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Efficacy and safety of clarithromycin for patients with sepsis or septic shock:a systematic review and meta-analysis

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Emergency and Critical Care Medicine 2024年第2期4卷 90-96页

作者： Pengyue Zhao Renqi Yao Jiaqi Yang Wei Wen Yongming Yao Xiaohui Du Department of General Surgery First Medical Center of the Chinese PLA General HospitalBeijingChina Translational Medicine research Center Medical Innovation Research Division and Fourth Medical Center of the Chinese PLA General HospitalBeijingChina Department of Burn Surgery the First Affiliated Hospital of Naval Medical UniversityShanghaiChina Department of General Surgery Hainan Hospital of Chinese PLA General HospitalSanyaHainanChina

Background:Clarithromycin exerts an immunomodulatory role in several human ***,whether this effect improves the prognosis in patients with sepsis remains controversial,and higher levels of clinical evidence are urgently *** the best of our knowledge,no meta-analysis to date has reported the clinical efficacy and safety of clarithromycin in ***:A comprehensive literature search of PubMed,EMBASE,and the Cochrane Library was conducted up to December 31,*** randomized controlled trials comparing the clinical efficacy and safety of clarithromycin with controls among patients with sepsis or septic shock were *** were pooled by applying a fixed-effects model and a relative risk(RR)estimate with 95%confidence intervals(CIs)using Review Manager(version 5.3;Cochrane Collaboration,Copenhagen,Denmark).Results:Three randomized controlled trials involving a total of 910 patients were *** pooled results confirmed that clarithromycin had no beneficial effect on progression to multiple organ dysfunction syndrome(RR:1.51;95%CI:1.02-2.25;P=0.04;I^(2)=0%),28-day mortality(RR:1.09;95%CI:0.87-1.36;P=0.46;I^(2)=0%),and 90-day mortality(RR:0.86;95%CI:0.71-1.03;P=0.10;I^(2)=81%)in patients with sepsis or septic ***,there was no difference in other serious adverse events between patients who received clarithromycin and those in the control group(RR:1.02;95%CI:0.87-1.19;P=0.83;I^(2)=18%).Conclusion:Our meta-analysis did not reveal an improvement to short-term outcomes in patients with sepsis treated with ***,administration of clarithromycin did not increase the risk of adverse events.

关键词： Clarithromycin Meta-analysis Outcomes Sepsis Septic shock

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Study of Type-B QPOs Observed in Black Hole X-Ray Binary Swift J1728.9-3613

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research in Astronomy and Astrophysics 2024年第3期24卷 1-9页

作者： Raj Kumar Astrophysical Sciences division Bhabha Atomic Research CentreMumbai 400085India Homi Bhabha National Institute Mumbai 400094India

We report the detection of type-B quasi-periodic oscillation(QPO)of the black hole X-ray binary Swift J1728.9-3613 observed by NICER during the 2019 outburst.A type-B QPO was observed for the first two days and it disappeared as flux increased,but again appeared at∼7.70 Hz when flux was dramatically *** source was found in the soft intermediate state during these *** further studied the energy dependence of the *** found that QPO was observed only for a higher energy range implying that the origin of QPO is possibly due to the corona emitting higher energy photons by the inverse Compton *** variation of spectral parameters can be explained with the disk truncation *** fractional rms was found to be monotonically increased with *** phase lag spectrum followed the“U-shaped”*** rms and phase lag spectrum are modeled and explained with the single-component Comptonization model vkompthdk.

关键词： X-rays binaries-accretion-accretion disks-X-rays individual (Swift J1728.9-3613)

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Room-temperature phonon-coupled single-photon emission in hexagonal boron nitride

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 109-114页

作者： Jia-Min Lai Qing-Hai Tan Feilong Song Haonan Chang Yanpei Lv Xue-Lu Liu Jinghua Teng Weibo Gao Ping-Heng Tan Jun Zhang State Key Laboratory of Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing100083China Key Laboratory of Magnetic Molecules and Magnetic Information Materials of Ministry of Education&research Institute of Materials Science Shanxi Normal UniversityTaiyuan 030000China Center of Materials Science and Optoelectronics engineering University of Chinese Academy of SciencesBeijing 100049China division of Physics and Applied Physics School of Physical and Mathematical SciencesNanyang Technological UniversitySingapore 637371Singapore Institute of Materials research and engineering(IMRE) Agency for ScienceTechnology and Research(A*STAR)Singapore 138634Singapore

Photon-lattice(phonon)coupling is fundamental to light-matter interaction,particularly when it reaches the quantum limit of the phonon-coupled single-photon emission,which holds great potential for quantum manipulation and quantum information ***,we report single defect state-phonon coupling in hexagonal boron nitride(h BN)at room *** ultrabroad spectrum of single-photon emissions can be achieved by selecting the excitation *** photoluminescence excitation spectroscopy,we observe single-phonon-assisted resonance-enhanced single-photon emission,along with multiple phonon replicas that herald the creation of phonon Fock *** also develop a transition model to gain insight into the physical process behind the single defect state-phonon *** work sets the stage for manipulating electron-phonon coupling state with single quantum-level precision at room temperature.

