize synthetic data as a practical application in this research.

关键词： Synthetic data Artificial intelligence Nephrology Blood pressure Research Editorial

Imbalance and dysfunction of transient receptor potential channels contribute to the pathogenesis of hypertension

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Science China(Life Sciences) 2014年第8期57卷 818-825页

作者： LIU DaoYan XIONG ShiQiang ZHU ZhiMing Center for hypertension and Metabolic diseases Department of Hypertension and EndocrinologyDaping HospitalThird Military Medical UniversityChongqing Institute of Hypertension

Intracellular Ca2+homeostasis is essential for vascular function and blood pressure *** of their unique roles in regulating intracellular Ca2+concentration and vascular function,a novel class of non-selective cation channels,called transient receptor potential(TRP)channels,have emerged at the frontier of hypertension *** on their role in vasculature function regulation,TRP channels can be divided into two functional subtypes:one that participates in vasoconstriction and one that participates in vasodilatation.A functional imbalance of these two subtypes of TRP channels may disturb intracellular calcium([Ca2+]i)homeostasis,and the consequent vascular dysfunction may contribute to the development of *** potential of these TRP channels as novel pharmacological targets for the treatment of human hypertension is of great interest.

关键词： TRP channels Ca2+ homeostasis vascular function hypertension

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Activation of the bitter taste sensor TRPM5 prevents high saltinduced cardiovascular dysfunction

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Science China(Life Sciences) 2020年第11期63卷 1665-1677页

作者： Hao Wu Yuanting Cui Chengkang He Peng Gao Qiang Li Hexuan Zhang Yanli Jiang Yingru Hu Xiao Wei Zongshi Lu Tianyi Ma Daoyan Liu Zhiming Zhu Department of hypertension and Endocrinology Center for Hypertension and Metabolic DiseasesDaping HospitalThird Military Medical UniversityChongqing Institute of HypertensionChongqing 400042China

High salt intake is a known risk factor of cardiovascular diseases. Our recent study demonstrated that long-term high salt intake impairs transient receptor potential channel M5(TRPM5)-mediated aversion to high salt concentrations, consequently promoting high salt intake and hypertension;however, it remains unknown whether TRPM5 activation ameliorates cardiovascular dysfunction. Herein we found that bitter melon extract(BME) and cucurbitacin E(CuE), a major compound in BME, lowered high salt-induced hypertension. Long-term BME intake significantly enhanced the aversion to high salt concentrations by upregulating TRPM5 expression and function, eventually decreasing excessive salt consumption in mice. Moreover, dietary BME ameliorated high salt-induced cardiovascular dysfunction and angiotensin II-induced hypertension in vivo. The mechanistic evidence demonstrated that dietary BME inhibited high salt-induced RhoA/Rho kinase pathway overactivation, leading to reduced phosphorylation levels of myosin light chain kinase and myosin phosphatase targeting subunit 1. Furthermore, CuE inhibited vasoconstriction by attenuating L-type Ca^(2+) channel-induced Ca^(2+) influx in vascular smooth muscle cells. To summarize, our findings indicate that dietary BME has a beneficial role in antagonizing excessive salt consumption and thus appears promising for the prevention of high salt-induced cardiovascular dysfunction.

关键词： transient receptor potential channel M5 bitter melon extract cardiovascular dysfunction

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The emerging role of tubulin posttranslational modifications in cilia and ciliopathies

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Biophysics Reports 2020年第4期6卷 89-104页

作者： Kai He Kun Ling Jinghua Hu Department of Biochemistry and Molecular Biology Mayo Clinic division of Nephrology and hypertension Mayo Clinic Mayo Translational Polycystic kidney diseases Center Mayo Clinic

Tubulin posttranslational modifications(PTMs) add ‘ tubulin code”” to generate functional diversities of microtubules. Several types of tubulin PTMs accumulate on axonemes and basal bodies of cilia,including acetylation, glutamylation, glycylation and detyrosination. Among them, glutamylation, glycylation and detyrosination are mostly enriched in the B-tubules, whereas acetylation occurs on both Aand B-tubule of the microtubule doublets in a similar level. Recent studies indicate that tubulin PTMs are critical for the fine tuning of assembly/disassembly, maintenance, motility, and signaling of *** tubulin PTMs are strongly implicated in human disorders including ciliopathies and neuron degeneration. Here, we review the current understanding how tubulin PTMs regulate cilia formation and function, and their relevance to human health.

