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Antioxidative study of Cerium Oxide nanoparticle functionalised PCL-Gelatin electrospun fibers for wound healing application

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Bioactive Materials 2018年第2期3卷 201-211页

作者： Hilal Ahmad Rather Ria Thakore Ragini Singh Dhwani Jhala Sanjay Singh Rajesh Vasita Biomaterials&biomimetics Laboratory School of Life SciencesCentral University of GujaratGandhinagar382030GujaratIndia division of Biological and Life Sciences School of Arts and ScienceAhmedabad UniversityNavrangpuraAhmedabad380009GujaratIndia

Skin wound healing involves a coordinated cellular response to achieve complete *** levels of reactive oxygen species(ROS)in the wound environment often pose a hindrance in wound healing resulting in impaired wound healing *** oxide nanoparticles(CeNPs)have the ability to protect the cells from oxidative damage by actively scavenging the ***,matrices like nanofibers have also been explored for enhancing wound *** the current study CeNP functionalised polycaprolactone(PCL)-gelatin nanofiber(PGNPNF)mesh was fabricated by electrospinning and evaluated for its antioxidative *** angle XRD analysis of randomly oriented nanofibers revealed^2.6 times reduced crystallinity than pristine PCL which aided in rapid degradation of nanofibers and release of ***,bioactive composite made between nanoparticles and PCLgelatin maintained the fibrous morphology of PGNPNF upto 14 *** PGNPNF mesh exhibited a superoxide dismutase(SOD)mimetic activity due to the incorporated *** PGNPNF mesh enhanced proliferation of 3T3-L1 cells by^48%as confirmed by alamar blue assay and SEM micrographs of cells grown on the nanofibrous ***,the PGNPNF mesh scavenged ROS,which was measured by relative DCF intensity and fluorescence microscopy;and subsequently increased the viability and proliferation of cells by three folds as it alleviated the oxidative ***,the results of this study suggest the potential of CeNP functionalised PCL-gelatin nanofibrous mesh for wound healing applications.

关键词： Electrospinning Ce nanoparticles Antioxidative Nanofiber

Functionally graded additive manufacturing to achieve functionality specifications of osteochondral scaffolds

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Bio-Design and Manufacturing 2018年第1期1卷 69-75页

作者： Mario Monzon Chaozong Liu Sara Ajami Miguel Oliveira Ricardo Donate Viviana Ribeiro Rui L. Reis Departamento de Ingenieria Mecanica Universidad de Las Palmas de Gran Canaria Edificio de fabricacion integrada 35017 Las Palmas de GC Spain division of Surgery and Interventional Science University College London Stanmore London HA7 4LP UK 3Bs Biomaterials Biodegradables and Biomimetics Universidade Do Minho Parque de Ciencia e Tecnologia Zona Industrial da Gandra 4805-17 Barco GMR Portugal Integrated and Advanced Manufacturing Processes Research Group Universidad de Las PaJmas de Gran Canaria Edificio de fabricacion integrada 35017 Las Palmas de GC Spain

Introduction Osteoarthritis （OA） is a degenerative joint disease, characterized by cartilage loss and changes in bone at the interface of a joint resulting in pain, stiffness and reduced mobility. OA is one of the most prevalent chronic conditions as identified in Bone and Joint Decade. According to the World Health Organization, 40% of people over the age of 70 have OA. This joint disease affects around 0.4 billion people with patients in Europe accounting for up to 30%. The figure is set to increase with the ageing problem.

关键词：骨性关节炎疾病治疗方法生物技术

Amorphous alloys for electrocatalysis:The significant role of the amorphous alloy structure

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Nano Research 2023年第4期16卷 4277-4288页

作者： Xingyun Li Weizheng Cai Dong-Sheng Li Jun Xu Huabing Tao Bin Liu School of Chemical and Biomedical Engineering Nanyang Technological University62 Nanyang DriveSingapore 637459Singapore Department of Biomaterials College of MaterialsXiamen UniversityXiamen 361005China Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials College of Materials and Chemical EngineeringChina Three Gorges UniversityYichang 443002China Fujian Provincial Key Laboratory for Soft Functional Materials Department of PhysicsResearch Institute for Biomimetics and Soft MatterXiamen UniversityXiamen 361005China State Key Laboratory of Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materials(iChEM)College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China division of Chemical and Biological Chemistry School of Physical and Mathematical SciencesNanyang Technological University21 Nanyang LinkSingapore 637371Singapore

