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Journal of Clinical and Translational Hepatology 2024年第10期12卷 886-891页

作者： Bin-Yan Zhong Zhong-Zhi Jia Wen Zhang Chang Liu Shi-Hong Ying Zhi-Ping Yan Cai-Fang Ni Clinical Guidelines Committee of Chinese College of interventionalists Department of interventional radiology The First Affiliated Hospital of Soochow UniversitySuzhouJiangsuChina Department of interventional and Vascular Surgery The Affiliated Changzhou Second People’s Hospital of Nanjing Medical UniversityChangzhouJiangsuChina Department of interventional radiology Zhongshan HospitalFudan University Shanghai Institution of Medical ImagingFudan UniversityShanghaiChina division of Liver Department of General SurgeryWest China HospitalSichuan UniversityChengduSichuanChina Department of Minimal Invasive Surgery Shangjin Nanfu HospitalChengduSichuanChina Department of radiology First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina 不详

Despite its crucial role in interventional therapies for liver malignancy,cone-beam computed tomography(CBCT)has not yet been fully integrated into clinical practice due to several complicating factors,including nonstandardized operations and limited recognition of CBCT among interventional *** response,the Chinese College of interventionalists has released a consensus statement aimed at standardizing and promoting the application of CBCT in the interventional therapies for liver *** statement summarizes CBCT scanning techniques,and operational standards,and highlights its potential applications in clinical practice.

关键词： Cone-beam computed tomography interventional radiology Liver malignancy Consensus statement Chemoembolization Ablation

Extravasated contrast volumetric assessment on computed tomography angiography in gastrointestinal bleeding:A useful predictor of positive angiographic findings

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World Journal of radiology 2024年第5期16卷 115-127页

作者： Laura Maria Cacioppa Chiara Floridi Alessandra Bruno NicolòRossini Tommaso Valeri Alessandra Borgheresi Riccardo Inchingolo Francesco Cortese Giacomo Novelli Alessandro Felicioli Mario Torresi Pietro Boscarato Letizia Ottaviani Andrea Giovagnoni division of interventional radiology Department of Radiological SciencesUniversity Politecnica Delle MarcheAncona 60126Italy Department of Clinical Special and Dental SciencesUniversity Politecnica Delle MarcheAncona 60126Italy division of radiology Department of Radiological SciencesUniversity Hospital"Azienda Ospedaliero Universitaria Delle Marche"Ancona 60126Italy interventional radiology Unit "F Miulli"Regional General HospitalAcquaviva delle Fonti 70021Italy Department of radiology IRCCS INRCAAncona 60126Italy

BACKGROUND Gastrointestinal bleeding(GIB)is a severe and potentially life-threatening condition,especially in cases of delayed *** tomography angiography(CTA)plays a pivotal role in the early identification of upper and lower GIB and in the prompt treatment of the *** To determine whether a volumetric estimation of the extravasated contrast at CTA in GIB may be a predictor of subsequent positive angiographic *** In this retrospective single-centre study,35 patients(22 men;median age 69 years;range 16-92 years)admitted to our institution for active GIB detected at CTA and further submitted to catheter angiography between January 2018 and February 2022 were ***-three(65.7%)patients underwent endoscopy before *** volumetry was evaluated in both arterial and venous phases via a semi-automated dedicated *** rate was obtained from volume change between the two phases and standardised for unit *** were divided into two groups,according to the angiographic signs and their concordance with *** Upper bleeding accounted for 42.9%and lower GIB for 57.1%.Mean haemoglobin value at the admission was 7.7 g/dL.A concordance between positive CTA and direct angiographic bleeding signs was found in 19(54.3%)*** no significant differences in terms of bleeding volume in the arterial phase(0.55 mL vs 0.33 mL,P=0.35),a statistically significant volume increase in the venous phase was identified in the group of patients with positive angiography(2.06 mL vs 0.9 mL,P=0.02).In the latter patient group,a significant increase in bleeding rate was also detected(2.18 mL/min vs 0.19 mL/min,P=0.02).CONCLUSION In GIB of any origin,extravasated contrast volumetric analysis at CTA could be a predictor of positive angiography and may help in avoiding further unnecessary procedures.