关键词： Acetylation Tubulin posttranslational modifications (PTMs) Cilia Ciliopathies Glutamylation Glycylation

More than skin deep? Potential nicotinamide treatment applications in chronic kidney transplant recipients

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World Journal of Transplantation 2016年第4期6卷 658-664页

作者： Andrew G Bostom Basma Merhi Joanna Walker Leslie Robinson-Bostom division of hypertension and kidney diseases Department of Medicine Rhode Island Hospital division of hypertension and kidney diseases Department of Medicine Rhode Island Hospital and Organ Transplantation Department of Dermatology Rhode Island Hospital

Non-melanoma cutaneous carcinomas, or skin cancers, predominantly squamous cell carcinomas(SCCs), are the most common malignancies occurring in kidney transplant recipients(KTRs). Squamous cell carcinoma risk is dramatically elevated in KTRs, occurring at rates of up 45-250 times those reported in general populations. New non-melanoma skin cancers in KTRs with a prior non-melanoma skin cancer also develop at 3-times the rate reported in non-KTRs with the same clinical history. The unique aggressiveness of SCCs in KTRs increases patient morbidity, due to the high rate of new lesions requiring treatment, frequently surgical excision. Oral nicotinamide shows promise in the chemoprevention of the especially aggressive non-melanoma skin cancers which occur in KTRs. This benefit might be conferred via its inhibition of sirtuin enzymatic pathways. Nicotinamide's concurrent hypophosphatemic effect may also partially ameliorate the disturbed calcium-phosphorus homeostasis in these patients-a putative risk factor for mortality, and graft failure. Conceivably, a phase 3 trial of nicotinamide for the prevention of non-melanoma skin cancers in KTRs, lasting at least 12-mo, could also incorporate imaging and laboratory measures which assess nicotinamide's impact on subclinical cardiovascular and chronic kidney disease risk, and progression.

关键词： kidney transplantation Skin neoplasms Niacinamide Phosphorus

Metabolic hypertension:concept and practice

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Frontiers of Medicine 2013年第2期7卷 201-206页

作者： Zhiming Zhu Peijian Wang Shuangtao Ma Center for hypertension and Metabolic diseases Department of Hypertension and EndocrinologyDaping HospitalThird Military Medical UniversityChongqing Institute of HypertensionChongqing 400042China Department of Cardiology General Hospital of PLA Chengdu Military Area CommandChengdu 610083China

hypertension is a serious public health problem *** than 60%of the risk factors for hypertension are associated with metabolic *** abnormalities increase the risk for hypertension and cause high blood *** metabolic disturbances is beneficial for hypertension *** to the importance of metabolic abnormalities in the pathogenesis of hypertension,we propose a concept of metabolic *** this review,we discuss and review the clinical types,pathogenesis,risk evaluation and management of metabolic *** of the mechanism of metabolic hypertension should facilitate the design of novel pharmacotherapeutics and dedicated antihypertensive manipulations.

