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The impact of the coronavirus disease 2019 pandemic on physical activity in U.S. children

Journal of sport and Health science 2021年第3期10卷 323-332页

作者： Kirsten Tulchin-Francis Wilshaw Stevens Jr Xiangli Gu Tao Zhang Heather Roberts Jean Keller Dana Dempsey Justine Borchard Kelly Jeans Jonathan VanPelt division of Movement science Research DepartmentScottish Rite for ChildrenDallasTX 75219USA Department of Health Care sciences School of Health ProfessionsUniversity of Texas Southwestern Medical CenterDallasTX 75235USA Department of Kinesiology University of Texas at ArlingtonArlingtonTX 76019USA Departrment of Kinesiology Health Promotion and RecreationCollege of EducationUniversity of North TexasDentonTX 76201USA Department of Occupational Therapy Texas Woman’s UniversityDentonTX 76204USA division of Clinical Research Research DepartmentScottish Rite for ChildrenDallasTX 75219USA Therapeutic Recreation Department Scottish Rite for ChildrenDallasTX 75219USA

Background:Daily moderate-to-vigorous physical activity(MVPA)is vital to the physical,mental,and social well-being of *** restrictions during the coronavirus disease 2019(COVID-19)pandemic included the closure of schools and physical activity(PA)amenities across the *** study aimed to examine the impact of the pandemic on the PA and play behavior of *** and to provide evidencebased recommendations to improve their ***:A cross-sectional,online,parent-reported survey was conducted of children aged 318 years between April and June 2020 to assess light PA and MVPA using a modified Godin Leisure-Time Exercise *** items included family/child socioeconomic demographics,child adaptability to the pandemic,and community *** survey was shared through social media and snowball sampling ***:Analysis of 1310 surveys indicated child PA scores declined significantly during the pandemic(from 56.6 to 44.6,max 119,p<0.001).Specifically,MVPA score decreased(from 46.7 to 34.7,max 98,p<0.001)while light PA remained the ***-based changes were seen in the quantity,variety,and intensity of PA,with the lowest pandemic-related impact seen in preschoolers and the highest in high schoolers(4.7 vs.17.2,p<0.001).Community-based peer PA decreased across all age ***:This study shows decreased PA levels in ***,according to parent reporting,during the COVID-19 *** for community leaders,educators,and parents to improve PA in children are *** continued spread of COVID-19,these results and recommendations may be imperative to the physical well-being of ***.

关键词： Adolescents COVID-19 Moderate-to-vigorous physical activity Pediatric Youth

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Changes in the number of circulating CD34＋ cells after eccentric exercise of the elbow flexors in relation to muscle damage

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Journal of sport and Health science 2015年第3期4卷 275-281页

作者： Ho Seong Lee Makii Muthalib Takayuki Akimoto Kazunori Nosaka Department of Kinesiologic Medical science Dankook University Choongnam 330-714 South Korea Institute of Health and Biomedical Innovation School of Human Movement Studies Queensland University of Technology Brisbane 4000 Australia division of Regenerative Medical Engineering Center for Disease Biology and Integrative Medicine Graduate School of Medicine University of Tokyo Tokyo 113-8654 Japan School of Exercise and Health sciences Edith Cowan University Joondalup Western Australia 6027 Australia

背景:有研究报道剧烈运动能增加血液中骨髓祖细胞(如CD34^+细胞)数量,但尚未见研究报道抗阻运动后循环CD34^+细胞的变化。本研究旨在验证肘关节屈肌离心运动后血液中CD34^+细胞数量增加但恢复期减少,其数量变化幅度与肌肉损伤程度有关... 详细信息

背景:有研究报道剧烈运动能增加血液中骨髓祖细胞(如CD34^+细胞)数量,但尚未见研究报道抗阻运动后循环CD34^+细胞的变化。本研究旨在验证肘关节屈肌离心运动后血液中CD34^+细胞数量增加但恢复期减少,其数量变化幅度与肌肉损伤程度有关。方法:9名男性(28.0±6.6岁)用非惯用侧上肢完成10组(每组6次)最大自主肘关节屈肌离心运动,其中6名男性4周后用同一侧手臂完成同样的运动。在运动前、运动后、运动后2、24、48、72、96 h测量间接标记的肌肉损伤变化、白细胞分类计数(白细胞总数、中性粒细胞、淋巴细胞和单核细胞)以及血液中的CD34^+细胞数量。结果:离心运动后,最大自主等长收缩力矩显著缩小(p<0.05),延迟性肌肉酸痛增加,血浆肌酸激酶活性增加。然而,白细胞无显著性变化,CD34^+细胞发生明显变化。与第一次运动后相比,第二次运动后肌肉损伤标记物的变化显著减小(p<0.05)。但两次运动前后,白细胞和CD34^+细胞的变化无显著不同。结论:研究结果不能证实提出的假设,表明肘关节屈肌离心收缩诱导的肌肉损伤对CD34^+循环细胞没有影响。

