检索结果-南通市图书馆

The septin complex links the catenin complex to the actin cytoskeleton for establishing epithelial cell polarity

Journal of Molecular Cell Biology 2021年第6期13卷 395-408页

作者： Xueying Wang Wenwen Wang Xiwei Wang Ming Wang Lijuan Zhu Fatima Garba Chuanhai Fu Barbara Zieger Xu Liu Xing Liu Xuebiao Yao MOE Key Laboratory for Membraneless Organelles&Cellular Dynamics and Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230027China Keck center for Organoids Plasticity control AtlantaGA 30310USA Anhui Key Laboratory for Cellular Dynamics&Chemical Biology and CAS center for Excellence in Molecular Cell Science Hefei 230027China Department of Pediatrics and Adolescent Medicine Division of Pediatric Hematology and OncologyMedical CenterFaculty of MedicineUniversity of Freiburg79106 FreiburgGermany

Cell polarity is essential for spatially regulating of physiological processes in metazoans by which hormonal stimulation‒secretion coupling is precisely coupled for tissue homeostasis and organ ***,the molecular mechanisms underlying epithelial cell polarity establishment remain ***,we show that septin cytoskeleton interacts with catenin complex to organize a functional domain to separate apical from basal membranes in polarized epithelial *** polarized epithelial cell monolayer as a model system with transepithelial electrical resistance as functional readout,our studies show that septins are essential for epithelial cell *** proteomic analyses discovered a novel septin‒catenin complex during epithelial cell *** functional relevance of septin‒catenin complex was then examined in three-dimensional(3D)culture in which suppression of septins resulted in deformation of apical lumen in cysts,a hallmark seen in polarity-deficient 3D cultures and ***,septin cytoskeleton stabilizes the association of adherens catenin complex with actin cytoskeleton,and depletion or disruption of septin cytoskeleton liberates adherens junction and polarity complexes into the ***,these findings reveal a previously unrecognized role for septin cytoskeleton in the polarization of the apical‒basal axis and lumen formation in polarized epithelial cells.

关键词： septin cytoskeleton cell polarity adherens junction epithelial cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sensitivity of the simulated CO2 concentration to inter-annual variations of its sources and sinks over East Asia

引用

Advances in Climate Change Research 2019年第4期10卷 250-263页

作者： FU Yu LIAO Hong TIAN Xiang-Jun GAO Hao CAI Zhao-Nan HAN Rui Climate Change Research center Chinese Academy of SciencesBeijing100029China Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution control Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and EngineeringNanjing University of Information Science and TechnologyNanjing210044China International center for Climate and Environment Sciences Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing10029China National Satellite Meteorological center China Meteorological AdministrationBeijing100081China Key Laboratory of Middle Atmosphere and Global Environment Observation.Institute of Atmospheric Physics Chinese Academy of SciencesBeijing10029China

The study on how the variations in CO2 sources and sinks can affect the CO2 concentration over East Asia would be useful to provide information for policymaker concerning carbon emission *** this study,a nested-grid version of global chemical transport model(GEOS-Chem)is employed to assess the impacts of variations in meteorological parameters,terrestrial fluxes,fossil fuel emissions,and biomass burning on inter-annual variations of CO2 concentrations over East Asia in 2004—*** CO2 concentrations are compared with observations at 14 surface stations from the World Data Centre for Greenhouse Gases(WDCGG)and satellite-derived C 02 column density(XCO,)from the Gases Observing SATellite(GOSAT).The comparison shows that the simulated CO2 column density is generally higher than that of GOSAT by 1.33×10^6(annual mean point by point biases averaged over East Asia).The model reasonably captures the temporal variations of CO2 concentrations observed at the ground-based stations,but it is likely to underestimate the peaks-to-troughs amplitude of the seasonal cycle by 50%or *** simulated surface CO2 concentration in East Asia exhibits the largest inter-annual variation in December-January—February(DJF).The regional mean absolute deviation(MAD)values over East Asia are within(4.4—5.0)×10^-6 for all *** sensitivity simulations indicate that the inter-annual variations of surface CO2 concentrations are mainly driven by variations of meteorological parameters,and partly modulated by the inter-annual variations of terrestrial fluxes and fossil fuel emissions in local *** variations of the terrestrial fluxes and fossil fuel emissions may account for〜28%of the inter-annual variation of surface CO2 concentration in southern *** inter-annual variations of the peaks-to-troughs amplitude are dependent on variations of meteorological parameters,terrestrial fluxes and fossil fuel emissions in local *** influence of biomass burning emi

