检索结果-南通市图书馆

Oncology Research 2023年第4期31卷 423-436页

作者： LAURA MARRONe MASSIMO D’AGOSTINO CAROLINA GIORDANO VALeRIA di GIACOMO SIMONA URZINI CHIARA MALASOMMA MARIA PAOLA GAMMeLLA MARTINA TUFANO SIMONA ROMANO MARIA FIAMMeTTA ROMANO Department of Molecular Medicine and Medical Biotechnology University of Naples Federico IINaples80131Italy dipartimento di diagnostica per immagini e neuroradiologia Fondazione Policlinico Universitario“A.Gemelli”IRCCSUniversitàCattolica S.CuoreRomeItaly

Scaffold proteins are crucial regulators of signaling networks,and their abnormal expression may favor the development of *** the scaffold proteins,immunophilin covers a unique role as‘protein-philin’(Greek‘philin’=friend)that interacts with proteins to guide their proper *** growing list of human syndromes associated with the immunophilin defect underscores the biological relevance of these proteins that are largely opportunistically exploited by cancer cells to support and enable the tumor’s intrinsic *** the members of the immunophilin family,the FKBP5 gene was the only one identified to have a splicing *** cells impose unique demands on the splicing machinery,thus acquiring a particular susceptibility to splicing *** review article aims to overview the current knowledge of the FKBP5 gene functions in human cancer,illustrating how cancer cells exploit the scaffolding function of canonical FKBP51 to foster signaling networks that support their intrinsic tumor properties and the spliced FKBP51s to gain the capacity to evade the immune system.

关键词： Immunophilin Alternative splicing Signal transduction

A rare case of epiploic appendagitis in a patient affected by ulcerative colitis on vedolizumab therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Gastroenterology Report 2022年第1期10卷 661-664页

作者： Daniela Pugliese Giuseppe Privitera Luigi Larosa Valentin Calvez diana Broglia Nicoletta de Matthaeis Alessandro Armuzzi CeMAD IBD UNITUnita Operativa Complessa di Medicina Interna e GastroenterologiaDipartimento di Scienze Mediche e ChirurgicheFondazione Policlinico Universitario“A.Gemelli”IRCCSRomeItaly dipartimento Universitario di Medicina e Chirurgia Traslazionale Universita Cattolica del Sacro CuoreRomeItaly Fondazione Policlinico Universitario A.Gemelli IRCCS UOC di Radiodiagnostica Presidio ColumbusDipartimento di Diagnostica per immaginiRadioterapia Oncologica ed EmatologiaLargo Francesco VitoRomeItaly Universita Cattolica del Sacro Cuore RomeItaly IBD Center IRCCS Humanitas Research HospitalRozzanoMilanItaly Department of Biomedical Sciences Humanitas UniversityPieve EmanueleMilanItaly

Introduction epiploic appendagitis(eA)is an acute inflammation of the pedunculated mesenteric fat attached to the colonic surface,distinguished into two forms:primary eA,seemingly elicited by local ischaemic factors;and secondary eA(SeA),elicited by the inflammation of the adjacent organs,with diverticulitis being the most common trigger[1].Few case series have described the association between SeA and inflammatory bowel disease(IBD);however,information about clinical,laboratory and imaging findings,outcomes,and the impact of IBD-specific therapy were not *** first report the case of a woman affected by ulcerative colitis(UC)who developed a SeA during vedolizumab therapy(Figure 1A).

