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The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan Sun Lingyun Nie Jing Zhang Xue Fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

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Liver transplantation for recurrent hepatic adenoma

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World Journal of Hepatology 2013年第3期5卷 145-148页

作者： Giovanni Vennarecci Roberto Santoro Mario Antonini Cecilia Ceribelli Andrea Laurenzi Enrico Moroni Mirco Burocchi Pasquale Lepiane Giuseppe Maria Ettorre division of Liver Transplantation San Camillo Hospital Intensive Care Unit National Institute for Infectious Disease "Lazzaro Spallanzani"

Hepatic adenoma (HA) is a rare indication for liver transplantation (LTx). So far 20 cases of LTx for HA are reported in PubMed. In rare cases HA presents as multiple hepatic adenomas or recurrent adenoma after initial liver resection and in such cases LTx is the only potential cure and prevents the risk of bleeding or cancer transformation into hepatocellular carcinoma. We report the case of a 56 years old lady who underwent a left hepatectomy for giant adenoma in 2005 and resection of segment Ⅴ-Ⅵ for recurrence of liver adenoma in 2007. She developed a second recurrence of HA with 3 new lesions in the right liver in 2008. The patient underwent LTx. After 3 years the patient is alive with no evidence of disease. LTx is indicated in patients with HA in which resection is not technically feasible.

关键词： Liver transplantation Liver adenoma Liver resection Recurrent disease Immunosuppression

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Comparative Study on the Immunogenicity and Efficacy of Different Post-exposure Intramuscular Rabies Vaccination Regimens in China

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Biomedical and Environmental Sciences 2024年第2期37卷 178-186页

作者： SONG Yun HE Ying LU Xue Xin ZHANG Xiao Mei JIANG XIAO Lin SONG Qing HUANG Xue Yong MA Hong Xia YU Peng Cheng ZHU Wu Yang Henan Provincial Center for disease Control and Prevention Infectious Disease Prevention and Control InstituteHenan Provincial Key Laboratory of Infectious Disease PathogensZhengzhou 450000HenanChina National Institute for Viral disease Control and Prevention China CDCKey Laboratory of BiosafetyNational Health CommissionBeijing 102206China Shandong Provincial Center for disease Control and Prevention Jinan 250014ShandongChina Qingdao Chengyang District Center for disease Control and Prevention Qingdao 266108ShandongChina

Objective This study aimed to compare the current Essen rabies post-exposure immunization schedule(0-3-7-14-28)in China and the simple 4-dose schedule(0-3-7-14)newly recommended by the World Health Organization in terms of their safety,efficacy,and *** Mice were vaccinated according to different immunization schedules,and blood was collected for detection of rabies virus neutralizing antibodies(RVNAs)on days 14,21,28,35,and 120after the first ***,different groups of mice were injected with lethal doses of the CVS-11 virus on day 0,subjected to different rabies immunization schedules,and assessed for morbidity and death *** a clinical trial,185 rabies-exposed individuals were selected for post-exposure vaccination according to the Essen schedule,and blood was collected for RVNAs detection on days 28and 42 after the first *** A statistically significant difference in RVNAs between mice in the Essen and 0-3-7-14 schedule groups was observed on the 35th day(P0.05)in RVNAs levels at any time *** post-exposure immune protective test showed that the survival rate of mice in the control group was 20%,whereas that in the immunization groups was 40%.In the clinical trial,the RVNAs positive conversion rates on days 28(14 days after 4 doses)and 42(14 days after 5 doses)were both 100%,and no significant difference in RVNAs levels was observed(P>0.05).Conclusion The simple 4-dose schedule can produce sufficient RVNAs levels,with no significant effect of a delayed fourth vaccine dose(14–28 d)on the immunization potential.

关键词： Rabies Post-exposure immunization Essen regimen RVNAs

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Negative conversion of autoantibody profile in chronic hepatitis B:A case report

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World Journal of Clinical Cases 2021年第5期9卷 1196-1203页

作者： Xun Zhang Qin-Xiu Xie Dong-Mei Zhao Department of infectious disease The Fourth Affiliated Hospital of Anhui Medical UniversityHefei 230012Anhui ProvinceChina Department of infectious disease The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina

BACKGROUND Autoimmune antibodies are detected in many *** infections are accompanied by several immunopathological *** autoimmune antibodies have been associated with the immune response induced by virus or ***,a comprehensive diagnosis of chronic hepatitis B combined with autoimmune hepatitis is required,and immunosuppressant or antiviral therapy should be carefully *** SUMMARY We present a case of a patient who had negative transformation of autoimmune antibodies during chronic active hepatitis B.A 50-year-old female who had a history of asymptomatic hepatitis B virus carriers for more than 10 years presented to the hospital with the complaint of weakness for 1 *** tests revealed elevated liver enzymes;the detection of autoantibodies was *** B viral load was 72100000 IU/*** patient started tenofovir alafenamide fumigate 25 mg *** biopsy was performed,which was consistent with chronic active hepatitis *** final diagnosis of the case was chronic active hepatitis *** autoimmune antibodies turned negative after 4 wk of antiviral *** patient recovered and was discharged with normal liver *** was no appearance of autoantibodies,and liver function was normal at regular *** Autoimmune antibodies may appear in patients with chronic active *** is necessary to differentiate the diagnosis with autoimmune hepatitis.