关键词： Carbon dioxide Inter-annual variation Terrestrial biosphere flux Fossil fuel emission

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mosquito densovirus signifcantly reduces the vector susceptibility to dengue virus serotype 2 in Aedes albopictus mosquitoes(Diptera:Culicidae)

引用

Infectious Diseases of Poverty 2023年第3期12卷 91-92页

作者： Ling Kong Jie Xiao Lu Yang Yuan Sui Duoquan Wang Shaoqiang Chen Peiwen Liu Xiao-Guang Chen Jinbao Gu Guangdong Provincial Key Laboratory of Tropical Disease Research Depart-ment of Pathogen BiologySchool of Public HealthSouthern Medical Uni-versityGuangzhou 510515GuangdongChina Brown School Washington UniversitySt.LouisMO 63130USA National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionShanghai 200025China Shenzhen Aiming Pest control Operation Service Company Limited Shenz-henGuangdongChina

Background Dengue virus(DENV)is a major public health threat,with Aedes albopictus being the confrmed vector responsible for dengue epidemics in Guangzhou,*** densoviruses(MDVs)are pathogenic mosquitospecifc viruses,and a novel MDV was previously isolated from *** in *** study aims to determine the prevalence of MDVs in wild *** populations and investigate their potential interactions with DENV and impact on vector susceptibility for *** The prevalence of MDV in wild mosquitoes in China was investigated using open access sequencing data and PCR detection in *** in *** viral infection rate and titers in MDV-persistent C6/36 cells were evaluated at 12,24,48,72,96,and 120 h post infection(hpi)by indirect immunofuorescence assay(IFA)and real time quantitative PCR(RT-qPCR).The midgut infection rate(MIR),dissemination rate(DR),and salivary gland infection rate(SGIR)in various tissues of MDV-infected mosquitoes were detected and quantifed at 0,5,10,and 15 days post infection(dpi)by RT-PCR and *** chi-square test evaluated dengue virus serotype 2(DENV-2)and Aedes aegypti densovirus(AaeDV)infection rates and related indices in mosquitoes,while Tukey’s LSD and t-tests compared viral titers in C6/36 cells and tissues over *** The results revealed a relatively wide distribution of MDVs in Aedes,Culex,and Anopheles mosquitoes in China and an over 68%positive *** vitro,signifcant reductions in DENV-2 titers in supernatant at 120 hpi,and an appar‑ent decrease in DENV-2-positive cells at 96 and 120 hpi were *** vivo,DENV-2 in the ovaries and salivary glands was frst detected at 10 dpi in both monoinfected and superinfected *** females,while MDV super‑infection with DENV-2 suppressed the salivary gland infection rate at 15 ***-2 titer in the ovary and salivary glands of *** was reduced in superinfected mosquitoes at 15 *** MDVs is widespread in nat

关键词： DENV-2 Mosquito densovirus Superinfection Aedes albopictus Vector susceptibility

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Epidemiological Features and Spatial-Temporal Clustering of Visceral Leishmaniasis—China,2011–2022

引用

China CDC weekly 2024年第46期6卷 1201-1205页

作者： Zhengbin Zhou Zhuowei Luo Gaiqin Pan Yuanyuan Li Zhongqiu Li Qin Liu Yuwan Hao Limin Yang Zelin Zhu Qiang Wang Yi Zhang Shizhu Li National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute of Parasitic Diseases at Chinese Center for Disease Control and PreventionChinese Center for Tropical Diseases ResearchNHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Center for Tropical DiseasesNational Center for International Research on Tropical DiseasesMinistry of Science and TechnologyChina Beijing center for Disease control and Prevention BeijingChina Liaocheng People’s Hospital Liaocheng CityShandong ProvinceChina School of Global Health Chinese Center for Tropical Diseases Research-Shanghai Jiao Tong University School of MedicineShanghaiChina.

What is already known about this topic?Visceral leishmaniasis(VL),transmitted by sandflies,is a zoonotic disease of public health importance in central and western *** is added by this report?A number of VL hotspots were identified in the border areas of Shanxi-Hebei,Shanxi-Shaanxi,Gansu-Sichuan,as well as the southern Xinjiang provinciallevel administrative division(PLAD).Mountain zoonotic visceral leishmaniasis(MT-ZVL)expanded rapidly in the mountainous regions of Shaanxi,Shanxi,Henan,Hebei,Beijing,and Gansu PLADs from 2011 to 2022.A notable resurgence of MT-ZVL has occurred,with 671 cases in 66 historically endemic *** are the implications for public health practice?Actions are recommended to restrain the rapid expansion of MT-ZVL:Firstly,implement One Health approaches,such as timely diagnosis and treatment of patients,promoting insecticide-impregnated dog collars,and restraining the number of dogs in endemic ***,surveillance-response systems for sandflies and infective dogs in potential risk areas should be strengthened.