关键词： temperature phonon hexagonal

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Cross-Domain Bilateral Access Control on Blockchain-Cloud Based Data Trading System

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Computer Modeling in engineering & Sciences 2024年第10期141卷 671-688页

作者： Youngho Park Su Jin Shin Sang Uk Shin Electronics and Information Communications research Center Pukyong National UniversityBusan48513Republic of Korea Department of Information Security Graduate SchoolPukyong National UniversityBusan48513Republic of Korea division of Computer engineering Pukyong National UniversityBusan48513Republic of Korea

Data trading enables data owners and data requesters to sell and purchase *** the emergence of blockchain technology,research on blockchain-based data trading systems is receiving a lot of ***,to reduce the on-chain storage cost,a novel paradigm of blockchain and cloud fusion has been widely considered as a promising data trading ***,the fact that data can be used for commercial purposes will encourage users and organizations from various fields to participate in the data *** the data marketplace,it is a challenge how to trade the data securely outsourced to the external cloud in a way that restricts access to the data only to authorized users across multiple *** this paper,we propose a cross-domain bilateral access control protocol for blockchain-cloud based data trading *** consider a system model that consists of domain authorities,data senders,data receivers,a blockchain layer,and a cloud *** proposed protocol enables access control and source identification of the outsourced data by leveraging identity-based cryptographic *** the proposed protocol,the outsourced data of the sender is encrypted under the target receiver’s identity,and the cloud provider performs policy-match verification on the authorization tags of the sender and receiver generated by the identity-based signature ***,data trading can be achieved only if the identities of the data sender and receiver simultaneously meet the policies specified by each *** demonstrate efficiency,we evaluate the performance of the proposed protocol and compare it with existing studies.

关键词： Bilateral access control blockchain data sharing policy-match

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Accurate estimation of Li/Ni mixing degree of lithium nickel oxide cathode materials

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Chinese Physics B 2024年第5期33卷 631-635页

作者：陈鹏浩徐磊禹习谦李泓 Institute of Physics Chinese Academy of SciencesBeijing 100190China Center of Materials Science and Optoelectronics engineering University of Chinese Academy of SciencesBeijing 100049China Beijing Frontier research Center on Clean Energy Huairou DivisionInstitute of PhysicsChinese Academy of SciencesBeijing 101400China

Li/Ni mixing negatively influences the discharge capacity of lithium nickel oxide and high-nickel ternary cathode ***,accurately measuring the Li/Ni mixing degree is difficult due to the preferred orientation of labbased XRD measurements using Bragg–Brentano ***,we find that employing spherical harmonics in Rietveld refinement to eliminate the preferred orientation can significantly decrease the measurement error of the Li/Ni mixing *** Li/Ni mixing ratio obtained from Rietveld refinement with spherical harmonics shows a strong correlation with discharge capacity,which means the electrochemical capacity of lithium nickel oxide and high-nickel ternary cathode can be estimated by the Li/Ni mixing *** findings provide a simple and accurate method to estimate the Li/Ni mixing degree,which is valuable to the structural analysis and screening of the synthesis conditions of lithium nickel oxide and high-nickel ternary cathode materials.

关键词： lithium nickel oxide high-nickel ternary cathode Li/Ni mixing spherical harmonics function discharge capacity

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Study of plasma parameters of coaxial plasma source using triple Langmuir probe and Faraday cup diagnostics

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Plasma Science and Technology 2024年第4期26卷 94-100页

作者： Sunil KANCHI Rohit SHUKLA Archana SHARMA Pulsed Power and Electromagnetics division Bhabha Atomic Research CentreVisakhapatnam 531011India Homi Bhabha National Institute Mumbai 400085India Beam Technology Development Group Bhabha Atomic Research CentreMumbai 400085India

