检索结果-南通市图书馆

Timing of post-vaccination tests in infants born to mothers with chronic hepatitis B virus infection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2025年第1期17卷 176-177页

作者： Halil Haldun Emiroglu Melike Emiroglu division of Pediatric Gastroenterology Department of PediatricsSelcuk University Faculty of MedicineKonya 42130Türkiye division of Pediatric infectious diseases Department of PediatricsSelcuk University Faculty of MedicineKonya 42130Türkiye

Immunoprophylaxis is routinely recommended for infants born to mothers with hepatitis B virus(HBV)infection within the first 12-24 *** of he-patitis B surface antibody(HBsAb)resulting from hepatitis B immunoglobulin administered at birth may be perceived as a real vaccine *** makes it difficult to detect HBV *** this reason,it is recommended that infants born to hepatitis B surface antigen positive mothers and who received immunop-rophylaxis at birth should have HBsAb testing when they are 9-15 months old.

关键词： Hepatitis B virus Infant Hepatitis B vaccine Hepatitis B hyperimmune globulin Vaccination

Advances on ALV-J in China over the past two decades

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2025年第2期24卷 429-440页

作者： Wenrui Fan Yuntong Chen Mengmeng Yu Yongzhen Liu Yulong Gao Avian Immunosuppressive diseases division State Key Laboratory for Animal Disease Control and PreventinonHarbin Veterinary Research InstituteChinese Academy of Agricultural Sciences Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal infectious Disease and Zoonose Yangzhou University

Avian leukosis is an important tumorigenic disease caused by the avian leukosis virus(ALV) in poultry. ALVs belong to the retroviral family and are classified into 11 subgroups(ALV-A to ALV-K). Among them, ALV-J was first introduced into China in 1999, spreading widely and evolving from infecting meat-type chickens to layer chickens and Chinese local chickens. ALV-J typically induces myeloid leukosis in infected chickens, but also induces a high proportion of hemangiomas in infected layer chickens, posing a serious threat to poultry breeds in China. As a retrovirus, the genome of ALV-J has undergone significant mutations, which may be related to the expansion of the infection host range and increased pathogenicity of ALV-J. Over the last two decades, the introduction and spread of ALV-J in China have caused substantial losses to the poultry industry. Specialized detection assays have been developed to combat ALV-J infections in China. Additionally, ongoing research aims to employ gene-editing technology as a novel antiviral strategy to control the spread of ALV infections. This review highlights the importance of understanding the impact of ALV-J on the Chinese poultry industry and emphasizes the need for ongoing research and innovation to safeguard poultry health and promote sustainable poultry farming practices in China.

关键词： subgroup J avian leucosis epidemiology molecular variation pathogenicity prevention and control

Neuroprotective potential for mitigating ischemia-reperfusion-induced damage

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2199-2217页

作者： Zi Ye Runqing Liu Hangxing Wang Aizhen Zuo Cen Jin Nan Wang Huiqi Sun Luqian Feng Hua Yang The Clinical Medical College Guizhou Medical UniversityGuiyangGuizhou ProvinceChina division of infectious diseases Department of Internal MedicinePeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina School of Medical Imaging Guizhou Medical UniversityGuiyangGuizhou ProvinceChina division of Gastroenterology First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina The Second Clinical Medical College Lanzhou UniversityLanzhouGansu ProvinceChina Department of Neurosurgery Affiliated Hospital of Guizhou Medical UniversityGuiyangGuizhou ProvinceChina

Reperfusion following cerebral ischemia causes both structural and functional damage to brain tissue and could aggravate a patient's condition;this phenomenon is known as cerebral ischemia-reperfusion *** studies have elucidated the neuroprotective role of the sirtuin protein family(Sirtuins)in modulating cerebral ischemia-reperfusion ***,the potential of utilizing it as a novel intervention target to influence the prognosis of cerebral ischemia-reperfusion injury requires additional *** this review,the origin and research progress of Sirtuins are summarized,suggesting the involvement of Sirtuins in diverse mechanisms that affect cerebral ischemia-reperfusion injury,including inflammation,oxidative stress,blood-brain barrier damage,apoptosis,pyroptosis,and *** therapeutic avenues related to Sirtuins that may improve the prognosis of cerebral ischemia-reperfusion injury were also investigated by modulating Sirtuins expression and affecting representative pathways,such as nuclear factor-kappa B signaling,oxidative stress mediated by adenosine monophosphate-activated protein kinase,and the forkhead box *** review also summarizes the potential of endogenous substances,such as RNA and hormones,drugs,dietary supplements,and emerging therapies that regulate Sirtuins *** review also reveals that regulating Sirtuins mitigates cerebral ischemia-reperfusion injury when combined with other risk *** Sirtuins show promise as a potential target for the treatment of cerebral ischemiareperfusion injury,most recent studies are based on rodent models with circadian rhythms that are distinct from those of humans,potentially influencing the efficacy of Sirtuinstargeting drug ***,this review provides new insights into the role of Sirtuins in the pathology and treatment of cerebral ischemia-reperfusion injury.