Amorphous alloys,also known as metallic glasses,are solid metallic materials having long-range disordered atomic *** to crystalline alloys,amorphous alloys not only have metallic characters,but also possess several distinct properties associated to the amorphous structure,such as isotropy,composition flexibility,unsaturated surface,*** a result,amorphous alloys offer a class of highly promising materials for catalyzing electrochemical *** this minireview,the preparation,characterization and electrocatalytic performances of a variety of metallic amorphous alloy materials are *** influences of the amorphous alloy structure on different electrochemical reactions are ***,a summary on the advantages and challenges of amorphous alloys in electrocatalysis is provided,along with some perspectives about the future research directions.

关键词： amorphous alloys electrocatalysis nonperiodic atomic structure isotropy metastability

Application of Hypoxic Exposure Combined with Osteogenic Induction for the Enhancement of Multiple Osteoinductive Capabilities in Rat Mesenchymal Cells

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Open Journal of Stomatology 2018年第2期8卷 53-69页

作者： Naoaki Saito Hiroko Kato Yosuke Akiba Yuko Hara Taku Kojima Michiko Yoshizawa Atsushi Ohazama Takeyasu Maeda Tadaharu Kobayashi Kenji Izumi division of Reconstructive Surgery for Oral and Maxillofacial Region Department of Tissue Regeneration and Reconstruction Niigata University Graduate School of Medical and Dental Sciences Niigata Japan division of biomimetics Department of Oral Health Science Niigata University Graduate School of Medical and Dental Sciences Niigata Japan division of Oral Anatomy Department of Oral Biological Science Niigata University Graduate School of Medical and Dental Sciences Niigata Japan Research Center for Advanced Oral Science Niigata University Graduate School of Medical and Dental Sciences Niigata Japan division of Bio-Prosthodontics Department of Oral Health Science Niigata University Graduate School of Medical and Dental Sciences Niigata Japan

Objective: The enhancement of multiple functions, including osteogenesis, angiogenesis, and cell recruitment, is required for efficient bone regeneration therapy. Recently, special attention has been focused on the microenvironment of stem cells to facilitate bone regeneration. Herein, we examined the effects of various combinations of hypoxic conditions and osteogenic induction on rat mesenchymal cells, to develop a specific protocol for enhancing the multiple cellular functions beneficial to bone regeneration. Methods: Rat mesenchymal cells, isolated from bone marrow, adipose tissue, and periodontal ligament, were examined. The cells were cultured under varied conditions of O2 tension (hypoxia) and duration and timing of hypoxic exposure, with or without osteogenic induction. Consequently, four different protocols were examined by measuring the gene expression levels of Runx2, Vegfa, and Cxcl12, indicating a capability for osteogenesis, angiogenesis, and cell recruitment, respectively. Finally, the mineralization ability of the rat mesenchymal cells was assessed by quantitating their calcified nodule formation. Results: The simultaneous application of hypoxic exposure and osteogenic induction promoted Vegfa expression in all types of cells, but suppressed Runx2. In contrast, hypoxic preconditioning, followed by osteogenic induction, did not increase the expression of these genes;in fact, Vegfa expression decreased significantly. Among the various protocols, 0.5% O2 exposure for 12 h after osteogenic induction exhibited the largest fold changes of gene expression level, especially of Vegfa. Hypoxic post-conditioning enhanced the formation of calcified nodules in periodontal ligament-derived cells. Conclusion: Short-term hypoxic exposure after osteogenic induction could be used to improve the efficiency of mesenchymal cells for bone regeneration.

