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现代生物医学进展 2017年第22期17卷 I0001-I0001页

作者： Peter See,* Singapore Immunology Network (SIgN) A*STAR 8A Biomedical Grove Immunos Building Level 4 Singapore 138648 Singapore.Program in Emerging Infectious Disease Duke-NUS Medical School 8 College Road 169857 Singapore.Genomics and Immunoregulation Life and Medical Sciences (LIMES) Institute University of Bonn 32115 Bonn Germany.Institute of Cellular Medicine Newcastle University Newcastle UK.Platform for Single Cell Genomics and Epigenomics at the German Center for Neurodegenerative Diseases and the University of Bonn 53175 Bonn Germany.Institut Curie Paris Sciences et Lettres (PSL) Research University INSERM U 932 F-75005 Paris France.Department of Pediatrics Academic Medical Centre University of Amsterdam Amsterdam Netherlands.Department of Anatomical Pathology Singapore General Hospital Singapore.Department of Health Promotion Board (HPB) and Transplant Surgery Singapore General Hospital Singapore.Department of Microbiology and Immunology Yong Loo Lin School of Medicine National University of Singapore Singapore.Singapore Health Services Flow Cytometry Core Platform 20 College Road The Academia Discovery Tower Level 10 Singapore 169856 Singapore.Department of Reproductive Medicine Division of Obstetrics and Gynaecology KK Women’s and Children’s Hospital Singapore.Cancer and Stem Cell Biology Program Duke-NUS Graduate Medical School Singapore.Experimental Fetal Medicine Group Yong Loo Lin School of Medicine National University of Singapore Singapore.Humanized Mouse Unit Institute of Molecular and Cell Biology (IMCB) A*STAR Singapore.Myeloid Cell Biology Life and Medical Sciences (LIMES) Institute University of Bonn 53115 Bonn Germany.

树突细胞是机体免疫力的”门卫”，其能够帮助机体有效检测并且开启抵御外来病原体或异物的免疫力，截止到目前为止，研究者认为树突细胞的亚型是从一种共同的祖细胞分化而来；近日，一项刊登在国际杂志science上的研究报告中，来自新加... 详细信息

树突细胞是机体免疫力的”门卫”，其能够帮助机体有效检测并且开启抵御外来病原体或异物的免疫力，截止到目前为止，研究者认为树突细胞的亚型是从一种共同的祖细胞分化而来；近日，一项刊登在国际杂志science上的研究报告中，来自新加坡ASTAR研究所等机构的研究人员通过研究发现，人类机体的免疫细胞或许是从特殊的祖细胞衍生而来，相关研究或为后期开发新型疫苗并且优化疫苗提供了新的线索。

关键词：树突细胞祖细胞科学家机体免疫力细胞分化研究人员免疫细胞后期开发

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First-line atezolizumab monotherapy versus single-agent chemotherapy in patients with non-small-cell lung cancer ineligible for treatment with a platinum-containing regimen(IPSOS):a phase 3,global,multicentre,open-label,randomised controlled study

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四川生理科学杂志 2023年第8期45卷 1332-1332页

作者： Siow Ming Lee Christian Schulz Kumar Prabhash Department of Oncology University College London Hospitals NHS Foundation Trust CRUK Lung Cancer Centre of Excellence and UCL Cancer Institute London UK Bereich Pneumologie Klinik und Poliklinik für Innere Medizin II University Hospital Regensburg Regensburg Germany Department of Medical Oncology Tata Memorial Hospital Mumbai India Department of Lung Cancer and Thoracic Tumors Maria Sklodowska-Curie National Research Institute of Oncology Warsaw Poland Department of Lung Diseases Mazowieckie Centrum Leczenia Chorób Płuc i Gruźlicy Otwock Poland Department of Pulmonary Medicine Shanghai Chest Hospital Shanghai Jiao Tong University Shanghai China Department of Thoracic Oncology LKI Lungenfachklinik Immenhausen Immenhausen Germany Department of Oncology Royal Cornwall Hospitals NHS Trust Truro UK Medical Oncology Department Hospital Universitario Virgen Macarena Seville Spain Department of Medical Oncology The Christie NHS Foundation Trust and Division of Cancer Sciences University of Manchester Manchester UK Department of Medical Oncology AAST H S Gerardo Monza Monza Italy Cho Ray Cancer Centre Cho Ray Hospital Ho Chi Minh City Viet Nam Department of Thoracic Oncology National Clinical Research Centre for Cancer Tianjin Medical University Cancer Institute & Hospital Tianjin China Medical Oncology and Hematology Princess Margaret Cancer Centre Toronto ON Canada Department of Oncology National Cancer Institute IRCCS Regina Elena Rome Italy Oncologico Potosino San Luis Potosí Mexico Department of Thoracic Oncology Lungen Clinic Grosshansdorf Airway Research Centre North German Centre for Lung Research Grosshansdorf Germany Department of Medical Oncology Catalan Institute of Oncology Hospital Duran i Reynals L'Hospitalet Barcelona Spain Department of Medical Oncology Instituto do Cancer do Estado de Sao Paulo Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo Sao Paulo Brazil F Hoffmann-La Roche Basel Switzerland Centre Hospita

