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Clinical profile and outcomes in very elderly patients with atrial fibrillation anticoagulated with rivaroxaban: data from the EMIR study

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Journal of Geriatric cardiology 2024年第7期21卷 723-732页

作者： Francisco Marín Manuel Anguita Sánchez Iñaki Lekuona Marcelo Sanmartín Fernán-dez Vivencio Barrios carlos Perez Muñoz Juan Cosín-Sales Alejandro IPérez Cabeza Vanesa Roldán Schilling carles Rafols Priu Esteban Orenes-Piñero María Asunción Es-teve-Pastor Department of cardiology Hospital Clínico Universitario Virgen de la ArrixacaIMIB-ArrixacaUniversity of MurciaCIBERCVMurciaSpain Department of cardiology Hospital Reina Sofía CórdobaIMIBICUniversity of CordobaCIBERCVCórdobaSpain Hospital Galdakao-Usansolo BizkaiaSpain Department of cardiology Hospital Uni-versitario Ramony CajalCIBERCVMadridSpain Department of cardiology University Hospital Ramóny CajalAl-caláUniversityMadridSpain Medical Center La Capillita Sanlúcar de Barrameda.Private cardiology clinicJerez de la FronteraSpain Department of cardiology Hospital Arnau de VilanovaValenciaSpain Department of car-diology Virgen de la Victoria University HospitalCIBERCV.MalagaSpain Department of Haematology Hospital Clínico Universitario Virgen de la ArrixacaUniversity of MurciaMurciaSpain Department of Medical Affairs Bayer HispaniaBarcelonaSpain Department of Biochemistry and Molecular Biology-A University of MurciaMurciaSpain

Objectives To analyze the clinical profile,adequacy of treatment with rivaroxaban and outcomes in octogenarians with atrial fibrillation(AF),taking rivaroxaban in clinical *** Observational and non-interventional study that included AF adults recruited from 79 Spanish centers,anticoagulated with rivaroxaban ≥ 6 months before being *** were analyzed according to age(≥ 80 vs.cardiovascular death and major bleeding were 1.03%,1.24%,1.03% and 1.75%,respectively,in octogenarian *** for progressive heart failure death and major bleeding,rates of outcomes in octogenarians were similar compared to younger *** octogenarians,the concomitant use of antiplatelet agents and non-severe dementia were independently associated with the development of ischemic stroke,whereas previous coronary revascularization and heart failure with MACE,and higher HAS-BLED score with major *** In clinical practice,around one third of patients taking rivaroxaban are *** patients have many comorbidities and a high thromboembolic *** that,rates of adverse events remain *** is adequately prescribed in the majority of octogenarians.

关键词： patients atrial bleeding

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Interleukin-10 gives exhausted chimeric antigen receptor(car)T cells a second breath

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Cancer Communications 2024年第7期44卷 787-790页

作者： Christoph Heuser-Loy Leibniz Institute for Immunotherapy Division for Functional Immune Cell ModulationRegensburgGermany

Adoptive cell therapy(ACT)represents a major pillar of modern *** or synthetically endowed with the ability to recognize tumor-associated antigens,tumor-infiltrating lymphocytes(TILs)or T cells engineered to transgenically express T cell receptors or chimeric antigen receptors(cars)are expanded and infused to tumor patients to lyse tumor ***,despite tremendous response rates against liquid tumors,many patients undergo relapses,and treatment outcomes in solid tumors have been disappointing so far[1].The harsh tumor microenvironment,including nutrient deprivation,acidification,hypoxia,and immunosuppressive signals[2,3],in conjunction with persistent antigen stimulation triggers a program of exhaustion in T cells(Figure 1A).Exhausted T cells exhibit reduced cytotoxicity and minimal proliferation potential,physiologically balancing tissue health with control of chronic viral infection or of tumor growth[4,5].Strategies to disengage or rewire the“erroneously”deployed exhaustion program to exploit the full potential of tumor-fighting T cells are highly sought after(Figure 1B).

关键词： Interleukin stimulation Figure

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Clinical cardiac regenerative studies in children

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World Journal of cardiology 2017年第2期9卷 147-153页

作者： Imre J Pavo Ina Michel-Behnke division of Pediatric car-diology Department of Pediatrics and Adolescent MedicineMedical University of ViennaA1090 ViennaAustria

