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AB026. Referrals from optometry-a comparative study (the R.O.C.S study)

Annals of Eye Science 2018年第1期 432-432页

作者： Christopher McLaughlin Michelle Biehl Brian Chan Sarah Mullen Lily Zhao Laura Donaldson Niro Sivachandran Prima Moinul Joshua Barbosa Varun Chaudhary Department of Medicine Universitéde MontréalMontréalQuébecQCCanada division Signaling and Functional Genomics and Heidelberg University Department of Cell and Molecular BiologyFaculty of Medicine MannheimGerman Cancer Research Center(DKFZ)HeidelbergGermany

Background:To characterize emergency optometrist referrals triaged at a tertiary ophthalmology care center by pathology,physical exam findings,and provisional diagnosis ***:Variables extracted from the patients’charts included date of referral,age,sex,eye(s)under examination,visual acuity(VA)at the time of referral,intraocular pressure(IOP)at the time of the referral,the referring optometrist’s provisional diagnosis,VA at the time of the ophthalmologist consultation,IOP at the time of the ophthalmologist consultation,number of days between referral and ophthalmic consultation,and the ophthalmologist’s ***:After categorizing disease by anatomical location,absolute agreement between optometrist provisional diagnosis and ophthalmologist diagnosis was 60%.A strong correlation was found between optometrist and ophthalmologist VA *** measurements were checked less frequently by *** cases where referral IOP was documented,no significant difference was observed between optometrist and ophthalmologist IOP ***:VA and IOP measurements by optometrists are reliable,but IOP is less frequently checked in the optometry *** optometrist referrals correctly localized eye pathology in 60%of cases,posterior pathology was missed in two cases of retinal tear and retinal detachment.

关键词： Optometry referral emerg clinic

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SARS-CoV-2 spike protein as a bacterial lipopolysaccharide delivery system in an overzealous inflammatory cascade

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Journal of Molecular Cell biology 2022年第9期14卷 26-39页

作者： Firdaus Samsudin Palur Raghuvamsi Ganna Petruk Manoj Puthia Jitka Petrlova Paul MacAry Ganesh S.Anand Peter J.Bond Artur Schmidtchen Bioinformatics Institute(BIl) Agency for ScienceTechnology and Research(A*STAR)Singapore 138671Singapore Department of Biological Sciences National University of SingaporeSingapore 117543Singapore division of Dermatology and Venereology Department of Clinical SciencesLund UniversitySE-22184 LundSweden Life Sciences Institute Centre for Life SciencesNational University of SingaporeSingapore 117546Singapore Department of Chemistry The Pennsylvania State UniversityPA 16801USA Copenhagen Wound Healing center Bispebjerg HospitalDepartment of Biomedical SciencesUniversity of CopenhagenDK-2400 CopenhagenDenmark

Accumulating evidence indicates a potential role for bacterial lipopolysaccharide(LPs)in the overactivation of the immune response during SARS-CoV-2 *** is recognized by Toll-like receptor 4,mediating proinflammatory *** previously reported that LPS directly interacts with SARS-CoV-2 spike(S)protein and enhances proinflammatory *** native gel electrophoresis and hydrogen-deuterium exchange mass spectrometry,we showed that LPS binds to multiple hydrophobic pockets spanning both the S1 and S2 subunits of the S *** simulations validated by a microscale thermophoresis binding assay revealed that LPS binds to the S2 pocket with a lower affinity compared to S1,suggesting a role as an intermediate in LPS ***,nuclear factor-kappa B(NF-kB)activation in monocytic THP-1 cells is strongly boosted by *** NF-kB reporter mice followed by bioimaging,a boosting effect was observed for both S1 and S2,with the former potentially facilitated by *** Omicron S variant binds to LPS,but with reduced affinity and LPS boosting in vitro and in *** together,the data provide a molecular mechanism by which S protein augments LPS-mediated hyperinflammation.