关键词： Gastrointestinal haemorrhage Computed tomography angiography Volumetric analysis Computer-assisted image interpretation Therapeutic embolization Transcatheter arterial embolization

Current remarks and future directions on the interactions between metabolic dysfunction-associated fatty liver disease and COVID-19

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World Journal of Gastroenterology 2024年第11期30卷 1480-1487页

作者： Leonidas Brilakis Eirini Theofilogiannakou Panagis M Lykoudis School of Medicine National&Kapodistrian University of AthensAthens 11527Greece division of Surgery&interventional Science University College LondonLondon WC1E 6BTUnited Kingdom

During the outbreak of the coronavirus disease 2019(COVID-19)pandemic,particular interest rose regarding the interaction between metabolic dysfunctionassociated fatty liver disease(MAFLD)and the COVID-19 *** studies highlighted the fact that individuals with MAFLD had higher probability of severe acute respiratory syndrome coronavirus 2 infection and more severe adverse clinical *** of the proposed mechanisms is the inflammatory response pathway,especially the one involving cytokines,such as interleukin 6,which appeared particularly elevated in those patients and was deemed responsible for additional insult to the already damaged *** should increase our vigilance in terms of early detection,close follow up and early treatment for individuals with MAFLD and COVID-19 *** the direction of early diagnosis,biomarkers such as cytokeratin-18 and scoring systems such as Fibrosis-4 index score are ***-19 is a newly described entity,expected to be of concern for the years to come,and MAFLD is a condition with an ever-increasing *** the interaction between these two entities should be brought into the focus of *** morbidity and mortality of patients with COVID-19 and MAFLD should be the ultimate objective,and the optimal way to achieve this is by designing evidence-based prevention and treatment policies.

关键词： Metabolic dysfunction-associated fatty liver disease COVID-19 Liver fibrosis Cytokine storm Drug induced liver injury

Bringing gut microbiota into the spotlight of clinical research and medical practice

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World Journal of Clinical Cases 2024年第14期12卷 2293-2300页

作者： Efstathia Davoutis Zoi Gkiafi Panagis M Lykoudis School of Medicine National and Kapodistrian University of AthensAthens 11527Greece division of Surgery and interventional Science University College LondonLondon WC1E 6BTUnited Kingdom

Despite the increasing scientific interest and expanding role of gut microbiota(GM)in human health,it is rarely reported in case reports and deployed in cli-nical *** and metabolites produced by microbiota contribute to im-mune system development,energy homeostasis and ***-and endoge-nous factors can alter its *** of microbiota,also known as dysbiosis,is associated with various pathological *** bacterial taxa and related metabolites are involved in disease pathogenesis and therefore can serve as a diagnostic *** could also be a useful prognostic factor by predicting future disease onset and preventing hospital-associated ***-ditionally,it can influence response to treatments,including those for cancers,by altering drug bioavailability.A thorough understanding of its function has per-mitted significant development in therapeutics,such as probiotics and fecal ***,GM should be considered as a ground-breaking biological parameter,and it is advisable to be investigated and reported in literature in a more consistent and systematic way.

关键词： Gut microbiota Biomarker Fecal microbiota transplantation Dysbiosis Prebiotics

Overcoming geographical and socioeconomic limitations in colorectal cancer screening

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1683-1689页

作者： Sofia Rozani Panagis M Lykoudis School of Medicine National and Kapodistrian University of AthensAthens 11527Greece division of Surgery and interventional Science University College LondonLondon WC1E 6BTUnited Kingdom

Despite colorectal cancer’s(CRC)high global incidence,residents of low-and middle-income countries,as well as low-income minorities in advanced economies have low screening *** studies demonstrate that in these groups higher incidence of CRC is observed,yet screening rates remain low for consistent *** income,low educational background,and lack of awareness in combination with inadequate social security of certain population groups impede access and compliance rates to CRC *** the other hand,despite the global availability of multiple screening approaches(colonoscopy,sigmoidoscopy,faecal occult blood test,faecal immunochemical test,computed tomography-colonography,etc.)with proven diagnostic validity,many low-income countries still lack established screening *** absence of screening guidelines in these countries along with the heterogeneity of guidelines in the rest of the world,demonstrate the need for global measures to tackle this issue *** essential step forward is to develop a global approach that will link specific elements of screening with the incidence and available resources in each country,to ensure the achievement of at least a minimum screening program in low-income *** cheaper,cost-effective techniques,which can be carried out by less specialized healthcare providers,might not be equivalent to endoscopy for CRC screening but seems more realistic for areas with fewer *** has been highlighted as the most pivotal element for the effective implementation of any screening program concerning ***,multiple studies have demonstrated that outreach strategies and community-based educational programs are associated with encouraging outcomes,yet a centrally coordinated expansion of these programs could provide more consistent ***,patient navigator programs,wherever implemented,have increased CRC screening and improved ***,global coordin