Background:Despite immunotherapy advancements for patients with advanced or metastatic non-small-cell lung cancer(NSCLC),pivotal first-line trials were limited to patients with an Eastern Cooperative Oncology Group performance status(ECOG PS)0-1 and a median age of 65 years or *** aimed to compare the efficacy and safety of first-line atezolizumab monotherapy with single-agent chemotherapy in patients ineligible for platinum-based ***:This trial was a phase 3,open-label,randomised controlled study conducted at 91 sites in 23 countries across Asia,Europe,North America,and South *** patients had stage IIIB or IV NSCLC in whom platinum-doublet chemotherapy was deemed unsuitable by the investigator due to an ECOG PS 2 or 3,or alternatively,being 70 years or older with an ECOG PS 0-1 with substantial comorbidities or contraindications for platinum-doublet *** were randomised 2:1 by permuted-block randomisation(block size of six)to receive 1200 mg of atezolizumab given intravenously every 3 weeks or single-agent chemotherapy(vinorelbine[oral or intravenous]or gemcitabine[intravenous];dosing per local label)at 3-weekly or 4-weekly *** primary endpoint was overall survival assessed in the intention-to-treat *** analyses were conducted in the safety-evaluable population,which included all randomised patients who received any amount of atezolizumab or *** trial is registered with ***,NCT03191786.

关键词： patients platinum random

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Subcutaneous or Transvenous Defibrillator Therapy

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四川生理科学杂志 2021年第1期43卷 125-125页

作者： Reinoud E Knops From the Heart Center Department of Clinical and Experimental Cardiology Amsterdam Cardiovascular Sciences Amsterdam University Medical Centers University of Amsterdam (R.E.K. L.R.A.O.N. L.V.A.B. T.F.B. A.-F.B.E.Q. L.S. W.S. A.W. K.C.W. J.R.G. K.M.K. M.C.B. J.G.P.T. A.A.M.W.) ERN GUARD-Heart (E.R.B. P.D.L. A.A.M.W.) and the Department of Cardiology OLVG (J.S.S.G.J.) Amsterdam the Department of Cardiology Isala Heart Centre Zwolle (P.-P.H.M.D.) the Department of Cardiology St. Antonius Hospital Nieuwegein (L.V.A.B.) the Department of Cardiology Flevoziekenhuis Almere (N.R.B.) the Department of Cardiology Radboud University Medical Center Nijmegen (M.A.B.) the Department of Cardiology Cardiovascular Research Institute Maastricht Maastricht University Medical Center Maastricht (K.V.) the Department of Cardiology Amphia Hospital Breda (M.A.) Werkgroep Cardiologische Centra Nederland Utrecht (M.A.) and the Department of Electrophysiology Catharina Hospital Eindhoven (F.A.L.E.B.) - all in the Netherlands the First Department of Medicine-Cardiology University Medical Center Mannheim and the German Center for Cardiovascular Research Partner Site Heidelberg-Mannheim Mannheim (J.K.) Klinik für Innere Medizin III Schwerpunkt Kardiologie und Angiologie Universitätsklinikum Schleswig-Holstein Campus Kiel Kiel (H.B.) the Department of Medicine I Ludwig-Maximilians University Hospital and the German Center for Cardiovascular Research Munich Heart Alliance Munich (S.K.) and the Department of Electrophysiology Heart Center at University of Leipzig Leipzig (S.R.) - all in Germany the division of Cardiology Section of Electrophysiology Emory University Atlanta (M.F.E.-C.) the Cardiology Clinical Academic Group St. George's University of London and St. George's University Hospitals NHS Foundation Trust London (E.R.B.) and Office of the Director of Clinical Electrophysiology Research and Lead for Inherited Arrhythmia Specialist Services University College London and

