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A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon C.Daeschler Katelyn J.W.So Konstantin Feinberg Marina Manoraj Jenny Cheung Jennifer Zhang Kaveh Mirmoeini JPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical engineering University of TorontoTorontoONCanada Indiana University School of medicine IndianapolisINUSA division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

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Life-Cycle Bearing Capacity for Pre-Stressed T-beams Based on Full-Scale Destructive Test

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Structural Durability & Health Monitoring 2025年第1期19卷 145-166页

作者： Yushan Ye Tao Gao Liankun Wang Junjie Ma Yingchun Cai Heng Liu Xiaoge Liu China Construction Seventh engineering division Corp. Ltd.Zhengzhou450004China School of Water Conservancy and Transportation Zhengzhou UniversityZhengzhou450001China

To investigate the evolution of load-bearing characteristics of pre-stressed beams throughout their service life and to provide a basis for accurately assessing the actual working state of damaged pre-stressed concrete T-beams,destructive tests were conducted on full-scale pre-stressed concrete *** on the measurement and ana-lysis of beam deﬂection,strain,and crack development under various loading levels during the research tests,combined with the veriﬁcation coefﬁcient indicators speciﬁed in the codes,the veriﬁcation coefﬁcients of bridges at different stages of damage can be *** results indicate that the T-beams experience complete,incom-plete linear,and non-linear stages during the destructive test *** the complete linear elastic stage,both the deﬂection and bottom strain veriﬁcation coefﬁcients comply with the speciﬁcations,indicating a good structural load-bearing capacity no longer adheres to the code’s *** the non-linear stage,both coefﬁcients exhi-bit a sharp increase,resulting in a further decrease in the structure’s load-bearing *** to the pro-visions of the current code,the beam can be in the incomplete linear stage when both values fall within the code’s speciﬁed *** strain veriﬁcation coefﬁcient sourced from the compression zone at the bottom of theﬂange is not recommended for assessing the bridge’s load-bearing capacity.

关键词： Pre-stressed T-beams whole process destructive test bearing capacity veriﬁcation coefﬁcient

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Study on Blade Surface Flow around Wind Turbine by Using LDV Measurements

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Journal of Thermal Science 2015年第2期24卷 131-139页

作者： Tinnapob Phengpom Yasunari Kamada Takao Maeda Junsuke Murata Shogo Nishimura Tasuku Matsuno division of System engineering Mie University division of Mechanical engineering Mie University

This paper has attempted to study a mechanism of three-dimensional flow around a horizontal axis wind turbine(HAWT) rotor blade. An experimental study of the flow phenomenon in the vicinity of the wind turbine blade is a challenging endeavor. In this research, the HAWT model with 2.4 m diameter was tested in the large wind tunnel. The flow around the rotating blade surface was measured simultaneously for three velocity components, and two probes were used for the synchronized measurement of three-dimensional flow components. The local velocity was detected for the single seeding particle measured in the point where three pairs of laser beams intersected. Blade sections of interest in this study are composed of radial positions r/R = 0.3, 0.5 and 0.7. Optimum and low tip speed ratio flow characteristics were also compared. The velocity flow vector, skin friction coefficient and bound circulation were calculated from LDV measurements, and the experimental research showed reasonably and clearly the experimental results.

关键词： LDV measurement Sectional performance Wind turbine Boundary layer flow Span-wise flow

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Novel Gelatin-based Nano-gels with Coordination-induced Drug Loading for Intracellular Delivery

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Journal of Materials Science & Technology 2016年第9期32卷 840-844页

作者： Changjiang Fan Dong-An Wang division of Bioengineering School of Chemical and Biomedical Engineering Nanyang Technological University Institute for Translational medicine College of Medicine Qingdao University

In this study, we develop the gelatin-dopamine （Gel-Dopa） nano-gels （GDNGs） and explore their potential as drug delivery vehicles. The GeI-Dopa precursor is synthesized using EDC/NHS coupling reaction, in which the catechols can coordinate with transition metal ions such as Fe^3＋. These novel GDNGs exhibit excellent cytocompatibility. The model drug, doxorubicin （Dox）, is readily conjugated into catechol of GDNGs by the coordination cross-link of Fe^3＋ ion. The morphology and size distribution of the nanogels are characterized via field emission scanning electron microscopy and particle size analyzer, respectively. The GDNGs loaded with Dox （GDNGs-Dox） is capable of efficiently penetrating ceil membrane and enter the HeLa cells. The endocytosed GDNGs-Dox release Dox molecules and subsequently kill the tumor cells.