Coaxial plasma guns are a type of plasma source that produces plasma which propagates radially and axially controlled by the shape of the ground electrode, which has attracted much interest in several applications. In this work, a 120° opening angle of CPG nozzle is used as a plasma gun configuration that operates at the energy of 150 J. The ionization of polyethylene insulator between the electrodes of the gun produces a cloud of hydrogen and carbon *** triple Langmuir probe and Faraday cup are used to measure plasma density and plasma temperature. These methods are used to measure the on-axis and off-axis plasma divergence of the coaxial plasma gun. The peak values of ion densities measured at a distance of 25 mm on-axis from the plasma gun are(1.6±0.5)×10^(19)m^(-3)and(2.8±0.6)×10^(19)m^(-3)for hydrogen and carbon plasma respectively and the peak temperature is 3.02±0.5 eV. The mean propagation velocity of plasma is calculated using the transit times of plasma at different distances from the plasma gun and is found to be 4.54±0.25 cm/μs and 1.81±0.18 cm/μs for hydrogen and carbon plasma respectively. The Debye radius is obtained from the measured experimental data that satisfies the thin sheath approximation. The shot-to-shot stability of plasma parameters facilitates the use of plasma guns in laboratory experiments. These types of plasma sources can be used in many applications like plasma opening switches, plasma devices, and as plasma sources.

关键词： coaxial plasma source triple Langmuir probe Faraday cup plasma density plasma temperature

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Optimal combination of the correction model and parameters for the precision geometric correction of UAV hyperspectral images

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International Journal of Agricultural and Biological engineering 2024年第3期17卷 173-184页

作者： Wenzhong Tian Za Kan Qingzhan Zhao Ping Jiang Xuewen Wang Hanqing Liu College of Mechanical and Electrical engineering Shihezi UniversityShihezi 832000XinjiangChina research Center for Space Information engineering Technology Shihezi 832000XinjiangChina XPCC division of National Remote Sensing Center of China Shihezi 832000XinjiangChina College of Information Science and Technology Shihezi UniversityShihezi 832000XinjiangChina

Nowadays,with the rapid development of quantitative remote sensing represented by high-resolution UAV hyperspectral remote sensing observation technology,people have put forward higher requirements for the rapid preprocessing and geometric correction accuracy of hyperspectral *** optimal geometric correction model and parameter combination of UAV hyperspectral images need to be determined to reduce unnecessary waste of time in the preprocessing and provide high-precision data support for the application of UAV hyperspectral *** this study,the geometric correction accuracy under various geometric correction models(including affine transformation model,local triangulation model,polynomial model,direct linear transformation model,and rational function model)and resampling methods(including nearest neighbor resampling method,bilinear interpolation resampling method,and cubic convolution resampling method)were ***,the distribution,number,and accuracy of control points were analyzed based on the control variable method,and precise ground control points(GCPs)were *** results showed that the average geometric positioning error of UAV hyperspectral images(at 80 m altitude AGL)without geometric correction was as high as 3.4041 m(about 65 pixels).The optimal geometric correction model and parameter combination of the UAV hyperspectral image(at 80 m altitude AGL)used a local triangulation model,adopted a bilinear interpolation resampling method,and selected 12 edgemiddle distributed *** correction accuracy could reach 0.0493 m(less than one pixel).This study provides a reference for the geometric correction of UAV hyperspectral images.

关键词： geometric correction hyperspectral images unmanned aerial vehicle(UAV) ground control point(GCP)

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Ten- year follow- up investigation of stroke risk in systemic lupus erythematosus

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Stroke & Vascular Neurology 2024年第1期9卷 1-7页

作者： Jin-An Huang Ching-Heng Lin Ming-Ju Wu Yi-Hsing Chen Kuo-Cheng Chang Chung-Wei Hou division of Neurology Neurological InstituteTaichung Veterans General HospitalTaichungTaiwan Department of Health Business Administration Hungkuang UniversityTaichungTaiwan Department of medical research Taichung Veterans General HospitalTaichungTaiwan division of Nephrology Department of Internal MedicineTaichung Veterans General HospitalTaichungTaiwan School of Medicine Chung Shan Medical UniversityTaichungTaiwan College of Medicine National Chung Hsing UniversityTaichungTaiwan division of Allergy Immunology and RheumatologyDepartment of Internal MedicineTaichung Veterans General HospitalTaichungTaiwan School of Medicine National Yang-Ming Chiao Tung UniversityTaichungTaiwan