关键词： Colorectal cancer Screening Low-and middle-income countries Socioeconomic disparities Cancer

Superior rectus/levator complex in acquired anophthalmic socket repaired with spheric implant—a computed tomography scan and topographic study

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1483-1488页

作者： Shaikha Al Eid Hamad M AlSulaiman Sahar M Elkhamary Osama Al Sheikh Alicia Ferrero-Galindo Rajiv Kandekhar Silvana A Schellini Oculoplastic division King Khaled Eye Specialist HospitalRiyadh 11462Saudi Arabia radiology division King Khaled Eye Specialist HospitalRiyadh 11462Saudi Arabia Department of Diagnostic radiology Mansoura Faculty of MedicineMansoura 35511Egypt University Hospital Rio Hortega Valladolid 47012Spain Research Department King Khaled Eye Specialist HospitalRiyadh 11462Saudi Arabia Ophthalmology Department Medical SchoolState University of Sao PauloBotucatu 18618-687Brazil

AIM:To determine whether the levator palpebrae superioris(LPS)/superior rectus(SR)muscle complex,can influence the position of the upper lid and fornix in acquired anophthalmic ***:This comparative non-randomized and non-interventional study included retrospective data of 21 patients with unilateral acquired anophthalmic sockets repaired with spheric ***-resolution computed tomography(CT)measurements of the LPM/SR muscle complex and clinical topographic position of the upper lid,superior and inferior fornix depth in primary gaze position were *** data were presented as frequency and percentage proportions and quantitative variables comparing the socket measurements with the normal contralateral orbit was statistically analyzed using non-parametric tests considering P0.05,all comparisons).The superior fornix depth was similar in the anophthalmic socket and the contralateral normal orbit(P=0.192)as well the inferior fornix depth(P=0.351).CONCLUSION:Acquired anophthalmic sockets repaired with spheric implants have shorter LPS,thicker SR,and more lagophthalmos than normal *** relationship of the LPS and SR with other orbital structures,associated with passive or active forces acting in the final position of the lids and external ocular prosthesis should be further investigated.

关键词： anophthalmic socket spheric implant levator palpebrae superioris superior rectus lagophthalmos fornix depth

Predictive value of multi-detector computed tomography for accurate diagnosis of serous cystadenoma:Radiologic-pathologic correlation

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World Journal of Gastroenterology 2009年第22期15卷 2739-2747页

作者： Anjuli A Shah Nisha I Sainani Avinash Kambadakone Ramesh Zarine K Shah Vikram Deshpande Peter F Hahn Dushyant V Sahani Department of radiology Division of Abdominal Imaging and Interventional RadiologyWhite Bldg.270Massachusetts General Hospital Department of Pathology Massachusetts General Hospital

AIM： To identify multi-detector computed tomography （MDCT） features most predictive of serous cystadenomas （SCAs）, correlating with histopathology, and to study the impact of cyst size and MDCT technique on reader performance. METHODS： The MDCT scans of 164 patients with surgically verified pancreatic cystic lesions were reviewed by two readers to study the predictive value of various morphological features for establishing a diagnosis of SCAs. Accuracy in lesion characterization and reader confidence were correlated with lesion size （≤3 cm or 〉≥3 cm） and scanning protocols （dedicated vs routine）. RESULTS： 28/164 cysts （mean size, 39 mm; range, 8-92 mm） were diagnosed as SCA on pathology. The MDCT features predictive of diagnosis of SCA were microcystic appearance （22/28, 78.6%）, surface Iobulations （25/28, 89.3%） and central scar （9/28, 32.4%）. Stepwise logistic regression analysis showed that only microcystic appearance was significant for CT diagnosis of SCA （P = 0.0001）. The sensitivity, specificity and PPV of central scar and of combined microcystic appearance and Iobulations were 32.4%/100%/100% and 68%/100%/100%, respectively. The reader confidence was higher for lesions 〉 3 cm （P = 0.02） and for MDCT scans performed using thin collimation （1.25-2.5 mm） compared to routine 5 mm collimation exams （P 〉 0.05）. CONCLUSION： Central scar on MDCT is diagnostic of SCA but is seen in only one third of SCAs. Microcystic morphology is the most significant CT feature in diagnosis of SCA. A combination of microcystic appearance and surface Iobulations offers accuracy comparable to central scar with higher sensitivity.