关键词： restrain expanded Spatial

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Impacts of a comprehensive tuberculosis control model on the quality of clinical services and the financial burden of treatment for patients with drug-resistant tuberculosis in China:a mixed-methods evaluation

引用

Infectious Diseases of Poverty 2021年第2期10卷 92-93页

作者： Wei-Xi Jiang Zhi-Peng Li Qi Zhao Meng-Qiu Gao Qian Long Wei-Bing Wang Fei Huang Ni Wang Sheng-Lan Tang 不详 National center for Tuberculosis control and Prevention China CDCNo.27 Nanwei RoadXicheng DistrictBeijing 100050China Duke Global Health Institute Duke University310Trent DriveDurhamNC 27710USA

Background:The China National Health Commission-GatesTB Project Phase III implemented a comprehensive TB control model including multiple interventions to address the burden of drug-resistant TB(DRTB).This study aims to evaluate the quality of DRTB clinical services and assess the financial burden of DRTB patients during the intervention period.

关键词： Drug-resistant tuberculosis Quality of health services Financial burden

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Numerical Analysis of Space Charge Characteristics in Low-density Polyethylene Nanocomposite Under External DC Electric Field

引用

高电压技术 2013年第8期39卷 1813-1820页

作者： ZHOU Yuanxiang ZHANG Ling SHA Yanchao TIAN Jihuan State Key Laboratory of control and Simulation of Power System and Generation Equipments Tsinghua University Beijing 100084 China ABB Corporate Research center Beijing 100015 China

The dynamic characteristics of space charge in nanocomposite of low-density polyethylene (LDPE) mixed with inorganic nano- fillers. Different from previous qualitatively theoretical works, we investigated the influence of trap depth, trap volume charge density and injection barrier height on the space charge and the electric field distribution in the nanocomposite under a DC external electric field (100 MV/m) systematically and quantificationally, through numerical simulations based on a bipolar charge transport model. The simulation re- sults showed that, the increase of trap depth would severely distort the balanced electric field distribution with the highest and the lowest electric field of 119 MV/m and 47 MV/m, respectively. It is concluded that the introduction of nanofillers creates more deep traps, which would block space charges by capturing most of them in the vicinity of electrode and hence reduce the local electric field largely. Further theoretical analysis of the simulation indicates that both the high permittivity and the low local electric field of the nanocomposite contri- buted to the increase of injection barrier height, and almost no charge could overcome an injection barrier higher than 1.25 eV. At last, a mechanism of space charge suppression in the LDPE nanocomposite was presented.

关键词：纳米复合材料低密度聚乙烯直流电场空间电荷电荷特性数值分析无机纳米填料陷阱深度

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A New Coumarin-Based Fluorescent pH Probe

引用

Journal of Donghua University(English Edition) 2015年第5期32卷 787-791页

作者：李洪启方宁张学斌杨一航周志鹏宋燕西丛培红 College of Chemistry Chemical Engineering & BiotechnologyDonghua University School of Environmental Science and Engineering State Environmental Protection Engineering Center for Pollution Treatment and Control in Textile IndustryDonghua University State Key Laboratory of Molecular Engineering of Polymers Fudan University

A new iminocoumarin-derived colorimetric and fluorescent pH probe was developed for rapid and sensitive detection of pH changes in biological and environmental media. With the decrease of pH value( from 6. 24 to 3. 00),an obvious color change of the probe in ethanol-water solution from green to yellow was observed under nature light. The intensity of the maximum fluorescence emission peak of the probe decreased gradually with the acidity increase of the solution. While the fluorescence intensity of the emission peak of the probe did not exhibit distinct change when pH was less than 11. 00 and the fluorescence was almost quenched at pH 13. 50. Sensitivity of the fluorescent pH probe was not interfered by the presence of common metal cations and anions.

