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Effects of acupuncture and moxa treatment in patients with semen abnormalities

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Asian Journal of Andrology 2003年第4期5卷 345-348页

作者： Edson Gurfinkel Agnaldo P.Cedenho Ysao Yamamura Miguel Srougi Human Reproduction Division discipline of urology Sao Paulo Federal University Paulista School of Medicine Sao Paulo BrazilHuman Reproduction Division Discipline of Urology Sao Paulo Federal University Paulista School of Medicine Sao Paulo BrazilHuman Reproduction Division Discipline of Urology Sao Paulo Federal University Paulista School of Medicine Sao Paulo BrazilHuman Reproduction Division Discipline of Urology Sao Paulo Federal University Paulista School of Medicine Sao Paulo Brazil

Aim: To evaluate the effect of Chinese Traditional Medicine, acupuncture and moxa treatment, on the semen quality in patients with semen abnormalities. Methods: In a prospective, controlled and blind study, nineteen patients, aged 24 years-42 years and married for 3 years-11 years without children with semen abnormalities in concentration, morphology and/or progressive motility without apparent cause, were randomized into two groups and submitted to acupuncture and moxa treatment at the therapeutic (Study Group) and the indifferent points (Control Group), respectively, for 10 weeks. Semen analyses were performed before and after the treatment course. Results: The patients of the Study Group presented a significant increase in the percentage of normal-form sperm compared to the Control Group (calculated U=16.0, critical U=17.0). Conclusion: The Chinese Traditional Medicine acupuncture and moxa techniques significantly increase the percentage of normal-form sperm in infertile patients with oligoastenoteratozoospermia without apparent cause.

关键词： acupuncture Chinese traditional medicine infertility moxibustion oligozoospermia teratozoospermia semen

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Primary Ewing＇s sarcoma/primitive neuroectodermal tumor of the urogenital tract in children

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Chinese Medical Journal 2012年第5期125卷 932-936页

作者： SONG Hong-cheng SUN Ning ZHANG Wei-ping HUANG Cheng-ru National Key discipline of Pediatrics Ministry of EducationDepartment of UrologyBeijing Children's HospitalCapital Medical UniversityBeijing 100045China

Background Primary Ewing＇s sarcoma/primitive neuroectodermal tumor （ES/PNET） of urogenital tract is a rare condition with non-specific clinical presentations, which can make it difficult to diagnose. In this study,... 详细信息

关键词： children Ewing's sarcoma primitive neuroectodermal tumor urogenital tract

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Clinical outcomes for men with positive surgical margins after radical prostatectomy—results from the South Australian Prostate Cancer Clinical Outcomes Collaborative community-based registry

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Asian Journal of urology 2023年第4期10卷 502-511页

作者： Kerri R.Beckmann Michael E.O'Callaghan Andrew D.Vincent Kim L.Moretti Nicholas R.Brook Cancer Epidemiology and Population Health Research University of South AustraliaAdelaideAustralia Translational Oncology and urology Research Division of Pharmaceutical and Cancer StudiesKings College LondonLondonUK South Australian Prostate Cancer Clinical Outcomes Collaborative Flinders Medical CentreAdelaideAustralia The Freemason's Foundation Centre for Men's Health Adelaide Medical SchoolUniversity of AdelaideAdelaideAustralia discipline of Surgery University of AdelaideAdelaideAustralia Department of urology Royal Adelaide HospitalAdelaideAustralia