关键词： apoptosis autophagy blood-brain barrier dietary supplements drug hormones inflammation neuroprotection oxidative stress prognosis pyroptosis reperfusion injury risk factors RNA therapeutics

维普期刊数据库

Safety and efficacy of selective RIPK1 inhibitor SIR1-365 in hospitalized patients with severe COVID-19: A multicenter, randomized, double-blind, phase 1b trial

在线全文

学校读者我要写书评

暂无评论

重症医学（英文） 2025年第1期5卷 70-78页

作者： Chavez-Tapia Norberto Sayeed Muneeba Ahsan Luxmi Shobha Kasper Douglas J. Xue Fenchao Shen Yang Fan Weiliang Yuan Wei Du Bin Obesity and Digestive Disease Unit Medica Sur Clinic and Foundation Mexico City Mexico Sindh infectious diseases Hospital and Research Centre Dow University of Health Sciences Karachi Sindh Pakistan Department of Medicine Division of Infectious Disease University of Illinois School of Medicine OSF HealthCare System d/b/a Saint Francis Medical Center Peoria IL USA Sironax USA Inc. Edison NJ USA Medical Intensive Care Unit State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Beijing China

Background::Receptor-interacting protein kinase 1 (RIPK1), a serine/threonine protein kinase, is mainly activated by pro-inflammatory cytokines and pathogens, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and its activation could result in apoptosis, necroptosis, or inflammation. This study was conducted to evaluate the safety and efficacy of a potent and selective inhibitor of RIPK1, SIR1-365, in hospitalized patients with severe coronavirus disease 2019 (COVID-19).Methods::This multicenter, randomized, double-blind, phase 1b study screened patients from December 18, 2020 until November 27, 2021. Adults hospitalized with severe COVID-19 (diagnosed ≤2 weeks before screening) were randomized 1:1 to receive oral placebo or SIR1-365 100 mg three times daily for ≤14 consecutive days, with standard-of-care. The primary objective was to evaluate SIR1-365 safety and tolerability. Secondary objectives included an assessment of SIR1-365 efficacy. Descriptive statistics were used to summarize safety. The study was not powered for efficacy testing. Relevant inferential statistical tests were used to aid interpretation of differences in clinical ***::Forty-five patients were randomized, 42 were treated. Eighteen patients experienced treatment-emergent adverse events (TEAEs) and 7 patients were ≥ grade 3. Fewer SIR1-365-treated vs. placebo-treated patients experienced TEAEs (30.4% vs. 57.9%) and serious TEAEs (13.0% vs. 26.3%) within 28 days of the first dose. There were no serious treatment-related TEAEs or deaths. Compare to placebo, SIR1-365 significantly increased arterial oxygenation from baseline to day 7 (least-squares mean change [standard error]: 109.4 [26.4] vs. -24.2 [23.6];P=0.0095), significantly reduced hospitalization duration after treatment (mean±standard deviation: [4.7±3.7] days vs. [8.6±5.6] days;P=0.0145) and respiratory failure incidence (8.3% vs. 38.1%;two-sided P=0.0291

关键词： COVID-19 Phase 1b trial Receptor-interacting protein 1 RIPK1 RIPK1 inhibitor SIR1-365

The Impacts of Climate Change on the Environment and Human health in China:A Call for more Ambitious Action