关键词： inflammation organs acute

Post-transplantation hepatocellular carcinoma recurrence: Patterns and relation between vascularity and differentiation degree

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2015年第2期7卷 276-284页

作者： Annarita Pecchi Giulia Besutti Mario De Santis Cinzia Del Giovane Sofia Nosseir Giuseppe Tarantino Fabrizio di Benedetto Pietro Torricelli dipartimento di diagnostica per immagini Azienda Ospedaliero-Universitaria Policlinico di Modena Unità di Statistica Medica Dipartimento di Medicina Diagnostica Clinica e Sanità Pubblica Università di Modena e Reggio Emilia dipartimento dei Laboratori Anatomia Patologica e Medicina Legale Università degli studi di Modena e Reggio Emilia dipartimento Chirurgico Medico Odontoiatrico e di Scienze Morfologiche con interesse Trapiantologico Oncologico e di Medicina Rigenerativa Università di Modena e Reggio Emilia

AIM: To evaluate the relationship between hepatocellular carcinoma(HCC) vascularity and grade; to describe patterns and vascular/histopathological variations of post-transplantation ***: This retrospective study included 165 patients(143 men, 22 women; median age 56.8 years, range 28-70.4 years) transplanted for HCC who had a follow-up period longer than 2 mo. Pre-transplantation dynamic computed tomography or magnetic resonance examinations were retrospectively reviewed, classifying HCC imaging enhancement pattern into hypervascular and hypovascular based on presence of wash-in during arterial phase. All pathologic reports of the explanted livers were reviewed, collecting data about HCC differentiation degree. The association between imaging vascular pattern and pathological grade was estimated using the Fisher exact test. All follow-up clinical and imaging data were reviewed for evidence of recurrence. Recurrence rate was calculated and imaging features of recurrent tumor were collected, classifying early and late recurrences based on timing(ears after transplantation) and intrahepatic, extrahepatic and both intrahepatic and extrahepatic recurrences based onlocation. All intrahepatic recurrences were classified as hypervascular or hypovascular and the differentiation degree was collected where available. The presence of variations in imaging enhancement pattern and pathological grade between the primary tumor and the intrahepatic recurrence was evaluated and the association between imaging and histopatholgical variations was estimated by using the χ2 test. ReSULTS: Of the 163 patients with imaging evidence of viable tumor, 156(95.7%) had hypervascular and 7(4.3%) hypovascular HCC. Among the 125 patients with evidence of viable tumor in the explanted liver, 19(15.2%) had grade 1, 56(44.8%) grade 2, 40(32%) grade 3 and 4(3.2%) grade 4 HCC, while the differentiation degree was not assessable for 6 patients(4.8%). A significant association was

关键词： Contrast media Hepatocellular carcinoma Liver transplantation Cell differentiation Recurrence

一项对取自抗生素耐受性眼内炎患者尼龙状角膜缝线的黏稠液态表皮葡萄球菌组织进行的微生物学及共焦显微镜研究

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

世界核心医学期刊文摘(眼科学分册) 2006年第1期 52-53页

作者： Nucci C. Artini M. Pasmore M. 王文军 Cattedra di Ottica Fisiopatologia dipartimento di Biopatologia e diagnostica per immagini Università di RomaTor Vergata Via Montpellier 1 00133 Rome Italy

Background: We describe a case of posttraumatic endophthalmitis unresponsive to systemic (amoxicillin+ clavulanic acid and piperacillin/tazobactam), intra ocular (vancomycin) and topical (ofloxacin, tetracycline and sulfametoxazole) antibiotic therapy. Microbiological and confocal microscopy studies of a nylon corneal suture revealed the presence of a slime-producing strain of Staphylococcus epidermidis. Methods: We describe the history and clinical presentation of a 77-year-old man in whom a high-grade posttraumatic endophthalmitis resolved only after the removal of a single nylon corneal suture. Microbiological investigations of the aqueous, vitreous and suture were performed, and the propensity of the suture-associated isolate to form biofilm was assessed using confocal microscopy. Results: A single stain of S. epidermidis was isolated from both aqueous and vitreous specimens and from the suture. The planktonic form of the isolate was susceptible in vitro to the antibiotics administered to the patient, but the strain was capable of forming biofilms and this phenotype showed resistance to high concentrations of the same antibiotics. Conclusions: The presence of a slime-producing strain of S. epidermidis should be considered in endophthalmitis that is unresponsive to specific antibiotic therapy, especially in cases in which an intra-ocular foreign body (e.g., a suture) is present.

