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The physiological polyphosphate as a healing biomaterial for chronic wounds:Crucial roles of its antibacterial and unique metabolic energy supplying properties

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Journal of Materials Science & Technology 2023年第4期135卷 170-185页

作者： Werner e.G.Müller Hadrian Schepler Meik Neufurth Shunfeng Wang Veronica Ferrucci Massimo Zollo Rongwei Tan Heinz C.Schröder Xiaohong Wang eRC Advanced Investigator Grant Research Group at the Institute for Physiological Chemistry University Medical Center of the Johannes Gutenberg UniversityDuesbergweg 6Mainz D-55128Germany Department of Dermatology University Clinic MainzLangenbeckstr.1Mainz D-55131Germany dipartimento di medicina molecolare e biotecnologie mediche Universitàdegli Studi di Napoli Federico IIVia Sergio Pansini 5Naples 80131Italy ceinge biotecnologie avanzate Francesco Salvatore Via G.Salvatore 486Naples 80145Italy Shenzhen Lando Biomaterials Co. Ltd.Shenzhen 518107China

Insufficient metabolic energy,in the form of adenosine triphosphate(ATP),and bacterial infections are among the main causes for the development of chronic *** we showed that the physi-ological inorganic polymer polyphosphate(polyP)massively accelerates wound healing both in animals(diabetic mice)and,when incorporated into mats,in patients with chronic ***,we focused on a hydrogel-based gel formulation,supplemented with both soluble sodium polyP(Na-polyP)and amor-phous calcium polyP nanoparticles(Ca-polyP-NP).exposure of human epidermal keratinocytes to the gel caused a significant increase in extracellular ATP level,an effect that was even enhanced when Na-polyP was combined with ***,it is shown that the added polyP in the gel is converted into a coacervate,leading to encapsulation and killing of *** data on human chronic wounds showed that the administration of hydrogel leads to the complete closure of these *** analysis of biopsies showed an increased granulation of the wounds and an enhanced microvessel *** results indicate that the polyP hydrogel,due to its properties to entrap bacteria and generate metabolic energy,is a very promising formulation for a new therapy for chronic wounds.

关键词： Inorganic polyphosphate Nanoparticles Hydrogel Coacervate Human chronic wounds Antibacterial activity Metabolic energy

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Hereditary gastrointestinal polyposis: diagnosis, genetic test and risk assessment

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Open Journal of Genetics 2013年第2期3卷 50-58页

作者： Marina De Rosa Francesca Duraturo Raffaella Liccardo Paola Izzo dipartimento di medicina molecolare e biotecnologie mediche and ceinge biotecnologie avanzate Università di Napoli Federico II Naples Italy

Colorectal cancer (CRC) is the second cause of cancer deaths, with over 1 million new cases estimated every year. Familial adenomatous polyposis, MUTYH-associated polyposis and hamartomatous polyposis are inherited syndromes that account for 2%-5% of all colon cancer. The mutated genes responsible for the vast majority of these disorders, are now known (MLH1, MSH2, MSH6, PMS2, APC, MYH, LKB1, SMAD4, BMPR1A, and PTeN) and specific mutations have been identified. Molecular caracterization of inherited CRCs allows pre-symptomatic diagnosis identifying at-risk individuals and improving cancer surveillance. Adenomatous polyposis includes familial adenomatous polyposis (FAP), attenuated FAP (AFAP), and MUTYH-associated polyposis (MAP). Hamartomatous polyposis comprises Peutz-Jeghers syndrome (PJS), juvenile polyposis syndrome (JPS) and “PTeN hamartoma tumour syndrome” (PHTS). MAP is an autosomal recessive condition, while all other disorders are inherited in an autosomal dominant manner. differential dyagnosis could be very difficult between syndromes because of their phenotypic variability. Attenuated FAP, MAP and Lynch syndrome could be all associated with fewer numbers of adenomas (3-10 polyps), nevertheless, each syndrome has distinct cancer risks, characteristic clinical features, and separate genetic etiologies. Thus, differential diagnosis is essential for correct management of the specific disease. In our laboratory we set up a methodology for genetic tests of the colorectal polyposis syndrome. In these reviews we summarize the literature data and our experience about diagnosis, genetic tests and cancer risk assesment associated with colorectal polyposis. According to literature data, in our experience, there is a portion of analyzing patients that remain without identified mutation, after molecular screening of the specific gene involved in the pathogenesis of the disease. Since the sensibility of used techniques, such as DHPLC, MLPA and sequencing, is now very h

关键词： Familial Adenomatous Polyposis (FAP) MUTYH-Associated Polyposis (MAP) Peutz-Jeghers Syndrome (PJS) PTeN Hamartoma Tumour Syndrome (PHTS)

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