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AtSYP51/52 Functions diverge in the Post-Golgi Traffic and differently Affect Vacuolar Sorting

Molecular Plant 2013年第3期6卷 916-930页

作者： Maria De Benedictis Gianluca Bleve Marianna Faraco Egidio Stigliano Francesco Grieco Gabriella Piro Giuseppe Dalessandro Gian Pietro di Sansebastiano dipartimento di scienze e Tecnologie Biologiche ed Ambientali University of Salento Campus Ecotekne 73100 Lecce Italy Present address: dipartimento di Bioscienze Universita degli Studi di Parma Parco Area delle Scienze 11/A 43124 Parma Italy Institute of Science of Food Production National Research Council via Provinciale Lecce-Monteroni 73100 Lecce Italy laboratory of Cell and Molecular Biology University of Neuchatel Rue Emile-Argand 11 CP 158 2009 Neuchatel Switzerland

Plant sensitive factor attachment protein receptors （SNAREs） encoded by genes of the same sub-family are generally considered as redundant in promoting vesicle-associated membrane fusion events. Nonetheless, the application of innovative experimental approaches highlighted that members of the same gene sub-family often have different functional specificities. In this work, two closely related Qc-SNAREs--the AtSYP51 and the AtSYP52--are compared in their ability to influence different secretory pathways. Their role in the vesicle sorting to the central vacuole has been revised and they were found to have a novel inhibitory function. When transiently overexpressed, the SYP51 and the SYP52 distributed between the TGN and the tonoplast. Our data demonstrate that these SYPs （syntaxin of plants） act as t-SNARE when present on the membrane of TGN/PVC, whereas they behave as inhibitory or interfering SNAREs （i-SNAREs） when they accumulate on the tonoplast. Moreover, the performed functional analysis indicated that the AtSYP51 and the AtSYP52 roles differ in the traffic to the vacuole. The findings are a novel contribution to the functional characterization of plant SNAREs that reveals additional non-fusogenic roles.

关键词： endocytosis endosome Golgi i-SNARE plant endomembranes protoplast SNARE TGN tonoplast vacuole.

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Strongly enhanced light trapping in a two-dimensional silicon nanowire random fractal array

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Light(Science & Applications) 2016年第1期5卷 855-861页

作者： Barbara Fazio Pietro Artoni Maria Antonia Iatì Cristiano D’Andrea Maria JosèLo Faro Salvatore Del Sorbo Stefano Pirotta Pietro Giuseppe Gucciardi Paolo Musumeci Cirino Salvatore Vasi Rosalba Saija Matteo Galli Francesco Priolo Alessia Irrera CNR-IPCF Istituto per i Processi Chimico Fisici98158 MessinaItaly dipartimento di Fisica e Astronomia Universitàdi Catania95123 CataniaItaly CNR-MATIS IMM Istituto per la Microelettronica e Microsistemi95123 CataniaItaly dipartimento di Fisica Universitàdegli Studi di Pavia27100 PaviaItaly dipartimento di scienze Matematiche e Informatiche Scienze Fisiche e Scienze della TerraUniversitàdi Messina98166 MessinaItaly Scuola Superiore di Catania Universitàdi Cataniavia Valdisavoia995123 CataniaItaly

We report on the unconventional optical properties exhibited by a two-dimensional array of thin Si nanowires arranged in a random fractal geometry and fabricated using an inexpensive,fast and maskless process compatible with Si *** structure allows for a high light-trapping efficiency across the entire visible range,attaining total reflectance values as low as 0.1%when the wavelength in the medium matches the length scale of maximum heterogeneity in the *** show that the random fractal structure of our nanowire array is responsible for a strong in-plane multiple scattering,which is related to the material refractive index fluctuations and leads to a greatly enhanced Raman scattering and a bright *** strong emissions are correlated on all length scales according to the refractive index *** relevance and the perspectives of the reported results are discussed as promising for Si-based photovoltaic and photonic applications.

