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Small heat shock protein B8:from cell functions to its involvement in diseases and potential therapeutic applications

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Neural Regeneration Research 2025年第10期20卷 2872-2886页

作者： Marta Chierichetti Riccardo Cristofani Valeria Crippa Veronica Ferrari Marta Cozzi Elena Casarotto Paola Pramaggiore Laura Cornaggia Guglielmo Patelli Ali Mohamed Margherita Piccolella Mariarita Galbiati Paola Rusmini Barbara Tedesco Angelo Poletti Laboratory of Experimental Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock ***8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in other processes such as inflammation,cell division,and ***8 binds misfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective *** line with this function,the pro-degradative activity of HSPB8 has been found protective in several neurodegenerative and neuromuscular diseases characterized by protein misfolding and *** cancer,HSPB8 has a dual role being capable of exerting either a pro-or an anti-tumoral activity depending on the pathways and factors expressed by the model of cancer under ***,HSPB8 exerts a protective function in different diseases by modulating the inflammatory response,which characterizes not only neurodegenerative diseases,but also other chronic or acute conditions affecting the nervous system,such as multiple sclerosis and intracerebellar *** note,HSPB8 modulation may represent a therapeutic approach in other neurological conditions that develop as a secondary consequence of other *** is the case of cognitive impairment related to diabetes mellitus,in which HSPB8 exerts a protective activity by assuring mitochondrial *** review aims to summarize the diverse and multiple functions of HSPB8 in different pathological conditions,focusing on the beneficial effects of its ***-based and alternative therapeutic approaches targeting HSPB8 and its regulated pathways will be discussed,emphasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatments.

关键词： aggregation autophagy cancer chaperone chaperone-assisted selective autophagy cognitive impairment HSPB8 neuroinflammation neuromuscular diseases therapy

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高组分稀磁半导体Cd_(1-x)Mn_xTe/CdTe超晶格的荧光谱研究

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光谱学与光谱分析 2006年第3期26卷 396-398页

作者：陈辰嘉王学忠 Bellani V Stella A 北京大学物理学院 dipartimento di fisica "a.volta" and infm Università degli Studi Pavia 27100 Pavia Italy

报道用分子束外延(MBE)技术生长的x=0.4,0.8的高组分稀磁半导体Cd1-xMnxTe/CdTe超晶格低温和室温荧光谱研究结果。基态激子跃迁能级荧光谱实验结果显示高组分超晶格中具有高量子效率和高质量光发射。对激子能级随温度的变化进行了详细研... 详细信息

报道用分子束外延(MBE)技术生长的x=0.4,0.8的高组分稀磁半导体Cd1-xMnxTe/CdTe超晶格低温和室温荧光谱研究结果。基态激子跃迁能级荧光谱实验结果显示高组分超晶格中具有高量子效率和高质量光发射。对激子能级随温度的变化进行了详细研究,给出激子跃迁能量的温度系数。激子能级线型的展宽随温度变化关系可用激子-纵向光学声子耦合模型解释。与光调制反射谱实验结果进行了比较。

关键词：荧光谱超晶格稀磁半导体光学声子激子跃迁

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高组分稀磁半导体Cd_(1 -x)Mn_xTe/CdTe超晶格的光调制反射谱研究

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红外与毫米波学报 2002年第5期21卷 332-336页

作者：陈辰嘉王学忠梁晓甘李海涛凌震王迅 V Bellani M Geddo A Stella S Tavazzi A Borghesi A Sassella 北京大学物理系北京100871 复旦大学应用表面物理实验室上海200433 infm-dipartimento di fisica"a.volta"dell’Universitiy di pavia infm-dipartimento di Scienza dei Materiali University di Milano Bicocca milanoitaly20125

报道用分子束外延 (MEB)技术生长的x =0 4 ,0 8的高组分稀磁半导体Cd1-xMnxTe/CdTe超晶格的光调制反射谱在室温和液氮下的实验结果 .观测到 11H ,2 2H ,33H和 11L等激子跃迁结构 ,计及子能级的量子限定效应和晶格失配导致的应力效应 ... 详细信息

报道用分子束外延 (MEB)技术生长的x =0 4 ,0 8的高组分稀磁半导体Cd1-xMnxTe/CdTe超晶格的光调制反射谱在室温和液氮下的实验结果 .观测到 11H ,2 2H ,33H和 11L等激子跃迁结构 ,计及子能级的量子限定效应和晶格失配导致的应力效应 ,对子能级结构进行了计算 ,除x =0 8样品的 33H能量计算值与实验值有较大偏差外 ,实验结果与理论符合得很好 .还与光致发光谱实验结果进行了比较 .

