检索结果-南通市图书馆

Small extracellular vesicles derived from cerebral endothelial cells with elevated microRNA 27a promote ischemic stroke recovery

引用

Neural Regeneration Research 2025年第1期20卷 224-233页

作者： Yi Zhang Zhongwu Liu Michael Chopp Michael Millman Yanfeng Li Pasquale Cepparulo Amy Kemper Chao Li Li Zhang Zheng Gang Zhang Department of Neurology Henry Ford HospitalDetroitMIUSA Department of Physics Oakland UniversityRochesterMIUSA Department of Pathology Henry Ford HospitalDetroitMIUSA division of Pharmacology Department of NeuroscienceReproductive and Dentistry SciencesSchool of MedicineUniversity of Naples“Federico Ⅱ”NaplesItaly

Axonal remodeling is a critical aspect of ischemic brain repair processes and contributes to spontaneous functional *** previous in vitro study demonstrated that exosomes/small extracellular vesicles(sEVs)isolated from cerebral endothelial cells(CEC-sEVs)of ischemic brain promote axonal growth of embryonic cortical neurons and that microRNA 27a(miR-27a)is an elevated miRNA in ischemic *** the present study,we investigated whether normal CEC-sEVs engineered to enrich their levels of miR-27a(27a-sEVs)further enhance axonal growth and improve neurological outcomes after ischemic stroke when compared with treatment with non-engineered CEC-sEVs.27a-sEVs were isolated from the conditioned medium of healthy mouse CECs transfected with a lentiviral miR-27a expression *** EVs isolated from CECs transfected with a scramble vector(Scra-sEVs)were used as a *** male mice were subjected to permanent middle cerebral artery occlusion and then were randomly treated with 27a-sEVs or *** array of behavior assays was used to measure neurological *** with treatment of ischemic stroke with Scra-sEVs,treatment with 27a-sEVs significantly augmented axons and spines in the peri-infarct zone and in the corticospinal tract of the spinal grey matter of the denervated side,and significantly improved neurological *** vitro studies demonstrated that CEC-sEVs carrying reduced miR-27a abolished 27a-sEV-augmented axonal *** analysis revealed that 27a-sEVs systemically administered preferentially localized to the pre-synaptic active zone,while quantitative reverse transcription-polymerase chain reaction and Western Blot analysis showed elevated miR-27a,and reduced axonal inhibitory proteins Semaphorin 6A and Ras Homolog Family Member A in the peri-infarct *** of the Clathrin-dependent endocytosis pathway substantially reduced neuronal internalization of *** data provide evidence that 27a-sEVs have

关键词： axonal remodeling cerebral endothelial cells exosomes miR-27a mitochondria Semaphorin 6A small extracellular vesicles stroke

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

引用

Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon C.Daeschler Katelyn J.W.So Konstantin Feinberg Marina Manoraj Jenny Cheung Jennifer Zhang Kaveh Mirmoeini JPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Insights into bacterial protein glycosylation in human microbiota

引用

Science China(Life Sciences) 2016年第1期59卷 11-18页

作者： Fan Zhu Hui Wu Departments of Microbiology and pediatric dentistry Schools of Dentistry and Medicine University of Alabama at Birmingham

The study of human microbiota is an emerging research topic. The past efforts have mainly centered on studying the composition and genomic landscape of bacterial species within the targeted communities. The interaction between bacteria and hosts is the pivotal event in the initiation and progression of infectious diseases. There is a great need to identify and characterize the molecules that mediate the bacteria-host interaction. Bacterial surface exposed proteins play an important role in the bacteria-host interaction. Numerous surface proteins are glycosylated, and the glycosylation is crucial for their function in mediating the bacterial interaction with hosts. Here we present an overview of surface glycoproteins from bacteria that inhabit three major mucosal environments across human body: oral, gut and skin. We describe the important enzymes involved in the process of protein glycosylation, and discuss how the process impacts the bacteria-host interaction. Emerging molecular details underlying glycosylation of bacterial surface proteins may lead to new opportunities for designing anti-infective small molecules, and developing novel vaccines in order to treat or prevent bacterial infection.