关键词： Osteogenesis Hypoxia Angiogenesis Cell Recruitment Mesenchymal Stem Cells

Biomimetic Capillary Inspired Heat Pipe Wicks

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Journal of Bionic Engineering 2014年第3期11卷 469-480页

作者： Qian Wang Jiaju Hong Yuying Yan Energy & Sustainability Research division of Faculty of Engineering University of Nottingham University Park Nottingham NG7 2RD UK

The possibility of mimicking desirable properties from nature accelerates material improvement and generates commercial interests. For heat pipe development, many attempts have been made in heat pipe wicks to enhance its capillary performance by mimicking biology. Constructing biporous, composite, or nanopillar wicks with aim of achieving hierarchical structure has been found in many studies. Mimicking beetle shell surface to obtain hybrid wettability shows biomimetic potential in heat pipe wicks. This paper firstly reviews some fundamental studies in biomimetics, establishing a general idea of surface wetting and capillary effect. MR/scanning of two live plants （Musa X Paradisiaca and Salix Flamingo） provides the possibility of visualising internal structures in vivo and obtaining rates of water transport in xylem vessels. In addition, by investigating the work inspired directly or indirectly from biomimetics, the role that biomimetics plays in modern heat pipe technology is revealed. Our innovation which syntheses a low level of hierarchical structure and integrates integral wicks for different heat pipe sections including evaporator, adiabatic, and condenser is introduced. Mathematical modelling in terms of capillary pressure and capillary rise rate to characterise such new structure is provided.

关键词： biomimetics heat pipe surface wetting capillary effect wick structure

Translation through collaboration:practice applied in BAMOS project in in vivo testing of innovative osteochondral scaffolds

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Biomaterials Translational 2022年第2期3卷 102-104页

作者： Ricardo Donate Maryam Tamaddon Viviana Ribeiro Mario Monzón J.Miguel Oliveira Chaozong Liu Departamento de Ingeniería Mecánica Grupo de Investigación en Fabricación Integrada y AvanzadaUniversidad de Las Palmas de Gran CanariaLas PalmasSpain division of Surgery&Interventional Science University College LondonRoyal National Orthopaedic HospitalStanmoreUK B’s Research Group I3B’s-Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoBarcoGuimarãesPortugal ICVS/3B’s-PT Government Associated Laboratory BragaGuimarãesPortugal.

Osteoarthritis is the most common chronic degenerative joint disease,recognized by the World Health Organization as a public health problem that affects millions of people *** project Biomaterials and Additive Manufacturing:Osteochondral Scaffold(BAMOS)innovation applied to osteoarthritis,funded under the frame of the Horizon 2020 Research and Innovation Staff Exchanges(RISE)program,aims to delay or avoid the use of joint replacements by developing novel cost-effective osteochondral scaffold technology for early intervention of *** multidisciplinary consortium of BAMOS,formed by international leading research centres,collaborates through research and innovation staff *** project covers all the stages of the development before the clinical trials:design of scaffolds,biomaterials development,processability under additive manufacturing,in vitro test,and in vivo *** paper reports the translational practice adopted in the project in in vivo assessment of the osteochondral scaffolds developed.

关键词： bone cartilage in vivo evaluation regenerative medicine tissue engineering

Dynamic asymmetric mechanical responsive carbon nanotube fiber for ionic logic gate

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Chinese Chemical Letters 2024年第6期35卷 249-253页

作者： Pei Cao Yilan Wang Lejian Yu Miao Wang Liming Zhao Xu Hou State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361005China The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province Department of BiomaterialsResearch Center of Biomedical Engineering of XiamenCollege of MaterialsXiamen UniversityXiamen 361005China Key Laboratory of Multifunctional Nanomaterials and Smart Systems Advanced Materials DivisionSuzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China Institute of Artificial Intelligence Xiamen UniversityXiamen 361005China Department of Physics Research Institute for Biomimetics and Soft MatterFujian Provincial Key Laboratory for Soft Functional Materials ResearchJiujiang Research InstituteCollege of Physical Science and TechnologyXiamen UniversityXiamen 361005China Engineering Research Center of Electrochemical Technologies of Ministry of Education Xiamen UniversityXiamen 361005China

Inspired by biological ion channels,numerous artificial asymmetric ion channels have been synthesized to facilitate the fabrication of ionic ***,the creation of biomimetic asymmetric ion channels necessitates expensive scientific apparatus and intricate material processing procedures,which constrains its advancement within the realm of ionic *** this study,we have devised dynamic asymmetric ion channels with mechanical responsiveness by combining polymers of varying elastic modulus along the longitudinal axis of carbon nanotube fiber(CNTF).The ion rectification can be modulated via the disparate response of CNTF-based ion channels to mechanical *** have effectively employed these asymmetric ion channels with mechanical sensitivity in the design of a logic gate device,achieving logic operations such as“AND”and“OR”.The conception of these dynamic asymmetric ion channels with mechanical sensitivity offers a straightforward,cost-effective,and versatile approach for generating ion channels,highlighting their potential application in intricate,highly integrated ionic circuits.