关键词：肌肉损伤离心运动祖细胞白细胞总数白细胞分类计数 CD34 中性粒细胞细胞数量

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Exercise-mediated regulation of autophagy in the cardiovascular system

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Journal of sport and Health science 2020年第3期9卷 203-210页

作者： Lijun Wang Jiaqi Wang Dragos Cretoiu Guoping Li Junjie Xiao Cardiac Regeneration and Ageing Lab Institute of Cardiovascular SciencesSchool of Life ScienceShanghai UniversityShanghai 200444China Department of Cell and Molecular Biology and Histology Carol Davila University of Medicine and PharmacyBucharest 050474Romania Alessandrescu-Rusescu National Institute of Mother and Child Health Fetal Medicine Excellence Research CenterBucharest 020395Romania Cardiovascular division of the Massachusetts General Hospital and Harvard Medical School BostonMA 02215USA

Cardiovascular disease is the leading cause of human death worldwide. Autophagy is an evolutionarily conserved degradation pathway,which is a highly conserved cellular degradation process in which lysosomes decompose their own organelles and recycle the resulting *** is critical in maintaining cardiovascular homeostasis and function, and excessive or insufficient autophagy or autophagic flux can lead to cardiovascular disease. Enormous evidence indicates that exercise training plays a beneficial role in the prevention and treatment of cardiovascular diseases. The regulation of autophagy during exercise is a bidirectional process. For cardiovascular disease caused by either insufficient or excessive autophagy, exercise training restores normal autophagy function and delays the progression of cardiovascular *** in-depth exploration and discussion of exercise-mediated regulation of autophagy in the cardiovascular system can broaden our view about the prevention of various autophagy-related diseases through exercise training. In this article, we review autophagy and its related signaling pathways,as well as autophagy-dependent beneficial effects of exercise in cardiovascular system.

关键词： Autophagy Cardiovascular diseases Exercise

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Research highlights from the Status report for step it up! The surgeon general's call to action to promote walking and walkable communities

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Journal of sport and Health science 2018年第1期7卷 5-6页

作者： David R.Brown Susan A.Carlson Gayathri S.Kumar Janet E.Fulton National Center for Chronic Disease Prevention and Health Promotion Centers for Disease Control and Prevention Division of NutritionPhysical Activity and Obesity Physical Activity and Health Branch

In September 2015,the Office of the Surgeon General,*** of Health and Human Services,released Step it up!The surgeon general’s call to action to promote walking and walkable communities(Call to Action)to increase walking among people across the USA.1The Call to Action also recognized that walkable communities can accommodate wheelchair rolling and are inclusive of persons with *** Status Report for the Call to Action was released in 2017。

关键词：电话医生外科社区办公室

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Beyond cardiomyocytes:Cellular diversity in the heart's response to exercise

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运动与健康科学(英文) 2023年第4期12卷 423-437,F0003页

作者： Lena E.Trager Margaret Lyons Alexandra Kuznetsov Cedric Sheffield Kangsan Roh Rebecca Freeman James Rhee J.Sawalla Guseh Haobo Li Anthony Rosenzweig Corrigan Minehan Heart Center Division of CardiologyCardiovascular Research CenterDepartment of MedicineMassachusetts General HospitalHarvard Medical SchoolBostonMA 02114USA University of Minnesota Medical School MinneapolisMI 55455USA Department of Anesthesiology and Critical Care Massachusetts General HospitalHarvard Medical SchoolBostonMA 02115USA Institute for Heart and Brain Health University of Michigan Medical CenterAnn ArborMI 48109USA

Cardiomyocytes comprise~70%to 85%of the total volume of the adult mammalian heart but only about 25%to 35%of its total number of *** in single cell and single nuclei RNA sequencing have greatly facilitated investigation into and increased appreciation of the potential functions of non-cardiomyocytes in the *** much of this work has focused on the relationship between non-cardiomyocytes,disease,and the heart's response to pathological stress,it will also be important to understand the roles that these cells play in the healthy heart,cardiac homeostasis,and the response to physiological stress such as *** present review summarizes recent research highlighting dynamic changes in non-cardiomyocytes in response to the physiological stress of *** particular interest are changes in fibrotic pathways,the cardiac vasculature,and immune or inflammatory *** many instances,limited data are available about how specific lineages change in response to exercise or whether the changes observed are functionally important,underscoring the need for further research.