关键词： pH probe fluorescence colorimetric iminocoumarin

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Simulating potential outbreaks of Delta and Omicron variants based on contact-tracing data:A modelling study in Fujian Province,China

引用

Infectious Disease Modelling 2023年第1期8卷 270-281页

作者： Yichao Guo Wenjing Ye Zeyu Zhao Xiaohao Guo Wentao Song Yanhua Su Benhua Zhao Jianming Ou Yanqin Deng Tianmu Chen State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics School of Public HealthXiamen UniversityXiamen City361102Fujian ProvincePR China Fujian Provincial center for Disease control and Prevention Fujian ProvincePR China

Although studies have compared the relative severity of Omicron and Delta variants by assessing the relative risks,there are still gaps in the knowledge of the potential COVID-19 burden these variations may *** the contact patterns in Fujian Province,China,have not been *** identified 8969 transmission pairs in Fujian,China,by analyzing a contact-tracing database that recorded a SARS-CoV-2 outbreak in September *** estimated the waning vaccine effectiveness against Delta variant infection,contact patterns,and epidemiology distributions,then simulated potential outbreaks of Delta and Omicron variants using a multi-group mathematical *** instance,in the contact setting without stringent lockdowns,we estimated that in a potential Omicron wave,only 4.7%of infections would occur in Fujian Province among individuals aged>60 *** comparison,58.75%of the death toll would occur in unvaccinated individuals aged>60 *** with no strict lockdowns,combining school or factory closure alone reduced cumulative deaths of Delta and Omicron by 28.5%and 6.1%,*** conclusion,this study validates the need for continuous mass immunization,especially among elderly aged over 60 years *** it confirms that the effect of lockdowns alone in reducing infections or deaths is ***,these measurements will still contribute to lowering peak daily incidence and delaying the epidemic,easing the healthcare system's burden.

关键词： Contact tracing Vaccine effectiveness Variant of concern Mathematical model COVID-19

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Quality control indices for standardized diagnosis and treatment of esophageal cancer in China (2022 edition)

引用

Journal of the National Cancer center 2023年第3期3卷 167-174页

作者： Ruixiang Zhang Zhen Wang Xiaozheng Kang Xin Wang Bo Zhang Hoi-loi Ng Liyan Xue Wenjing Yang Liming Shi Hui Wang Lvhua Wang Yin Li Esophageal Cancer Quality control Expert Committee of the National Cancer center#1 Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Radiotherapy National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Endoscopy National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Cancer Diagnosis and Treatment Quality control Office National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Esophageal cancer(EC)is particularly common in *** the continuing progress of multi-disciplinary therapy including early screening,minimally invasive techniques,radiotherapy and chemotherapy,the 5-year survival of EC has been improved in ***,there are considerable disparities in the diagnosis and treatment quality among different *** Esophageal Cancer Expert Committee of the National Cancer Quality control center(NCQCC)considers a set of authoritative quality control standards as an opportunity to eliminate the disparities and improve the overall survival and quality of life of *** further promote the quality control for standardized diagnosis and treatment of EC,the National Cancer center commissioned the Esophageal Cancer Quality control Expert Committee to draft and formulate the Chinese Quality control Indices for Standardized Diagnosis and Treatment of Esophageal Cancer(2022 edition).The Indices includes 21 items that cover all key areas in the diagnosis and treatment of esophageal cancer,such as medical oncology,radiation oncology,endoscopy,and pathology.

关键词： Esophageal cancer Standardized diagnosis and treatment Quality control index

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oxygen adatoms and vacancies on the (110) surface of CeO2

引用

Science China(Technological Sciences) 2018年第1期61卷 135-139页

作者： HUANG JingLu YU YunBo ZHU Jing YU Rong National center for Electron Microscopy in Beijing Key Laboratory of Advanced Materials of Ministry of Education of China State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and Engineering Tsinghua University Beijing 100084 China State Key Joint Laboratory of Environment Simulation and Pollution control Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China center for Excellence in Regional Atmospheric Environment Institute of Urban Environment Chinese Academy of Sciences Xiamen 361021 China University of Chinese Academy of Sciences Beijing 100049 China

The behavior of oxygen on ceria surfaces is closely related with the applications of ceria as a catalyst and oxygen conductor in solid-oxide fuel cells. Here, the atomic configurations of oxygen adatoms and vacancies on the(110) surface of CeO_2 have been studied combining aberration-corrected transmission electron microscopy and first-principles calculations. The oxygen adatoms were estimated to be located on top of Ce atoms with 50% coverage, forming a c(2×2) reconstruction. The oxygen vacancies can form stable configuration, with the Ce atoms partly reduced.

关键词： surface structure ceria oxygen adatoms oxygen vacancies aberration-corrected TEM first-principles calculations

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：