关键词： light trapping multiple scattering Raman enhancement random fractal silicon nanowires

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Tribological behaviour of Ti_(3)C_(2)T_(x) nano-sheets: Substrate-dependent tribo-chemical reactions

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Friction 2023年第8期11卷 1522-1533页

作者： Alberto ROTA Nicolas BELLINA Bo WANG Andreas ROSENKRANZ dipartimento di scienze Fisiche Informatiche e MatematicheUniversitàdi Modena e Reggio EmiliaModena 41125Italy CNR-Istituto di Nanoscienze Centro S3Modena 41125Italy Centro Interdipartimentale per la Ricerca Applicata e i Servizi nel settore della Meccanica Avanzata e della Motoristica Universitàdi Modena e Reggio EmiliaModena 41125Italy Key laboratory of Marine New Materials and Related Technology Zhejiang Key Laboratory of Marine Materials and Protection TechnologyNingbo Institute of Material Technology&EngineeringChinese Academy of SciencesNingbo 315201China Department of Chemical Engineering Biotechnology and MaterialsUniversity of ChileSantiago 8370456Chile

MXenes,a newly emerging class of layered two dimensional(2D)materials,are promising solid lubricants due to their 2D structure consisting of weakly-bonded layers with a low shear strength and ability to form beneficial *** work aims at evaluating for the first time MXenes lubrication performance and tribofilm formation ability on different metallic substrates(mirror-lapped Fe and Cu discs).After depositing MXenes via ethanol(1 wt%)on the substrates,pronounced differences in the resulting substrate-dependent frictional evolution are *** MXenes are capable to reduce friction for both substrates after the full evaporation of ethanol,MXenes lubricating effect on Cu is long-lasting,with a 35-fold increased lifetime compared to *** spectra acquired in the wear-tracks of the substrates and counter-bodies reveal notable differences in the friction-induced chemical changes depending on the substrate *** case of Fe,the progressive failure of MXenes lubrication generates different Fe oxides on both the substrate and the ball,resulting in continuously increasing friction and a poor lubrication *** Cu,sliding induces the formation of a Ti_(3)C_(2)-based tribofilm on both rubbing surfaces,enabling a long-lasting lubricating *** work boosts further experimental and theoretical work on MXenes involved tribo-chemical processes.

关键词： Mxenes Ti_(3)C_(2)T_(x) nano-sheets coefficient of friction Raman spectroscopy tribochemistry

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NOTE SULla LINEA FILETICA di Phaneropella JEANNEL, 1910 CON DESCRIZIONE di TRE NUOVI SOTTOGENERI E di UNA NUOVA SPECIE di TURCHIA(Coleoptera Cholevidae Bathysciinae)

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Natural disaster Reduction in China 1989年第1期 197-222页

作者： ACHILLE CASALE PIER MAURO GIACHINO DANTE VAIlaTI e MAURO RAMPINI Istituto Museo Regionale di scienze Naturali di Torino. Museo Civico di scienze Naturali di Brescia. dipartimento

Nella presente nora viene fornita una ridefinizione morfologica e sistematica del generePhaneropella Jeannel, 1910, alia luce di nuovi dati e della revisione delle specie note attribuite a questogenere. L’esame delle affinità reciproche dei taxa noti ha portato oltre che alla descrizione di una nuovaspecie e di tre nuovi sottogeneri anche a stabilire la sinonimia Muelleriella bonzanoi Casale, 1984 =Phaneropella (Epiroella) muelleriana Paoletti, 1975 el’attribuzione di Muelleriella epirota Giachino, 1989al genere Phaneropella (nov. comb.). Attualmente il genere risulta cosi articolato: subgen. ***, per P. lesinae Reitter, Epiroella n. subgen, per P. (E.) muelleriana Paoletti, P. (E.) epirota (Giachi-no), Hittitia n. subgen, per P. (H.) turcica Reitter e Uludagites n. subgen, per P. (U.) minuta n. ***, vengono discussi alcuni aspetti filetici e zoogeografici relativi alla 《linea filetica di Phaneropella》intesa in senso nuovo, formata cioè, per ora, da questo solo genere. Notes on the phyletic line of Phaneropella Jeannel, 1910 and description of three newsubgenera and one new species from Turkey. This article considers the morphologic and systematic re-definition of the genus Phaneropella Jeannel, 1910, at the light of the new data and of the re-examinationof the species attributed to this genus. The study of the reciprocal affinities of the known taxa, ledto the description of a new species and of three new subgenera as well as to establish the synonymyMuelleriella bonzanoi Casale, 1984 = Phaneropella (Epiroella) muelleriana Paoletti, 1975 and the appar-tenence of Muelleriella epirota Giachino, 1989 to the genus Phaneropella (nov. comb.). At present thisgenus is subdivided into subgen. Phaneropella ***, for P. lesinae Reitter, Epiroella n. subgen, for P.(E.) muelleriana Paoletti, Hittitia n. subgen, for P. (H.) turcica Reitter and Uludagites n. subgen, forP. (U.) minuta n. sp. To conclude the Authors re-consider some phyletic and zoogeographic a

