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Trends in colorectal cancer incidence according to an increase in the number of colonoscopy cases in Korea

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 51-60页

作者： Ga Hee Kim Yeong Chan Lee Tae Jun Kim Sung Noh Hong Dong Kyung Chang Young-Ho Kim Dong-Hoon Yang Chang Mo Moon Kyunga Kim Hyun Gun Kim Eun-Ran Kim division of Gastroenterology Department of Internal MedicineAsan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Digital Health Samsung Advanced Institute for Health Science and TechnologySungkyunkwan University School of MedicineSeoul 06351South Korea division of Gastroenterology Department of Internal MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea division of Gastroenterology Department of Internal MedicineEwha Womans UniversitySeoul 07985South Korea biomedical statistics Center Samsung Medical CenterSeoul 06351South Korea division of Gastroenterology Department of Internal MedicineSoonchunhyang University College of MedicineSeoul 04401South Korea

BACKGROUND The incidence of colorectal cancer(CRC)and preinvasive CRC(e.g.,early colon cancer and advanced adenoma)is gradually increasing in several *** To evaluate the trend in incidence of CRC and preinvasive CRC according to the increase in the number of colonoscopies performed in *** This retrospective cohort study enrolled Korean patients from 2002 to 2020 to evaluate the incidence of CRC and preinvasive CRC,and assess the numbers of diagnostic colonoscopies and colonoscopic ***-related complications by age group were also *** The incidence of CRC showed a rapid increase,then decreased after 2012 in the 50-75 year-age *** the study period,the rate of incidence of preinvasive CRC increased at a similar level in patients under 50 and 50-75 years of *** 2009,the increase has been rapid,showing a pattern similar to the increase in *** rate of colonoscopic polypectomy in patients aged under 50 was similar to the rate in patients over 75 years of age after *** rate of complications after colonoscopy and related deaths within 3 mo was high for those over 75 years of *** The diagnosis of preinvasive CRC increased with the increase in the number of colonoscopies *** the risk of colonoscopy-related hospitalization and death is high in the elderly,if early lesions at risk of developing CRC are diagnosed and treated under or at the age of 75,colonoscopy-related complications can be reduced for those aged 76 years or over.

关键词： Colorectal cancer Preinvasive colorectal cancer Colorectal polypectomy Colonoscopy

Are dogs not susceptible to retroviral infections?

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Animal Diseases 2024年第3期4卷 217-223页

作者： Jorge Casseb João Henrique Campos Luciano Rodrigo Lopes Laboratory of Investigation in Dermatology and Immunodefciencies Department of DermatologyUniversity of São Paulo Medical SchoolSão PauloSPBrazil Igen-Institute of Immunogenetics São PauloSPBrazil Bioinformatics and biomedical Data Science division Health Informatics DepartmentUniversidade Federal de São Paulo–UNIFESP.Rua Botucatu 862Prédio Leal PradotérreoVila ClementinoCEP 04023-062São PauloSPBrazil

Retroviruses have been proven to cause infections and diseases in a series of mammalian hosts but not in ***,this letter discussed the dog susceptibility to retrovirus infection,encompassing arguments to understand why dogs may have not been infected by retroviruses thus *** potential resistance of retrovirus in dogs enables this provocative short communication to discuss this question,looking at some evolutive *** lineage of canids has shown,throughout its evolutionary history,a smaller accumulation of retroviruses in canid genomes,classifed as endogenous *** this context,the genomes of canids seem to ofer obstacles,which have been evolutionarily conserved,in the face of retroviral infection.