Objective Positive surgical margins(PSMs)after radical prostatectomy(RP)indicate failure of surgery to completely clear *** confer an increased risk of biochemical recurrence(BCR),but how more robust outcomes are affected is *** study investigated factors associated with PSMs following RP and determined their impact on clinical outcomes(BCR,second treatment[radiotherapy and/or androgen deprivation therapy],and prostate cancer-specific mortality[PCSM]).Methods The study cohort included men diagnosed with prostate cancer(pT2-3b/N0/M0)between January 1998 and June 2016 who underwent RP from the South Australian Prostate Cancer Clinical Outcomes Collaborative *** associated with risk of PSMs were identified using Poisson *** impact of PSMs on clinical outcomes(BCR,second treatment,and PCSM)was assessed using competing risk *** Of the 2827 eligible participants,28%had PSMs—10%apical,6%bladder neck,17%posterolateral,and 5%at multiple *** follow-up was 9.6 years with 81 deaths from prostate cancer *** of PSM increased with higher pathological grade and pathological tumor stage,and greater tumour volume,but decreased with increasing surgeon volume(odds ratio[OR]:0.93;95%confidence interval[CI]:0.88-0.98,per 100 previous prostatectomies).PSMs were associated with increased risk of BCR(adjusted sub-distribution hazard ratio[sHR]2.5;95%CI 2.1-3.1)and second treatment(sHR 2.9;95%CI 2.4-3.5).Risk of BCR was increased similarly for each PSM location,but was higher for multiple margin *** found no association between PSMs and *** Our findings support previous research suggesting that PSMs are not independently associated with PCSM despite strong association with *** PSM rates remains an important objective,given the higher likelihood of secondary treatment with associated comorbidities.

关键词： Prostate cancer Positive surgical margin Biochemical recurrence Radical

Phase Ib study of anti-EGFR antibody(SCT200) in combination with anti-PD-1 antibody(SCT-I10A) for patients with RAS/BRAF wild-type metastatic colorectal cancer

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Cancer Biology & Medicine 2024年第7期21卷 636-650页

作者： Ming Bai Yao Lu Chunmei Shi Jianwei Yang Wei Li Xianli Yin Chenghui Huang Lin Shen Liangzhi Xie Yi Ba Department of GI Medical Oncology Tianjin Medical University Cancer Institute & Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and TherapyTianjin Tianjin's Clinical Research Center for Cancer Tianjin Key Laboratory of Digestive Cancer Fujian Medical University Union Hospital Fujian Provincial Cancer Hospital Cancer Center The First Hospital of Jilin University Department of Medical Oncology Gastroenterology and urology Hunan Cancer Hospital Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Department of Oncology The Third Xiangya Hospital Central South University Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Peking University Cancer Hospital and Institute Beijing Engineering Research Center of Protein and Antibody Sinocelltech Ltd. Department of Cancer Center Peking Union Medical College Hospital Chinese Academy of Medical Sciences

Objective: This study evaluated the safety and efficacy of an anti-epidermal growth factor receptor(EGFR) antibody(SCT200) and an anti-programmed cell death 1(PD-1) antibody(SCT-I10A) as third-line or subsequent therapies in patients with rat sarcoma viral oncogene(RAS)/v-raf murine sarcoma viral oncogene homolog B(BRAF) wild-type(wt) metastatic colorectal cancer(mCRC).Methods: We conducted a multicenter, open-label, phase Ib clinical trial. Patients with histologically confirmed RAS/BRAF wt m CRC with more than two lines of treatment were enrolled and treated with SCT-I10A and SCT200. The primary endpoints were the objective response rate(ORR) and safety. The secondary endpoints included disease control rate(DCR), progression-free survival(PFS), and overall survival(OS).Results: Twenty-one patients were enrolled in the study through January 28, 2023. The ORR was 28.57% and the DCR was 85.71%(18/21). The median PFS and OS were 4.14 and 12.84 months, respectively. The treatment-related adverse events(TRAEs) were tolerable. Moreover, compared with the monotherapy cohort from our previous phase I study evaluating SCT200 for RAS/BRAF wt m CRC in a third-line setting, no significant improvements in PFS and OS were observed in the combination ***: SCT200 combined with SCT-I10A demonstrated promising efficacy in previously treated RAS/BRAF wt m CRC patients with an acceptable safety profile. Further head-to-head studies with larger sample sizes are needed to validate whether the efficacy and safety of combined anti-EGFR and anti-PD-1 therapy are superior to anti-EGFR monotherapy in the third-line setting.(Registration No. NCT04229537).

