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Textural and geochemical characteristics of late Pleistocene to Holocene fine-grained deep-sea sediment cores(GM6 and GM7),recovered from southwestern Gulf of Mexico

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Journal of Palaeogeography 2018年第3期7卷 253-271页

作者： Abigail Anaya-Gregorio John S.Armstrong-Altrin Marfa Luisa Machain-Castillo Patricia C.Montiel-Garcia Mayla A.Ramos-Vazquez Licenciatura en Ingenieria en Geologia Ambiental Area Academica de Ciencias de la Tierra y MaterialesUniversidad Autonoma del Estado de HidalgoMineral de la ReformaHidalgoMexico. Instituto de Ciencias del Mary Limnologia Universidad Nacional Autenoma de MexicoUnidad de Procesos Oceanicos y CosterosCiudad Universitaria04510 Ciudad de MexicoMexico. Area Academica de Ciencias de la Tierra y Materiales Universidad Autonoma del Estado de HidalgoCiudad UniversitariaCarretera Pachuca-Tulancingo Km 4.5Col.CarbonerasC.P.42184 Mineral de la ReformaHidalgoMexico. posgrado en Ciencias del Mary Limnologia Universidad Nacional Autonoma de MexicoCiudad Universitaria3000CoyoacanC.P.04510 Ciudad de MexicoMexico.

Texture, mineralogy, geochemistry, and 14C ages of two deep-sea sediment cores （GM6 and GM7） recovered in the southwestern Gulf of Mexico were investigated to infer their provenance and depositional condition. The sediments are enriched in fine-grained silt and clay and poor in sand content. Mineralogically, the sediments consist of quartz, calcite, smectite, and kaolinite. Based on the ]4C data, the age of the GM6 and GM7 sediment cores were calculated as 23,615 cal yrs. BP and 19,007 cal yrs. BP, respectively. The weathering indices such as chemical index of alteration （CIA）, chemical index of weathering （CIW）, and plagioclase index of alteration （PIA） in GM6 （56-69, 60-74, and 6]-73, respectively） and GM7 （54-69, 57-76, and 55-74, respectively） cores revealed a moderate-to-high intensity of weathering. The rare earth element （REE） patterns suggested that the sediments were derived mostly by the weathering of intermediate rocks, exposed along the coastal regions of the Gulf of Mexico. The trace elemental ratios like V/Cr （〈2）, ni/Co （〈2）, and Cu/Zn （〈1）, authigenic uranium content （〈1）, and Ce anomaly （Ce/Ce＊ ≤1） suggested that the sediments were deposited under an oxic condition, which was also revealed by the benthic foraminiferal assemblages throughout the GM6 and GM7 sediment cores.

关键词： Radiocarbon age Manganosite Weathering Palaeoredox condition Provenance Holocene Gulf of Mexico

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Effectiveness of Opuntia ficus-indica mucilage as a carrier agent in microencapsulation of bioactive compounds of Amaranthus hypochondriacus var. nutrisol

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Food Bioscience 2023年第2期52卷 468-478页

作者： Danger Tabio-Garcia Francisco Paraguay-delgado Daniel Lardizabal Gutierrez Armando Quintero-Ramos Carmen O.Melendez-Pizarro Luz A.Ochoa-Martinez Miguel A.Sanchez-Madrigal Martha G.Ruiz-Gutierrez Jose C.Espinoza-Hicks Universidad Autonoma de Chihuahua Facultad de Ciencias QuimicasCircuito Universitario s/nCampus Universitario#2ChihuahuaChihuahuaC.P.31125Mexico Centro de investigacion en Materiales Avanzados S.C. CIMAVMiguel de Cervantes 120ChihuahuaChihuahuaC.P.31136Mexico Tecnologico nacional de Mexico/IT de Durango Division de Estudios de Posgrado de InvestigacionBlvdFelipe Pescador 1830 OteColonia Nueva VizcayaC.P.34080DurangoDgoMexico

The effectiveness of maltodextrin(10%)and cactus mucilage(CM)(0%,0.25%,0.50%,0.75%,and 1%)as carrier agents was evaluated in the encapsulation of bioactive amaranth *** drying,an efficient encapsulation method,achieved high yields(62.9%-68%).The increase in CM concentration significantly augmented the water absorption index(WAI),bulk density,and hygroscopicity of the encapsulated amaranth ***,it significantly decreased the moisture content,water activity,and water solubility index(WSI).The glass transition temperatures(>40℃),Hausner ratio(HR),and Carr’s index(CI)values indicated the suitability of powders for handling and ***,no cracks were observed in the microcapsules surface,which favoured the bioactive amaranth compounds retention and ***,low degradation rate constants and long half-life time values were determined for the encapsulated amaranth powders,indicative of its storage *** of 0.75%CM was an efficient concentration to achieve high percentage retention of betacyanins(55.5%),betaxanthins(58%),total polyphenols(73.3%),amaranthine(56.8%),isoamaranthine(62.7%),individual polyphenols(44.6%-81%),and antioxidant activity(79.6%).These results demonstrated the efficiency of CM as an encapsulating agent in the food industry.