关键词： Angiogenesis Cardiac fibrosis Cardioprotection Hypertrophy Non-cardiomyocytes Proliferation

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非接触式前交叉韧带损伤的生物力学风险因素：一项随机的生物力学模型研究(英文)

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Journal of sport and Health science 2012年第1期1卷 36-42页

作者： Cheng-Feng Lin Hui Liu Michael T.Gros Paul Weinhold William E.Garrett Bing Yu Department of Physical Therapy National Cheng Kung University sports Biomechanics Laboratory Beijing Sports University Center for Human Movement science Division of Physical TherapyThe University of North Carolina at Chapel HillChapel HillNC 27599USA Department of Orthopaedic Surgery The University of North Carolina at Chapel HillChapel HillNC 27599USA Department of Biomedical Engineering The University of North Carolina at Chapel HillChapel HillNC 27599USA division of Orthopaedic Surgery Duke University Medical CenterDurhamNC 27710USA Center for Human Movement science Division of Physical Therapy The University of North Carolina at Chapel HillChapel HillNC 27599USA

Background:Significant efforts have been made to identify modifiable risk factors of non-contact anterior cruciate ligament(ACL) injuries in male and female ***,current literature on the risk factors for ACL injury are purely *** understanding of biomechanical relationship between risk and risk factors of the non-contact ACL injury is necessary to develop effective prevention programs. Purpose:To compare lower extremity kinematics and kinetics between trials with and without non-contact ACL injuries and to determine if any difference exists between male and female trials with non-contact ACL injuries regarding the lower extremity motion patterns. Methods:In this computer simulation study,a stochastic biomechanical model was used to estimate the ACL loading at the time of peak posterior ground reaction force(GRF) during landing of the stop-jump *** Carlo simulations were performed to simulate the ACL injuries with repeated random samples of independent *** distributions of independent variables were determined from in vivo laboratory data of 40 male and 40 female recreational athletes. Results:In the simulated injured trials,both male and female athletes had significantly smaller knee flexion angles,greater normalized peak posterior and vertical *** knee valgus moment,greater patella tendon force,greater quadriceps force,greater knee extension moment. and greater proximal tibia anterior shear force in comparison to the simulated uninjured *** significant difference was found between genders in any of the selected biomechanical variables in the trials with simulated non-contact ACL injuries. Conclusion:Small knee flexion angle,large posterior *** large knee valgus moment are risk factors of non-contact ACL injury determined by a stochastic biomechanical model with a cause-and-effect relationship.

关键词： Anterior cruciate ligament Risk factors Stochastic

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Highlights of the 2nd International Symposium on Tribbles and Diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer

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Acta Pharmaceutica Sinica B 2019年第2期9卷 443-454页