关键词： Colorectal cancer SCT-I10A SCT200 epidermal growth factor receptor programmed cell death 1

Study of the efficacy of Korean Red Ginseng in the treatment of erectile dysfunction

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Asian Journal of Andrology 2007年第2期9卷 241-244页

作者： Enrico de Andrade Alexandre A. de Mesquita Joaquim de Almeida Claro Priscila M. de Andrade Valdemar Ortiz Mário Paranhos Miguel Srougi Sector of Sexual Medicine Division of Urological Clinic of Sāo Paulo University Sāo Paulo Brazil discipline of urology Sāo Paulo Federal University Sāo Paulo Brazil

Aim： To examine the treatment efficacy of Korean Red Ginseng （KRG） in impotent men with erectile dysfunction （ED）. Methods： A total of 60 patients presenting mild or mild to moderate ED were enrolled in a double-blind, placebo-controlled study in which the efficacies of KRG and a placebo were compared. The patients received either 1 000 mg （3 times daily） of KRG or a placebo. Results： The five-item version of the International Index of Erectile Function （IIEF-5） score after the treatment was significantly higher in the KRG group compared with that before the treatment （from 16.4±2.9 to 21.0±6.3, P 〈 0.0001）. In contrast, there was no difference before and after the treatment in the placebo group （from 17.0±3.1 to 17.7±5.6, P 〉 0.05）. In the KRG group, 20 patients （66.6%）, reported improved erection, significant in the global efficacy question （P 〈 0.01）; in the placebo group there was no significance. Scores on questions 2 （rigidity）, 3 （penetration）, 4 and 5 （maintenance）, were significantly higher for KRG than those for the placebo when those questions were answered after 12 weeks of each treatment （P 〈 0.01）. When the score in the KRG group was compared to the placebo group after the treatment, there was a significant improvement in total score （IIEF-5 score） in questions 3 and 5 for the KRG-treated group （P 〈 0.001 and P 〈 0.0001, respectively）. The levels of serum testosterone, prolactine and cholesterol after the treatment were not statistically significant different between the KRG and the placebo group （P 〉 0.05）. Conclusion： Our data show that KRG can be an effective alternative to the invasive approaches for treating male ED.

关键词： penis impotence ginseng penile erection

A systematic review of dedicated models of care for emergency urological patients

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Asian Journal of urology 2021年第3期8卷 315-323页

作者： Ned Kinnear Matheesha Herath Dylan Barnett Derek Hennessey Christopher Dobbins Tarik Sammour James Moore discipline of Surgery Faculty of Health and Medical SciencesUniversity of AdelaideAdelaideAustralia Department of Surgery Royal Adelaide HospitalAdelaideAustralia Department of urology Mercy University HospitalCorkIreland

Objective:To systematically evaluate the spectrum of models providing dedicated resources for emergency urological patients(EUPs).Methods:A search of Cochrane,Embase,Medline and grey literature from January 1,2000 to March 26,2019 was performed using methods pre-published on *** followed Preferred Reporting Items for Systematic Review and meta-analysis *** studies were articles or abstracts published in English describing dedicated models of care for EUPs,which reported at least one secondary *** were excluded if they examined pathways dedicated only to single presentations,such as torsion,or outpatient solutions,such as rapid access *** primary outcome was the spectrum of *** outcomes were time-to-theatre,length of stay,complications and ***:Seven studies were identified,totalling 487 *** studies were conference abstracts,while one study was of full-text length but published in grey *** distinct models were *** included consultant urologists allocated solely to the care of EUPs(“Acute Urological Unit”)or dedicated registrars or operating theatres(“Hybrid structures”).In some services,EUPs bypassed emergency department assessment and were referred directly to urology(“Urological Assessment Unit”)or were managed by other dedicated *** services to EUPs was associated with reduced time-to-theatre,length of stay and hospital cost,and improved supervision of junior medical ***:Multiple dedicated models of care exist for ***-level evidence suggests these may improve outcomes for patients,staff and *** quality studies are required to explore patient outcomes and minimum requirements to establish these models.

