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Serum chromogranin-A in hepatocellular carcinoma: diagnostic utility and limits

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World Journal of Gastroenterology 2005年第13期11卷 1987-1990页

作者： Aldo Spadaro Antonino Ajello Carmela Morace Agata Zirilli Graziella D'arrigo Carmelo Luigiano Francesco Martino Anna Bene Domenico Migliorato Santi Turiano Oscar Ferraù Maria Antonietta Freni dipartimento Clinico Sperimentale di Medicina e Farmacologia dipartimento di Statistica dipartimento di Scienze Radiologiche Unità Operativa di Gastroenterologia

AIM: The utility of serum alpha-fetoprotein (α-FP) for the detection of hepatocellular carcinoma (HCC) is questionable. High serum levels of chromogranin-A (CgA) have recently been reported in HCC. Impaired hepatic, renal, and heart functions influence circulating CgA. The aim of this study was to assess sensitivity and specificity of serum CgA as a marker of HCC in patients with liver cirrhosis (LC). MeTHODS: Serum CgA levels were measured by RIA in 339 patients of which 54 HCC, 132 LC, 45 chronic hepatitis (CH), 27 chronic heart failure (CHF), 36 chronic renal failure (CRF), 45 chronic inflammatory bowel disease (IBD) as disease controls and in 75 healthy controls. Patients with liver disease or IBD and concomitant renal and/or heart failure were excluded. Pearson correlation, non-parametric combination test and confidence interval analysis were used for statistical analysis. ReSULTS: Serum CgA above normal values (100 ng/mL) were found in 83% of HCC patients, in 48% of LC patients, in 20% of CH patients, in 33% of IBD patients, in 92% of CRF patients, in 100% of CHF patients, and in none of the healthy controls. The mean CgA values in HCC (769±1046), in LC (249±369), in CH (87±94), in CRF (1390±1401), in CHF (577±539), in IBD (146±287) were significantly higher than those in healthy controls (48±18). HCC patients had higher CgA values (Pents but did not differ from those with CRF or CHF. The 95% CI for the mean (250-1289 ng/mL) in HCC patients was selected as a CgA range and the lower value of such range was assumed as cut-off. Sensitivity and specificity of CgA, calculated in relation to the cut-off in patients with cirrhosis and HCC, were respectively 61% (CI 48-73%) and 82% (CI 75-88%). Serum a-FP values were >200 ng/mL in 21% of the HCC patients and in none of the LC patients. No significant correlation was found between a-FP and CgA in patients with HCC and in patients with cirrhosis. CONCLUSION: When HCC is suspected and a-FP

关键词： Chromogranin-A Hepatocellular carcinoma Liver cirrhosis Chronic hepatitis diagnosis

The relationship between the radio core-dominance parameter and spectral index in different classes of extragalactic radio sources(Ⅲ)

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Research in Astronomy and Astrophysics 2020年第2期20卷 101-111页

作者： Zhi-Yuan Pei Jun-Hui Fan Denis Bastieri Jiang-He Yang Hu-Bing Xiao Wen-Xin Yang Center for Astrophysics Guangzhou UniversityGuangzhou 510006China Astronomy Science and Technology Research Laboratory of Department of education of Guangdong Province Guangzhou 510006China dipartimento di fisica e astronomia“G.Galilei” Universita di Padova1-35131 PadovaItaly Istituto Nazionale di fisica Nucleare Sezione di Padova1-35131 PadovaItaly Department of Physics and electronics Science Hunan University of Arts and ScienceChangde 415000China

Active galactic nuclei(AGNs) can be divided into two major classes,namely radio-loud and radio-quiet AGNs.A small subset of the radio-loud AGNs is called blazars,which are believed to be unified with Fanaroff-Riley type Ⅰ and type Ⅱ(FRI&Ⅱ) radio *** our previous work,we present a latest sample of 966 sources with measured radio flux densities of the core and extended *** sample includes 83 BL Lacs,473 flat spectrum radio quasars,101 Seyferts,245 galaxies,52 FRIs&Ⅱs and12 unidentified *** then calculate the radio core-dominance parameters and spectral indices and study their *** analysis shows that the core-dominance parameters and spectral indices are quite different for different types of *** also confirm that the correlation between core-dominance parameter and radio spectral index extends over all the sources in a large sample presented.

