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Go to the back before going forward:Addressing psychological responses in anterior cruciate ligament reconstruction rehabilitation

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Journal of Sport and Health Science 2024年第5期13卷 666-669页

作者： Terese L.Chmielewski Adam Meierbachtol Rick Aberman Travis Gunderson Jonathon Sikorski Kathleen Cummer TRIA Orthopedic Center BloomingtonMN 55431USA Rehabilitation Science Graduate Program Department of Family Medicine and Community HealthMedical SchoolUniversity of MinnesotaMinneapolisMN 55455USA Optum Inc. Clinical OperationsPhysical Health DivisionEden PrairieMN 55344USA Dr.Rick Aberman Consulting MinnetonkaMN 55305USA Department of Rehabilitation Medicine Division of Physical TherapyUniversity of WashingtonSeattleWA 98195USA

Helping athletes return to sports participation is a primary goal of anterior cruciate ligament(ACL)reconstruction *** facilitate the achievement of this goal,decades of research studies have sought to identify knee impairments that reduce knee function as well as interventions to resolve them.1Yet,over the past 10 years,research pertaining to psychological responses(i.e.,cognitions and emotions)after ACL reconstruction has grown exponentially—a phenomenon that can be visualized by entering the search terms"psychological"and"anterior cruciate ligament reconstruction"into the PubMed search engine.

关键词： ligament return psychological

Investigation and Mitigation of Carbon Deposition over Copper Catalyst during Electrochemical CO_(2)Reduction

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Precision Chemistry 2024年第4期2卷 151-160页

作者： Jing-Wen DuanMu Zhi-Zheng Wu Fei-Yue Gao Peng-Peng Yang Zhuang-Zhuang Niu Yu-Cai Zhang Li-Ping Chi Min-Rui Gao division of Nanomaterials and Chemistry Hefei National Laboratory for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026China

Copper(Cu)is considered to be the most effective catalyst for electrochemical conversion of carbon dioxide(CO_(2))into value-added hydrocarbons,but its stability still faces considerable ***,we report the poisoning effect of carbon deposition during CO_(2)reduction on the active sites of Cu electrodea critical deactivation factor that is often *** find that,*C,an intermediate toward methane formation,could desorb on the electrode surface to form carbon *** reveal a strong correlation between the formation of methane and the carbon deposition,and the reaction conditions favoring methane production result in more carbon *** deposited carbon blocks the active sites and consequently causes rapid deterioration of the catalytic *** further demonstrate that the carbon deposition can be mitigated by increasing the roughness of the electrode and increasing the pH of the *** work offers a new guidance for designing more stable catalysts for CO_(2)reduction.

关键词： carbon deposition roughness in situ spectrum CO_(2)electroreduction copper catalyst

Assembly of highly efficient aqueous light-harvesting system from sequence-defined peptoids for cytosolic microRNA detection

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Nano Research 2024年第2期17卷 788-796页

作者： Yang Song Xiaoli Cai Mingming Wang Dan Du Yuehe Lin Chun-Long Chen Department of Mechanical and Materials Engineering Washington State UniversityPullmanWA 99164USA division of physical Sciences Pacific Northwest National LaboratoryRichlandWA 99352USA Department of Chemical Engineering University of WashingtonSeattleWA 98195USA

Precisely controlled spatial distributions of artificial light-harvesting systems in aqueous media are of significant importance for mimicking natural light-harvesting systems;however,they are often restrained by the solubility and the aggregation-caused quenching effect of the hydrophobic ***,we report one highly efficient artificial light-harvesting system based on peptoid nanotubes that mimic the hierarchical cylindrical structure of natural *** high crystallinity of these nanotubes enabled the organization of arrays of donor chromophores with precisely controlled spatial distributions,favoring an efficient Förster resonance energy transfer(FRET)process in aqueous *** FRET system exhibits an extremely high efficiency of 98.6%with a fluorescence quantum yield of 40%and an antenna effect of *** further demonstrated the use of this artificial light-harvesting system for quantifying miR-210 within cancer *** fluorescence intensity ratio of donor to acceptor is linearly related to the concentration of intercellular miR-210 in the range of 3.3–156 copies/*** high sensitivity in intracellular detection of miR-210 using this artificial light-harvesting system offers a great opportunity and pathways for biological imaging and detection,and for the further creation of microRNA(miRNA)toolbox for quantitative epigenetics and personalized medicine.