作者： Bing Cui Patrick A. Eyers Leonard L. Dobens Nguan Soon Tan Peter D. Mace Wolfgang A. Link Endre Kiss-Toth Karen Keeshan Takuro Nakamura Warren S. Pear Yodit Feseha Jessica Johnston Arkatiz Carracedo Marcel Scheideler Zabran llyas Robert C. Bauer Jorge D. Erusalimsky Dominika Grzesik Juan Salamanca-Viloria Xiaoxi Lv Yishi Jin Ke Li Guillermo Velasco Shuang Shang Jose M. Lizcano Xiaowei Zhang Jichao Zhou Jiaojiao Yu Fang Hua Feng Wang Shanshan Liu Jinmei Yu Zhuowei Hu State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Department of Biochemistry Institute of Integrative Biology University of Liverpool division of Molecular Biology and Biochemistry School of Biological Sciences University of Missouri-Kansas City School of Biological sciences Nanyang Technological University Lee Kong Chian School of Medicine Nanyang Technological University Institute of Molecular and Cell Biology KK Women's and Children Hospital Biochemistry Department School of Biomedical Sciences University of Otago Centre for Biomedical Research (CBMR) University of Algarve Campus de Gambelas Department of Biomedical sciences and Medicine University of Algarve Algarve Biomedical Center (ABC) University of Algarve Campus de Gambelas Department of Infection Immunity and Cardiovascular Disease University of Sheffield Paul O'Gorman Leukaemia Research Centre Institute of Cancer Sciences University of Glasgow division of Carcinogenesis The Cancer Institute Japanese Foundation for Cancer Research Department of Pathology and Laboratory Medicine Abramson Family Cancer Research Institute Perelman School of Medicine at the University of Pennsylvania Centre de Recherche en Transplantation et Immunologie (ou CRTI) Inserm Université de Nantes Nantes France Institut de Transplantation Urologie Néphrologie (ou ITUN) CIC bioGUNE CIBERONC Ikerbasque Basque Foundation for Science Biochemistry and Molecular Biology Department University of the Basque Country (UPV/EHU) Institute for Diabetes and Cancer IDC Helmholtz Center Munich Joint Heidelberg-IDC Translational Diabetes Program University Hospital Heidelberg Molecular Metabolic Control Medical Faculty Technical University Munich German Center for Diabetes Research (DZD) division of Cardiology Department of Medicine Columbia University Irving Medical Center School of sport and Health sciences Cardiff Metropolitan Universit

The Tribbles(TRIB) family of pseudokinase proteins has been shown to play key roles in cell cycle, metabolic diseases, chronic inflammatory disease, and cancer development. A better understanding of the mechanisms of TRIB pseudokinases could provide new insights for disease development and help promote TRIB proteins as novel therapeutic targets for drug discovery. At the 2 nd International Symposium on Tribbles and Diseases held on May 7–9, 2018 in Beijing, China, a group of leading Tribbles scientists reported their findings and ongoing studies about the effects of the different TRIB proteins in the areas of immunity, metabolism, fundamental cell biology and cancer. Here, we summarize important and insightful overviews from 4 keynote lectures, 13 plenary lectures and 8 short talks that took place during this meeting. These findings may offer new insights for the understanding of the roles of TRIB pseudokinases in the development of various diseases.

关键词： Tribbles Immunology Metabolism Cell biology Kinase inhibitor Tumorigenesis Metastasis TRIB1 TRIB2 TRIB3 Pseudokinase Inflammation Atomic structure Protein quality control Ubiqutin

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A physically active lifestyle is related to a lower level of skin autofluorescence in a large population with chronic-disease(LifeLines cohort)

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Journal of sport and Health science 2022年第2期11卷 260-265页

作者： Saskia Corine van de Zande Jeroen Klaas de Vries Inge van den Akker-Scheek Johannes Zwerver Andries Jan Smit Department of Internal Medicine Division of Vascular MedicineUniversity of GroningenUniversity Medical Center GroningenGroningen9700 RBthe Netherlands Department of Internal Medicine Antonius Hospital SneekSneek8601 ZKthe Netherlands Department of Orthopaedics University of GroningenUniversity Medical Center GroningenGroningen9700 RBthe Netherlands Center for Human Movement sciences University of GroningenUniversity Medical Center GroningenGroningen9700 RBthe Netherlands sports Valley Gelderse Vallei HospitalEde6716 RPthe Netherlands

Background:Physical activity(PA)has substantial health benefits and is important in combatting chronic diseases,which have been associated with elevated levels of advanced glycation endproducts(AGEs).AGEs play a role in the aging process,and an association between PA and AGEs has been *** aimed to investigate the relationship between PA and AGE accumulation in a general population and in a population with chronic ***:This large cross-sectional population study used data from adult participants in the LifeLines project,with participant information drawn from the LifeLines database as well data from patients with diabetes mellitus or renal and/or cardiovascular *** AGE accumulation was assessed non-invasively by skin-autofluorescence(SAF)using an AGE reader(DiagnOptics Technologies BV,Groningen,the Netherlands).PA was assessed using the short questionnaire to assess health-enhancing physical activity(SQUASH).Multivariate linear regression analyses were adjusted for age,body mass index,sex,and smoking ***:Data from 63,452 participants(general population n=59,177,chronic disease n=4275)were *** general population was significantly younger(43.58±11.77 years,mean±SD)and had significantly lower SAF(1.90±0.42 arbitrary units(AU))compared to the population with chronic disease(age:55.51±12.07 years;SAF:2.27±0.51 AU).In the group with chronic disease,more hours of moderate to vigorous physical activities per week were associated with lower SAF(β=-0.002,95%confidence interval(95%CI):-0.002 to-0.001).For the general population,there was no association between hours of moderate to vigorous activity and SAF(β=3.2×10^(-5),95%CI:0.000-0.001,p=0.742).However,there was an association in the general population between total hours of PA per week and SAF(β=4.2×10^(-4),95%CI:0.000-0.001,p<0.001),but this association was not found in the chronic disease population(β=-3.2×10^(-4),95%CI:-0.001 to 0.000,p=0.347).Conclusion:Our study demons