关键词： galaxies:active galaxies:general galaxies:jets quasars:general

On “Over-Sized” High-Gain Practical Observers for Nonlinear Systems

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Ieee/CAA Journal of Automatica Sinica 2018年第3期5卷 691-698页

作者： Daniele Carnevale Corrado Possieri Antonio Tornambè dipartimento di Ingegneria Civile e Ingegneria Informatica Universita di Roma Tor Vergata

In this paper,it is shown that the performances of a class of high-gain practical observers can be improved by estimating the time derivatives of the output up to an order that is greater than the dimension of the system, which is assumed to be in observability form and, possibly, time-varying. Such an improvement is achieved without increasing the gain of the observers, thus allowing their use in a wide variety of control and identification applications.

关键词： Filtering properties nonlinear systems observability observer design

Competition between fusion-evaporation and multifragmentation in central collisions in ^(58)Ni+^(48)Ca at 25A MeV

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Nuclear Science and Techniques 2013年第5期24卷 82-88页

作者： FRANCALANZA L ABBONDANNO U AMORINI F BARLINI S BINI M BOUGAULT R BRUNO M CARDeLLA G CASINI G AGOSTINO M D' De FILIPPO V De SANCTIS J GeRACI e GIUSSANI A GRAMeGNA F GUIOT B KRAVCHUK V La GUIDARA e LANZALONe G Le NeINDRe N MAIOLINO C MARINI P MOReLLI L OLMI A PAGANO A PAPA M PIANTeLLI S PIRRONe S POLITI G POGGI G PORTO F RUSSOTTO P RIZZO F VANNINI G VANNUCCI L INFN Laboratori Nazionali del Sud-LNS Catania 95123Italy dipartimento di fisica Universitàdi Catania I-95129Italy INFN Sezione di Trieste Trieste I-34127Italy dipartimento di fisica Universitàdi FirenzeINFN Sezione di Firenze 1-50139Italy LPC Caen IN2P3-CNRS/ENSICAEN and UniversitéF-14050 Caen cedex 5-140France dipartimento di fisica Universitàdi Bologna and INFN Sezione di Bologna 4-50121Italy INFN Sezione di Catania I-95129 Italy INFN Sezione di Firenze I-50139 Italy dipartimento di fisica Universitàdi Milano and INFN Sezione di Milano1-20126Italy INFN Laboratori Nazionali di Legnaro 1-35020 Italy Centro Siciliano di fisica Nucleare e Struttura della Materia Catania 1-95129Italy UniversitàKore Enna 1-94100Italy

The experimental data concerning the58Ni+48Ca reaction at elab(Ni)=25A MeV,collected by using the CHIMeRA 4π device,have been analyzed in order to investigate the competition among different reaction mechanisms for central collisions in the Fermi energy *** a main criterion for centrality selection we have chosen the flow angle(flow) method,making an event-by-event analysis that considers the shape of events,as it is determined by the eigenvectors of the experimental kinetic-energy *** the selected central events(flow >60°) some global variables,good to characterize the pattern of central collisions have been *** main features of the reaction products were explored by using different constraints on some of the relevant observables,like mass and velocity distributions and their *** emphasis was devoted,for central collisions,to the competition between fusion-evaporation processes with subsequent identification of a heavy residue and a possible multifragmentation mechanism of a well defined(if any) transient nuclear *** evolution of the system and pre-equilibrium emission were taken into account by simulating the reactions in the framework of transport *** approaches have been envisaged(dynamical stochastic BNV calculations + sequential SIMON code,QMD,CoMD,etc.).Preliminary comparison of the experimental data with BNV calculations shows reasonable agreement with the assumption of sequential multifragmentation emission in the mass region of IMFs close to the heavy *** deviations from sequential processes were found for those IMFs in the region of masses intermediate between the mass of heavy residues and the mass of light *** simulations are in *** experimental analysis will be enriched also by information obtained inspecting the IMF-IMF correlation function,in order to elucidated the nature of space-time decay property of the emitting source associated with events having

关键词：多重碎裂中心碰撞蒸发过程 MeV 竞争熔合国际货币基金组织事件分析

effect of omeprazole on symptoms and ultrastructural esophageal damage in acid bile reflux