关键词：光调制反射激子跃迁应力效应超晶格

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On the Large-Scale Structure of the Universe as given by the Voronoi diagrams

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Chinese Journal of Astronomy and Astrophysics 2006年第4期6卷 387-395页

作者： L. Zaninetti dipartimento di fisica Generale

The size distributions of 2D and 3D Voronoi cells and of cells of Vp（2, 3）,--2D cut of 3D Voronoi diagram--are explored, with the slngle-parameter （re-scaled） gamma distribution playing a central role in the analytical fitting. Observational evidence for a cellular universe is briefly reviewed. A simulated Vp（2, 3） map with galaxies lying on the cell boundaries is constructed to compare, as regards general appearance, with the observed CfA map of galaxies and voids, the parameters of the simulation being so chosen as to reproduce the largest observed void size.

关键词： surveys -- galaxies clusters general -- (cosmology:) large-scale structure of Universe

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Mn/Sb多层膜的磁性和磁光特性(英文)

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红外与毫米波学报 2004年第4期23卷 241-245页

作者：陈辰嘉王学忠蔡明吴克丁晓民孙允希 Filippo Maglia A.Stella 北京大学物理系北京100871 Department of Physical Chemistry University of Pavia infm-dipartimento of fisica"a.volta"dell’Universita

用超高真空蒸发技术在GaAs(10 0 )和玻璃衬底上生长不同厚度Mn/Sb多层膜 ,并经短时间热退火 (～ 1,2 0min) .磁化强度测量显示具有很强的室温铁磁特性 .当多层膜厚度从 70 0 增至 16 0 0 时 ,饱和强度增加了近一倍 ,极向和纵向克尔角... 详细信息

用超高真空蒸发技术在GaAs(10 0 )和玻璃衬底上生长不同厚度Mn/Sb多层膜 ,并经短时间热退火 (～ 1,2 0min) .磁化强度测量显示具有很强的室温铁磁特性 .当多层膜厚度从 70 0 增至 16 0 0 时 ,饱和强度增加了近一倍 ,极向和纵向克尔角也增加了 ,但不到一倍 .这表明磁化强度和克尔角两者均依赖于多层摸的厚度 ,但不是简单的正比于厚度的关系 .增加Mn/Sb多层膜的厚度能增强饱和磁化强度和极向和纵向克尔饱和角 .X射线衍射谱图结果表明高质量单晶结构的Mn/Sb多层膜能用超高真空蒸发技术生长 ,对较厚的多层薄膜 ,热退火的时间可很短(约 1min) .

关键词：锰/锑多层膜铁磁性磁光克尔效应 X射线衍射退火处理

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Probing Local Lattice Fluctautions in Cuprates and Manganites by High k-Resolution EXAFS

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中国科学技术大学学报 2001年第3期31卷 289-298页

作者： N.L. Saini (Unitá infm and dipartimento di fisica, Università di Roma “La Sapienza” P.le Aldo Moro 2, 00185 Roma, Italy) Unita infm and dipartimento di fisica Universita di Roma“La Sapienza”P 意大利 20 0 1 85

X ray absorption fine structure has been exploited as a tool to study local lattice distortions in the perovskite cuperates and manganites, showing novel phenomena as high temperature superconductivity and colossal magneto resistance. Temperature dependent Cu K \%edge\% and Mn K \%edge\% EXAFS have been used to investigate the local lattice distortions associated with the doped charge at metallic densities in these materials. Temperature dependent correlated Debye Waller factors of the Cu O in the cuprates shows an upturn at the stripe formation temperature T \%so\% . Capabilities of the EXAFS technique have been further demonstrated for the case of the manganites, revealing key information on their metal insulator transition. The EXAFS has been shown to be capable of providing quantitative local distortions that are closely associated with the characteristic properties of these complex materials.