关键词： Carbon nanotubes fibers Mechanical response Rectification effect Ionic logic gate

A Miniaturized Tadpole Robot Using an Electromagnetic Oscillatory Actuator

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Journal of Bionic Engineering 2015年第1期12卷 29-36页

作者： Bu Hyun Shin Kyung-Min Lee Seung-Yop Lee Department of Mechanical Engineering Hanbat National University Daejeon 305-719 Korea Convergence Technology Examination division Korean Intellectual Property Office Daejeon 302-701 Korea Department of Mechanical Engineering Sogang University Seoul 121-742 Korea

In this paper, we propose a miniaturized tadpole-like robot using an electromagnetic oscillatory actuator. The electro- magnetic actuator has a simple structure with a moving-magnet type and the body size is 13 mm （length） × 11 mm （height） ×10 mm （width）. A tail has the thickness of 100 μm and the length of 20 mm which is twice of the body-length （BL）. The tail attached to the oscillatory actuator generates undulatory propulsion for the forward swimming. Moreover, the tadpole robot enables the change of the direction by controlling input signal pattems applied to the oscillatory actuator. Prototypes of the tadpole robot have been manufactured and the thrust force and swimming speed are measured to evaluate the performance of the biomimetic robot in water at various tail-beat frequencies. The maximum thrust force is 42 mN at the tail-beat frequency of 30 Hz with voltage of 3 V, enabling the tadpole robot to swim at the speed of 210 mm·s^-1 （6 BL·s^-1）. The tadpole robot can also change its moving direction with the angular velocity of 21 deg·s^-1 at the half pulse pattem of 30 Hz.

关键词： fish robot biomimetics tadpole robot electromagnetic actuator

Biomimetic Precipitation of Uniaxially Grown Calcium Phosphate Crystals from Full-Length Human Amelogenin Sols

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Journal of Bionic Engineering 2011年第2期8卷 114-121页

作者： Vuk Uskokovie Wu Li Stefan Habelitz division of Biomaterials and Bioengineering Department of Preventive and Restorative Dental Sciences University of Calil'ornia 707 Parnassus Avenue San Francisco CA 94143 USA Department of Orofacial Sciences University of California 513 Parnassus Avenue San Francisco CA 94143 USA

Human dental enamel forms over a period of 2 4 years by substituting the enamel matrix, a protein gel mostly composed of a single protein, amelogenin with fibrous apatite nanocrystals. Self-assembly of a dense amelogenin matrix is presumed to direct the growth of apatite fibers and their organization into bundles that eventually comprise the mature enamel, the hardest tissue in the mammalian body. This work aims to establish the physicochemical and biochemical conditions for the synthesis of fibrous apatite crystals under the control of a recombinant full-length human amelogenin rnatrix in combination with a pro- grammable titration system. The growth of apatite substrates was initiated from supersaturated calcium phosphate solutions in the presence of dispersed amelogenin assemblies. It was shown earlier and confirmed in this study that binding of amelogenin onto apatite surfaces presents the first step that leads to substrate-specific crystal growth. In this work, we report enhanced nucleation and growth under conditions at which amelogenin and apatite carry opposite charges and adsorption of the protein onto the apatite seeds is even more favored. Experiments at pH below the isoelectric point of amelogenin showed increased protein binding to apatite and at low Ca/P molar ratios resulted in a change in crystal morphology from plate-like to fibrous and rod-shaped. Concentrations of calcium and phosphate ions in the supernatant did not show drastic decreases throughout the titration period, indicating controlled precipitation from the protein suspension metastable with respect to calcium phosphate. It is argued that amelobtasts in the developing enamel may vary the density of the protein matrix at the nano scale by varying local pH, and thus control the interaction between the mineral and protein phases. The biomimetic experimental setting applied in this study has thus proven as convenient for gaining insight into the fundamental nature of the process ofamelogenesi

关键词： enamel amelogenin biomineralization apatite biomimetics