Although the incidence of pediatric heart failure is low, the mortality is relatively high, with severe clinical symptoms requiring repeated hospitalization or intensive care treatment in the surviving patients. cardiac biopsy specimens have revealed a higher number of resident human cardiac progenitor cells, with greater proliferation and differentiation capacity, in the neonatal period as compared with adults, demonstrating the regeneration potential of the young heart, with rising interest in cardiac regeneration therapy in critically ill pediatric patients. We review here the available literature data, searching the MEDLINE, Google Scholar and EMBASE database for completed, and *** homepage for ongoing studies involving pediatric cardiac regeneration reports. Because of difficulties conducting randomized blinded clinical trials in pediatric patients, mostly case reports or cohort studies with a limited number of individuals have been published in the field of pediatric regenerative cardiology. The majority of pediatric autologous cell transplantations into the cardiac tissue have been performed in critically ill children with severe or terminal heart failure. Congenital heart disease, myocarditis, and idiopathic hypertrophic or dilated cardiomyopathy leading to congestive heart failure are some possible areas of interest for pediatric cardiac regeneration therapy. Autologous bone marrow mononuclear cells, progenitor cells, or cardiospheres have been applied either intracoronary or percutaneously intramyocardially in severely ill children, leading to a reported clinical benefit of cell-based cardiac therapies. In conclusion, compassionate use of autologous stem cell administration has led to at least short-term improvement in heart function and clinical stability in the majority of the critically ill pediatric patients.

关键词： Congenital heart disease Heart failure cardiac regeneration Cell-based therapy Hospitalization Children

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Interfacial modulation of bifunctional electrolyte additive engineering for dendrite-free and robust lithium metal anode

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Journal of Energy Chemistry 2024年第10期97卷 120-127,I0003页

作者： Mahammad Rafi Shaik Yongmin Park Young-Kwang Jung Won Bin Im division of Materials Science and Engineering Hanyang University222Wangsimni-roSeongdongguSeoul 0473Republic of Kor Department of Chemical Engineering and Biotechnology University of CambridgeCambridge CB3 OASUK

Anode materials for rechargeable electric car batteries are obtained from Li-metal owing to their extremely high specific capacity and low redox ***,safety concerns related to dendrite formation on the anode surface caused by the uneven distribution of Li-ions during the discharge process interfere with the use of Li-metal in industrial *** this study,methyl vinyl sulfone(MVS),a sulfone-based functional electrolyte additive,is used in an additive engineering strategy to control Lielectrolyte interactions and address the aforementioned *** dendrite growth may be restricted,and transition metal degradation on the surface of the cathode can be reduced by the MVS-derived functional electrolyte additive interfacial *** electrochemical performance of an ethylene carbonate/dimethyl carbonate(EC/DMC)+1 wt% MVS Li-metal anode of a Li||Li symmetric cell exhibits remarkable cycle stability,maintaining a low overvoltage for over 750 h at 1 mA cm^(-2),and capacity of 1 mA h cm^(-2).Additionally,LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811) full cells with the MVS additive exhibit enhanced electrochemical stability for 250 cycles at a current density of 100 mA g^(-1).This study provides an innovative approach for stabilizing the metal-electrolyte interfacial layer that may be used for practical applications in metal-based rechargeable batteries.

关键词： Lithium rechargeable battery Dendrite-free Electrolyte additive Bifunctional electrolyte Interfacial layer

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Beyond reproduction:unraveling the impact of sex hormones on cardiometabolic health

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Medical Review 2024年第4期4卷 284-300页

作者： Viktoria Xega Jun-Li Liu MeDiC Program The Research Institute of McGill University Health CentreMontrealCanada division of Endocrinology and Metabolism Department of MedicineMcGill UniversityMontrealCanada

This review thoroughly explores the multifaceted roles of sexual hormones,emphasizing their impact beyond reproductive functions and underscoring their signiﬁcant inﬂuence on cardiometabolic *** analyzes the broader physiological implications of estrogen,testosterone,and progesterone,highlighting their eﬀects on metabolic syndrome,lipid metabolism,glucose homeostasis,and car-diovascular *** from diverse molecular,clin-ical,and therapeutic studies,the paper delves into the intricate interplay between these hormones and car-diometabolic *** presenting a comprehensive analysis that goes beyond traditional perspectives,and recognizing sexual hormones as more than reproductive agents,the review sheds light on their broader signiﬁcance in health and disease management,advocating for holistic and personalized medical approaches.