关键词：铜系化合物锰系化合物局域晶格形变 EXAFS

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The race for quantum supremacy: pushing the classical limit for photonic hardware

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National Science Review 2019年第1期6卷 2-3页

作者： Nicolò Spagnolo Fabio Sciarrino Quantum Lab Dipartimento di FisicaSapienza Università di Roma

The strong efforts towards the realization of scalable quantum computing are motivated by the promise of super-polynomial speed-up in several computational tasks.A first fundamental step in this route is to provide concrete evidence of ‘quantum supremacy’. Such a regime is obtained when a quantum device is capable of solving a specific problem faster than the best classical hardware. A serious attempt to provide a first demonstration of quantum speed-up with affordable resources is represented by boson sampling [1,2],

关键词： The race for quantum supremacy pushing the classical limit for photonic hardware

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KLOE results on light mesons

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Chinese Physics C 2010年第9期34卷 1379-1382页

作者： S.Fiore dipartimento di fisica Sapienza Universitàdi Roma

The KLOE collaboration has recently published new results concerning scalar and pseudoscalar *** the φ → a 0 （980）γ → ηπ 0 γ decay analysis and the search for the φ → K 0 K 0 γ decay are discussed,together with the η → π ＋ π-e ＋ edecay measurements annd the new results for the pseudoscalar mixing angle and gluonium content of the η’ meson.

关键词： KLOE light mesons

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Updating the orbital ephemeris of the dipping source XB 1254–690 and the distance to the source

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Research in Astronomy and Astrophysics 2017年第10期17卷 97-108页

作者： Angelo F.Gambino Rosario Iaria Tiziana di Salvo Marco Matranga Luciano Burderi Fabio Pintore Alessandro Riggio Andrea Sanna Universita degli Studi di Palermo Dipartimento di Fisica e Chimica Universita degli Studi di Cagliari Dipartimento di Fisica INAF-Istituto di Astrofisica Spaziale e fisica Cosmica - Milano

XB 1254-690 is a dipping low mass X-ray binary system hosting a neutron star and showing type I X-ray bursts. We aim at obtaining a more accurate orbital ephemeris and at constraining the orbital period derivative of the system for the first time. In addition, we want to better constrain the distance to the source in order to locate the system in a well defined evolutive scenario. We apply, for the first time, an orbital timing technique to XB 1254-690, using the arrival times of the dips present in the light curves that have been collected during 26 yr of X-ray pointed observations acquired from different space missions. We estimate the dip arrival times using a statistical method that weights the count-rate inside the dip with respect to the level of persistent emission outside the dip. We fit the obtained delays as a function of the orbital cycles both with a linear and a quadratic function. We infer the orbital ephemeris of XB 1254-690, improving the accuracy of the orbital period with respect to previous estimates. We infer a mass of M2 = 0.42 ± 0.04 M for the donor star, in agreement with estimations already present in literature, assuming that the star is in thermal equilibrium while it transfers part of its mass via the inner Lagrangian point, and assuming a neutron star mass of 1.4 Mo. Using these assumptions, we also constrain the distance to the source, finding a value of 7.6±0.8 kpc. Finally, we discuss the evolution of the system, suggesting that it is compatible with a conservative mass transfer driven by magnetic braking.

关键词： stars: neutron -- stars: individual (XB 1254-690) -- X-rays: binaries -- X-rays: stars --Astrometry and celestial mechanics: ephemerides

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Generation of Pair Coherent States in Two dimensional Trapped Ion

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Chinese Physics Letters 2001年第3期18卷 367-369页

作者： WANG Kai-Ge S Maniscalco A Napoli A Messina Department of Physics Beijing Normal UniversityBeijing 100875 infm and dipartimento di Scienze Fisiche ed Astronomiche dell’Universitädi Palermo Palermo 90123Italy

We consider a two-dimensional(2D)trapped ion model in which two laser beams drive the corresponding vibrational motions and are carrier resonant with the two-level of the *** to the coherent superposition of two sub-Rabi oscillations involved in the bimodal vibrations,the Rabi frequency degeneration and offset may occur in this *** provides a possibility to generate the pair coherent state in the 2D trapped ion.

关键词： coherent degeneration modal

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