关键词： Retrovirus dogs Endogenous retrovirus

Aldo-keto reductase family member C3(AKR1C3)promotes hepatocellular carcinoma cell growth by producing prostaglandin F2α

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Oncology Research 2024年第1期32卷 163-174页

作者： KUO-SHYANG JENG PO-YU CHENG YUEH-HSIEN LIN PO-CHUN LIU PING-HUI TSENG YU-CHAO WANG CHIUNG-FANG CHANG CHUEN-MIIN LEU division of General Surgery Far Eastern Memorial HospitalNew Taipei City22060Taiwan Institute of Microbiology and Immunology National Yang Ming Chiao Tung UniversityTaipei City11221Taiwan Institute of Biochemistry and Molecular Biology National Yang Ming Chiao Tung UniversityTaipei City11221Taiwan Institute of biomedical informatics National Yang Ming Chiao Tung UniversityTaipei City11221Taiwan Department of Medical Research Far Eastern Memorial HospitalNew Taipei City22060Taiwan

Hepatocellular carcinoma(HCC)is a leading cause of death *** therapies are effective for HCC patients with early disease,but many patients suffer recurrence after surgery and have a poor response to ***,new therapeutic targets are *** analyzed gene expression profiles between HCC tissues and normal adjacent tissues from public databases and found that the expression of genes involved in lipid metabolism was significantly *** analysis showed that AKR1C3 was upregulated in tumors,and high AKR1C3 expression was associated with a poorer prognosis in HCC *** vitro,assays demonstrated that the knockdown of AKR1C3 or the addition of the AKR1C3 inhibitor indomethacin suppressed the growth and colony formation of HCC cell *** of AKR1C3 in Huh7 cells reduced tumor growth in *** explore the mechanism,we performed pathway enrichment analysis,and the results linked the expression of AKR1C3 with prostaglandin F2 alpha(PGF2a)downstream target *** of AKR1C3 activity reduced the production of PGF2a,and supplementation with PGF2a restored the growth of indomethacin-treated Huh7 *** of the PGF receptor(PTGFR)and treatment with a PTGFR inhibitor significantly reduced HCC *** showed that indomethacin potentiated the sensitivity of Huh7 cells to *** summary,our results indicate that AKR1C3 upregulation may promote HCC growth by promoting the production of PGF2α,and suppression of PTGFR limited HCC ***,targeting the AKR1C3-PGF2a-PTGFR axis may be a new strategy for the treatment of HCC.

关键词： Hepatocellular carcinoma Aldo-keto reductase family member C3 Prostaglandin F2 alpha Prostaglandin F receptor

Evaluating a combined bowel preparation for small-bowel capsule endoscopy:a prospective randomized–controlled study

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Gastroenterology Report 2020年第1期8卷 31-35,I0001,I0002页

作者： Stephanie L.Hansel Joseph A.Murray Jeffrey A.Alexander David H.Bruining Mark V.Larson Thomas F.Mangan Ross A.Dierkhising Ann E.Almazar Elizabeth Rajan division of Gastroenterology and Hepatology Mayo ClinicRochesterMNUSA division of biomedical statistics and informatics Mayo ClinicRochesterMNUSA

Background:Capsule endoscopy(CE)is frequently hindered by intra-luminal *** aim was to determine whether a combination bowel preparation would improve small-bowel visualization,diagnostic yield,and the completion rate of ***:Single-blind,prospective randomized–controlled study of outpatients scheduled for ***-preparation subjects ingested 2 L of polyethylene glycol solution the night prior to CE,5mL simethicone and 5mg metoclopramide 20 minutes prior to CE and laid in the right lateral position 30 minutes after swallowing *** had no solid food after 7 *** night prior to CE and no liquids 4 hours prior to *** completed a satisfaction *** readers completed a small-bowel-visualization ***:Fifty patients were prospectively enrolled(56%female)with a median age of 54.4 years and 44 completed the study(23 patients in the control group and 21 in the preparation group).There was no significant difference between groups on quartile-based small-bowel visualization(all P>0.05).There was no significant difference between groups in diagnostic yield(P=0.69),mean gastric(P=0.10)or small-bowel transit time(P=0.89).The small-bowel completion rate was significantly higher in the preparation group(100%vs 78%;P=0.02).Bowel-preparation subjects reported significantly more discomfort than controls(62%vs 17%;P=0.01).Conclusions:Combined bowel preparation did not improve small-bowel visualization but did significantly increase patient *** CE completion rate improved in the preparation group but the diagnostic yield was *** on our findings,a bowel preparation prior to CE does not appear to improve CE performance and results in decreased patient satisfaction(***,***01243736).