关键词： microbiota surface glycoprotein glycosylation bacteria-host interaction glycosyltransferase

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Common dental diseases in children and malocclusion

引用

International Journal of Oral Science 2018年第2期10卷 65-71页

作者： Jing Zou Mingmei Meng Clarice S Law Yale Rao Xuedong Zhou State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of pediatric dentistry West China School of StomatologySichuan UniversityChengdu 610041China Sections of pediatric dentistry and Orthodontics Division of Growth and DevelopmentUCLA School of DentistryUniversity of CaliforniaLos AngelesCAUSA Victoria General Hospital VictoriaBCCanada

Malocclusion is a worldwide dental problem that influences the affected individuals to varying degrees. Many factors contribute to the anomaly in dentition, including hereditary and environmental aspects. Dental caries, pulpal and periapical lesions, dental trauma, abnormality of development, and oral habits are most common dental diseases in children that strongly relate to malocclusion. Management of oral health in the early childhood stage is carried out in clinic work of pediatric dentistry to minimize the unwanted effect of these diseases on dentition. This article highlights these diseases and their impacts on malocclusion in sequence. Prevention, treatment, and management of these conditions are also illustrated in order to achieve successful oral health for children and adolescents, even for their adult stage.

关键词：错牙合龋齿口腔卫生保健知识

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Spontaneous healing of complicated crown-root fractures in children:Two case reports

引用

World Journal of Clinical Cases 2022年第18期10卷 6298-6306页

作者： Zi-Ling Zhou Lei Gao Shu-Kai Sun Hong-Shi Li Cai-Di Zhang Wen-Wen Kou Zheng Xu Li-An Wu Department of pediatric dentistry School of StomatologyFourth Military Medical UniversityXi’an 710032Shaanxi ProvinceChina Institute of Stomatology The General Air Force Hospital of PLABeijing 110142China The Center for pediatric dentistry Department of Pediatric DentistryUniversity of WashingtonSeaatleWA 98115United States Department of pediatric dentistry School of StomatologyThe Fourth Military Medical UniversityXi’an 710032Shaanxi ProvinceChina

BACKGROUND Complicated crown-root fracture is considered a severe dental trauma and is unlikely to heal without ***,dentists have to remove the loose coronal fragment of the fractured tooth and treat the remaining part with multidisciplinary ***,we observed spontaneous healing of fracture in two pediatric cases with a history of complicated crown-root fractures over 4 years *** SUMMARY In case 1,a 12-year-old boy complained of pain at tooth 11 following an accidental fall 1 d *** examination showed a crack line on the crown of tooth *** beam computed tomography(CBCT)images of tooth 11 showed signs of hard tissue deposition between the fractured *** patient recalled that tooth 11 had struck the floor 1 year ago without seeking any other *** case 2,a 10-year-old girl fell down 1 d ago and wanted to have her teeth *** examination showed a fracture line on the crown of tooth *** images of tooth 21 also showed signs of hard tissue deposition between the fractured *** also had a history of dental trauma 1 year ago and her tooth 11 received dental treatment by another *** to her periapical radiograph at that time,tooth 21 was fractured 1 year ago and the fracture was overlooked by her *** of these two cases showed spontaneous healing of complicated crown-root *** over 4 years of follow-up,both fractured teeth showed no signs of *** These findings may provide new insights and perspectives on the management and treatment of crown-root fractures in children.