关键词： COVID-19 SARS-CoV-2 spike protein lipopolysaccharide TLR4 hyperinflammation

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Assemblage-based biomonitoring of freshwater ecosystem health via multimetric indices:A critical review and suggestions for improving their applicability

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Water biology and Security 2022年第3期1卷 28-42页

作者： Robert L.Vadas Jr. Robert M.Hughes Yeon Jae Bae Min Jeong Baek Orestes Carlos Bello Gonzáles Marcos Callisto Débora ReisdeCarvalho Kai Chen Maria T.Ferreira Pablo Fierro Jon S.Harding Dana M.Infante C.J.Kleynhans Diego R.Macedo Isabela Martins Norman Mercado Silva Nabor Moya Susan J.Nichols Paulo S.Pompeu Renata Ruaro Deborah R.O.Silva R.Jan Stevenson Bianca de Freitas Terra Christa Thirion Douglas Ticiani Lizhu Wang Chris O.Yoder 2909 Boulevard Rd SEOlympiaWA98501-3971USA Amnis Opes Institute 2895 SE GlennCorvallisOR97333USA Department of Fisheries Wildlife&Conservation SciencesOregon State UniversityCorvallisOR97331USA division of Environmental Science&Ecological Engineering Korea University145 Anam-roSeongbuk-guSeoul02841South Korea National Institute of Biological Resources Ministry of Environment42 Hwangyeong-roSeo-guIncheon22689South Korea Centro de Investigacion en Biodiversidad y Conservacion Universidad Autonoma del Estado de Morelos1001Col.ChamilpaC.P62209CuernavacaMorelosMexico Departamento de Genética Ecologia e EvoluçaoInstituto de Ciências BiologicaUniversidade Federal de Minas GeraisAvenida Ant^onio Carlos 6627CEP31270-901Belo HorizonteMGBrazil Departamento de Ecologia e Conservaçao Universidade Federal de Lavras37200-900LavrasMGBrazil State Key Laboratory of Marine Resource Utiliization in South China Sea Hainan UniversityHaikou570228China Forest Research Centre&Associate Laboratory TERRA University of LisbonTapada da Ajuda1349-017LisbonPortugal Instituto de Ciencias Marinas y Limnologicas Universidad Austral de ChileValdiviaChile School of Biological Sciences University of CanterburyPrivate Bag 4800Christchurch8140New Zealand Department of Fisheries&Wildlife Michigan State University1405 South Harrison Road#318East LansingMI48823USA Department of Water Affairs and Forestry(retired) 8th Avenue 771Wonderboom South0084PretoriaSouth Africa Departamento de Geografia Instituto de GeociênciasUniversidade Federal de Minas GeraisAvenida Antônio Carlos 6627CEP31270-901Belo HorizonteMGBrazil Instituto Guaicuy 109 Rua BrasopolisBelo HorizonteMG31150-170Brazil Centro de Investigación en Biodiversidad y Conservación Universidad Autónoma del Estado de MorelosAvenida Universidad 1001Col.ChamilpaC.P.62209CuernavacaMorelosMexico Instituto Experimental de Biología Universidad San Francisco Xavier de ChuquisacaSucreBolivia Centre for Applied Water Science Un

Freshwater biota are more comprehensive and direct indicators of biological impacts,and more meaningful to the public than water quality or physical habitat *** biotic data and the multiple biological indicators developed from them offer a much richer array of data for assessing the impacts of pollution controls than a limited set of physical or chemical *** recent decades,assemblage-based assessments by ecologists,environmental scientists,and water quality agencies have been employed globally for determining the condition of,and threats to,freshwater ecosystems.A key step in this advance has been the development of multimetric indices(MMIs)or indices of biotic integrity(IBIs)based on quantitative assessments of algae,macrophyte,macroinvertebrate,fish or riparian bird *** Europe,where biological assemblages are mandated for assessing freshwater ecosystem health,many indices are ***,the proliferation of MMIs globally has not always occurred through the application of rigorous study designs and monitoring protocols,nor have they always effectively incorporated functional metrics,stressor assessments,and statistical ***,in this review,we discuss eleven major concerns with the development and application(including logistical limitations)of multimetric indicators based on freshwater biota to encourage more rigorous and widely applicable(transferable)MMI use and ***,our concerns focus on reference conditions;sampling effort,methods,and season;trophic guild definition;metric comprehensiveness,options,screening and scoring;and MMI *** could also benefit from increased attention to ecological mechanisms and metric development,to further improve our understanding of anthropogenic impacts as well as rehabilitation effects on freshwater ecosystems *** closer attention to study designs,ecological mechanisms and metric development should further improve our understa

关键词： IBI MMI Fish Macroinvertebrates Algae Streams Rivers Lakes Wetlands Biological monitoring

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