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2025年第2期38卷 127-143页

作者： Shilu Tong Yu Wang Yonglong Lu Cunde Xiao Qiyong Liu Qi Zhao Cunrui Huang Jiayu Xu Ning Kang Tong Zhu Dahe Qin Ying Xu Buda Su Xiaoming Shi National Institute of Environmental health Chinese Center for Disease Control and PreventionBeijing 100021China School of Public health and Social Work Queensland University of TechnologyBrisbane 4001Australia State Key Laboratory of Marine Environmental Science and international Institute for Sustainability Science College of the Environment and EcologyXiamen UniversityXiamen 361102FujianChina State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal UniversityBeijing 100875China National Key Laboratory of Intelligent Tracking and Forecasting for infectious diseases National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China School of Public health Shandong UniversityJinan 250012ShandongChina Vanke School of Public health Tsinghua UniversityBeijing 100084China Institute of Reproductive and Child health/National health Commission Key Laboratory of Reproductive health and Department of Epidemiology and Biostatistics/Ministryof Education Key Laboratory of Epidemiology of Major diseases(PKU) School of Public HealthPeking University Health Science CentreBeijing 100191China SKL-ESPC&SEPKL-AERM Department of Environmental HealthCollege of Environmental Sciences and Engineering&Center for Environment and HealthPeking UniversityBeijing 100871China China Meteorological Administration Beijing 100081China National Climate Centre China Meteorological AdministrationBeijing 100081China Nanjing University of Information Science and Technology Nanjing 210044JiangsuChina Chinese Center for Disease Control and Prevention Beijing 102206China

As global greenhouse gases continue rising,the urgency of more ambitious action is clearer than ever *** is the world’s biggest emitter of greenhouse gases and one of the countries affected most by climate *** evidence about the impacts of climate change on the environment and human health may encourage China to take more decisive action to mitigate greenhouse gas emissions and adapt to climate impacts.

关键词： change greenhouse climate

维普期刊数据库

Traditional Chinese medicine for chronic atrophic gastritis:Efficacy,mechanisms and targets

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第9期31卷 9-29页

作者： Li Wang Yan-Jie Lian Jin-Sheng Dong Ming-Kun Liu Hong-Liang Liu Zheng-Min Cao Qing-Nan Wang Wen-Liang Lyu Yu-Ning Bai Department of Gastroenterology Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China division of Cardiovascular Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing 100010China Department of infectious diseases Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Department of Dermatology Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China

Chronic atrophic gastritis(CAG)is an important stage of precancerous lesions of gastric *** treatment and regulation of CAG are essential to prevent its progression to *** Chinese medicine(TCM)has shown multi-targeted efficacy in CAG treatment,with advantages in enhancing gastric mucosal barrier defense,improving microcirculation,modulating inflammatory and immune responses,and promoting lesion healing,*** studies and meta-analyses indicate that TCM provides significant benefits,with specific Chinese herbal compounds and monomers demonstrating protective effects on the gastric mucosa through mechanisms including anti-inflammation,antioxidation,and regulation of cellular proliferation and apoptosis,***,it is pointed out that the efficacy of TCM in the treatment of CAG requires standardized research and unified standards,and constantly clarifies and improves the evaluation criteria of each dimension of gastric mucosal barrier function.

关键词： Traditional Chinese medicine Gastric mucosal barrier Chronic atrophic gastritis Therapeutic efficacy Treating target

COVID-19’s effects on microvascular structure in a healthy retina:an OCTA study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

international Journal of Ophthalmology(English edition) 2025年第2期18卷 283-289页

作者： Kazim Kiratli Hazan Gul Kahraman Yusuf Ziya Guven Fahrettin Akay Murat Aysin Department of infectious diseases and Clinical Microbiology Katip Celebi University Ataturk Educating and Research HospitalIzmir 35360Türkiye Department of Ophthalmology Democracy University Buca Seyfi Demirsoy Educating and Research HospitalIzmir 35390Türkiye Department of Ophthalmology KatipÇelebi University Atatürk Educating and Research HospitalIzmir 35360Türkey Department of Ophthalmology Health Sciences University Gülhane Educating and Research HospitalAnkara 06010Türkiye Department of Public health Balikesir University Faculty of MedicineBalikesir 10230Türkiye

AIM:To examine the subclinical alterations in the retina and choroid between patients with 2019 coronavirus disease(COVID-19)-related lung involvement and the healthy control ***:In this prospective case-control study,85 cases with lung involvement due to COVID-19 and 50 healthy cases were ***-corrected visual acuity,intraocular pressure measurement,and anterior and posterior segment examination were performed on both eyes for each *** and retinal changes were examined and recorded by optical coherence tomography ***:All choroidal thickness measurements of the COVID-19 group showed no statistically significant difference when compared to healthy *** vascular density and perfusion density values were compared,there was a decrease in the average of these values in the COVID-19 group,although it was not statistically significant(P=0.088,P=0.065 respectively).When the fovea avascular zone(FAZ)area values were compared,the average was 0.57±0.38 in the COVID-19 group,while it was 0.54±0.24 in the control ***:Although our data are not statistically significant,the decrease in vascularity and perfusion and the accompanying FAZ expansion are detected in the acute period(1st month).These changes may anatomically alter the retina in the long term and affect functional *** ischemia-related alterations in the retina caused by a prior COVID-19 infection may arise in situations without comorbidities and may require concern in the patient’s systemic assessment.

