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Intratumoral sampling variability in hepatocellular carcinoma: A case report

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World Journal of Gastroenterology 2007年第29期13卷 4019-4021页

作者： Giancarlo Senes Daniela Fanni Alessandro Cois Alessandro Uccheddu Gavino Faa dipartimento di Citomorfologia Divisione di Anatomia Patologica University of Cagliari Cagliari Italy dipartimento Chirurgico Materno Infantile e di Scienze delle Immagini Clinica Chirurgica University of Cagliari Cagliari Italy

The differential diagnosis between hepatocellular carcinoma （HCC） and regenerative liver nodules and other primary liver tumors may be very difficult, particularly when performed on liver biopsies. difficulties in histological typing may be often minimized by immunohistochemistry. Among the numerous markers proposed, CK18, Hep Par1 and glypican 3 （GPC3） are considered the most useful in HCC diagnosis. Here we report a case of HCC in a 72-year-old male with HBV- related chronic liver disease, characterized by a marked morphological and immunohistochemical intratumoral variability. In this case, tumor grading ranged from areas extremely well differentiated, similar to regenerative nodule, to undifferentiated regions, with large atypical multinucleated cells. While almost all sub nodules were immunostained by Hep Par 1, immunoreactivity for glypican 3 and for Ckl8 was patchy, with negative tumor region adjacent to the highly immunoreactive areas. Our case stresses the relevance of sampling variability in the diagnosis of HCC, and indicates that caution should be taken in grading an HCC and in the interpretation of immunohistochemical stains when only small core biopsies from liver nodules are available.

关键词： Liver Hepatocellular carcinoma Sampling variability Hep Par 1 GPC3 differentiation

Complete pancreatic heterotopia of gallbladder with hypertrophic duct simulating an adenomyoma

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World Journal of Gastroenterology 2006年第11期12卷 1786-1787页

作者： Luca Pilloni Alessandro Cois Alessandro Uccheddu Rossano Ambu Pierpaolo Coni Gavino Faa Istituto di Anatomia Patologica dipartimento di Citomorfologia Universita degli Studi di CagliariItaly Semeiotica Chirurgica dipartimento Chirurgico Materno Infantile e di scienze delle Immagini Università degli Studi di CagliariItaly Istituto di Anatomia Patologica dipartimento di Citomorfologia Università degli Studi di CagliariItaly

The gallbladder is an unusual location of pancreatic heterotopia, defined as the presence of pancreatic tissue lacking anatomical and vascular continuity with the main body of the gland. A 28-year-old man presented with anorexia, nausea and pain in the right upper abdomen. On physical examination, the abdomen was tender to palpation and Murphy sign was positive. The patient underwent a cholecystecomy. This case, in our opinion, is very interesting since it permits to consider a controversial issue in the pathology of the gallbladder. The histological appearance of ductal structure in pancreatic heterotopia resembles the histological picture of both Aschoff-Rokitansky （AR） sinuses and adenomyomas. This finding suggests that these lesions are linked by a common histogenetic origin. We suggest that the finding of an adenomyoma in the gallbladder should prompt an extensive sampling of the organ in order to verify the coexistence of pancreatic rests.

关键词： Pancreatic heterotopia Gallbladder Hypertrophic duct Adenomyoma Aschoff-Rokitansky sinuses

Ligninolytic Peroxidase-Like Activity of a Synthetic Metalloporphine Immobilized onto Mercapto-Grafted Crosslinked PVA Inspired by the Active Site of Cytochrome P450

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催化学报 2011年第11期32卷 1663-1666页

作者： Paolo ZUCCA Antonio RESCIGNO Enrico SANJUST dipartimento di scienze e Tecnologie Biomediche Università di Cagliari Monserrato 09042 Italy Consorzio per lo Sviluppo dei Sistemi a Grande Interfase Sesto Fiorentino 50019 Italy

A synthetic metalloporphine was immobilized onto a PVA-based and mercapto-grafted solid support, emulating the active site of cytochrome P450. Its ligninolytic peroxidase-like catalytic activity was studied. The coordinated mercapto ligand significantly affected the catalytic features of the catalyst because the oxidation of lignin-model compounds was very slow by comparison with imidazoleand pyridine-coordinated immobilized metalloporphines. Conversely, the catalyst efficiently bleached several industrial dyes and thus demonstrated promising activity for this application. Based on this altered substrate specificity the oxygen-donor catalytic route seems to be more favorable than a single electron oxidation pathway.