Background:The subcutaneous implantable cardioverter-defibrillator(ICD)was designed to avoid complications related to the transvenous ICD lead by using an entirely extrathoracic *** comparing these systems has been based primarily on observational ***:We conducted a noninferiority trial in which patients with an indication for an ICD but no indication for pacing were assigned to receive a subcutaneous ICD or transvenous *** primary end point was the composite of device-related complications and inappropriate shocks;the noninferiority margin for the upper boundary of the 95%confidence interval for the hazard ratio(subcutaneous ICD *** ICD)was 1.45.A superiority analysis was prespecified if noninferiority was established.

关键词： venous Therapy entirely

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AME证据系列001--转化医学协会:脓毒症诊断和早期识别的临床实践指南

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临床与病理杂志 2016年第10期36卷 1467-1476页

作者： Zhongheng Zhang Nathan J.Smischney Haibo Zhang Sven Van Poucke Panagiotis Tsirigotis Jordi Rello Patrick M.Honore Win Sen Kuan Juliet June Ray Jiancang Zhou You Shang Yuetian Yu Christian Jung Chiara Robba Fabio Silvio Taccone Pietro Caironi David Grimaldi Stefan Hofer George Dimopoulos Marc Leone Sang-Bum Hong Mabrouk Bahloul Laurent Argaud Won Young Kim Herbert D.Spapen Jose Rodolfo Rocco 张建成(译) 尚游(译) 钟鸣(校) Department of Emergency Medicine Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016 Department of Critical Care Medicine Jinhua Hospital of Zhejiang UniversityJinhua Zhejiang 321000 Department of Anesthesiology Mayo ClinicRochesterMNUSA Keenan Research Center for biomedical Science of St.Michael's Hospital Departments of Anesthesia and PhysiologyInterdepartmental Division of Critical Care MedicineUniversity of TorontoTorontoONCanada Departments of Anesthesiology Critical CareEmergency Medicine and Pain TherapyZiekenhuis Oost-Limburgy GenkBelgium 2nd Department of Internal Medicine Attikcon University HospitalMedical SchoolNational and Kapodistrian University of AthensAthensGreece CIBERES Vall d'Hebron Institut of ResearchUniversitat Autonoma de BarcelonaSpain Universitair Ziekenhuis Brussely Vrije Universiteit Brussel Brussels BrusselsBelgium Emergency Medicine Department National University HospitalNational University Health SystemSingapore and the Department of SurgeryYong Loo Lin School of MedicineNational University of SingaporeSingapore DeWitt Daughtry Family Department of Surgery Jackson Memorial HospitalUniversity of Miami Leonard M.Miller School of MedicineMiamiFLUSA Department of Critical Care Medicine Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016 Department of Critical Care Medicine Union HospitalTongji Medical CollegueHuazhong University of Science and TechnologyWuhan 430022 Department of Critical Care Medicine Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200001 University Hospital Dusseldorf Heinrich-Heine-University DusseldorfMedical FacultyDivision of CardiologyPulmonology and Vascular MedicineDusseldorfGermany Neurosciences Critical Care Unit Addenbrooke's HospitalCambridgeUK Department of Intensive Care Hopital ErasmeUniversite Libre de Bruxelles(ULB)BrusselsBelgium Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti Fondazione IRCCS Ca'Granda-Ospedale

脓毒症是一种由感染引起的异质性疾病,感染触发了一系列复杂的局部或者全身的免疫炎症反应,引起多器官功能衰竭,发病率和病死率显著升高。由于至今仍然没有诊断脓毒症的金标准,所以脓毒症的临床诊断仍是一个难题。因此,脓毒症的临床诊... 详细信息

