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A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon C.Daeschler Katelyn J.W.So Konstantin Feinberg Marina Manoraj Jenny Cheung Jennifer Zhang Kaveh Mirmoeini JPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of biomaterials and Biomedical engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

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Setting kinetics and mechanical properties of flax fibre reinforced glass ionomer restorative materials

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The Journal of Biomedical Research 2017年第3期31卷 264-272页

作者： Ensanya Ali Abou Neel Anne M.Young division of biomaterials Conservative Dental Sciences DepartmentKing Abdualziz University biomaterials Department Faculty of DentistryTanta University division of biomaterials and tissue engineering UCL Eastman Dental Institute

Regardless of the excellent properties of glass ionomer cements,their poor mechanical properties limit their applications to non-load bearing *** study aimed to investigate the effect of incorporated short,chopped and randomly distributed flax fibers（0,0.5,1,2.5,5 and 25 wt%） on setting reaction kinetics,and mechanical and morphological properties of glass ionomer *** of flax fibers did not significantly affect the setting reaction *** to their content,flax fibers increased the compressive（from 148 to 250 MPa） and flexure strength（from 20 to 42 MPa）.They also changed the brittle behavior of glass ionomer cements to a plastic *** significantly reduced the compressive（from 3 to 1.3 GPa） and flexure modulus（from 19 to 14 GPa）.Accordingly,flax fiber-modified glass ionomer cements could be potentially used in high-stress bearing areas.

关键词： setting kinetics flax fibre glass ionomer cements

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Current research on electrospinning of silk fibroin and its blends with natural and synthetic biodegradable polymers

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Frontiers of Materials Science 2013年第2期7卷 129-142页

作者： Jian-Guang ZHANG Xiu-Mei MO biomaterials and tissue engineering Lab College of Chemistry Chemical Engineering & Biotechnology Donghua University Shanghai 201620 China

Silk fibroin （SF） is a kind of natural polymers with a great potential in biomedical application. Due to its good biocompatibility, biodegradability and minimal inflammatory reaction, SF is an excellent candidate for generating tissue engineering scaffolds. Electrospinning is a simple and effective method to fabricate nanofibers, which has several amazing characteristics such as very large surface area to volume ratio, flexibility in surface functionalities, and superior mechanical performance. The electro- spun nanofibers from SF and its blends have been used for varied tissue engineering. This paper will give a brief review about the structure, properties and applications of SF and blend nanofibers via electrospinning.

关键词： electrospinning nanofiber silk fibroin (SF) biodegradable polymer

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Quaternary ammonium-induced multidrug tolerant Streptococcus mutans persisters elevate cariogenic virulence in vitro

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International Journal of Oral Science 2017年第4期9卷 224-231页

作者： Ya-Ling Jiang Wei Qiu Xue-Dong Zhou Hao Li Jun-Zhuo Lu Hockin HK Xu Xian Peng Ming-Yun Li Ming-Ye Feng Lei Cheng Biao Ren State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Operative Dentistry and Endodontics West China Hospital of StomatologySichuan UniversityChengduChina biomaterials&tissue engineering division Department of EndodonticsProsthodontics and Operative DentistryUniversity of Maryland Dental SchoolBaltimoreUSA

Dental caries are the most prevalent chronic infections in the oral cavity, and Streptococcus mutans acts as the main cariogenic bacterial species. Antibacterial quaternary ammonium compounds （QAs） have been developed to preveFnt or treat dental caries. However, there is no report on the tolerance of S. mutans to QAs. In this study, we investigated the development of S. mutans persistence induced by a novel dental caries defensive agent, dimethylaminododecyl methacrylate （DMADDM）, for the first time. Typical biphasic killing kinetics for persisters were observed in both S. mutans planktonic and biofilm cultures challenged by DMADDM at concentrations of 20 and 200 ***- z respectively. The persisters tolerated six other antibiotics with different antibacterial mechanisms, while only daptomycin and vancomycin could slightly reduce the persister numbers in planktonic cultures. The distribution of persisters in DMADDM-treated biofilms was similar to that in the untreated control, except that the total biomass and biofilm height were significantly reduced. A higher exopolysaccharides （EPS）：bacteria ratio was observed in DMADDM-treated biofilms. Persisters in biofilms significantly upregulated gtf gene expression, indicating an increase in the bacteria＇s ability to produce EPS and an elevated capability of cariogenic virulence. Carbon source metabolism was significantly reduced, as related metabolic genes were all downregulated in persisters. Concentrations of 0.1 mM, 1 mM and 10 mM of extra glucose significantly reduced the number of persisters both in planktonic and biofilm conditions. The formation of non- inheritable and multidrug tolerant persisters induced by DMADDM suggested that drug tolerance and new persistent eradication strategies should be considered for oral antibacterial agents.