关键词： porphine porphyrin lignin peroxidase cytochrome P450 biomimetic

Geomorphosites: Concepts,methods and examples of geomorphological survey

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Chinese Science Bulletin 2001年第S1期46卷 4-6页

作者： Mario Panizzadipartimento di scienze della Terra, Universita degli Studi di Modena e Reggio Emilia, Largo S. Eufemia 19-41100, Modena, Italy (e-mail: pit?unimo.it) dipartimento di scienze della Terra Università degli Studi di Modena e Reggio Emilia Modena Italy

Some fundamental concepts on geosites and particularly on geomorphological assets (geomorphosites) are reviewed and a methodology for their survey and assessment is presented and pointed out. Also, a case study in the... 详细信息

关键词： geomorphosite geomorphological asset geosite Modena Italy.

Generation of Pair Coherent States in Two dimensional Trapped Ion

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Chinese Physics Letters 2001年第3期18卷 367-369页

作者： WANG Kai-Ge S Maniscalco A Napoli A Messina Department of Physics Beijing Normal UniversityBeijing 100875 INFM and dipartimento di scienze Fisiche ed Astronomiche dell’Universitädi Palermo Palermo 90123Italy

We consider a two-dimensional(2D)trapped ion model in which two laser beams drive the corresponding vibrational motions and are carrier resonant with the two-level of the *** to the coherent superposition of two sub-Rabi oscillations involved in the bimodal vibrations,the Rabi frequency degeneration and offset may occur in this *** provides a possibility to generate the pair coherent state in the 2D trapped ion.

关键词： coherent degeneration modal

Helicobacter pylori and extragastric diseases: A review

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World Journal of Gastroenterology 2018年第29期24卷 3204-3221页

作者： Antonietta Gerarda Gravina Rocco Maurizio Zagari Cristiana De Musis Lorenzo Romano Carmelina Loguercio Marco Romano dipartimento di "Medicina di Precisione" UOC Epatogastroenterologia Università della Campania "Luigi Vanvitelli" dipertimento di scienze Mediche e Chirurgiche Università di Bologna

Helicobacter pylori(H. pylori) infection is very common and affects approximately half of the world population. It causes gastric diseases, but some authors have reported an association of H. pylori infection with other systemic manifestations beginning in 1994. The list of potential effects of H. pylori outside the stomach includes a number of extragastric manifestations and we focused on neurological, dermatological, hematologic, ocular, cardiovascular, metabolic, allergic, and hepatobiliary diseases. This review discusses these important reported manifestations that are not related to the gastrointestinal tract.

关键词： Helicobacter pylori Extragastric disease Neurological diseases Dermatological diseases Hematologic diseases Ocular diseases Cardiovascular diseases Metabolic diseases Allergic diseases Hepatobiliary diseases

diagnosis and management of choledocholithiasis in the golden age of imaging, endoscopy and laparoscopy

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World Journal of Gastroenterology 2014年第37期20卷 13382-13401页

作者： Renato Costi Alessandro Gnocchi Francesco di Mario Leopoldo Sarli dipartimento di scienze Chirurgiche Università di ParmaAzienda Ospedaliero-Universitaria di Parma dipartimento Materno Infantile Unità Operativa di Gastroenterologia ed Endoscopia DigestivaAzienda Ospedaliero-Universitaria di Parma dipartimento di Medicina Clinica e Sperimentale Università di ParmaAzienda Ospedaliero-Universitaria di Parma

Biliary lithiasis is an endemic condition in both Western and Eastern countries, in some studies affecting 20% of the general population. In up to 20% of cases, gallbladder stones are associated with common bile duct stones (CBDS), which are asymptomatic in up to one half of cases. Despite the wide variety of examinations and techniques available nowadays, two main open issues remain without a clear answer: how to cost-effectively diagnose CBDS and, when they are finally found, how to deal with them. CBDS diagnosis and management has radically changed over the last 30 years, following the dramatic diffusion of imaging, including endoscopic ultrasound (EUS) and magnetic resonance cholangiography (MRC), endoscopy and laparoscopy. Since accuracy, invasiveness, potential therapeutic use and cost-effectiveness of imaging techniques used to identify CBDS increase together in a parallel way, the concept of “risk of carrying CBDS” has become pivotal to identifying the most appropriate management of a specific patient in order to avoid the risk of “under-studying” by poor diagnostic work up or “over-studying” by excessively invasive examinations. The risk of carrying CBDS is deduced by symptoms, liver/pancreas serology and ultrasound. “Low risk” patients do not require further examination before laparoscopic cholecystectomy. Two main “philosophical approaches” face each other for patients with an “intermediate to high risk” of carrying CBDS: on one hand, the “laparoscopy-first” approach, which mainly relies on intraoperative cholangiography for diagnosis and laparoscopic common bile duct exploration for treatment, and, on the other hand, the “endoscopy-first” attitude, variously referring to MRC, EUS and/or endoscopic retrograde cholangiography for diagnosis and endoscopic sphincterotomy for management. Concerning CBDS diagnosis, intraoperative chol