关键词： Dental trauma Complicated crown-root fracture Spontaneous healing Children Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Immunomodulatory properties of dental tissue-derived mesenchymal stem cells: Implication in disease and tissue regeneration

引用

World Journal of Stem Cells 2019年第9期11卷 604-617页

作者： Oleh Andrukhov Christian Behm Alice Blufstein Xiaohui Rausch-Fan division of Conservative dentistry and Periodontology University Clinic of Dentistry Medical University of Vienna

Mesenchymal stem cells(MSCs)are considered as an attractive tool for tissue regeneration and possess a strong immunomodulatory *** tissuederived MSCs can be isolated from different sources,such as the dental pulp,periodontal ligament,deciduous teeth,apical papilla,dental follicles and *** to numerous in vitro studies,the effect of dental MSCs on immune cells might depend on several factors,such as the experimental setting,MSC tissue source and type of immune cell *** studies have shown that the immunomodulatory activity of dental MSCs is strongly upregulated by activated immune *** exert mostly immunosuppressive effects,leading to the dampening of immune cell ***,the reciprocal interaction between dental MSCs and immune cells represents an elegant mechanism that potentially contributes to tissue homeostasis and inflammatory disease *** the immunomodulatory potential of dental MSCs has been extensively investigated in vitro,its role in vivo remains obscure.A few studies have reported that the MSCs isolated from inflamed dental tissues have a compromised immunomodulatory ***,the expression of some immunomodulatory proteins is enhanced in periodontal disease and even shows some correlation with disease ***-based immunomodulation may play an essential role in the regeneration of different dental ***,immunomodulation-based strategies may be a very promising tool in regenerative dentistry.

关键词： Mesenchymal stem cells Dental tissue Immunomodulation Peripheral blood mononuclear cells Oral diseases Tissue regeneration

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Stress distributions on crown-luting cement-substrate system with finite element method

引用

Journal of Central South University 2012年第8期19卷 2115-2124页

作者： S.SEN M.S.GULER C.GULER Department of Mechanical Engineering Ataturk University Department of pediatric dentistry Inonu Univer sityFaculty of Dentistry

The aim of this work is to analyze the stress distributions on a crown-luting cement-substrate system with a finite-element method in order to predict the likelihood of interfacial micro cracks, radial or circumferential cracks, delamination, fracture and delamination with torsion. The contact and layer interface stresses in elastic layered half-space indented by an elastic sphere were examined using finite element method. The model consists of crown, luting cement and substrate. The solutions were carried out for three different elastic moduli of luting cement. It was placed between the cement and the substrate as a middle layer and its elastic module was chosen lower than the elastic module of crown and higher than the elastic module of dentin. An axisymmetric finite element mesh was set up for the stress analysis. Stress distributions on the contact surface and the interfaces of crown-luting cement and luting cement-dentin have been investigated for three different values of luting cement by using ANSYS. The effects of the luting cement which has three different elastic moduli on the pressure distribution and the location of interfacial stresses of the multi-layer model have been examined. The mechanism of crack initiation in the interfaces and interracial delamination was also studied quantitatively. For each luting cement, the pressure distribution is similar at the contact zone. Stress discontinuities occur at the perfect bonding interfaces of the crown-luting cement and the substrate-luting cement. The maximum stress jumps are obtained for the highest and the lowest elastic module of the luting cement. In the crown-luting cement-substrate system, failures may initiate at crown-luting cement region for luting cement with the lowest elastic module value. In addition, failures at luting cement-substrate region may occur for luting cement with the highest elastic module. In the luting cement, the medium elastic module value is more suitable for stress distributio

关键词： finite element modeling stress analysis adhesive and luting cement elastic deformation plastic deformation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

引用

Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi Juan Pablo de Rivero Vaccari Jennifer C.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref Kevin K.Wang J.Adrian Tyndall Binu Tharakan Firas Kobeissy Department of Surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological Surgery and the Miami Project to Cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA division of pediatric Critical Care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of Chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A review on biomedical and dental applications of cerium oxide nanoparticles——Unearthing the potential of this rare earth metal

