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The Porcine Pulmonary Surfactant Protein A (pSP-A) Immunogenicity Evaluation in the Murine Model

Pharmacology & Pharmacy 2010年第1期1卷 27-32页

作者： Sandra de Cássia Dias Fernanda Lucio dos Santos Dirce Sakauchi Dmitri Iourtov Isaias Raw Flavia Saldanha Kubrusly Engenharia de Bioprocessos-Campus Alto do Paraopeba Universidade Federal de São João Del-Rei divisão bioindustrial Instituto Butantan Centro de Biotecnologia Instituto Butantan

This paper investigated the porcine surfactant protein A (pSP-A) immunogenicity in murine model. Many elegant stu-dies about SP-A therapeutic applications are available however specific studies about its exogenous immunogenicity were not easily assumed. Therefore, we investigated the immunogenicity of this porcine protein in mice. The mice re-ceived pSP-A subcutaneously on days 0 and 7. The animals were observed during 90 days and the blood was collected on days 30, 60 and 90 for assessment the immunogenic potential of pSP-A. Some animals showed circulating antibodies above the screening cut point, which was calculated based on control mice sera signals. However, those antibodies were considered false positive read-outs by the performed competitive inhibition assay. Also no neutralizing antibodies were detected able to avoid the porcine protein ability to promote lipid aggregation. So far in this model, porcine surfactant protein-A could be considered not immunogenic.

关键词： Immunogenicity Porcine Surfactant Protein A Anti-Drug Antibody Murine Model

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