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Small heat shock protein B8:from cell functions to its involvement in diseases and potential therapeutic applications

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Neural Regeneration Research 2025年第10期20卷 2872-2886页

作者： Marta Chierichetti Riccardo Cristofani Valeria Crippa Veronica Ferrari Marta Cozzi Elena Casarotto Paola Pramaggiore Laura Cornaggia Guglielmo Patelli Ali Mohamed Margherita Piccolella Mariarita Galbiati Paola Rusmini Barbara Tedesco Angelo Poletti Laboratory of Experimental Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock ***8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in other processes such as inflammation,cell division,and ***8 binds misfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective *** line with this function,the pro-degradative activity of HSPB8 has been found protective in several neurodegenerative and neuromuscular diseases characterized by protein misfolding and *** cancer,HSPB8 has a dual role being capable of exerting either a pro-or an anti-tumoral activity depending on the pathways and factors expressed by the model of cancer under ***,HSPB8 exerts a protective function in different diseases by modulating the inflammatory response,which characterizes not only neurodegenerative diseases,but also other chronic or acute conditions affecting the nervous system,such as multiple sclerosis and intracerebellar *** note,HSPB8 modulation may represent a therapeutic approach in other neurological conditions that develop as a secondary consequence of other *** is the case of cognitive impairment related to diabetes mellitus,in which HSPB8 exerts a protective activity by assuring mitochondrial *** review aims to summarize the diverse and multiple functions of HSPB8 in different pathological conditions,focusing on the beneficial effects of its ***-based and alternative therapeutic approaches targeting HSPB8 and its regulated pathways will be discussed,emphasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatments.

关键词： aggregation autophagy cancer chaperone chaperone-assisted selective autophagy cognitive impairment HSPB8 neuroinflammation neuromuscular diseases therapy

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Electrophysiologic behaviour of a left sided accessory pathway with decremental (Mahaim-like) properties

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Open Journal of Internal Medicine 2012年第1期2卷 34-36页

作者： Marco Galeazzi Maurizio Russo Sabina Ficili Carlo Lavalle Claudio Pandozi dipartimento cardiovascolare Ospedale San Filippo Neri Rome Italy

The observation of a left sided accessory pathway with decremental properties is rare. We describe the behaviour of one of these pathways which was characterized by the presence of retrograde conduction (not previousl... 详细信息

关键词： Accessory Pathway Decremental Properties

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Prevalence of factor V Leiden and prothrombin G20210A in patients with gastric cancer

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World Journal of Gastroenterology 2006年第26期12卷 4179-4180页

作者： Sandra Battistelli Massimo Stefanoni Alberto Genovese Aurelio Vittoria Roberto Cappelli Franco Roviello dipartimento di Chirurgia e Specialità Chimrgiche Policlinico Le Scotte Viale Bracci53100 SienaItaly dipartimento di Medicina Clinica e Scienze Immunologiche Policlinico Le Scotte Viale Bracci53100 SienaItaly dipartimento di Medicina Interna cardiovascolare e Geriatrica Policlinico Le ScotteViale Bracci53100 SienaItaly dipartimento di Patologia Umana ed Oncologia Policlinico Le Scotte Viale Bracci53100 SienaItaly

AIM： To analyze the prevalence of the two commonest thrombophilic mutations, factor V Leiden and prothrombin G20210A, in patients with gastric cancer. METHODS： One hundred and twenty-one patients with primary gastric carcinoma and 130 healthy subjects, comparable for age and sex, were investigated. Factor V Leiden was detected by using polymerase chain reaction and restriction enzyme digestion, and prothrombin G20210A gene mutation by allele-specific PCR. RESULTS： Among the 121 cancer patients, factor V Leiden was found in 4 cases （GA genotype： 3.3%） and prothrombin G20210A in 10 cases （GA genotype： 8.3%）. Of the 130 control subjects, factor V Leiden was detected in 6 cases （GA genotype： 4.6%） and prothrombin G20210A in 8 cases （GA genotype： 6.1%）. No double heterozygous carriers of both mutations were found in either group. The prevalence of both factor V Leiden and prothrombin G20210A variant was not statistically different between the cancer patients and the healthy subjects. CONCLUSION： Our study suggests that, in gastric cancer, the risk factors of thrombophilic cancer state are on acquired rather than on a genetic basis and that prothrombin G20210A does not seem to be a cofactor in gastric cancer pathogenesis.