关键词： antibacterial quaternary ammoniums dental caries persistence multidrug tolerance Streptococcus mutans biofilms

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Preface to the Special Issue:Bioadaption of biomaterials

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Journal of Materials Science & Technology 2016年第9期32卷 799-800页

作者： Yingjun Wang biomaterials and biomedical engineering at south china university of technology chinese academy of engineering chinese society for biomaterials national engineering research center for tissue restoration and reconstruction

tissue repair is always a complex process and artificial biomaterials have never been perfect. For example, the mismatch of mechanical property between biomaterials and the host can result in stress shielding; the asy... 详细信息

关键词： Preface to the Special Issue Bioadaption of biomaterials

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Primer containing dimethylaminododecyl methacrylate kills bacteria impregnated in human dentin blocks

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International Journal of Oral Science 2016年第4期8卷 239-245页

作者： Chen Chen Lei Cheng Michael D Weir Nancy J Lin Sheng Lin-Gibson Xue-Dong Zhou Hockin HK Xu State Key Laboratory of Oral Diseases West China School of Stomatology Sichuan University biomaterials & tissue engineering division Department of Endodontics Periodontics and Prosthodontics University of Maryland Dental School biomaterials Group Biosystems and Biomaterials Division National Institute of Standards & Technology Center for Stem Cell Biology & Regenerative Medicine University of Maryland School of Medicine Department of Mechanical engineering University of Maryland

Antibacterial dimethylaminododecyl methacrylate （DMADDM） was recently synthesized. The objectives of this study were to：（1） investigate antibacterial activity of DMADDM-containing primer on Streptococcus mutans impregnated into dentin blocks for the first time, and （2） compare the antibacterial efficacy of DMADDM with a previous quaternary ammonium dimethacrylate （QADM）. Scotchbond Multi-Purpose （SBMP） bonding agent was used. DMADDM and QADM were mixed into SBMP primer. Six primers were tested： SBMP control primer P, P＋2.5% DMADDM, P＋5% DMADDM, P＋7.5% DMADDM, P＋10% DMADDM, and P＋10% QADM. S. mutans were impregnated into human dentin blocks, and each primer was applied to dentin to test its ability to kill bacteria in dentinal tubules. Bacteria in dentin were collected via a sonication method, and the colony-forming units （CFU） and inhibition zones were measured. The bacterial inhibition zone of P＋10% DMADDM was 10 times that of control primer （P〈0.05）. CFU in dentin with P＋10% DMADDM was reduced by three orders of magnitude, compared with control. DMADDM had a much stronger antibacterial effect than QADM, and antibacterial efficacy increased with increasing DMADDM concentration. Dentin shear bond strengths were similar among all groups （P〉0.1）. In conclusion, antibacterial DMADDM-containing primer was validated to kill bacteria inside dentin blocks, possessing a much stronger antibacterial potency than the previous QADM. DMADDM-containing bonding agent was effective in eradicating bacteria in dentin, and its efficacy was directly proportional to DMADDM mass fraction. Therefore, DMADDM may be promisine for use in bonding agents as well as in other restorative and oreventive materials to inhibit bacteria.

关键词： antibacterial bonding agent dental restoration dentin bond strength dimethylaminododecyl methacrylate kil]ing bacteriain dentin Streptococcus mutans

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PREPARATION AND CELL COMPATIBILITY OF FUNCTIONALIZED BIODEGRADABLE POLY(DL-LACTIDE-co-RS-β-MALIC ACID)

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Chinese Journal of Polymer Science 2008年第2期26卷 177-186页

作者：何斌顾忠伟 engineering Research Center of biomaterials Sichuan UniversityNational Engineering Research Center for Biomaterials

In order to create a functionalized biodegradable polymer for vascular tissue engineering application,poly(DL- lactide-co-RS-β-malic acid)(PDLLMAc)was *** was obtained after hydrogenolysis of poly(DL- lactide-co-RS-β-benzyl malolactonate)(PDLLMA),which was from the ring-opening polymerization of DL-lactide(DLLA) and RS-β-benzyl malolactonate(MA)using stannous octoate as *** copolymers were characterized by ~1H-NMR, FTIR,GPC and *** tensile strength and water uptake of the copoly...

关键词： Biodegradable Functionalization Poly(DL-lactide-co-RS-β-malic acid) tissue engineering.