关键词： Advanced glycation endproducts Chronic disease population General population Physical activity Skin autofluorescence

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耐力游泳与房颤风险增加(英文)

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Journal of sport and Health science 2016年第2期5卷 246-247页

作者： Andrew D.Schreiner Brad A.Keith Walter A.Brzezinski division of General Internal Medicine Medical University of South Carolina

Dear editor,Diet and exercise have always been part of a healthy ***,literature has identified an association between endurance exercise and atrial fibrillation with the

关键词：风险房颤游泳耐力

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预测中国男性前列腺癌切片检查阳性率的视距诺模图：基于台湾地区的研究

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Asian Journal of Andrology 2013年第6期15卷 780-784,I0008页

作者： Shu-Chun Kuo Shun-Hsing Hung Hsien-Yi Wang Chih-Chiang Chien Chin-Li Lu Hung-Jung Lin How-Ran Guo Jian-Fang Zou Chian-Shiung Ling Chien-Cheng Huangs Department of Ophthalmology Chi-Mei Medical Center Tainan 710 Department of Optometry Chung Hwa University of Medical Technology Taina n 710 division of Urology Departments of Surgery Chi-Mei Medical Center Tainan 710 Department of Nephrology Chi-Mei Medical Center Tainan 710 Department of sport Management College of Leisure and Recreation Management Chia Nan University of Pharmacy and Science Tainan 710 Department of Food Nutrition Chung Hwa University of Medical TechnologyTainan 710 Chia-Yi Christian Hospital Chia-Yi 600 Department of Emergency Medicine Chi-Mei Medical Center Tainan 710 Department of Biotechnology Southern Taiwa n University of Science and Technology Tainan 710 Department of Envtronmental and Occupational Health Medical College National Cheng Kung University Tainan 710 Clinical division of Occupational Medicine Institute of Occupational Health and Occupational Medicine Academy of Medical Science Jinan 25000 China divisions of Urology Department of Surgery Chi-Mei Medical Center Liouying 736 Department of Child Care and Education Southern Taiwan University of Science and Technology Tainan 710

Several nomograms for prostate cancer detection have recently been developed. Because the incidence of prostate cancer is lower in Chinese men, nomograms based on other populations cannot be directly applied to Chinese men. We, therefore, developed a model for predicting the probability of a positive initial prostate biopsy using clinical and laboratory data from a Chinese male population. Data were collected from 893 Chinese male referrals, 697 in the derivation set and 196 in the external validation set, who underwent initial prostate biopsies as individual screening. We analyzed age, prostate volume, total prostate-specific antigen （PSA）, PSA density （PSAD）, digital rectal examinations （DRE） and transrectal ultrasound （TRUS） echogenicity. Logistic regression analysis estimated odds ratio, 95% confidence intervals and Pvalues. Independent predictors of a positive biopsy result included advanced age, small prostate volume, elevated total PSA, abnormal digital rectal examination, and hyperechoic or hypoechoic TRUS echogenicity. We developed a predictive nomogram for an initial positive biopsy using these variables. The area under the receiver-operating characteristic curve for the model was 88.8%, which was greater than that of the prediction based on total PSA alone （area under the receiver-operating characteristic curve 74.7%）. If externally validated, the predictive probability was 0.827 and the accuracy rate was 78.1%, respectively. Incorporating clinical and laboratory data into a prebiopsy nomogram improved the prediction of prostate cancer compared with predictions based solely on the individual factors.

关键词： biopsy Chinese nomogram prediction prostate cancer

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