Background and purpose To analyse the long-term risk of ischaemic stroke and the clinical effects of antithrombotics on the risk of haemorrhagic stroke in patients with systemic lupus erythematosus(SLE).Methods A retrospective cohort study was conducted using a population-based database taken from Taiwan National Health Insurance research *** with SLE between 2000 and 2008 were registered and matched with two controls by the index date,age,gender and Charlson Comorbidity Index(CCI).These subjects were followed until either stroke event or 31 December *** HRs(aHRs)for strokes were estimated with Cox regression models,and the cumulative incidence of ischaemic stroke was analysed by log-rank test and Kaplan-Meier survival *** In total,8310 patients with SLE and 16620 patients without SLE were *** general,patients with SLE had higher rates of ischaemic stroke(5.4%vs 3.3%)and haemorrhagic stroke(1.5%vs 0.6%)than in *** multivariate analysis adjusted to age,gender,CCI,urbanisation level and antithrombotics uses,aHRs of all strokes,ischaemic stroke and haemorrhagic stroke were 1.73(95%CI:1.54 to 1.94),1.65(95%CI:1.45 to 1.87)and 2.24(95%CI:1.71 to 2.95),respectively,in patients with *** with SLE were significantly more likely to suffer ischaemic stroke than patients without SLE,even 10 years after SLE diagnosis(6.12%vs 3.50%,p<0.001).Antiplatelet use increased the risk of haemorrhagic stroke in SLE group(aHR=1.74,95%CI:1.18 to 2.57).Conclusions Patients with SLE are at greater risk of developing ischaemic stroke that lasts for 10 *** should be carefully administered to prevent cardiovascular events in patients with SLE due to the risk of haemorrhagic stroke.

关键词： erythematosus diagnosis likely

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Unified deep learning model for predicting fundus fluorescein angiography image from fundus structure image

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Journal of Innovative Optical Health Sciences 2024年第3期17卷 105-113页

作者： Yiwei Chen Yi He Hong Ye Lina Xing Xin Zhang Guohua Shi Jiangsu Key Laboratory of medical Optics Suzhou Institute of Biomedical Engineering and TechnologyChinese Academy of SciencesSuzhou 215163P.R.China School of Biomedical engineering(Suzhou) Division of Life Sciences and MedicineUniversity of Science and Technology of China Hefei 230026P.R.China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200031P.R.China

The prediction of fundus fluorescein angiography(FFA)images from fundus structural images is a cutting-edge research topic in ophthalmological image *** comprises estimating FFA from fundus camera imaging,single-phase FFA from scanning laser ophthalmoscopy(SLO),and three-phase FFA also from *** many deep learning models are available,a single model can only perform one or two of these prediction *** accomplish three prediction tasks using a unified method,we propose a unified deep learning model for predicting FFA images from fundus structure images using a supervised generative adversarial *** three prediction tasks are processed as follows:data preparation,network training under FFA supervision,and FFA image prediction from fundus structure images on a test *** comparing the FFA images predicted by our model,pix2pix,and CycleGAN,we demonstrate the remarkable progress achieved by our *** high performance of our model is validated in terms of the peak signal-to-noise ratio,structural similarity index,and mean squared error.

关键词： Fundus fluorescein angiography image fundus structure image image translation unified deep learning model generative adversarial networks

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Investigation of Groundwater Quality with Borehole Depth in the Basin Granitoids of the Ashanti Region of Ghana

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Journal of Water Resource and Protection 2024年第5期16卷 381-394页

作者： Bernard Ofosu Augustine Kofi Asante Festus Anane Mensah Umar-Farouk Usman Naa Korkoi Ayeh Geotechnical and Materials engineering division CSIR-Building and Road Research Institute Kumasi Ghana

The dependence of groundwater quality on borehole depth is usually debatable in groundwater studies, especially in complex geological formations where aquifer characteristics vary spatially with depth. This study therefore seeks to investigate the relationship between borehole depth and groundwater quality across the granitoid aquifers within the Birimian Supergroup in the Ashanti Region. Physicochemical analysis records of groundwater quality data were collected from 23 boreholes of public and private institutions in the Ashanti Region of Ghana, and the parametric values of iron, fluoride, total hardness, pH, nitrate, and nitrite were used to study the groundwater quality-depth relationship. The results showed that the depth-to-groundwater quality indicated a marginal increase in water quality in the range of 30 to 50 m, which is mathematically represented by the low-value correlation coefficient (r2 = 0.026). A relatively significant increase occurs in the depth range of 50 to 80 m, which is given by a correlation coefficient of r2 = 0.298. The mean percent parameter compatibility was 74%, 82%, 89%, and 97% at 50, 60, 70, and 80 m depths, respectively. The variations in groundwater quality per depth ratio ranged from 1.48, 1.37, 1.27, and 1.21 for 50, 60, 70, and 80 m depth, respectively. The recommended minimum borehole depth for excellent groundwater quality is suggested with a compatibility per meter depth ratio of 1.37. This results in a range between 50 and 70 m as the most desirable drilling depth for excellent groundwater quality within the granitoids of the Birimian Supergroup of the Ashanti Region in Ghana.

关键词： Groundwater Quality Borehole Depth Birimian Supergroup Granitoid Aquifers Ashanti Region

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