关键词： estrogens progesterone androgens metabolic syndrome cardiovascular diseases

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Modified magnetic resonance angiography of the liver using sensitivity encoding in comparison with digital subtraction angiography and CT arterial portography

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Hepatobiliary & Pancreatic Diseases International 2005年第2期4卷 185-191页

作者： Masahiko Fujii Hideaki Kawamitsu Kazuro Sugimura First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China division of Ra diology Kobe Graduate School of Medicine Hyogo 6500017 Japan

BACKGROUND: Over 355 patients have received ortho- topic liver transplantation ( OLT) at this hospital since 1993. Preoperative imaging studies of both hepatic vessels and parenchyma in these recipients bettered surgical plan- ning or even precluded the necessity of surgery. Here we report our preliminary results of modified magnetic reso- nance angiography ( MRA ) using sensitivity encoding ( SENSE) through comparative study with conventional digital subtraction angiography (DSA) and CT arterial por- tography (CTAP). METHODS: Sixteen patients with suspected liver diseases were included in the study. All of them received both dy- namic MRI of the liver using SENSE and digital DSA with CTAP within a two-week interval. The four-phase MRA was reconstructed from source images of the coronal dy- namic study. The arterial phase of the modified MRA was compared with DSA in the evaluation of hepatic arteries and the portal phase compared with CT portography recon- structed from source images of CTAP. In dynamic study of the liver, a fixed dose (20 ml) of contrast medium and scan timing were used. RESULTS: The main branches and variations of the hepatic arterial system were well shown on the modified MRA, al- though the marginal branches of hepatic arteries were of poor quality. The figures of portal veins on MRA were as clear as or superior to those of CTAP. In addition, the su- prarenal inferior vena cava (IVC) was well demonstrated on MRA and/or non contrast-enhanced coronal balanced fast-field echo (b-FFE) scan sequence in most cases. MRI detected most parenchymal lesions of the liver and hemo- dynamics of these lesions could be evaluated on source ima- ges of the modified MRA. MRI/MRA also serendipitously revealed several extrahepatic disease entities or variations that were not found on DSA/CTAP. CONCLUSIONS: The modified MRA using SENSE is a cost-effective modality of examination for the demonstra- tion of the whole hepatic vascular system. Combined with MRI, it has t

关键词： orthotopic liver transplantation magnetic resonance imaging magnetic resonance angiography digital subtraction angiography

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Preclinical evaluation of cyclophosphamide and fludarabine combined with CD19 car-T in the treatment of B-cell hematologic malignancies in vivo

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Oncology Research 2024年第6期32卷 1109-1118页

作者： ZHIGANG XIA MENGYAO TIAN YUCAI CHENG WENFANG YI ZEFAN DU TIANWEN LI YUCHEN WEN LINDI LI YONG LIU CHUN CHEN Pediatric Hematology Laboratory Division of Hematology/OncologyDepartment of PediatricsThe Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen518107China Scientific Research Center The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen518107China

Background:Chimeric antigen receptor T(car-T)cell therapy has achieved marked therapeutic success in ameliorating hematological ***,there is an extant void in the clinical guidelines concerning the most effective chemotherapy regimen prior to chimeric antigen receptor T(car-T)cell therapy,as well as the optimal timing for car-T cell infusion *** and Methods:We employed cell-derived tumor xenograft(CDX)murine models to delineate the optimal pre-conditioning chemotherapy regimen and timing for car-T cell ***,transcriptome sequencing was implemented to identify the therapeutic targets and elucidate the underlying mechanisms governing the treatment ***:Our preclinical in vivo evaluation determined that a combination of cyclophosphamide and fludarabine,followed by the infusion of CD19 car-T cells five days subsequent to the chemotherapy,exerts the most efficacious therapeutic effect in B-cell hematological ***,RNA-seq data indicated that the therapeutic efficacy predominantly perturbs tumor cell metabolism,primarily through the inhibition of key mitochondrial targets,such as C-Jun Kinase enzyme(C-JUN).Conclusion:In summary,the present study offers critical clinical guidance and serves as an authoritative reference for the deployment of CD19 car-T cell therapy in the treatment of B-cell hematological malignancies.

关键词： CD19 car-T B-cell hematologic malignancies Metabolism In vivo

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cardiac Surgery in Octogenarians and Beyond: Single Center Experience

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Open Journal of Thoracic Surgery 2013年第2期3卷 51-56页

作者： Reda E. Al-Refaie Hashem Aliter Ricardo Gallo Ali Youssef Mushabab Al-Murayeh Edwin Ravikumar Department of cardiac Surgery and car- diology Armed Forces Hospitals Southern Region Khamis Mushayt KSA Department of cardiothoracic Surgery Mansoura University Hospitals Mansoura Egypt