关键词： Amaranth Betalains Polyphenols Cactus Mucilage Microencapsulation

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Phytochemical Composition, Anti-Inflammatory and Cytotoxic Activities of Chloroform Extract of <i>Senna crotalarioides</i>Kunth

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American Journal of Plant Sciences 2021年第6期12卷 887-900页

作者： Roberto Serrano-Vega Salud Pérez-Gutiérrez Francisco Alarcón-Aguilar Julio Almanza-Pérez Cuauhtémoc Pérez-González Marco Martín González-Chávez departamento de Sistemas Biológicos Universidad Autónoma Metropolitana-Xochimilco Mexico City México departamento de Ciencias de la Salud Universidad Autónoma Metropolitana-Iztapalapa Mexico City México Facultad de Ciencias Químicas Centro de Investigación y Estudios de Posgrado Universidad Autónoma de San Luis Potosí Zona Universitaria San Luis Potosí México

Senna crotalarioides is used in traditional medicine to treat inflammation. The aim of this work was to investigate the anti-inflammatory and cytotoxic activities and the possible mechanism of action of the chloroform extract washed with hexane of S. crotalarioides (CESC). The anti-inflammatory effect was tested on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema in mice. The levels of TNF-α, IL-1β, IL-6 and IL-10 were determined in macrophages J774A.1 stimulated by lipopolysaccharide (LPS). The cytotoxic activity was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay against six human cancer cell lines: HeLa (cervical cancer), SKLU-1 and A549 (lung cancer), LNCaP (prostate cancer), SW620 (colon cancer) and MCF7 (breast cancer). The composition of the CESC was determined by GC-MS analysis, and standardized by HPLC-ELSD with ursolic acid as the phytochemical marker. CESC inhibited ear edema 61.45%. In chronic ear edema, CESC diminished the inflammation by 53.77%. CESC decreased TNF-α, IL-1β and IL-6 concentrations, and increased the concentration of IL-10. The extract showed IC50n style="font-family:Verdana;"> values on HeLa, SKLU-1, A549, LnCaP, SW620 and MCF7 b

关键词： Senna crotalarioides Anti-Inflammatory Ursolic Acid Composition Cytotoxic

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Lignin in storage and renewable energy applications： A review

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Journal of Energy Chemistry 2018年第5期27卷 1422-1438页

作者： Jose Luis Espinoza-Acosta Patricia I. Torres-Chavez Jorge L. Olmedo-Martinez Alejandro Vega-Rios Sergio Flores-Gallardo E. Armando Zaragoza-Contreras department of Engineering and Materials Chemistry Centro de Investigacion en Materiales Avanzados Miguel de Cervantes # 120. Complejo Industrial Chihuahua Chihuahua Mexico departamento de investigacion y posgrado en Alimentos (DIPA) Universidad de Sonora Hermosillo Sonora Mexico

Lignin is a cheap, abundant and non-toxic group of complex phenolic polymers obtained in large amounts from the papermaking and cellulosic biofuel industries. Although the application of lignin has been ex- plored in these and several more industries, there are limited applications of lignin in the energy industry. However, numerous research revealed a great interest in the exploration of this renewable biopolymer in storage energy devices. Some of these applications include the use of lignin as an expander for lead-acid batteries, electrodes for primary and rechargeable batteries, electrodes for electronic double layer capac- itors and electrochemical pseudocapacitors, and to feed different types of fuel cells. The use of lignin in energy storage devices improves not only the performance of these devices but also decreases the price and toxicity, contributing to obtaining greener energy devices. Based on the above, this review provides an overview of the main research work related to the use of lignin as a renewable component, suitable to replace some synthetic and toxic compounds used in the fabrication of energy storage devices with particular emphasis on batteries, advanced supercapacitors, and solar and fuel cells.