关键词： bowel preparation capsule endoscopy small-bowel visualization patient satisfaction

Effects of transdermal magnesium chloride on quality of life for patients with fibromyalgia: a feasibility study

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Journal of Integrative Medicine 2015年第5期13卷 306-313页

作者： Deborah J.Engen Samantha J.Mc Allister Mary O.Whipple Stephen S.Cha Liza J.Dion Ann Vincent Brent A.Bauer Dietlind L.Wahner-Roedler Department of Physical Medicine and Rehabilitation Mayo Clinic division of General Internal Medicine Mayo Clinic division of biomedical statistics and informatics Mayo Clinic

BACKGROUND： Fibromyalgia is a syndrome characterized by chronic pain, fatigue, depression, and sleep disturbances. Its primary cause is unclear. Several studies have reported decreased intracellular magnesium levels in patients with fibromyalgia and have found negative correlation between magnesium levels and fibromyalgia symptoms.OBJECTIVE： To gather preliminary data on whether transdermal magnesium can improve quality of life for women who have fibromyalgia. DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS： This is a patient questionnaires and survey in a fibremyalgia clinic at a tertiary medical center. Forty female patients with the diagnosis of fibremyalgia were enrolled. Each participant was provided a spray bottle containing a transdermal magnesium chloride solution and asked to apply 4 sprays per limb twice daily for 4 weeks. Participants were asked to complete the Revised Fibromyalgia Impact Questionnaire, SF-36v2 Health Survey, and a quality-of-life analog scale at baseline, week 2, and week 4. MAIN OUTCOME MEASURE： Questionnaire and survey scores, evaluated through intent-to-treat and per-protocol analyses. RESULTS： Twenty-four patients completed the study （mean [SD] age, 57.2 [7.6] years; white, 95%; mean body mass index, 31.3 kg/m2）. With intention-to-treat analysis, Revised Fibromyalgia Impact Questionnaire subscale and total scores were significantly improved at week 2 and week 4 （total score, P = 0.001）. Per-protocol analysis results were similar： all subscales of the Revised Fibremyalgia Impact Questionnaire were significantly improved at week 2 and week 4 （total score, P = 0.001）. CONCLUSION： This pilot study suggests that transdermal magnesium chloride applied on upper and lower limbs may be beneficial to patients with fibromyalgia.

关键词： fibromyalgia magnesium chloride Revised Fibromyalgia Impact Questionnaire clinical trial

Comparison of sexual function and quality of life after pelvic trauma with and without Angioembolization

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Burns & Trauma 2015年第3期3卷 155-160页

作者： Naeem Goussous Mark D.Sawyer Lisa-Ann Wuersmer Marianne Huebner Molly L.Osborn Martin D.Zielinski Department of Surgery Mayo ClinicRochesterMNUSA Department of Physical Medicine and Rehabilitation RochesterMNUSA division of biomedical statistics&informatics Mayo ClinicRochesterMNUSA division of Trauma Critical Care and General SurgeryMary Brigh 2-818Mayo Clinic1216 Second Street SWRochesterMN 55902USA.