引用

Journal of Rare Earths 2023年第11期41卷 1645-1661,I0001页

作者： Lalitha S Jairam Akshatha Chandrashekar T.Niranjana Prabhu Sunil Babu Kotha M.S.Girish Indira Mysuru Devraj M.Dhanya Shri K.Prashantha Department of pediatric and Preventive dentistry Faculty of Dental SciencesM.S.Ramaiah University of Applied SciencesNew BEL RoadMSR NagarBangalore560054India Department of Chemistry Faculty of Mathematical and Physical SciencesM.S.Ramaiah University of Applied SciencesNo.470-PIV PhasePeenya Industrial AreaBangalore560058India Department of Preventive dentistry Pediatric Dentistry DivisionCollege of DentistryRiyadh Elm UniversityRiyadhKingdom of Saudi Arabia Department of pediatric and Preventive dentistry JSS Dental College&HospitalJSS Academy of Higher Education&ResearchMysuruIndia Center for Research and Innovation Adichunchanagiri School of Natural SciencesAdichunchanagiri UniversityBGSITB.G.Nagara571448India

Nanotechnology deals with particles ranging from 1 to 100 nm in size called as *** nano particles exhibit unique properties which find an application in many industries and medical fields.A growing body of evidence points out the newer developing technologies adopted in the field of medicine in terms of target therapies,imaging systems,drug deliveries,*** through the incorporation of *** oxide nanoparticles have gained attention in the last decade due to exceptional properties such as redox activity,biofilm inhibition,antibacterial activity,anti-inflammatory activity,*** method of synthesis of cerium oxide nanoparticles plays a pivotal role in its *** exhibits redox properties and catalytic activity and thus has found its use in biomedical *** are incorporated into dental materials such as restorative cements/sealants,adhesives,and denture systems to improve their *** the various metal oxide nanoparticles,ce rium oxide nanoparticles(CeO_(2)NPs)are known to exhibit lower toxicity to mammalian cells and possess unique antibacterial *** addition,they exhibit potent properties such as antitumor,antiinflammatory,antibacterial activities,and functions as an ***_(2)NPs have excellent scavenging properties for reactive oxygen species,which is why they are being considered for therapeutic *** this review,various methods of synthesis of CeO_(2)NPs are *** factors that determine the particle size and morphology of these materials are important for biomedical and dental *** is given to preparation methods and variables such as calcination temperature,which have a profound effect on particle size and *** article also presents various applications of CeO_(2)NPs in the biomedical and dental fields.

关键词： Cerium oxide nanoparticles Synthesis Antibacterial activity Biomedical applications Dental applications Rare earths

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of high-frequency loading and parathyroid hormone administration on peri-implant bone healing and osseointegration

引用

International Journal of Oral Science 2018年第1期10卷 50-64页

作者： Aya Shibamoto Toru Ogawa Joke Duyck Katleen Vandamme Ignace Naert Keiichi Sasaki division of Advanced Prosthetic dentistry Tohoku University Graduate School of Dentistry Department of Oral Health Sciences Prosthetic DentistryBIOMAT-BiomaterialsKatholieke Universiteit Leuven

The objective of this study is to examine the effect of low-magnitude, high-frequency(LMHF) loading, and anti-osteoporosis medications such as parathyroid hormone(PTH) and bisphosphonates on peri-implant bone healing in an osteoporosis model, and to assess their combined effects on these processes. Thirteen-week-old ovariectomized rats(n = 44) were divided into three groups:PTH, alendronate, and saline. After 3 weeks of drug administration, titanium implants were inserted into the tibiae. Each group was subdivided into two groups: with or without LMHF loading via whole-body vibration(50 Hz at 0.5 g, 15 min per day, 5 days per week). Rats were killed 4 weeks following implantation. Removal torque test, micro-CT analyses(relative gray(RG) value, water = 0,and implant = 100), and histomorphometric analyses(bone-to-implant contact(BIC) and peri-implant bone formation(bone volume/tissue volume(BV/TV))) were performed. Removal torque values and BIC were significantly differed by loading and drug administration(ANOVA). Post hoc analysis showed that PTH-treated groups were significantly higher than the other drug-treated groups. BV/TV was significantly enhanced by PTH administration. In cortical bone, RG values were significantly increased by *** trabecular bone, however, RG values were significantly increased by PTH administration. These findings suggest that LMHF loading and PTH can act locally and additively on the bone healing process, improving the condition of implant osseointegration.

关键词：

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：