关键词： Biliary lithiasis Choledocholithiasis Laparoscopy Endoscopy diagnosis Management

Giardia lamblia infection in patients with irritable bowel syndrome and dyspepsia:A prospective study

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World Journal of Gastroenterology 2006年第12期12卷 1941-1944页

作者： Barbara Grazioli Giovanni Matera Costanza Laratta Giuseppina Schipani Giovanni Guarnieri Ester Spiniello Maria Imeneo Andrea Amorosi Alfredo Focà Francesco Luzza dipartimento di Medicina Sperimentale e Clinica Cattedra di Gastroenterologia Università di Catanzaro 'Magma Graecia' Catanzaro Italy dipartimento di scienze Mediche Istituto di Microbiologia Università di Catanzaro 'Magna Graecia' Catanzaro Italy dipartimento di Medicina Sperimentale e Clinica Cattedra di Anatomia Patologica Universith di Catanzaro 'Magna Graecia' Catanzaro Italy

AIM： To evaluate the prevalence of Giardia lamblia （G. lamblia） infection in patients with irritable bowel syndrome （IBS） and dyspepsia and to establish which is the most accurate test to diagnose the infection in this setting. METHODS： One hundred and thirty-seven patients who consecutively attended the Outpatient Gastroenterology Clinic for the first time between January 2002 and Decernber 2003 due to symptoms of IBS and/or dyspepsia were recruited. All patients underwent clinical evaluation, first-step haematology and chemistry tests, serologic assays for celiac disease, lactose-H2 breath test, abdominal ultrasonography, and esophagogastroduodenoscopy. Helicobacterpylon status was evaluated. In patients with symptoms of IBS older than 45 years, colonoscopy was also performed. In all patients, duodenal biopsies and stool samples were examined for trophozoites and cysts of G. lamblia by several methods. RESULTS： G. lamblia was identified in 9 patients. The following diagnoses were also made： IBS （100/137, 73%）, functional dyspepsia （62/137, 45%）, organic dyspepsia （33/137, 24%）, and lactose intolerance （75/137, 55%）. A significant association was found between giardiasis and H pylori infection （x^2= 6.632, OR= 12.4, CI= 1.5-68.1）. There were no symptoms that reliably allowed the recognition of giardiasis. direct search of the parasite in duodenal biopsy and stool sample examinations gave concordant results in all cases while histological examination of duodenal biopsies displayed a low sensitivity （e.g., 22.2%）. CONCLUSION： In this consecutive series, diagnosis of *** infection accounted for 6.5% of patients with IBS and dyspepsia. Duodenal biopsies for diagnosis of giardiasis may be unnecessary if stool sample examination is performed.

关键词： Dyspepsia Giardiasis H pylori Irritablebowel syndrome

Emerging environmental stressors and oxidative pathways in marine organisms:Current knowledge on regulation mechanisms and functional effects

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BIOCELL 2022年第1期46卷 37-49页

作者： MAURA BENEDETTI MARIA ELISA GIULIANI MARICA MEZZELANI ALESSANDRO NARdi LUCIA PITTURA STEFANIA GORBI FRANCESCO REGOLI dipartimento di scienze della Vitaedell’Ambiente UniversitàPolitecnica delle MarcheAncona60131Italy

Oxidative stress is a critial condition derived from the imbalance between the genention of reactive oxygen species and the sophisticated network of antioidant *** pollut ants and envronmental factors can afet this system through connected mechanisms,indirect relationships,and cascade effects from pre-transcriptional to catalytic level,by either enhancing intracellular ROS formation or impairing antioxidant *** review summariaces the current kmnowledge on the pro oxidant challenges from emerging environmental stressors threatening marine organisms,such as pharmaceutials microplastics and dimate related ocean *** will be placed on oxidative pathways,including signaling proteins and transcription factors involved in regulation of antioxidant *** insights and lack of knowdedge will be pointed out by presenting single and combined efects of multiple stessors,unraveling questions to be adresed by future resarch in marine ectoicology.

关键词： Antioxidant Pharmaceuticals Microplastics/Nanoplastics Ocean acidification Thermal stress