关键词： Lignin Batteries Lithium-ion batteries Supercapacitors Solar cells Fuel cells

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Geophysical Modeling with Satellite Gravity Data: Eigen-6C4 vs. GGM Plus

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Engineering（科研） 2021年第12期13卷 690-706页

作者： Miguel Camacho Román Alvarez posgrado en Ciencias de la Tierra Universidad Nacional Autónoma de México Mexico City Mexico Román Alvarez Instituto de Investigaciones en Matemáticas Aplicadas y en Sistemas (IIMAS) Universidad Nacional Autónoma de México CDMX Mexico City Mexico

Satellite data sets are an asset in global gravity collections;their characteristics vary in coverage and resolution. new collections appear often, and the user must adapt fast to their characteristics. Their use in geophysical modeling is rapidly increasing;with this in mind we compare two of the most densely populated sets: EIGEn-6C4 and GGMplus. We characterize them in terms of their frequency histograms, Free Air anomalies, power spectrum, and simple Bouguer anomalies. The nature of the digital elevation models used for data reduction is discussed. We conclude that the GGMplus data set offers a better spatial resolution. To evaluate their effect in geophysical modelling, we chose an inland region with a prominent volcanic structure in which we perform 3D inversions of the respective Bouguer anomalies, obtaining density variations that in principle can be associated with the geologic materials and the structure of the volcanic edifice. Model results are analyzed along sections of the inverted data;we conclude that the GGMplus data set offers higher resolution in the cases analyzed.

关键词： EIGEn-6C4 GGMplus Satellite Gravity Data 3D inversions nevado de Toluca

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Epigenetic basis of Alzheimer disease

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World Journal of Biological Chemistry 2020年第2期11卷 62-75页

作者： Angeles C Tecalco-Cruz JosuéO Ramírez-Jarquín María E Alvarez-Sánchez Jesus Zepeda-Cervantes Programa en Ciencias Genómicas Universidad Autónoma de la Ciudad de MéxicoMexico 03100Mexico división de neurociencias Instituto de Fisiología CelularUniversidad Nacional Autónoma de MéxicoMexico 04510Mexico posgrado en Ciencias Genómicas Universidad Autónoma de la CiudadMexico 03100Mexico Biología celular y de desarrollo Instituto de Fisiología CelularUniversidad Nacional Autónoma de MéxicoMexico 04510Mexico

Alzheimer disease(AD)is the primary form of dementia that occurs spontaneously in older ***,the epigenetic profile of the cells forming the central nervous system changes during aging and may contribute to the progression of some neurodegenerative diseases such as *** this review,we present general insights into relevant epigenetic mechanisms and their relationship with aging and *** data suggest that some epigenetic changes during aging could be utilized as biomarkers and target molecules for the prevention and control of AD.

关键词： Epigenetics Aging neurodegenerative diseases Alzheimer disease

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TRIM25:A central factor in breast cancer

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World Journal of Clinical Oncology 2021年第8期12卷 646-655页

作者： Angeles C Tecalco-Cruz María Jazmin Abraham-Juárez Helena Solleiro-Villavicencio JosuéOrlando Ramírez-Jarquín posgrado en Ciencias Genómicas Universidad Autónoma de la Ciudad de México(UACM)Mexico 03100Mexico Laboratorio nacional de Genómica para la Biodiversidad(LAnGEBIO) Unidad de Genómica AvanzadaCentro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional(CINVESTAV-IPN)Irapuato 36821Mexico Instituto de Fisiología Celular Universidad Nacional Autónoma de MéxicoMexico 04510Mexico

TRIM25 is emerging as a central factor in breast cancer due to its regulation and *** particular,it has been shown that:(1)Estrogens modulate TRIM25 gene expression;(2)TRIM25 has activity as an E3-ligase enzyme for ubiquitin;and(3)TRIM25 is also an E3 ligase for interferon-stimulated gene 15 protein in the ISGylation ***,the proteome of mammary tissue is affected by TRIM25-associated pathways,involved in tumor development and ***,we discuss the findings on the mechanisms involved in regulating TRIM25 expression and its functional relevance in breast cancer *** studies suggest that TRIM25 may be a biomarker and a therapeutic target for breast cancer.

关键词： TRIM25 Interferon-stimulated gene 15 Ubiquitin Estrogens Breast cancer

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An overview of resistance to chemotherapy in osteosarcoma and future perspectives

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Cancer Drug Resistance 2022年第3期5卷 762-793页

作者： Dorian yarih Garcia-Ortega Sara Aileen Cabrera-nieto Haydee Sarai Caro-Sanchez Marlid Cruz-Ramos Cirugia Oncologica Instituto Nacional de Cancerologia(INCAN)Ciudad de Mexico 14080Mexico posgrado en Ciencias Medicas Facultad de Ciencias de la SaludUniversidad AnahuacCiudad de Mexico 52786Mexico departamento de Patologi Instituto Nacional de Cancerologia(INCAN)Ciudad de México 14080Mexico Catedras de Consejo nacional de Ciencia y Tecnologia(COnACyT) Instituto Nacional de CancerologiaCiudad de Mexico 14080Mexico