关键词： Gelatin Dopamine Doxorubicin Coordination interaction Drug delivery

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A 3D in vitro co-culture model for evaluating biomaterial-mediated modulation of foreign-body responses

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Bio-Design and Manufacturing 2022年第3期5卷 465-480页

作者： Betul Cakmak Pelin Saglam-Metiner Goze Beceren Yu S.Zhang Ozlem Yesil-Celiktas Department of Bioengineering Faculty of EngineeringEge University35100 IzmirTurkey division of engineering in medicine Brigham and Women’s HospitalDepartment of MedicineHarvard Medical SchoolCambridgeMAUSA

The immune response after implantation of a biomaterial may shorten the functional life of the implant,depending on the degree of the *** this study,we used a polyacrylamide-alginate(PAAm-Alg)hydrogel,which has been previously characterized as a biocompatible material and shown to enhance regeneration of cartilage in vivo,along with a graphiteenhanced hydrogel(PAAm-Alg-G)as a non-biocompatible counterpart,to evaluate macrophage attachment and polarization to pro-or anti-inflammatory *** performance of each biomaterial in the presence of fibroblasts and chondrocytes was validated by an in vitro model which demonstrated modulation of the foreign-body response.A blend of 5%gelatin methacryloyl and 0.1%methacrylated hyaluronic acid was optimized to mimic the extracellular matrix(ECM)and support cell viability,proliferation,migration,and functionality at an initial concentration of 3.25×10^(5) cells/*** PAAm-Alg-G hydrogel localized in the simulated ECM showed cytotoxic and genotoxic effects for both fibroblasts and chondrocytes,while exhibiting a proliferative effect on macrophages with elevated immune *** M1/M2 ratio was 0.73 for PAAm-Alg hydrogel but 2.64 for PAAm-Alg-G,leading to significant M1 dominance(p0.05).The interleukin-6(IL-6)concentration secreted in the presence of PAAm-Alg hydrogel(4.58 pg/mL)significantly decreased(p<0.0001)on day 13,while the increase(p<0.0001)in interleukin-10(IL-10)concentration(120.73 pg/mL)confirmed the switch from a pro-inflammatory to an anti-inflammatory *** immune responses by developing a simplistic yet powerful three-dimensional in vitro model provides advantages in preparing for clinical use of biomaterials.

关键词： Biomaterial Macrophage polarization Genotoxicity Biocompatibility Immune response

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De Novo Assembly Methods for Next Generation Sequencing Data

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Tsinghua Science and Technology 2013年第5期18卷 500-514页

作者： Yiming He Zhen Zhang Xiaoqing Peng Fangxiang Wu Jianxin Wang the School of Information Science and engineering Central South University the Morehouse School of medicine the Department of Mechanical engineering and division of Biomedical engineering University of Saskatchewan

The recent breakthroughs in next-generation sequencing technologies, such as those of Roche 454,Illumina/Solexa, and ABI SOLID, have dramatically reduced the cost of producing short reads of the genome of new species. The huge volume of reads, along with short read length, high coverage, and sequencing errors, poses a great challenge to de novo genome assembly. However, the paired-end information provides a new solution to these problems. In this paper, we review and compare some current assembly tools, including Newbler, CAP3, Velvet,SOAPdenovo, AllPaths, Abyss, IDBA, PE-Assembly, and Telescoper. In general, we compare the seed extension and graph-based methods that use the overlap/lapout/consensus approach and the de Bruijn graph approach for assembly. At the end of the paper, we summarize these methods and discuss the future directions of genome assembly.

关键词： next-generation sequencing genome assembly overlap/lapout/consensus de Bruijn graph

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Bioprinting of Small-Diameter Blood Vessels

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engineering 2021年第6期7卷 832-844页

作者： Xia Cao Sushila Maharjan Ramla Ashfaq Jane Shin Yu Shrike Zhang division of engineering in medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolCambridgeMA 02139USA

There has been an increasing demand for bioengineered blood vessels for utilization in both regenerative medicine and drug ***,the availability of a true bioengineered vascular graft remains ***-dimensional(3D)bioprinting presents a potential approach for fabricating blood vessels or vascularized tissue constructs of various architectures and sizes for transplantation and *** this review,we summarize the basic biology of different blood vessels,as well as 3D bioprinting approaches and bioink designs that have been applied to fabricate vascular and vascularized tissue constructs,with a focus on small-diameter blood vessels.