关键词：刀口人口

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NUOVE DATAZIONI 14C per IL QUATERNARIO SUperIORE DELLE ALPI CENTRALI

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Natural disaster Reduction in China 1986年第1期 343-346页

作者： GIUSEPPE OROMBELLI dipartimento di scienze della Terra dell’Università di Milano.lavoro svolto nell’ambito dei programmi del Centro di Studio per la Stratigrafia e Petrografia delle Alpi Centrali CNR

NewC ages for the late Quaternary of the Central Alps.A group of newC ages has beenobtained from organic remains connected with the late Pleistocene and Holocene glacial history of theCentral Alps and their piedmont a... 详细信息

关键词： Pro BP Pi C per IL QUATERNARIO SUperIORE DELLE ALPI CENTRALI NUOVE DATAZIONI 110 la PIO

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A new approach for the treatment of CLL using chlorambucil/hydroxychloroquine-loaded anti-CD20 nanoparticles

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Nano Research 2016年第2期9卷 537-548页

作者： Sara Capolla Nelly Mezzaroba Sonia Zorzet Claudio Tripodo Ramiro Mendoza-Maldonado Marilena Granzotto Francesca Vita Ruben Spretz Gustavo larsen Sandra Noriega Eduardo Mansilla Michele Dal Bo Valter Gattei Gabriele Pozzato Luis Nunez Paolo Macor Department of Life Sciences University of Trieste 34127 Trieste Italy Department of Human Pathology University of Palermo 90133 Sicilia Italy Molecular Oncology Unit National Laboratory Consorzio Interuniversitatio per le Biotecnologie (CIB) 34012 Trieste Italy dipartimento Universitario Clinico di scienze mediche Chirurgiche e della Salute University of Trieste 34149 Trieste Italy LNK Chemsolutions LLC Lincoln NE 68521 USA Bio-Target Inc. Chicago IL 60637 USA Centro Unico Coordinador de Ablacion e Implante Provincia de Buenos Aires (C.U.CA.I.B.A.) Ministry of Health La Plata Buenos AiresArgentina Clinical and Experimental Onco-Hematology Unit Centro di Riferimento Oncologico Istituto di Ricerca e Cura a Carattere Scientifico(I.R.C.C.S.) 33081 Aviano Italy Callerio Foundation Onlus Institutes of Biological Researches 34127 Trieste Italy

Current approaches for the treatment of chronic lymphocytic leukemia （CLL） have greatly improved the prognosis for survival, but some patients remain refractive to these therapeutic regimens. Hence, in addition to reducing the long-term side- effects of therapeutics for all leukemia patients, there is an urgent need for novel therapeutic strategies for difficult-to-treat leukemia cases. Due to the cytotoxicity of drugs, the major challenge currently is to deliver the therapeutic agents to neoplastic cells while preserving the viability of non-malignant ceils. In this study, we propose a therapeutic approach in which high doses of hydroxychloroquine and chlorambucil were loaded into biodegradable polymeric nanopartides coated with an anti-CD20 *** first demonstrated the ability of the nanoparticles to target and internalize in tumor B-cells. Moreover, these nanoparticles could kill not only p53-mutated]deleted leukemia cells expressing a low amount of CD20, but also circulating primary ceils isolated from chronic lymphocytic leukemia patients. The safety of these nanoparticles was also demonstrated in healthy mice, and their therapeutic effects were shown in a new model of aggressive leukemia. These results showed that anti-CD20 nanoparticles containing hydroxychloroquine and chlorambucil can be effective in controlling aggressive leukemia and provided a rationale for adopting this approach for the treatment of other B-cell disorders.