关键词： light-harvesting peptoid nanotube Förster resonance energy transfer intracellular RNA detection

Microfluidic bubble-generator enables digital light processing 3D printing of porous structures

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Aggregate 2024年第1期5卷 280-291页

作者： Philipp Weber Ling Cai Francisco Javier Aguilar Rojas Carlos Ezio Garciamendez-Mijares Maria Celeste Tirelli Francesco Nalin Jakub Jaroszewicz Wojciech Swi eszkowski Marco Costantini Yu Shrike Zhang division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolCambridgeMassachusettsUSA Institute of physical Chemistry—Polish Academy of Sciences KasprzakaPoland Biomaterials Group Materials Design DivisionFaculty of Materials Science and EngineeringWarsaw University of TechnologyWoloskaPoland

Three-dimensional(3D)printing is an emerging technique that has shown promising success in engineering human tissues in recent *** development of vatphotopolymerization printing modalities has significantly enhanced the complexity level for 3D printing of various functional structures and ***,the development of microfluidic chip systems is an emerging research sector with promising medical *** work demonstrates the coupling of a digital light processing(DLP)printing procedure with a microfluidic chip system to produce size-tunable,3D-printable porosities with narrow pore size distributions within a gelatin methacryloyl(GelMA)hydrogel *** is found that the generation of size-tunable gas bubbles trapped within an aqueous GelMA hydrogel-precursor can be controlled with high ***,the porosities are printed in two-dimensional(2D)as well as in 3D using the DLP *** addition,the cytocompatibility of the printed porous scaffolds is investigated using fibroblasts,where high cell viabilities as well as cell proliferation,spreading,and migration are *** is anticipated that the strategy is widely applicable in a range of application areas such as tissue engineering and regenerative medicine,among others.

关键词： 3D printing biofabrication bubble digital light processing microfluidics porous

Rotating magnetic field inhibits Aβ protein aggregation and alleviates cognitive impairment in Alzheimer’s disease mice

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Zoological Research 2024年第4期45卷 924-936页

作者： Ruo-Wen Guo Wen-Jing Xie Biao Yu Chao Song Xin-Miao Ji Xin-Yu Wang Mei Zhang Xin Zhang High Magnetic Field Laboratory CAS Key Laboratory of High Magnetic Field and Ion Beam Physical BiologyHefei Institutes of Physical ScienceChinese Academy of SciencesHefeiAnhui 230031China Science Island Branch of Graduate School University of Science and Technology of ChinaHefeiAnhui 230036China Institutes of physical Science and Information Technology Anhui UniversityHefeiAnhui 230601China School of Life Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230026China

Amyloid beta(Aβ)monomers aggregate to form fibrils and amyloid plaques,which are critical mechanisms in the pathogenesis of Alzheimer’s disease(AD).Given the important role of Aβ1-42 aggregation in plaque formation,leading to brain lesions and cognitive impairment,numerous studies have aimed to reduce Aβaggregation and slow AD *** diphenylalanine(FF)sequence is critical for amyloid aggregation,and magnetic fields can affect peptide alignment due to the diamagnetic anisotropy of aromatic *** this study,we examined the effects of a moderate-intensity rotating magnetic field(RMF)on Aβaggregation and AD *** indicated that the RMF directly inhibited Aβamyloid fibril formation and reduced Aβ-induced cytotoxicity in neural cells in *** the AD mouse model APP/PS1,RMF restored motor abilities to healthy control levels and significantly alleviated cognitive impairments,including exploration and spatial and non-spatial memory *** examinations demonstrated that RMF reduced amyloid plaque accumulation,attenuated microglial activation,and reduced oxidative stress in the APP/PS1 mouse *** findings suggest that RMF holds considerable potential as a non-invasive,high-penetration physical approach for AD treatment.

关键词： lzheimer’s disease Rotating magnetic field Amyloid-β Cognitive function Alzheimer’s disease animal models

New insights into the therapeutic approaches for the treatment of tauopathies

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Neural Regeneration Research 2024年第5期19卷 1020-1026页

作者： Himanshi Singh Asmita Das Mohammad Moshahid Khan Tayebeh Pourmotabbed Department of Microbiology Immunology and BiochemistryUniversity of Tennessee Health Science CenterMemphisTNUSA Department of Biotechnology Delhi Technological UniversityShahbad DaulatpurDelhiIndia Department of Neurology College of MedicineUniversity of Tennessee Health Science CenterMemphisTNUSA Neuroscience Institute University of Tennessee Health Science CenterMemphisTNUSA Center for Muscle Metabolism and NeuropathologyDivision of Regenerative and Rehabilitation Sciences and Department of Physical TherapyCollege of Health ProfessionsUniversity of Tennessee Health Science CenterMemphisTNUSA

Tauopathies are a group of neurological disorders,including Alzheimer’s disease and frontotemporal dementia,which involve progressive neurodegeneration,cognitive deficits,and aberrant tau protein *** development of tauopathies cannot currently be stopped or slowed down by treatment *** the significant contribution of tau burden in primary tauopathies and the strong association between pathogenic tau accumulation and cognitive deficits,there has been a lot of interest in creating therapies that can alleviate tau pathology and render neuroprotective ***,small molecules,immunotherapies,and gene therapy have been used to reduce the pathological tau burden and prevent neurodegeneration in animal models of ***,the major pitfall of the current therapeutic approach is the difficulty of drugs and gene-targeting modalities to cross the blood-brain barrier and their unintended side *** this review,the current therapeutic strategies used for tauopathies including the use of oligonucleotide-based gene therapy approaches that have shown a promising result for the treatment of tauopathies and Alzheimer’s disease in preclinical animal models,have been discussed.