关键词： hypertension cardiometabolic risk factors metabolic abnormalities

Neuroprotective potential for mitigating ischemia-reperfusion-induced damage

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Neural Regeneration Research 2025年第8期20卷 2199-2217页

作者： Zi Ye Runqing Liu Hangxing Wang Aizhen Zuo Cen Jin Nan Wang Huiqi Sun Luqian Feng Hua Yang The Clinical Medical College Guizhou Medical UniversityGuiyangGuizhou ProvinceChina division of Infectious diseases Department of Internal MedicinePeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina School of Medical Imaging Guizhou Medical UniversityGuiyangGuizhou ProvinceChina division of Gastroenterology First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina The Second Clinical Medical College Lanzhou UniversityLanzhouGansu ProvinceChina Department of Neurosurgery Affiliated Hospital of Guizhou Medical UniversityGuiyangGuizhou ProvinceChina

Reperfusion following cerebral ischemia causes both structural and functional damage to brain tissue and could aggravate a patient's condition;this phenomenon is known as cerebral ischemia-reperfusion *** studies have elucidated the neuroprotective role of the sirtuin protein family(Sirtuins)in modulating cerebral ischemia-reperfusion ***,the potential of utilizing it as a novel intervention target to influence the prognosis of cerebral ischemia-reperfusion injury requires additional *** this review,the origin and research progress of Sirtuins are summarized,suggesting the involvement of Sirtuins in diverse mechanisms that affect cerebral ischemia-reperfusion injury,including inflammation,oxidative stress,blood-brain barrier damage,apoptosis,pyroptosis,and *** therapeutic avenues related to Sirtuins that may improve the prognosis of cerebral ischemia-reperfusion injury were also investigated by modulating Sirtuins expression and affecting representative pathways,such as nuclear factor-kappa B signaling,oxidative stress mediated by adenosine monophosphate-activated protein kinase,and the forkhead box *** review also summarizes the potential of endogenous substances,such as RNA and hormones,drugs,dietary supplements,and emerging therapies that regulate Sirtuins *** review also reveals that regulating Sirtuins mitigates cerebral ischemia-reperfusion injury when combined with other risk *** Sirtuins show promise as a potential target for the treatment of cerebral ischemiareperfusion injury,most recent studies are based on rodent models with circadian rhythms that are distinct from those of humans,potentially influencing the efficacy of Sirtuinstargeting drug ***,this review provides new insights into the role of Sirtuins in the pathology and treatment of cerebral ischemia-reperfusion injury.

关键词： apoptosis autophagy blood-brain barrier dietary supplements drug hormones inflammation neuroprotection oxidative stress prognosis pyroptosis reperfusion injury risk factors RNA therapeutics

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Rhabdomyolysis-related acute kidney injury in COVID-19:A critical concern

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World Journal of Virology 2025年第1期14卷 127-129页

作者： Md Safiullah Sarker Virology Laboratory Infectious Diseases DivisionDhaka 1212Bangladesh

Rhabdomyolysis is a severe condition characterized by the breakdown of muscle tissue leading to the release of intracellular components into the *** condition,when associated with acute kidney injury(AKI),can result in significant morbidity and mortality,particularly in the context of coronavirus disease 2019(COVID-19).This editorial discusses a retrospective study on patients with COVID-19 who developed rhabdomyolysis-related *** study highlights that patients with rhabdomyolysis exhibited higher inflammatory markers,such as Creactive protein,ferritin,and procalcitonin,and experienced worse clinical outcomes compared to those with other causes of *** findings underscore the importance of early recognition and management of rhabdomyolysis in COVID-19 patients to improve prognosis and reduce mortality rates.

关键词： Rhabdomyolysis Acute kidney injury COVID-19 SARS-CoV-2 Creatine kinase Inflammation Prognosis Mortality

hypertension in patients with CKD in China： clinical characteristics and management

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Frontiers of Medicine 2017年第3期11卷 307-309页

作者： Guangyan Cai Xiangmei Chen Department of Nephrology Chinese PLA General Hospital Chinese PLA Institute of Nephrology State Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney Diseases Beijing 100853 China

Chronic kidney disease （CKD） is a life-threatening disease that results in end-stage renal disease （ESRD） and consumes substantial health resources. In China, the prevalence of CKD in the general population is 10....

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