Background: Increasing numbers of octogenarians and improvements in surgical techniques and postoperative care have resulted in increasing cardiac operations in this age. The aim is to analyze our experience of cardiac surgery on octogenarians and beyond concerning postoperative morbidities and mortality. Methods: 67 octogenarians and nonagenarians underwent open heart surgery in our hospital between 2001 to 2009 were retrospectively reviewed. Data included baseline preoperative status, intraoperative and perioperative course, and immediate outcomes. Results: The mean age was 86.22 ± 6.1 years. 86.6% patients were males. Symptoms were dyspnea;Class II in 13.4%, Class III in 55.2%, Class IV in 31.4% patients;angina in 82.1%, and CHF in 25.4% patients. The mean EF was 37.8% ± 10. Risk factors include smoking in 52.2%, DM in 37.3%, hypertension in 28.4%, obesity in 25.4%, previous MI in 22.4%, COPD in 17.9%, renal insufficiency in 11.9%, pulmonary hypertension in 7.5%, PVD in 6%, and cerebrovascular disease in 3% patients. The procedures were isolated CABG in 73%, AVR in 9%, MVR in 6%, CABG/valve in 9%, and MVR and AVR in 3% patients. Complications were 18%. It included renal impairment in 18%, arrhythmias in 14.9%, bleeding in 6%, prolonged ventilation in 13.4%, CHF in 4.5%, gastrointestinal bleeding in 4.5%, wound infection in 7.5%, and cerebrovascular accident in 3%. Hospital mortality was 9% patients. Conclusions: cardiac surgery can be performed safely with acceptable hospital morbidity and mortality in octogenarians and beyond. Early referral and proper selection of patients are mandatory to improve immediate postoperative survival.

关键词： Coronary Artery Bypass Graft Valve Octogenarians Nonagenarian

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IVUS-guided rotational atherectomy for unexpandable paclitaxel-eluting stent:A case report and review of literature

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Journal of Geriatric cardiology 2013年第3期10卷 226-229页

作者： Po-Ming Ku Tsuei-Yuen Huang Zhih-Cherng Chen Max Woo Jui-Sung Hung Section of cardiology Chi-Mei Medical Center Tainan 71087 Taiwan China division of cardiology China Medical University Hospital Taichung 40454 TaiwanChina division of car diology Ch ina Medical University Hospital Taichung 40454 Taiwan China

We describe a patient suffering from late stent thrombosis in a paclitaxel-eluting stent which had an underexpanded ring due to the three-hundred-sixty-degree circumferential calcified plaque. Intravascular ultrasound (IVUS) revealed rotational atherectomy could success-fully ablate both the metallic ring and the calcified ring. The ablated segment was scaffolded with a new paclitaxel-eluting stent, well ex-panded and documented by IVUS. To our knowledge, this is the first case report of stent ablation for an unexpanded paclitaxel-eluting stent. From the Medline index, there were only six case reports of stent ablation. We review and summarize the operation details of stent ablation from these reports.

关键词： Intravascular ultrasound Rotational atherectomy Stent thrombosis Unexpanded stent

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Essen score in the prediction of cerebrovascular events compared with cardiovascular events after ischaemic stroke or transient ischaemic attack:a nationwide registry analysis

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Journal of Geriatric cardiology 2022年第4期19卷 265-275页

作者： Long LI Ze-Ning JIN Yue-Song PAN Jing JING Xia MENG Yong JIANG Hao LI Cai-Xia GUO Yong-Jun WANG Department of cardiology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of car-diology and Beijing Key Laboratory of Hypertension Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Department of cardiology Beijing Tongren HospitalCapital Medical UniversityBeijingChina

BACKGROUND The Essen risk score improves stratification of patients with acute ischemic stroke by early stroke *** study showed it could also predict myocardial infarction(MI).This study aimed to compare the Essen score’s ability to predict cerebrovascular events with compared cardiovascular *** We included patients with acute ischaemic stroke or transient ischaemic attack within seven days from the Third China National Stroke ***-year cumulative event rates of combined vascular events(a composite of MI,stroke recurrence or vascular death)and cardiac events(a composite of MI,heart failure or cardiac death)was estimated using the Kaplan-Meier *** predictive value of the Essen score was assessed with *** multivariate Cox regression analyses,we assessed whether Essen score,etiological subtype and imaging parameters were associated with *** Of 13,012 patients were included,the cumulative one-year event rates were 10.03%for combined vascular events and 0.77%for cardiac events,*** with those with an Essen scorecardiac events(HR=2.30,95%CI:1.53−3.44).The score tended to be more predictive of the risk of MI(C-statistic=0.63,95%CI:0.55−0.71)and cardiac events(C-statistic=0.62,95%CI:0.56−0.67)than stroke recurrence(C-statistic=0.55,95%CI:0.54−0.57)and combined vascular events(C-statistic=0.56,95%CI:0.54−0.57).In multivariable analysis after adjusted Essen score,patients with multiple acute in-farctions or single acute infarctions and large artery atherosclerosis subtype were independently associated with an increased risk of combined vascular *** the cardioembolism subtype was associated with an increased risk of cardiac *** The Essen score is potentially more suitable for risk stratification of cardiovascular events than cerebrovasc

关键词： transient score statistic

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