Osteosarcoma(OS)is the most common type of bone *** the availability of multimodal treatment with surgery and chemotherapy,the clinical results remain *** main reason for the poor outcomes in patients with OS is the development of resistance to methotrexate,cisplatin,doxorubicin,and *** and cellular mechanisms associated with resistance to chemotherapy include DnA repair and cell-cycle alterations,enhanced drug efflux,increased detoxification,resistance to apoptosis,autophagy,tumor extracellular matrix,and *** versatility of cells to generate chemoresistance has motivated the use of anti-angiogenic therapy based on tyrosine kinase *** approach has shown that other therapies,along with standard chemotherapy,can improve responses to therapy in patients with ***,microRnAs may act as predictors of drug resistance in *** review provides insight into the molecular and cellular mechanisms involved in the development of resistance during the treatment of OS and discusses promising novel therapies(e.g.,afatinib and palbociclib)for overcoming resistance to chemotherapy in OS.

关键词： Osteosarcoma therapy resistance tyrosine kinase inhibitor tumoral extracellular microenvironment cell cycle

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Anaplerosis in cancer: Another step beyond the warburg effect

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American Journal of Molecular Biology 2012年第4期2卷 291-303页

作者： Estefania Ochoa-Ruiz Rodrigo Diaz-Ruiz Facultad de Medicina Programa de Posgrado en Ciencias Médicas Odontológicas y de la Salud Universidad Nacional Autónoma de México Mexico City Mexico Unidad de Genética de la nutrición Instituto de Investigaciones Biomédicas Universidad Nacional Autónoma de México Mexico City Mexico

Biosynthesis is up-regulated in tumors and thus the demand for anabolic intermediates is increased. The metabolic routes providing the building blocks for macromolecules are thus a very attractive target as they are not normally up-regulated in a normal quiescent cell. Some routes for glycolysis-derived intermediates production have been identified, but these do not constitute the whole pool of biosynthetic molecules in the cell, as many of these derive from mitochondria in the Krebs cycle. Indeed, this metabolic pathway is considered a “biosynthetic hub” from which anabolism is fed. If a metabolite efflux is indeed occurring, anaplerotic reactions must keep a steady supply of substrates. In spite of this obvious relevance of anaplerosis, it has been poorly characterized in the malignant cell context. Glutaminolysis and and pyruvate carboxylation are two pathways that function in an anaplerotic fashion. In spite of the increasing evidence implicating these two processes in cancer metabolism their role as intermediate providers is overlooked. In this review we analyze the implications of an active anaplerosis in cancer and we discuss experimental evidence showing the relevance of these metabolic routes in tumor physiology.

关键词： Anaplerosis Biosynthesis Cancer Glutaminase Krebs Cycle Metabolism Mitochondria Pyruvate Carboxylase Warburg Effect

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Hydraulic Jump in the Gulf of California

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Open Journal of Marine Science 2012年第4期2卷 141-149页

作者： David Salas-Monreal David Alberto Salas-de-Leon María Adela Monreal-Gomez Mayra Lorena Riverón-Enzástiga Erika Mojica-Ramírez Instituto de Ciencias del Mar y Limnología Mexico City Mexico Instituto de Ciencias Marinas y Pesquerias Universidad Veracruzana Veracruz Mexico posgrado en Ciencias del Mar y Limnología Mexico City Mexico

Acoustic Doppler current profiles and water density profiles were measured over the 280 m deep continental slope of the Gulf of California to elucidate the bathymetric effect on zooplankton distribution. These measurements were combined with water velocity and density simulations from the Regional Ocean Model System with and without the influence of Coriolis acceleration. The data revealed an acceleration of the near-bottom flow as it moved toward increasing depths. This acceleration was produced by the adjustment of the isopycnals to bathymetry (hydraulic jump). Zooplankton patches moved downward at the continental slope and then upward, thus exhibiting wave patterns. Model outputs without the effect of Coriolis acceleration also suggested that vertical zooplankton concentration followed a wave pattern. However, when Coriolis acceleration was added to the momentum equation, the horizontal zooplankton distribution was enhanced, which reduced the vertical zooplankton concentration observed over irregular bathymetries. Coriolis acceleration was responsible for horizontal dispersal of up to 20% of the total zooplankton concentration located over the wave trough.

关键词： Hydraulic Jump Acoustic Doppler Current Profiles Internal Waves Zooplankton Biovolumes Gulf of California

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