关键词： Autoantibodies Autoimmune hepatitis Chronic hepatitis B Immune responses Case report

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Updated Guidelines for the Diagnosis of Human Brucellosis—China,2019

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China CDC weekly 2020年第26期2卷 487-489页

作者： Hai Jiang Lan Feng Jinxing Lu State Key Laboratory for infectious disease Prevention and Control Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesNational Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina

Brucellosis is a neglected infection that has a widespread geographic *** on an evaluation from the World Health Organization(WHO),brucellosis cases have been reported in more than 170 countries with about 500,000 new cases being reported each ***,the actual number of brucellosis patients is much higher,and it is believed to be approximately 10–25 times the number of reported cases(1).

关键词： cases distribution. neglected

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Effects of Lactobacillus paracasei N1115 on gut microbial imbalance and liver function in patients with hepatitis B-related cirrhosis

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World Journal of Gastroenterology 2024年第11期30卷 1556-1571页

作者： Yan-Chao Hu Xiang-Chun Ding Hui-Juan Liu Wan-Long Ma Xue-Yan Feng Li-Na Ma Department of infectious disease General Hospital of Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina infectious disease Clinical Research Center of Ningxia Yinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Hepatitis B cirrhosis(HBC)is a chronic disease characterized by irreversible diffuse liver damage and aggravated by intestinal microbial imbalance and metabolic *** the relationship between certain single probiotics and HBC has been explored,the impact of the complex ready-to-eat Lactobacillus paracasei N1115(LP N1115)supplement on patients with HBC has not been *** To compare the changes in the microbiota,inflammatory factor levels,and liver function before and after probiotic treatment in HBC *** This study included 160 HBC patients diagnosed at the General Hospital of Ningxia Medical University between October 2018 and December *** were randomly divided into an intervention group that received LP N1115 supplementation and routine treatment and a control group that received routine treatment *** samples were collected at the onset and conclusion of the 12-wk intervention *** structure of the intestinal microbiota and the levels of serological indicators,such as liver function and inflammatory factors,were *** Following LP N1115 intervention,the intestinal microbial diversity significantly increased in the intervention group(P<0.05),and the structure of the intestinal microbiota was characterized by an increase in the proportions of probiotic microbes and a reduction in harmful ***,the intervention group demonstrated notable improvements in liver function indices and significantly lower levels of inflammatory factors(P<0.05).CONCLUSION LP N1115 is a promising treatment for ameliorating intestinal microbial imbalance in HBC patients by modulating the structure of the intestinal microbiota,improving liver function,and reducing inflammatory factor levels.

关键词： Hepatitis B cirrhosis N1115 ready-to-eat lactobacillus Inflammation Liver function Lachnospiraceae incertae sedis Probiotic

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Serological Prevalence Survey Among the High-Risk Populations of Brucellosis-Endemic Areas-China,2019−2020

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China CDC weekly 2021年第6期3卷 101-105页

作者： Shenghong Lin Zhe Wang Xinrong Liu Aizhi Yu Muhtar·Hasan Jiensi·Bayidawulieti Haitan·Aximujiang Ruiqing Li Guoxing Zheng Xinwang Liang Xiaoling Fan Biqiao Hou Xiaolong Fan Dilxat·Abuliti Lusha Shi Cuihong Zhang Yifei Wang Pengjing Ning Caixiong Liu Zhongjie Li Liping Wang division of infectious disease Key Laboratory of Surveillance and Early Warning on Infectious DiseaseChina Center for Disease Control and PreventionBeijingChina Hangzhou Center for disease Control and Prevention HangzhouZhejiangChina Datong Center for disease Control and Prevention DatongShanxiChina Huocheng Center for disease Control and Prevention YiliXinjiangChina Xinjiang Uygur Autonomous Region Center for disease Control and Prevention UrumqiXinjiangChina Yili Kazakh Autonomous Prefecture Center for disease Control and Prevention YiliXinjiangChina Yanggao Center for disease Control and Prevention DatongShanxiChina Zuoyun Center for disease Control and Prevention DatongShanxiChina Hunyuan Center for disease Control and Prevention DatongShanxiChina

What is already known about this topic?Timely screening of high-risk population is important to improve the early detection of brucellosis among the endemic areas during the high incidence seasons,which is also required by the National Brucellosis Prevention and Control Plan(2016–2020)(NBPCP).What is added by this report?Seroepidemiological characteristics of brucellosis in high-risk populations were obtained and special occupational populations were *** seroprevalence of brucellosis has been decreasing compared with that reported in the recent years due to the ongoing implementation of control measures in endemic *** are the implications for public health practice?Special occupational populations could be promptly detected using routine screening,which makes it possible to initiate standardized treatment for infected patients as early as *** also reminds us to pay attention to special occupational populations to improve their knowledge of brucellosis and reduce the risk of infection.