关键词：缝线生物材料眼内炎角膜表皮葡萄球菌葡萄球菌属耐受性尼龙抗生素微生物学显微镜实验设备患者液态

前瞻性多模态成像评估局部晚期宫颈癌病人放化疗后行根治手术——“宫颈癌的前瞻性影像学及新辅助治疗”研究2:常规序列和DW-MRI扫描的作用

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

国际医学放射学杂志 2019年第3期 379-379页

作者：于子川 B.Gui M.Miccò A.L.Valentini F.Cambi T.Pasciuto A.Testa Radiologia diagnostica e Interventistica Generale Area Diagnosticaper ImmaginiDipartimento Diagnostica per ImmaginiRadioterapia Oncologica ed EmatologiaFondazione Policlinico Universitario A.Gemelli IRCCS

摘要目的评价常规和DW-MRI检查对局部晚期宫颈癌(LACC)行新辅助放化疗(nCRT)及根治性手术后病人肿瘤残留的诊断价值。方法在2010年10月—2014年6月

关键词：常规序列特异度局部晚期宫颈癌 DW-MRI

Immunosuppressive treatment and radiotherapy in kidney transplant patients:A systematic review

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Radiology 2022年第3期14卷 60-69页

作者： Valentina Lancellotta Andrea D'Aviero Bruno Fionda Calogero Casà Ilaria esposito Francesco Preziosi Anna Acampora Fabio Marazzi György Kovács Barbara Alicja Jereczek-Fossa Alessio Giuseppe Morganti Vincenzo Valentini Maria Antonietta Gambacorta Jacopo Romagnoli Luca Tagliaferri UOC Radioterapia Oncologica Dipartimento di Diagnostica per ImmaginiRadioterapia Oncologica ed EmatologiaFondazione Policlinico Universitario A.Gemelli IRCCSRome 00168RomeItaly Sezione di Igiene Dipartimento Universitario di Scienze della Vita e SanitàPubblicaUniversitàCattolica del Sacro CuoreRome 00168RomeItaly UniversitàCattolica del Sacro Cuore Gemelli-INTERACTSRome00168 RomeItaly Department of Oncology and Hemato-oncology European Institute of OncologyUniversity of MilanMilan 20141Italy Radiotherapy Center IRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40121Italy Renal Transplant Unit Fondazione Policlinico Universitario A.Gemelli IRCCSRome 00168RomeItaly

BACKGROUND Immunosuppression(IS)therapy may contribute to cancer *** authors have proposed to reduce immunosuppression drugs dose in case of viral infections,in immunosuppression-related diseases,and in patients undergoing *** present analysis reports the results of a systematic review on kidney transplant recipients undergoing immunosuppression and *** To define if it is necessary reduce immunosuppression drugs during *** The literature search was based on three electronic databases(Pubmed,Scopus,and Web of Science)using selected keywords linked through the"AND"and"OR"Boolean operators to build specific strings for each electronic search *** researchers independently screened the citations,and disagreement was resolved by discussion or through the intervention of a third *** review was conducted and reported according to the PRISMA *** data were narratively synthesized,and,where possible,frequencies,percentages,and ranges were *** The literature search resulted in 147 *** abstracts screening,21 records were selected for full-text *** of these were excluded,leaving six papers considered suitable for *** is still no clear evidence that withdrawing antimetabolites and/or calcineurin inhibitors and/or mammalian target of rapamycin-inhibitors,as opposed to continuing maintenance IS,improves patient survival in kidney transplant recipients with cancer undergoing *** few retrospective studies on small cancer patient cohorts are available in this setting,but without comparison of different immunosuppression *** where immunosuppression therapy was described,patient survival seemed to be correlated only with cancer stage and *** The results of this systematic review do not support the reduction of immunosuppression dose in patients undergoing radiotherapy.

关键词： Renal transplant patients Graft rejection Immunosuppression Radiotherapy Survival