关键词： COVID-19 pneumonia perfusion density vascular density optical coherence tomography angiography

Identification of novel rodent and shrew orthohepeviruses sheds light on hepatitis E virus evolution

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Zoological Research 2025年第01期 103-121页

作者： Fu-Li Li Bo Wang Pei-Yu Han Bei Li Hao-Rui Si Yan Zhu Hong-Min Yin Li-Dong Zong Yi Tang Zheng-Li Shi Ben Hu Xing-Lou Yang Yun-Zhi Zhang Institute of Preventive Medicine School of Public Health Dali University Yunnan Key Laboratory of Screening and Research on Antipathogenic Plant Resources from Western Yunnan Yunnan Key Laboratory of Zoonotic Disease Cross-border Prevention and Quarantine Second People's Hospital of Qujing Programme in Emerging infectious diseases Duke-NUS Medical School CAS Key Laboratory of Special Pathogens Wuhan Institute of Virology Chinese Academy of Sciences Key Laboratory of Genetic Evolution & Animal Models Yunnan International Joint Laboratory of Zoonotic Viruses Yunnan Key Laboratory of Biodiversity Information Kunming Institute of Zoology Chinese Academy of Sciences

The family Hepeviridae has seen an explosive expansion in its host range in recent years, yet the evolutionary trajectory of this zoonotic pathogen remains largely unknown. The emergence of rat hepatitis E virus(HEV)has introduced a new public health threat due to its potential for zoonotic transmission. This study investigated2 ?464 wild small mammals spanning four animal orders,eight families, 21 genera, and 37 species in Yunnan Province, China. Using broadly reactive reverse transcription-polymerase chain reaction(RT-PCR), we systematically screened the presence and prevalence of Orthohepevirus and identified 192 positive specimens from10 species, corresponding to an overall detection rate of7.79%. Next-generation sequencing enabled the recovery of 24 full-length genomic sequences from eight host species, including Bandicota bengalensis, Eothenomys eleusis, and Episoriculus caudatus, representing newly reported host species for Orthohepevirus *** and sequence analyses revealed extensive genetic diversity within orthohepeviruses infecting rodents and shrews. Notably, among the identified strains, 20 were classified as Rocahepevirus ratti C1, two as C3, and one as Rocahepevirus eothenomi, while the remaining strain exhibited significant divergence, precluding *** analyses highlighted close associations between orthohepeviruses and their respective host taxa,with distinct phylogenetic clustering patterns observed across different host orders. These findings emphasize the critical roles of co-speciation and cross-species transmission in shaping the evolutionary trajectories of the genera Paslahepevirus and Rocahepevirus.

关键词：

Research landmarks on the 60th anniversary of Epstein-Barr virus

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2025年第2期68卷 354-380页

作者： Lan-Yi Zhong Chu Xie Le-Le Zhang Yan-Lin Yang Yuan-Tao Liu Ge-Xin Zhao Guo-Long Bu Xian-Shu Tian Zi-Ying Jiang Bo-Yu Yuan Peng-Lin Li Pei-Huang Wu Wei-Hua Jia Christian Münz Benjamin E.Gewurz Qian Zhong Cong Sun Mu-Sheng Zeng State Key Laboratory of Oncology in South China Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China Viral Immunobiology Institute of Experimental ImmunologyUniversity of ZürichZürich 8092Switzerland division of infectious diseases Department of MedicineBrigham and Women’s HospitalBoston MA 02115USA Department of Microbiology Harvard Medical SchoolBoston MA 02115USA Harvard Program in Virology Boston MA 02115USA Broad Institute of Harvard and MIT Cambridge MA 02142USA

Epstein-Barr virus(EBV),the first human oncovirus discovered in 1964,has become a focal point in virology,immunology,and oncology because of its unique biological characteristics and significant role in human *** we commemorate the 60th anniversary of EBV's discovery,it is an opportune moment to reflect on the major advancements in our understanding of this complex *** this review,we highlight key milestones in EBV research,including its virion structure and life cycle,interactions with the host immune system,association with EBV-associated diseases,and targeted intervention strategies.

关键词： Epstein-Barr virus oncovirus immune response epidemiology vaccines antibodies

维普期刊数据库