Background:The aim is to study the safety of Angioembolization on long-term sexual function and quality of ***:IRB approval was gained to review the prospectively collected trauma database as well as prospective questionnaires of patients at least 1 year out from pelvic fractures that occurred between 1996 and *** included the SF36v2,Female Sexual Function Index and the International Index of Erectile *** for each domain were compared between patients treated with AE and 2:1 case-matched control patients as well as between the national *** are presented as percentages or means with 95%CI.P<0.05 was considered statistically ***:Thirty Seven cases and 74 matched controls were identified.42 patients completed the *** were 13 cases(12 males),and 29 controls(22 males).There was a higher ISS(Injury Severity Score)(32 vs 27;p=0.048)in the cases,but no difference in pelvic AIS(Abbreviated Injury Severity Score)(3 vs 3).Both groups scored similarly in the SF36 in all domains,but the entire cohort scored lower than the national norms in the physical functioning(41.9(37.8–46.0)vs50),role physical(40.9(36.2–45.7)vs50),body pain 43.8(40.7–46.9)vs50),role emotional 46.3(42.8–49.8)vs50),and physical composite score(42.1(38.0–46.3)vs50).All domains of the sexual function in both questionnaires showed significant impairment in our cohort compared with *** cases had similar scores to the ***:Pelvic fractures portend a worse long-term QOL and sexual function than the general ***,however,does not have an additive affect to these indices.

关键词： Pelvic fracture Angioembolization Sexual function Quality of life

Transcriptional activators and activation mechanisms

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Protein & Cell 2011年第11期2卷 879-888页

作者： Jun Ma division of biomedical informatics Division of Developmental BiologyCincinnati Children's Research FoundationUniversity of Cincinnati College of MedicineCincinnatiOH 45229USA

Transcriptional activators are required to turn on the expression of genes in a eukaryotic *** bound to the enhancer can facilitate either the recruitment of RNA polymerase II to the promoter or its *** article examin... 详细信息

关键词： activator transcription co-activator enhancer promoter signal transduction development

Metformin does not improve survival in patients with hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第42期20卷 15750-15755页

作者： Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts division of Gastroenterology and Hepatology Mayo Clinic College of Medicine division of Gastroenterology McGill University Health Centre Department of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital Thai Red Cross Society division of biomedical statistics and informatics Mayo Clinic College of Medicine

AIM: To assess whether metformin, which has a chemopreventive effect in chronic liver disease, has any chemotherapeutic effect in hepatocellular carcinoma.

关键词： Hepatocellular carcinoma Metformin Diabetes Survival Liver disease Lactic acidosis

Isolated hepatic non-obstructive sinusoidal dilatation, 20-year single center experience

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World Journal of Hepatology 2018年第5期10卷 417-424页

作者： Dharma Budi Sunjaya Guilherme Piovezani Ramos Manuel Bonfim Braga Neto Ryan Lennon Taofic Mounajjed Vijay Shah Patrick Sequeira Kamath Douglas Alano Simonetto School of Graduate Medical Education Mayo Clinic division of biomedical statistics and informatics Mayo Clinic Laboratory Medicine and Pathology Mayo Clinic Gastroenterology and Hepatology Mayo Clinic

AIM To characterize isolated non-obstructive sinusoidal dilatation(SD) by identifying associated conditions, laboratory findings, and histological patterns. METHODS Retrospectively reviewed 491 patients with SD between 1995 and 2015. Patients with obstruction at the level of the small/large hepatic veins, portal veins, or right-sided heart failure were excluded along with history of cirrhosis, hepatic malignancy, liver transplant, or absence of electrocardiogram/cardiac echocardiogram. Liver histology was reviewed for extent of SD, fibrosis, red blood cell extravasation, nodular regenerative hyperplasia, hepaticpeliosis, and hepatocellular plate atrophy(HPA). RESULTS We identified 88 patients with non-obstructive SD. Inflammatory conditions(32%) were the most common cause. The most common pattern of liver abnormalities was cholestatic(76%). Majority(78%) had localized SD to Zone Ⅲ. Medication-related SD had higher proportion of portal hypertension(53%), ascites(58%), and median AST(113 U/L) and ALT(90 U/L) levels. Nineteen patients in our study died within one-year after diagnosis of SD, majority from complications related to underlying *** Significant proportion of SD and HPA exist without impaired hepatic venous outflow. Isolated SD on liver biopsy, in the absence of congestive hepatopathy, requires further evaluation and portal hypertension should be rule out.

关键词： Sinusoidal dilatation Sinusoidal obstruction syndrome Hepatic plate atrophy