关键词： dementia gene therapies immunotherapy neurodegeneration oligonucleotides tau tauopathies therapies

Combinations of electron and proton donors in transition-metal complex mediated nitrogen reduction reactions

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Science China Chemistry 2024年第7期67卷 2136-2154页

作者： Delong Han Li Yang Hao Huang Priyanka Chakraborty Shashikant U.Dighe Kuo-Wei Huang KAUST Catalysis Center and division of physical Science and Engineering King Abdullah University of Science and TechnologyThuwal 23955Saudi Arabia Agency for Science Technologyand ResearchInstitute of Materials Research and Engineering and Institute of Sustainability for ChemicalsEnergy and EnvironmentSingapore 138634Singapore

Nitrogen fixation is a complex process involving the transfer of six electrons and *** from the conventional Haber-Bosch process,which relies on hydrogen(H_(2))to provide both electrons and protons to reduce nitrogen(N_(2)),homogeneous transition metal complex-catalyzed N_(2)reduction reactions(NRR)employ an array of electron and proton donors or even electron donors combined with *** the synthesis of diverse catalytic progress,the categories of donors have seen rapid ***,existing literature only provides summaries regarding the metal,ligands,and *** the significance of electron and proton donor combinations in nitrogen reduction reactions,no literature has thoroughly reviewed this ***,we hereby compiled a comprehensive list of commonly used reagents in N_(2)reduction and classified them according to their specific donor *** review presents clear and organized information about these combinations,along with a summary of their general performance trend in NRR with related ***,we conclude the discussion by highlighting key points for researchers to consider when selecting catalysts and donor combinations,with the ultimate goal of advancing the field of nitrogen fixation.

关键词： dinitrogen reduction reaction reducing donor combination transition metal complexes homogeneous catalysis

电催化CO_(2)还原的稳定性问题:评论性综述

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Science China Materials 2024年第6期67卷 1721-1739页

作者：端木静雯高飞跃高敏锐 division of Nanomaterials&Chemistry Hefei National Laboratory for Physical Sciences at the MicroscaleDepartment of ChemistryUniversity of Science and Technology of ChinaHefei 230026China

电催化二氧化碳还原反应(CO_(2)RR)能够利用可再生电能将CO_(2)转化为高附加值化学品和燃料,是一项有望缓解当下环境挑战的技术方案.本文总结了CO_(2)RR稳足性下降的根本原因,并探讨了解决这一问题的有效策略以及最新的研究进展.首先,... 详细信息

电催化二氧化碳还原反应(CO_(2)RR)能够利用可再生电能将CO_(2)转化为高附加值化学品和燃料,是一项有望缓解当下环境挑战的技术方案.本文总结了CO_(2)RR稳足性下降的根本原因,并探讨了解决这一问题的有效策略以及最新的研究进展.首先,在外加电位的作用下,催化剂会发生结构转变,且碳沉积或气体杂质引起的催化剂中毒都会降低CO_(2)RR的稳定性.其次,气体扩散层(GDL)附近发生水淹和盐沉淀会阻碍反应物/生成物的传输,三相界面会受到破坏.在长时间服役时,液压和电流的作用会导致GDL开裂.在电解质方面,碱性电解质会与CO_(2)中和,形成碳酸盐沉淀;而酸性介质腐蚀催化剂,并伴随严重的析氢副反应.另外,电解质中的金属离子杂质的优先还原进一步加剧了稳定性的衰减.深入理解CO_(2)RR中各类失活现象对设计稳定、高效的CO_(2)电催化系统具有指导意义.针对CO_(2)RR稳定性研究目前所面临的困境,本文最后展望了该领域未来的研究方向.

关键词： CO_(2)reduction stability catalyst gas diffusion layer electrolyte

Hydrazone derivatives in agrochemical discovery and development

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Chinese Chemical Letters 2024年第3期35卷 104-113页

作者： Ya Wang Shengxin Guo Lijiao Yu Wei Zhang Zhenchao Wang Yonggui Robin Chi Jian Wu National Key Laboratory of Green Pesticide Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationGuizhou UniversityHuaxi DistrictGuiyang 550025China division of Chemistry&Biological Chemistry School of Physical&Mathematical SciencesNanyang Technological UniversitySingapore 637371Singapore

As a common active substructure,hydrazone has attracted increasing attention and is considered essential for pesticide *** has been widely regarded as a potential insecticidal,antibacterial,antifungal,antiviral,and herbicidal *** this review,we highlight the pesticide versatility of hydrazone fragments and provide a comprehensive summary of the biological activity,structure-activity relationship analysis(SARs),and primary mechanism of their *** profile is expected to give valuable information for discovering new pesticides.

关键词： Hydrazone Agrochemicals Biological activity Structure-activity relationship Preliminary mechanism