关键词： Population Brucellosis incidence

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Seroconversion of HBsAG coincides with hepatitis A superinfection: A case report

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World Journal of Clinical Cases 2020年第9期8卷 1651-1655页

作者： Claudia Beisel Marylyn M Addo Julian Schulze zur Wiesch Department of Internal Medicine Division of Infectious DiseaseUniversity Medical Center Hamburg-EppendorfHamburg 20251Germany German Center for Infection Research Hamburg 20251Germany

BACKGROUND Hepatitis B virus(HBV)is a hepatotropic virus that can cause acute and chronic liver *** to the world health organization 257 million people are infected with chronic HBV infection ***-infection with other hepadnaviruses,including hepatitis A virus(HAV),hepatitis C virus,hepatitis D virus,and hepatitis E virus is associated with increased risk of acute liver failure in patients with chronic *** SUMMARY Here,we report a case of a 47-year old male patient with HBV-related compensated Child A cirrhosis,who presented with general fatigue,malaise and laboratory signs of acute *** the patient was regularly seen at a specialized university liver unit,the HAV vaccination status was *** HAV super-infection was diagnosed by positive serological and polymerase chain reaction *** acute HAV super-infection,spontaneous HBsAg elimination and development of an anti-HBs titer were *** This case illustrates the importance of carefully checking the vaccination *** our patient,unspecific immunological responses to HAV led to functional cure of HBV.

关键词： Chronic hepatitis B infection Liver cirrhosis Acute hepatitis A infection HBsAg clearance Functional cure Case report

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Clinical Characteristics of H1N1 Influenza A-Associated Mild Encephalopathy with Reversible Splenial Lesion: 4 Pediatric Cases

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Current Medical Science 2021年第4期41卷 815-820页

作者： Xu-fang LI Bin AI Jia-wei YE Li-mei TAN Hua-mei YANG Chun-xiao FANG Lan-hui SHE Yi XU Department of infectious disease Guangzhou Women and Children's Medical CenterGuangzhou 510000China

Objective Mild encephalopathy with reversible splenial lesion(MERS)is associated with a variety of infections and anti-epileptic drug *** we report the clinical characteristics of H1N1 influenza A-associated MERS based on our experience of four pediatric *** A detailed retrospective analysis of four patients with H1N1 influenza A-associated MERS was performed at Guangzhou Women and Children’s Medical *** All patients exhibited mild influenza-like illness and *** patients presented with a new-onset seizure with fever after 5 years of age.75%patients had altered mental *** all four patients,influenza A(H1N1)viral RNA was detected in throat swab specimens at least *** magnetic resonance images revealed similar ovoid lesions in the corpus callosum,mainly in the splenium and for one patient in the splenium and genu of the corpus *** one patient had an abnormal electroencephalogram *** and protein in the cerebrospinal fluid were normal in all *** patients received oseltamivir and one patient received intravenous *** a result,all patients fully recovered after 2 months and showed no neurologic sequelae at *** This case series provides insight towards clinical features of H1N1 influenza A-associated MERS.

关键词： mild encephalopathy with reversible splenial lesion H1N1 influenza A children corpus callosum encephalopathy

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An Update on the Efficacy and Functionality of Probiotics for the Treatment of Non-Alcoholic Fatty Liver disease

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Engineering 2021年第5期7卷 679-686页

作者： Mingfei Yao Lingling Qv Yanmeng Lu Baohong Wang Björn Berglund Lanjuan Li State Key Laboratory for Diagnosis and Treatment of infectious disease National Clinical Research Center for Infectious DiseaseCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003China Department of Clinical and Experimental Medicine Linköping UniversityLinköping SE 58183Sweden

Non-alcoholic fatty liver disease(NAFLD),which has a global prevalence of 20%–33%,has become the main cause of chronic liver *** for lifestyle medication,no definitive medical treatment has been established so far,making it urgent to find effective strategies for the treatment of *** the identification of the significant role played by the gut microbiota in the pathogenesis of NAFLD,studies on probiotics for the prevention and treatment of NAFLD are increasing in *** from the Bifidobacterium and Lactobacillus genera constitute the most widely used traditional *** recently,emerging next-generation probiotics(NGPs)such as Akkermansia muciniphila and Faecalibacterium prausnitzii have also gained attention due to their potential as therapeutic options for the treatment of *** review provides an overview of the effects of oral administration of traditional probiotics and NGPs on the development and progress of *** mechanisms by which probiotics directly or indirectly affect the disease are illustrated,based on the most recent animal and clinical *** numerous studies have been published on this topic,further research is required to comprehensively understand the specific underlying mechanisms among probiotics,gut microbiota,and NAFLD,and additional large-scale clinical trials are required to evaluate the therapeutic efficacy of probiotics for the treatment of NAFLD,as well as the safety of probiotics in the human body.

关键词： Non-alcoholic fatty liver disease(NAFLD) Gut microbiota Probiotics Next-generation probiotics(NGPs)

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