脓毒症是一种由感染引起的异质性疾病,感染触发了一系列复杂的局部或者全身的免疫炎症反应,引起多器官功能衰竭,发病率和病死率显著升高。由于至今仍然没有诊断脓毒症的金标准,所以脓毒症的临床诊断仍是一个难题。因此,脓毒症的临床诊断需要不断改变来满足临床和研究的要求。然而,尽管有许多新型的生物标记和筛选工具去预测脓毒症发生的风险,但是这些措施的诊断价值和有效性不足以让人满意,并且没有充分的证据去建议临床使用这些新技术。因此,脓毒症的临床诊断标准需要定期更新去适应不断产生的新证据。这篇综述旨在呈现当前脓毒症的诊断和早期识别方面的最新研究证据。临床运用不同的诊断方法的推荐意见依赖于推荐、评价、发展和评估分级体系(Grades of Recommendation Assessment,Development and Evaluation,GRADE),因为大部分的研究是观察性研究,并没有对这些方法进行可靠评估,采用的是两步推理方法。未来需要更多研究来确认或者反驳某一特殊的指标检测,同时应该直接采用相关病人的结果数据。

关键词：脓毒症早期识别诊断

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小P值并不能保证可靠结果:以帕金森病的静息态脑功能成像元分析为例

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Science Bulletin 2021年第21期66卷 2148-2152,M0003页

作者：贾熙泽赵娜董昊铭孙家伟 Marek Barton Roxana Burciu Nicolas Carrière Antonio Cerasa 陈博宇陈俊 Stephen Coombes Luc Defebvre Christine Delmaire Kathy Dujardin Fabrizio Esposito 范国光 Federica Di Nardo 冯怡萱 Brett W.Fling Saurabh Garg Moran Gilat Martin Gorges Shu-Leong Ho Fay B.Horak 胡晓胡晓飞黄飚黄沛钰贾泽娟 Christina Jones Jan Kassubek Lenka Krajcovicova Ajay Kurani 李静李晴刘爱萍刘波刘虎刘卫国 Renaud Lopes 娄毓婷罗巍 Tara Madhyastha 毛妮妮 Grainne McAlonan Martin J.McKeown Shirley Pang Andrea Quattrone Irena Rektorova Alessia Sarica 商慧芳 James M.Shine Priyank Shukla Tomas Slavicek 宋潇鹏 Gioacchino Tedeschi Alessandro Tessitore David Vaillancourt 王健王珏 Z.Jane Wang 魏鲁庆邬霞徐晓俊闫磊杨靓杨万群姚乃琳张得龙张久权张敏鸣张艳玲周彩红严超赣左西年 Mark Hallett 吴涛臧玉峰 Center for Cognition and Brain Disorders the Affiliated HospitalHangzhou Normal UniversityHangzhou 310015China Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments Hangzhou 311121China National Basic Science Data Center Beijing 100190China State Key Laboratory of Cognitive Neuroscience and Learning&McGovern Institute for Brain Research Beijing Normal UniversityBeijing 100875China School of Information and Electronics Technology Jiamusi UniversityJiamusi 154007China Neuroscience Program Central European Institute of TechnologyCEITECMasaryk UniversityBrno 62500Czech Republic Department of Applied Physiology and Kinesiology University of FloridaGainesville FL 32611USA Univ.Lille InsermCHU LilleU1172-LilNCog-Lille Neuroscience&CognitionLille F-59000France The Institute for biomedical Research and Innovation National Research CouncilMangone CS 87050Italy Department of Radiology The First Affiliated Hospital of China Medical UniversityShenyang 110001China Department of Radiology Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120China Department of Medicine Surgery and DentistryScuola Medica SalernitanaUniversity of SalernoFiscianoSA 132-84084Italy Department of Advanced Medical and Surgery Sciences University of Campania“Luigi Vanvitelli”Caserta 81100Italy Eye Center of the 2nd Affiliated Hospital Medical College of Zhejiang UniversityHangzhou 310020China Zhejiang Provincial Key Lab of Ophthalmology Hangzhou 310020China Department of Health and Exercise Science Colorado State UniversityFort Collins CO 80523USA Pacific Parkinson’s Research Centre University of British ColumbiaVancouver BC V6E 2M6Canada Department of Medicine(Neurology)University of British Columbia Vancouver BC V6T 1B7Canada Brain and Mind Center The University of SydneySydney NSW 2006Australia Department of Neurology Ulm UniversityUlm 89081Germany division of Neurology Department of MedicineQueen Mary HospitalUniversity of Hong KongHong Kong 999077China Department of