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World Journal of Gastroenterology 2005年第12期11卷 1876-1880页

作者： Carlo Calabrese Anna Fabbri Mauro Bortolotti Giovanna Cenacchi Scialpi Carlo Desiree Zahlane Mario Miglioli Giulio di Febo dipartimento di Medicina Interna e Gastroenterologia

AIM: To value whether omeprazole could induce the healing of diS and regression of symptoms in patients with DGeR. MeTHODS: We enrolled 15 symptomatic patients with a pathological esophageal 24-h pH-metry and bilimetry. Patients underwent endoscopy and biopsies were taken from the distal esophagus. Specimens were analyzed at histology and transmission electron microscopy (TeM). Patients were treated with omeprazole 40 mg/d for 3 mo and then endoscopy with biopsies was repeated. Patients with persistent heartburn and/or with an incomplete recovery of diS were treated for 3 more months and endoscopy with biopsies was performed. ReSULTS: Nine patients had a non-erosive reflux disease at endoscopy (NeRD) while 6 had erosive esophagitis (eRD). At histology, of the 6 patients with erosive esophagitis, 5 had mild esophagitis and 1 moderate esophagitis. No patients with NeRD showed histological signs of esophagitis. After 3 mo of therapy, 13/15 patients (86.7%,Ped a complete recovery of diS and disappearance of heartburn. Of the 2 patients treated for 3 more months, complete recovery of diS and heartburn were achieved in one. CONCLUSION: Three or 6 mo of omeprazole therapy led to a complete regression of the ultrastructural esophageal damage in 86.7% and in 93% of patients with DGeR, NeRD and eRD respectively. The ultrastructural recovery of the epithelium was accompanied by regression of heartburn in all cases.

关键词： Duodenogastroesophageal reflux Gastroeso phageal reflux disease Transmission electron Microscopy dilated Intercellular Spaces Non-erosive reflux disease

exact electronic Bands for a Periodic Pschl–Teller Potential

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Communications in Theoretical Physics 2016年第11期65卷 491-495页

作者： Francesco di Filippo Canio Noce CNR-SPIN 1-84084 Fisciano(Salerno)Italy and Dipartimento di Fisica"E.R.Caianiello"Universit~di Salerno1-84084Fisciano(Salerno)Italy

We show that supersymmetry is a simple but powerful tool to exactly solve quantum mechanics problems. Here, the supersymmetric approach is used to analyse a quantum system with periodic Poschl-Teller potential, and to... 详细信息

关键词： supersymmetric quantum mechanics periodic Poschl-Teller potential SchrSdinger equation en-ergy bands

Numerical entropy andAdaptivity for FiniteVolume Schemes

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Communications in Computational Physics 2011年第10期10卷 1132-1160页

作者： Gabriella Puppo Matteo Semplice dipartimento di Matematica Politecnico di TorinoCorso Duca degli Abruzzi 2410129 TorinoItalia dipartimento di fisica e Matematica Universit`a dell’InsubriaVia Valleggio 1122100 ComoItalia

We propose an a-posteriori error/smoothness indicator for standard semidiscrete finite volume schemes for systems of conservation laws,based on the numerical production of *** idea extends previous work by the first author limited to central finite volume schemes on staggered *** prove that the indicator converges to zero with the same rate of the error of the underlying numerical scheme on smooth flows under grid *** construct and test an adaptive scheme for systems of equations in which the mesh is driven by the entropy *** adaptive scheme uses a single nonuniform grid with a variable *** show how to implement a second order scheme on such a space-time non uniform grid,preserving accuracy and conservation *** also give an example of a p-adaptive strategy.

关键词： Finite volume schemes hyperbolic systems local grid refinement entropy

energy spectrum of cosmic protons and helium nuclei by a hybrid measurement at 4300 m a.s.l.

