检索结果-南通市图书馆

世界核心医学期刊文摘(眼科学分册) 2005年第2期 2-3页

作者： Pambakian A.L.M.,Mannan S.K. ,Hodgson T.L. ,Kennard C. ,杨建刚 Depart ment of Sensory Motor Systems div. of neurosci. and psychol. med. Imperial Coll ege School of med.cine London United Kingdom

Objectives: We describe a novel rehabilitation tool for patients with homonymo us hemianopia based on a visual search (VS) paradigm that is portable, inexpensi ve, and easy to deploy. We hypothesised that by training patients to improve the efficiency of eye movements made in their blind field their disability would be alleviated. Methods: Twenty nine patients with homonymous visual field defects (HVFD) without neglect practised VS paradigms in 20 daily sessions over one mont h. Search fields comprising randomly positioned target and distracter elements, differing by a single feature, were displayed for three seconds on a dedicated t elevision monitor in the patients'homes. Improvements were assessed by examinin g response time (RT), error rates in VS, perimetric visual fields (VFs) and visu al search fields (VSFs), before and after treatment. Functional improvements wer e measured using objective visual tasks which represented activities of daily li ving (ADL) and a subjective questionnaire. Results: As a group the patients had significantly shorter mean RT in VS after training (P < 0.001) and demonstrated a variety of mechanisms to account for this . Improvements were confined to the training period and maint ained at follow up. Three patients had significantly longer RT after training. T hey had high initial error rates which improved with training. Patients performe d ADL tasks significantly faster after training and reported significant subject ive improvements. There was no concomitant enlargement of the VF, but there was a small but significant enlargement of the VSF. Conclusion: Patients can improve VS with practice. This usually involves shorter RTs, but occasionally a longer RT in a complex speed- accuracy trade-off. These changes translate to improved overall visual functi on, assessed objectively and subjectively, suggesting that they represent robust training effects. The underlying mechanism may involve the adoption of compensa tory eye movement strate

关键词：同侧偏盲视觉搜索

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

扫视视觉搜索训练治疗同向偏盲

引用

世界核心医学期刊文摘（神经病学分册） 2005年第2期1卷 37-37页

作者： Pambakian A.L.M. Mannan S.K. Hodgson T.L. Kennard C. 夏峰 Department of Sensory Motor Systems Div. of Neurosci. and P sychol. Med. Imperial College School of Medicine London United Kingdom

Objectives: We describe a novel rehabilitation tool for patients with homonymo us hemianopia based on a visual search (VS) paradigm that is portable, inexpensi ve, and easy to deploy. We hypothesised that by training patients to improve the efficiency of eye movements made in their blind field their disability would be alleviated. Methods: Twenty nine patients with homonymous visual field defects (HVFD) without neglect practised VS paradigms in 20 daily sessions over one mont h. Search fields comprising randomly positioned target and distracter elements, differing by a single feature, were displayed for three seconds on a dedicated t elevision monitor in the patientshomes. Improvements were assessed by examinin g response time (RT), error rates in VS, perimetric visual fields (VFs) and visu al search fields (VSFs), before and after treatment. Functional improvements wer e measured using objective visual tasks which represented activities of daily li ving (ADL) and a subjective questionnaire. Results: As a group the patients had significantly shorter mean RT in VS after training (p med.ADL tasks significantly faster after training and repo rted significant subjective improvements. There was no concomitant enlargement o f the VF, but there was a small but significant enlargement of the VSF. Conclusi on: Patients can improve VS with *** usually involves shorter RTs, but occasionally a longer RT in a complex speed accuracy trade off. These changes translate to improved overall visual function, assessed objectively and subject ively, suggesting that they represent robust training effects. The underlying me chanism may involve the adoption of compensatory eye movement strateg

关键词：同向偏盲电视监视仪代偿机制眼球运动功能改善情况随访过程搜索范围客观评估问卷调查

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Caveolae-dependent Endocytosis Is Required for Class A Macrophage Scavenger Receptor-med.ated Apoptosis in Macrophages

引用

南京医科大学学报（自然科学版） 2011年第6期31卷 863-863页

作者： Zhu, Xu-Dong Zhuang, Yan Ben, Jing-Jing Qian, Ling-Ling Huang, Han-Peng Bai, Hui Sha, Jia-Hao He, Zhi-Gang Chen, Qi Nanjing med.Univ Atherosclerosis Res Ctr Key Lab Human Funct Gertom Nanjing 210029 Peoples R China. Nanjing med.Univ Inst Reprod Med Nanjing 210029 Peoples R China Harvard Univ Sch Med Childrens Hosp Div Neurosci Boston MA 02115 USA.

SR-A (classAmacrophage scavenger receptor) is a transmembrane receptor that can bind many different ligands, including modified lipoproteins that arc relevant to the development of vascular diseases. However, the precise endocytic pathways of SR-A/med.ated ligands internalization are not fully characterized. In this study, we show that the SR-A/ligand complex can be endocytosed by both clathrin-and caveolae-dependent pathways.

关键词：跨膜受体脂蛋白血管疾病医学研究

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Glucose-regulated protein 78 inhibits scavenger receptor A-med.ated internalization of acetylated low density lipoprotein

引用

南京医科大学学报（自然科学版） 2010年第1期30卷 105-105页

作者： Ben, Jingjing Gao, Song Zhu, Xudong Zheng, Yuan Zhuang, Yan Bai, Hui Xu, Yong Ji, Yong Sha, Jiahao He, Zhigang Chen, Qi Nanjing med.Univ Atherosclerosis Res Ctr Key Lab Human Funct Genom Nanjing 210029 Peoples R China. Nanjing med.Univ Inst Reprod Med Nanjing 210029 Peoples R China Harvard Univ Childrens Hosp Sch Med Div Neurosci Boston MA 02115 USA.

Class A scavenger receptor(SR-A) plays an important role in foam cell ***, the mechanism underlying the internalization of the receptor-ligand complexes remains *** aim of the present study was to investigate the molecular mechanism to regulate SR-A-med.ated intracellular lipid accumulation in macrophages A pull-clown assay was performed.and glucoseregulated protein 78(GRP78) was identified to bind with the cytoplasmic domain of SR-A(CSR-A).Immunoprecipitation and artificially expressed protein binding assay demonstrated the direct specific binding of GRP78 with SR-A in *** immunofluorescence assay and western blot analysis showed their co-localization in membrane and ***-expression of GRP78 specifically inhibited SR-A-med.ated uptake of fluorescent acetylated low-density lipoprotein, a specific ligand for SR-A, without altering cellular SR-A expression and binding ability, and significantly inhibited cholesterol ester accumulation in cells, which can be partly attributed to the suppression of c-Jun-NH2-terminal kinase signaling *** results suggest that GRP78 may act as an inhibitor of SR-A-med.ated internalization of modified low-density lipoprotein into macrophages(C) 2009 Elsevier *** rights reserved.

关键词：受体泡沫细胞免疫沉淀蛋白质

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：