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Protein-based functional hydrogel improves cutaneous nerve repair and diabetic wound healing

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Nano Research 2025年第1期18卷 586-596页

作者： Hanzhi Lu Mingrui Cui Yi Wang Xinran Du Xinyi Zhou Yuhan Fang Xiaoyan Gao Ying Peng Jianyong Zhu Guang Yang Fulun Li Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China Shanghai engineering Research Center of Nano-biomaterials and Regenerative Medicine College of Biological Science and Medical EngineeringDonghua UniversityShanghai 201620China Clinical Laboratory Medicine Center Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China

Cutaneous nerve regeneration in diabetic wounds remains a challenge for current clinical ***,a natural protein-based functional hydrogel is developed using keratin as the sole matrix,and protocatechuic aldehyde(PA)and zinc ions as the building blocks through dual-dynamic crosslinking reactions of thiol-aldehyde addition and catecholzinc ions *** unique structural design endows the hydrogel with excellent injectability,skin adhesion,self-healing and antibacterial ability,and *** addition,this hydrogel acts as a drug carrier for the loading and sustained release of phellopterin(PP),a natural compound extracted from traditional Chinese medicine Angelica *** findings demonstrate that the PP-loaded hydrogel promotes cutaneous nerve regeneration,angiogenesis and tissue remodeling in the full-thickness wounds in both db/db and streptozotocin-induced C57BL/6 diabetic mice,notably by the synergistic effect of zinc ions and PP,showing a great potential in diabetic wound therapy.

关键词： functional hydrogel cutaneous nerve regeneration dynamic crosslinking diabetic wounds

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Antibacterial Activity of Silicate Bioceramics

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Journal of Wuhan University of Technology(Materials Science) 2011年第2期26卷 227-231页

作者：扈盛常江 Department of Physical Education Huazhong Normal University biomaterials and tissue engineering Research Center Shanghai Institute of Ceramics

Four kinds of pure silicate ceramic particles,CaSiO3,Ca3SiO5,bredigite and akermanite were prepared and their bactericidal effects were systematically *** phase compositions of these silicate ceramics were characterized by *** ionic concentration measurement revealed that the Calcium （Ca） ion concentration were relatively higher in Ca3SiO5 and bredigite,and much lower in CaSiO3 and ***,the pH values of the four silicate ceramics extracts showed a positive correlation with the particle ***,by decreasing the particle size,higher Ca ion concentrations can be achieved,leading to the increase of aqueous pH value as *** summary,all of the four silicate ceramics tested in our study showed antibacterial effect in a dose-dependent ***,the order of their antibacterial activity against *** from strong to weak is Ca3SiO5,bredigite,CaSiO3 and akermanite.

关键词： silicate ceramics antibacterial activity specific surface area aqueous pH ionic concentration

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VE TPGS-Loaded Silk Fibroin / Hydroxybutyl Chitosan Nanofibrous Scaffolds for Skin Care Application

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Journal of Donghua University(English Edition) 2014年第4期31卷 533-537页

作者：周远南梁文浩阮标鹏姜芳王维汉张葵花莫秀梅 College of Materials and Textile engineering Jiaxing University biomaterials and tissue engineering Laboratory College of ChemistryChemical Engineering and BiotechnologyDonghua University

Vitamin E( VE) is an ideal antioxidant and a stabilizing agent in biological membranes. In this study,silk fibroin( SF) /hydroxybutyl chitosan( HBC) nanofibrous scaffolds are loaded with VE tocopherol polyethylene glycol 1000 succinate( VE TPGS) via electrospinning. SEM images show that the average nanofibrous diameter has no significant difference when the content of VE TPGS increases to 4. 0%( SF / HBC). However,the average nanofibrous diameter decreases largely to 200 nm when the VE TPGS content reaches 6. 0%. Furthermore,VE TPGS presents a sustained release behavior from the nanofibrous scaffolds. Cell viability studies of mouse skin fibroblasts( L929) demonstrate that VE TPGS loaded SF / HBC nanofibrous scaffolds present good cellular ***,the incorporation of VE TPGS could strengthen the ability of SF / HBC nanofibrous scaffolds on protecting the cells against oxidation stress using the Tertbutyl hydroperoxide( t-BHP)-induced oxidative injury model. Therefore,VE TPGS-loaded SF /HBC nanofibrous scaffolds might be potential candidates for personal skin care,wound dressing and skin tissue engineering scaffolds.

关键词： vitamin Etocopherol polyethylene glycol 1000 succinate(VE TPGS) silk fibroin(SF) /hydroxybutyl chitosan(HBC) nanofibrous scaffolds resistance to oxidation biocompatibility

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