关键词： Pancreas Serous cystadenoma Multidetector computed tomography Central scar Lobulations Microcystic

Spatial transcriptomics:recent developments and insights in respiratory research

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Military Medical Research 2024年第3期11卷 430-448页

作者： Wen-Jia Wang Liu-Xi Chu Li-Yong He Ming-Jing Zhang Kai-Tong Dang Chen Gao Qin-Yu Ge Zhou-Guang Wang Xiang-Wei Zhao State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)School of Pharmaceutical SciencesWenzhou Medical UniversityWenzhou 325035ZhejiangChina Orthopaedic Bioengineering Research Group Division of Surgery and Interventional ScienceUniversity College LondonLondon HA74LPUK

The respiratory system's complex cellular heterogeneity presents unique challenges to researchers in this *** bulk RNA sequencing and single-cell RNA sequencing(scRNA-seq)have provided insights into cell types and heterogeneity in the respiratory system,the relevant specific spatial localization and cellular interactions have not been clearly *** transcriptomics(ST)has filled this gap and has been widely used in respiratory *** review focuses on the latest iterative technology of ST in recent years,summarizing how ST can be applied to the physiological and pathological processes of the respiratory system,with emphasis on the ***,the current challenges and potential development directions are proposed,including high-throughput full-length transcriptome,integration of multi-omics,temporal and spatial omics,bioinformatics analysis,*** viewpoints are expected to advance the study of systematic mechanisms,including respiratory studies.

关键词： Spatial transcriptomics Lung Tumor Spatial multi-omics

Treatment modalities for hypersplenism in liver transplant recipients with recurrent hepatitis C

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World Journal of Gastroenterology 2009年第40期15卷 5010-5013页

作者： Lena Sibulesky Justin H Nguyen Ricardo Paz-Fumagalli C Burcin Taner Rolland C Dickson division of Transplant Surgery and Transplant Hepatology Division of Interventional Radiology

Hepatitis C is the most common indication for orthotopic liver transplantation in the United States. Unfortunately, hepatitis C recurs universally in the transplanted liver and is the major cause of decreased graft and patient survival. The combination therapy of interferon and ribavirin has been shown to be the most effective therapy for recurrent hepatitis C. However, pre-and post-transplant hypersplenism often precludes patients from receiving the antiviral therapy. Splenectomy and partial splenic embolization are the two invasive modalities that can correct the cytopenia associated with hypersplenism. In this report we review the two treatment options, their associated outcomes and complications.

关键词： Hypersplenism Leukopenia Recurrenthepatitis C Thrombocytopenia Liver transplant

Portal vein embolization for induction of selective hepatic hypertrophy prior to major hepatectomy: rationale,techniques, outcomes and future directions

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Cancer Biology & Medicine 2016年第4期13卷 426-442页

作者： David Li David C.Madoff Department of radiology Division of Interventional Radiology New York-Presbyterian Hospital Weill Cornell Medical Center

The ability to modulate the future liver remnant(FLR) is a key component of modern oncologic hepatobiliary surgery practice and has extended surgical candidacy for patients who may have been previously thought unable to survive liver resection. Multiple techniques have been developed to augment the FLR including portal vein embolization(PVE), associating liver partition and portal vein ligation(ALPPS), and the recently reported transhepatic liver venous deprivation(LVD). PVE is a well-established means to improve the safety of liver resection by redirecting blood flow to the FLR in an effort to selectively hypertrophy and ultimately improve functional reserve of the FLR. This article discusses the current practice of PVE with focus on summarizing the large number of published reports from which outcomes based practices have been developed. Both technical aspects of PVE including volumetry, approaches, and embolization agents; and clinical aspects of PVE including data supporting indications, and its role in conjunction with chemotherapy and transarterial embolization will be highlighted. PVE remains an important aspect of oncologic care; in large part due to the substantial foundation of information available demonstrating its clear clinical benefit for hepatic resection candidates with small anticipated FLRs.

关键词： Portal vein embolization future liver remnant hypertrophy liver regeneration liver cancer hepatocellular carcinoma liver metastases