Thousands of resting state functional magnetic resonance imaging(RS-f MRI)articles have been published on brain *** precise localization of abnormal brain activity,a voxel-level comparison is *** of the large number of voxels in the brain,multiple comparison correction(MCC)must be performed to reduce false positive rates,and a smaller P value(usually including either liberal or stringent MCC)is widely recommended[1].

关键词：帕金森病 precise correction

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Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis

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四川生理科学杂志 2020年第4期42卷 480-480页

作者： Carol C L Chen Department of Human Genetics McGill University Montreal QC H3A 0C7 Canada Canadian Centre for Computational Genomics McGill University Montreal QC H3A 0E9 Canada Dana-Farber/Boston Children’s Cancer and Blood Disorders Center Boston MA 02215 USA Department of Pathology Montreal Children’s Hospital McGill University Health Centre Montreal QC H4A 3J1 Canada UCL Queen Square Institute of Neurology London WC1N 3BG UK Department of Pediatrics McGill University and The Research Institute of the McGill University Health Centre Montreal QC H4A 3J1 Canada Samantha Dickson Brain Cancer Unit University College London Cancer Institute London United Kingdom Second Department of Paediatrics Semmelweis University Budapest 1094 Hungary Department of Neurosurgery University of Debrecen Debrecen 4032 Hungary Department of Paediatric Haematology and Oncology Second Faculty of Medicine Charles University and University Hospital Motol Prague 150 06 Czech Republic Department of Pathology and Molecular Medicine Second Faculty of Medicine Charles University and University Hospital Motol Prague 150 06 Czech Republic Children’s Cancer Center The Royal Children’s Hospital Murdoch Children’s Research Institute Department of Pediatrics University of Melbourne Parkville VIC 3052 Australia Kids Cancer Centre Sydney Children’s Hospital Randwick NSW 2031 Australia Department of Pathology Centre Hospitalier Universitaire Sainte-Justine Université de Montréal Montréal QC H3T 1C5 Canada Department of Pediatric Oncology Dana-Farber Boston Children’s Cancer and Blood Disorders Center Boston MA 02215 USA School of Computer Science McGill University Montreal QC H3A 2A7 Canada and Murdoch Children’s Research Institute Parkville VIC 3052 Australia Department of Biochemistry McGill University Montreal QC H3A 1A3 Canada Department of Pediatric Neurosurgery Centre Hospitalier Universitaire Sainte-Justine Université de Montréal Montréal QC H3T 1C5 Canada Department of Biochemistry and

Histone H3.3 glycine 34 to arginine/valine(G34R/V)mutations drive deadly gliomas and show exquisite regional and temporal specificity,suggesting a developmental context permissive to their *** we show that 50%of G34R/V tumors(n=95)bear activating PDGFRA mutations that display strong selection pressure at *** considered gliomas,G34R/V tumors actually arise in GSX2/DLX-expressing interneuron progenitors,where G34R/V mutations impair neuronal *** lineage of origin may facilitate PDGFRA co-option through a chromatin loop connecting PDGFRA to GSX2 regulatory elements,promoting PDGFRA overexpression and *** the single-cell level,G34R/V tumors harbor dual neuronal/astroglial identity and lack oligodendroglial programs,actively repressed by GSX2/DLX-mediated cell fate specification.G34R/V may become dispensable for tumor maintenance,whereas mutant-PDGFRA is potently ***,our results open novel research avenues in deadly tumors.G34R/V gliomas are neuronal malignancies where interneuron progenitors are stalled in differentiation by G34R/V mutations and malignant gliogenesis is promoted by co-option of a potentially targetable pathway,PDGFRA signaling.

关键词： PDGFRA specificity connecting

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