关键词： Bioprinting Small-diameter blood vessel Bioink Vascular engineering

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Potential application of high pressure carbon dioxide in treated wastewater and water disinfection:Recent overview and further trends

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Journal of Environmental Sciences 2015年第10期27卷 38-47页

作者： Huy Thanh Vo Tsuyoshi Imai Truc Thanh Ho Thanh-Loc Thi Dang Son Anh Hoang division of Urban Infrastructural engineering Mien trung University of Civil Engineering division of Environmental Science and engineering Yamaguchi University

Recently emerging disadvantages in conventional disinfection have heightened the need for finding a new solution. Developments in the use of high pressure carbon dioxide for food preservation and sterilization have led to a renewed interest in its applicability in wastewater treatment and water disinfection. Pressurized CO2 is one of the most investigated methods of antibacterial treatment and has been used extensively for decades to inhibit pathogens in dried food and liquid products. This study reviews the literature concerning the utility of CO2 as a disinfecting agent, and the pathogen inactivation mechanism of CO2 treatment is evaluated based on all available research. In this paper, it will be argued that the successful application and high effectiveness of CO2 treatment in liquid foods open a potential opportunity for its use in wastewater treatment and water disinfection. The findings from models with different operating conditions（pressure, temperature, microorganism, water content, media …） suggest that most microorganisms are successfully inhibited under CO2 treatment. It will also be shown that the bacterial deaths under CO2 treatment can be explained by many different ***, the findings in this study can help to address the recently emerging problems in water disinfection, such as disinfection by-products（resulting from chlorination or ozone treatment）.

关键词： High pressure CO2 Inactivation effect Inactivation mechanism

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Optimization of Manganese and Magnesium Contents in As-cast Aluminum-Zinc-Indium Alloy as Sacrificial Anode

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Journal of Materials Science & Technology 2011年第9期27卷 785-792页

作者： Mohammad R. Saeri Ahmad Keyvani Materials engineering division Faculty of Engineering Shahrekord University

In this study, effects of manganese and magnesium content on the electrochemical properties of Al-Zn-ln sacrificial anode were studied in 0.5 mol/L NaCl solution （pH=5）. The aluminum base alloy with different amounts of Mn and Mg were melted at 750℃, then casted at molds at 25℃. Corrosion experiments were mounted to determine the optimal effect of Mn and Mg on the efficiencies of the aluminum alloy anodes. The corroded and unexposed sample surfaces were subjected to microstructure characterization by optical and scanning electron microscopy. AI-Zn-ln alloy doped with 0%, 0.01%, 0.05%.0.2% and 0.3% by weights of Mn and 0%, 0.5%, 1.0%, 1.5%, 2.0%, 2.5% and 3.0% by weights of Mg were prepared to determine the effect of Mn and Mg on anode efficiency in the environment. The different microstructures of the evolved AI- Zn-ln-Mg-Mn alloy were correlated with the anode efficiencies. The Al-5.0%Zn-2.0%Mg-0.15%Mn-0.02%ln gave the best anode efficiency （about 83%）. The microstructures of the corroded surface of the optimized alloy revealed decreased distribution of the pockets of localized attacks which are characteristics of pitting （or crevice） corrosion.

关键词： Corrosion Aluminum alloy Sacrificial anode Manganese Magnesium Current capacity

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Amended influence matrix method for removal of rigid motion in the interior BVP for plane elasticity

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Applied Mathematics and Mechanics(English Edition) 2017年第10期38卷 1471-1480页

作者： Yizhou CHEN division of engineering Mechanics Jiangsu University

A conventional complex variable boundary integral equation （CVBIE） in plane elasticity is provided. After using the Somigliana identity between a particular fundamental stress field and a physical stress field, an additional integral equality is obtained. By adding both sides of this integral equality to both sides of the conventional CVBIE, the amended boundary integral equation （BIE） is obtained. The method based on the discretization of the amended BIE is called the amended influence matrix method. With this method, for the Neumann boundary value problem （BVP） of an interior region, a unique solution for the displacement can be obtained. Several numerical examples are provided to prove the efficiency of the suggested method.

关键词： complex variable boundary integral equation (CVBIE) amended influencematrix method removal of rigid body motion Neumann boundary value problem (BVP)

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