关键词： Acute surgical unit Acute care surgery urology Emergency Acute Dedicated

An insertion mutation in the androgen receptor gene in a patient with azoospermia

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Asian Journal of Andrology 2015年第5期17卷 857-858页

作者： Yun-Hao Chen Hui-Ying Xu Zhang-Yang Wang Zhe-Hui Zhu Cheng-Di Li Zhi-Gang Wu Bi-Cheng Chen Department of Surgery Zhejiang Provincial Top Key Discipline in Surgery Wenzhou Key Laboratory of Surgery The First Affiliated Hospital Wenzhou Medical University Wenzhou 325000 China Department of urology The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000 China

Dear Editor,We present here a case of an infertile man with azoospermia, from whom an insertion mutation （g. 1283_1284insAGTTTGCTG） near the beginning of the CAG repeat in the exon 1 of androgen receptor （AR） gene... 详细信息

关键词： present demonstrated androgen

The multikinase inhibitor sorafenib induces caspase-dependent apoptosis in PC-3 prostate cancer cells

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Asian Journal of Andrology 2010年第4期12卷 527-534页

作者： Rui Huang Xue-Qin Chen Ying Huang Ni Chen Hao Zeng Department of Nuclear Medicine National Key Discipline of Medical Imaging and Nuclear Medicine West China Hospital Sichuan University Chengdu 610041 China Laboratory of Pathology State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu 610041 China Department of urology West China Hospital Sichuan University Chengdu 610041 China

The present study investigated the effects of the multikinase inhibitor sorafenib on androgen-independent can- cer cells viability and intracellular signaling. Human androgen-independent PC-3 prostate cancer cells were treated with sorafenib. At concentration that suppresses extracellular signal-regulated kinase phosphorylation, sorafenib treatment reduced the mitochondrial transmembrane potential. Sorafenib also down-modulated the levels of mye- loid cell leukemia 1, survivin and cellular inhibitor of apoptosis protein 2. Sorafenib induced caspase-3 cleavage and the mitochondrial release of cytochrome c. However, no nuclear translocation of apoptosis inducing factor was detected after treatment and the pan-caspase inhibitor Z-VAD-FMK had an obvious protective effect against the drug. In conclusion, sorafenib induces apoptosis through a caspase-dependent mechanism with down-regulated antiapoptotic proteins in androgen-independent prostate cancer cells in vitro.

关键词： apoptosis PC-3 prostate cancer cells prostate cancer sorafenib

Improved closure techniques for laparoscopic partial nephrectomy in moderately complex renal cell carcinoma

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Chinese Medical Journal 2021年第2期134卷 228-230页

作者： Qi-Wei Yang Xiu-Wu Pan Jian-Qing Ye Chuan-Min Chu Fa-Jun Qu Lin Li Wei Yang Lei Wang Si-Shun Gan Xin-Gang Cui Department of urology The Third Affiliated Hospital of Naval Military Medical University(Eastern Hepatobiliary Surgery Hospital)Shanghai 201805China Department of urology Gongli HospitalShanghai 200135China Department of urology Changzheng HospitalNaval Military Medical UniversityShanghai 200003China

Laparoscopic partial nephrectomy(LPN)as a minimally invasive nephron-sparing surgery is gradually becoming the preferred surgical treatment for T1a renal carcinoma since it yields faster post-operative recovery and equivalent oncological outcomes to radical nephrectomy.[1]However,it is difficult to perform LPN for complex renal tumors,resulting in a longer warm ischemic time(WIT),which consequently affects the recovery of post-operative renal function.[2]With the development of laparoscopic instruments and techniques and the accumulating experience of surgeons,the WIT during LPN may be shortened using anatomy-based early unclamping(EUC)[1]after the placement of one or two running sutures on the tumor *** this study,we improved the closure techniques for LPN using EUC in patients with complex renal tumors and assessed their effectiveness.

关键词： anatomy operative closure

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