关键词： chronic lymphocytic leukemia immune targeted nanoparticles treatment xenograft model

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OSSERVAZIONI di GEOMORFOLOGIA GlaCIALE NEL TERRITORIO di OLEGGIO(Novara)

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Natural disaster Reduction in China 1986年第1期 365-368页

作者： ORNELla DA ROLD CATERINA OTTOMANO dipartimento di scienze della Terra dell'Università di Milano.Si ringraziano:i Proff.M.Gnaccolini e G.Orombelli ed il Dottior M.Cremaschi per i consigli dati e per la lettura critica del testo. dipartimento di scienze della Terra dell'Università di Milano.Si ringraziano:i Proff.M.Gnaccolini e G.Orombelli ed il Dottier M.Cremaschi per i consigli dati e per la lettura critica del testo.

Some observations of glacil geomorphology in the surroundings of Oleggio(Novara,NorthernItaly).The geological survey of a part of the more external area of the Verbano morainic amphitheatre led tothe identification of... 详细信息

关键词： di AL Novara OSSERVAZIONI di GEOMORFOLOGIA GlaCIALE NEL TERRITORIO di OLEGGIO

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Interindividual variation and consistency of migratory behavior in the Eurasian woodcock

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Current Zoology 2020年第2期66卷 155-163页

作者： Alessandro TEDESCHI Michele SORRENTI Michele BOTTAZZO Mario SPAGNESI Ibon TELLETXEA Ruben IBANEZ Nicola TORMEN Federico DE PASCALIS laura GUIDOLIN diego RUBOLINI Associazione"Amici di Scolopax" Via Roma57Mugnano del CardinaleAVI-83027Italy Federazione Italiana della Caccia Ufficio Avifauna MigratoriaVia Salaria 298/ARoma1-00199Italy Veneto Agricoltura Viale dell’Universita 14LegnaroP D1-35020Italy Ekoclub International Via per Volano 45Volano di CodigoroFE1-44020Italy Club de Cazadores de Becada Avda.Schulz 84 dchaGijonE-33208Spain dipartimento di Biologia Universita degli Studi di PadovaVia U.Bassi 58/bPadova1-35131Italy dipartimento di scienze e Politiche Ambientali Universita degli Studi di Milanovia Celoria 26Milano1-20133Italy

diverse spatio-temporal aspects of avian migration rely on relatively rigid endogenous ***,flexibility in migratory behavior may allow effective coping with unpredictable variation in ecological conditions that can occur during *** aimed at characterizing inter-and intraindividual variation of migratory behavior in a forest-dwelling wader species,the Eurasian woodcock Scolopax rusticola,focusing on spatio-temporal consistency across repeated migration *** satellite-tracking birds from their wintering sites along the Italian peninsula to their breeding areas,we disclosed a remarkable variability in migration distances,with some birds flying more than 6,000 km to Central Asian breeding grounds(up to 101°E).Prebreeding migration was faster and of shorter duration than postbreeding *** moving over longer distances migrated faster during prebreeding migration,and those breeding at northernmost latitudes left their wintering areas ***,birds making longer migrations departed earlier from their breeding *** site fidelity was very high,whereas fidelity to wintering areas increased with *** routes were significantly consistent,both among repeated migration episodes and between pre-and postbreeding *** migration departure date was not significantly repeatable,whereas arrival date to the breeding areas was highly ***,interindividual variation in migratory behavior of woodcocks was mostly explained by the location of the breeding areas,and spatial consistency was relatively large through the entire annual *** in prebreeding migration departure date may suggest that environmental effects have a larger influence on temporal than on spatial aspects of migratory behavior.