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Chinese Physics C 2014年第4期38卷 25-31页

作者： B.Bartoli P.Bernardini 毕效军 I.Bolognino P.Branchini A.Budano A.K.Calabrese Melcarne P.Camarri 曹臻 R.Cardarelli S.Catalanotti 陈松战陈天禄 P.Creti 崔树旺戴木忠 A.D'Amone 单增罗布 I.De Mitri B.D'ettorre Piazzoli T.di Girolamo G.di Sciascio 冯存峰冯朝阳冯振勇苟全补郭义庆何会海胡海兵胡红波 M.Iacovacci R.Iuppa 贾焕玉拉巴次仁厉海金 G.Liguori 刘成刘俊刘茂元卢红马玲玲马欣华 G.Mancarella S.M.Mari G.Marsella D.Martello S.Mastroianni P.Montini C.C.Ning M.Panareo B.Panico L.Perrone P.Pistilli F.Ruggieri P.Salvini R.Santonico S.N.Sbano 沈培若盛向东石峰 A.Surdo 谭有恒 P.Vallania S.Vernetto C.Vigorito 王辉吴超勇吴含荣薛良杨群羽杨先楚姚志国袁爱芳查敏张慧敏张力张学尧张勇赵静扎西次仁扎西桑珠周勋秀祝凤荣朱清棋 G.Zizzi 白云翔陈明君陈垚冯少辉高博顾旻皓侯超李晓晓刘佳刘加丽王旭肖刚张丙开张寿山周斌左雄 dipartimento di fisica dell’Università di Napoli "Federico II" Complesso Universitario di Monte Sant’Angelovia Cinthia Istituto Nazionale di fisica Nucleare Sezione di Napoli Complesso Universitario di Monte Sant’Angelovia Cinthia dipartimento di Matematica e fisica "ennio De Giorgi" Università del Salento via per Arnesano Istituto Nazionale di fisica Nucleare Sezione di Lecce via per Arnesano Key Laboratory of Particle Astrophysics Institute of High Energy Physics Chinese Academy of Sciences dipartimento di fisica dell’Università di Pavia via Bassi 627100 Pavia Italy Istituto Nazionale di fisica Nucleare Sezione di Pavia via Bassi 627100 Pavia Italy Istituto Nazionale di fisica Nucleare Sezione di Roma Tre via della Vasca Navale 8400146 Roma Italy Istituto Nazionale di fisica Nucleare-CNAF Viale Berti-Pichat 6/240127 Bologna Italy dipartimento di fisica dell’Università di Roma "Tor Vergata" via della Ricerca Scientifica Istituto Nazionale di fisica Nucleare Sezione di Roma Tor Vergata via della Ricerca Scientifica Tibet University Hebei Normal University Yunnan University Shandong University Southwest Jiaotong University dipartimento di fisica dell’Università "Roma Tre" via della Vasca Navale 8400146 Roma Italy Osservatorio Astrofisico di Torino dell’Istituto Nazionale di Astrofisica via P.Giuria 110125 Torino Italy Istituto Nazionale di fisica Nucleare Sezione di Torino via P.Giuria 110125 Torino Italy dipartimento di fisica dell’Università di Torino via P.Giuria 110125 Torino Italy Physics Department Kunming University Normal College of Fuyang

The energy spectrum of cosmic Hydrogen and Helium nuclei has been measured below the so-called ＂knee＂ by using a hybrid experiment with a wide field-of-view Cherenkov telescope and the Resistive Plate Chamber （RPC） array of the ARGO-YBJ experiment at 4300 m above sea level. The Hydrogen and Helium nuclei have been well separated from other cosmic ray components by using a multi-parameter technique. A highly uniform energy resolution of about 25% is achieved throughout the whole energy range （100-700 TeV）. The observed energy spectrum is compatible with a single power law with index γ=-2.63±0.06.

关键词： Cherenkov telescope ARGO-YBJ energy spectrum hybrid measurement composition

Moment Maps and equivariant Volumes

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Acta Mathematica Sinica,english Series 2007年第12期23卷 2155-2188页

作者： Alberto DeLLA VeDOVA Roberto PAOLeTTI dipartimento di Matematica Università degli Studi di Parma Viale dipartimento di Matematica e Applicazioni Università degli Studi di Milano Bicocca

The study of the volume of big line bundles on a complex projective manifold M has been one of the main veins in the recent interest in the asymptotic properties of linear series. In this article, we consider an equiv... 详细信息

关键词： big line bundle asymptotic invariant moment map GIT quotient