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HBV genotype C is independently associated with cirrhosis in community-based population

World Journal of Gastroenterology 2010年第3期16卷 379-383页

作者： Yin, Jian-Hua Zhao, Jun Zhang, Hong-Wei Xie, Jia-Xin Li, Wei-Ping Xu, Guo-Zhang Shen, Jie Dong, Hong-Jun Zhang, Jun Wang, Lin Han, Jian-Kang Wang, Hong-Yang Cao, Guang-Wen Second Mil Med Univ Dept Epidemiol Shanghai 200433 Peoples R China Second Mil Med Univ Affiliated Hosp 3 Dept Hepatobiliary Surg Shanghai 200438 Peoples R China Second Mil Med Univ Dept Ultrasonog Affiliated Hosp 1 Shanghai 200433 Peoples R China Municipal ctr dis control & prevent Ningbo Ningbo 315010 Zhejiang Peoples R China Municipal ctr dis control & prevent Soochow Suzhou 215007 Jiangsu Peoples R China dist ctr dis control & prevent yangpu Shanghai 200090 Peoples R China Municipal ctr dis control & prevent Huzhou Huzhou 313000 Zhejiang Peoples R China Second Mil Med Univ Lab Signal Transduct Affiliated Hosp 3 Shanghai 200438 Peoples R China

AIM:To determine the association of hepatitis B virus (HBV) genotypes with probable cirrhosis and fatty liver in community-based ***: A multi-stage cluster probability sampling method was applied to recruit 10 167 subjects aged between 6 and 72 years from our epidemiological bases in Eastern China. After excluding the subjects co-infected with hepatitis C or hepatitis D viruses, the hepatitis B surface antigen (HBsAg)-positive subjects were examined for HBV genotype, serum viral load, alanine aminotransferase (ALT), hepatitis B e antigen (HBeAg) status, and ultrasonographic changes. Logistic regression models were used to determine the factors associated with probable cirrhosis and fatty ***: Of 634 HBsAg-positive subjects with HBV genotype determined, 82 had probable cirrhosis (ultrasonographic score ≥5), 42 had ultrasonographic fatty liver. Probable cirrhosis was only found in the HBeAg-negative subjects, and more frequently found in the subjects with genotype C than in those with genotype B (14.8% vs 8.0%, P=0.018). In HBeAg-negative subjects, high viral load was frequently asso-ciated with abnormal ALT level, while ALT abnormality was more frequent in those with probable cirrhosis than those without (19.5% vs 7.8%, P=0.001). Univariate analysis showed that age, sex, HBV genotypes, and viral load were not significantly associated with ultrasonographic fatty liver, whereas ALT abnormality was significantly related to ultrasonographic fatty liver (OR=4.54,95% CI:2.11-9.75, P<0.001). Multivariate analysis demonstrated that HBV genotype C, age (≥45 years), male sex, and ALT abnormality were independently associated with probable cirrhosis (AOR=2.30,95% CI:1.26-4.19; AOR =1.81,95% CI:1.10-2.99;AOR=1.74,95% CI:1.03-2.95; AOR=2.98,95% CI:1.48-5.99, respectively).CONCLUSION: A crude prevalence of probable cirrhosis is 12.9% in the community-based HBV-infected subjects. HBV genotype C is independently associated with probable cirrhosis in the HBe

关键词： Hepatitis B virus Genotype Viral load Alanine aminotransferase Probable cirrhosis Ultrasonography

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Association between the incidence of typhoid and paratyphoid fever and meteorological variables in Guizhou, China

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Chinese Medical Journal 2012年第3期125卷 455-460页

作者： Wang Lu-xi Li Xiu-jun Fang Li-qun Wang Duo-chun Cao Wu-chun Kan Biao Beijing Inst Microbiol & Epidemiol State Key Lab Pathogen & Biosecur Beijing 100071 Peoples R China Chinese ctr dis control & prevent Natl Inst Communicable Dis Control & Prevent State Key Lab Infect Dis Prevent & Control Beijing 102206 Peoples R China Shandong Univ Sch Publ Hlth Jinan 250012 Shandong Peoples R China Changping dist ctr dis control & prevent Beijing 102200 Peoples R China

Background Typhoid/paratyphoid fever （TPF） is endemic in *** conducted wavelet analysis and Spearman＇s rank correlation analysis to explore the impact of meteorological variations on TPF infection in Guizhou,in an attempt to assess the risk factors associated with TPF *** We examined the association between TPF incidence in Guizhou and temperature,precipitation and relative humidity using 24 years of data from 1984 to *** of TPF incidence and the impact of climate factors on the TPF were detected by Spearman＇s rank correlation and wavelet analysis,Results Temperature and precipitation with a 1-month lag were positively correlated with the monthly incidence of *** multiyear incidence pattern of TPF in Guizhou was explicitly ***,the association and driving effect of precipitation on TPF were observed,and the results showed that the incidence of TPF in Guizhou had a closer correlation with precipitation than with *** Safe water supply is the key issue for TPF control in ***,climate variation might impact the enteric infections,which may inform policy assessment for TPF control in Guizhou.

关键词： typhoid/paratyphoid fever meteorological variables

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