关键词： arrival date breeding latitude flexibility repeatability satellite tracking wading birds

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GEOLOGIA E PEDOSTRATIGRAFIA DELla COLLINA di CILIVERGHE(Brescia)

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Natural disaster Reduction in China 1986年第1期 55-78页

作者： CARLO BARONI MAURO CREMASCHI Fasi glaciali pedogenesi e sedimentazione loessica al margine aipino durante il Pleistocene Museo Civico di scienze Naturali di Brescia:《frequentatore》del dipartimento di scienze della Terra dell'Università di Pavia Centro di Studio per la Stratigrafia e la Petrografia delle Alpi Centrali C.N.R..Milano lavoro lavoro eseguito nell'ambito del Progetto di Ricerca sui paleosuoli nel margine alpino del Centro C.N.R.per la Stratigrafia e la Petrografia delle Alpi Centrali e del Progetto Nazionale di Ricerca《Morfoncotettonica》 M.P.I.40% responsabile locale P.L.Vercesi eseguito nell'ambito del Progetto di Ricerca sui paleosuoli nel margine alpino del Centro C.N.R.per la Stratigrafia e la Petrografia delle Alpi Centrali e del Progetto Nazionale di Ricerca《Morfoncotettonica》 M.P.I.40% responsabile locale P.L.Vercesi.

Geology and pedo-stratigraphy of the Ciliverghe hill(glacial deposits,pedogenesis,and loess sedi-mentation along the Alpine fringe during the Pleistocene).-Ciliverghe hill consists of Pleistocene *** lowest units(CIL 1 and CIL 2).composed of till and related fluvioglacial *** oldest moraine ridge of the Garda lake moraine *** units are covered with angular unconfor-mity,by glacio-lacustrine marls(CIL 3),by fluviatile gravels supplied from a local source(CIL 4)and by flu-vio-glacial gravels(CIL 5)including Central-Alpine *** the upper unit a rubefied,strongly weatheredpalaeosol is *** the top of the sequence there is a polygenetic cover of loess consisting of at leastthree distinct layers intercalated with pedogenetic *** uppermost loess which includes mouste-rian artifacts dates back to the late Pleistocene,Five glacial stages are therefore recorded in the Ciliverghesequence,probably spanning the whole glacial *** stratigraphical and morphological develop-ment of the Ciliverghc hill has been tectonicallv controlled due to the activity of buried tectonic structures.

关键词： Pi Pro PI la GEOLOGIA E PEDOSTRATIGRAFIA DELla COLLINA di CILIVERGHE Brescia CIL

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Relevant incidental findings at abdominal multi-detector contrast-enhanced computed tomography:A collateral screening?

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World Journal of Radiology 2015年第10期7卷 350-356页

作者： Luca Maria Sconfienza Giovanni Mauri Claudia Muzzupappa Alessandro Poloni Michele Bandirali Anastassia Esseridou Stefania Tritella Francesco Secchi Giovanni di Leo Francesco Sardanelli Servizio di Radiologia IRCCS Policlinico San Donato dipartimento di scienze biomediche per la salute Università degli Studi di Milano Scuola di Specia-lizzazione in Radiodiagnostica Università degli Studi di Milano

AIM: To investigate the prevalence of relevant incidental findings(RIFs) detected during routine abdominal contrast-enhanced computed tomography(Ce CT).METHODS: We retrospectively evaluated the reports of a consecutive series of abdominal Ce CT studies performed between January and May 2013. For each report, patients' age and sex, admission as inpatient or outpatient, clinical suspicion as indicated by the requesting physician, availability of a previous abdominal examination, and name of the reporting radiologist were recorded. Based on the clinical suspicion, the presence and features of any RIFs(if needing additional workup) was ***: One thousand forty abdominal Ce CT were performed in 949 patients(528 males, mean age 66 ±14 years). No significant difference was found between inpatients and outpatients age and sex distribution(P > 0.472). RIFs were found in 195/1040(18.8%) Ce CT [inpatients = 108/470(23.0%); outpatients = 87/570(15.2%); P = 0.002]. RIFs were found in 30/440(6.8%) Ce CT with a previous exam and in 165/600(27.5%) without a previous exam(P diologists' distribution between inpatients or outpatients was significantly different(P ladder, and ***: A RIF is detected in 1/5 patients undergoing abdominal Ce CT. Risk of overdiagnosis should be taken into account.

关键词： Contrast-enhanced computed tomography Abdomen Inci

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