关键词： Gastric cancer Genetic polymorphism Factor V Leiden Prothrombin G20210A

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An Integrated Approach for Optimal Design of Micro Gas Turbine Combustors

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Journal of Thermal Science 2009年第2期18卷 173-184页

作者： Luca Fuligno Diego Micheli Carlo Poloni EnginSoft s.p.a. dipartimento di Ingegneria Meccanica Universita degli Studi di Trieste dipartimento

The present work presents an approach for the optimized design of small gas turbine combustors, that integrates a0-D code, CFD analyses and an advanced game theory multi-objective optimization algorithm. The output of the0-D code is a baseline design of the combustor, given the required fuel characteristics, the basic geometry (tubularor annular) and the combustion concept (i.e. lean premixed primary zone or diffusive processes). For the optimizationof the baseline design a simplified parametric CAD/mesher model is then defined and submitted to a CFDcode. Free parameters of the optimization process are position and size of the liner hole arrays, their total area andthe shape of the exit duct, while different objectives are the minimization of NOx emissions, pressure losses andcombustor exit Pattern Factor. A 3D simulation of the optimized geometry completes the design procedure. As afirst demonstrative example, the integrated design process was applied to a tubular combustion chamber with alean premixed primary zone for a recuperative methane-fuelled small gas turbine of the 100 kW class.

关键词： micro gas turbine combustor optimized design

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Heat Loss from Buried Vertical Plate with Assigned Temperature Distribution

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Journal of Thermal Science 2009年第3期18卷 253-255页

作者： L.Fontana A.Quintino dipartimento di Progettazione e Studio dell'Architettura Universita degli Studi"Roma Tre" dipartimento

Thermal losses for a buried vertical thin plate can be expressed as a function of the assigned temperature distribution,the medium conductivity and the geometrical properties that describe the model. When the geometricalproperties reduce to one, the plate-ground thermal resistance can be expressed regardless of plate dimension, dependingonly on temperature distribution given at surface plate and its temperature difference with medium.

关键词： thermal resistance buried vertical plate

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Serum chromogranin-A in hepatocellular carcinoma: Diagnostic utility and limits

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World Journal of Gastroenterology 2005年第13期11卷 1987-1990页

作者： Aldo Spadaro Antonino Ajello Carmela Morace Agata Zirilli Graziella D'arrigo Carmelo Luigiano Francesco Martino Anna Bene Domenico Migliorato Santi Turiano Oscar Ferraù Maria Antonietta Freni dipartimento Clinico Sperimentale di Medicina e Farmacologia dipartimento di Statistica dipartimento di Scienze Radiologiche Unità Operativa di Gastroenterologia

AIM: The utility of serum alpha-fetoprotein (α-FP) for the detection of hepatocellular carcinoma (HCC) is questionable. High serum levels of chromogranin-A (CgA) have recently been reported in HCC. Impaired hepatic, renal, and heart functions influence circulating CgA. The aim of this study was to assess sensitivity and specificity of serum CgA as a marker of HCC in patients with liver cirrhosis (LC). METHODS: Serum CgA levels were measured by RIA in 339 patients of which 54 HCC, 132 LC, 45 chronic hepatitis (CH), 27 chronic heart failure (CHF), 36 chronic renal failure (CRF), 45 chronic inflammatory bowel disease (IBD) as disease controls and in 75 healthy controls. Patients with liver disease or IBD and concomitant renal and/or heart failure were excluded. Pearson correlation, non-parametric combination test and confidence interval analysis were used for statistical analysis. RESULTS: Serum CgA above normal values (100 ng/mL) were found in 83% of HCC patients, in 48% of LC patients, in 20% of CH patients, in 33% of IBD patients, in 92% of CRF patients, in 100% of CHF patients, and in none of the healthy controls. The mean CgA values in HCC (769±1046), in LC (249±369), in CH (87±94), in CRF (1390±1401), in CHF (577±539), in IBD (146±287) were significantly higher than those in healthy controls (48±18). HCC patients had higher CgA values (P200 ng/mL in 21% of the HCC patients and in none of the LC patients. No significant correlation was found between a-FP and CgA in patients with HCC and in patients with cirrhosis. CONCLUSION: When HCC is suspected and a-FP

关键词： Chromogranin-A Hepatocellular carcinoma Liver cirrhosis Chronic hepatitis Diagnosis

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On the Large-Scale Structure of the Universe as given by the Voronoi Diagrams

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Chinese Journal of Astronomy and Astrophysics 2006年第4期6卷 387-395页

作者： L. Zaninetti dipartimento di Fisica Generale

The size distributions of 2D and 3D Voronoi cells and of cells of Vp（2, 3）,--2D cut of 3D Voronoi diagram--are explored, with the slngle-parameter （re-scaled） gamma distribution playing a central role in the analytical fitting. Observational evidence for a cellular universe is briefly reviewed. A simulated Vp（2, 3） map with galaxies lying on the cell boundaries is constructed to compare, as regards general appearance, with the observed CfA map of galaxies and voids, the parameters of the simulation being so chosen as to reproduce the largest observed void size.

关键词： surveys -- galaxies clusters general -- (cosmology:) large-scale structure of Universe

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Sensor Deployment and Relocation:A Unified Scheme

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Journal of Computer Science & Technology 2008年第3期23卷 400-412页

作者： Michele Garetto Marco Gribaudo Carla-Fabiana Chiasserini Emilio Leonardi dipartimento di Informatica Università di TorinoTorinoItaly dipartimento di Elettronica Politecnico di TorinoTorinoItaly

Sensor networks are envisioned to revolutionize our daily life by ubiquitously monitoring our environment and/or adjusting it to suit our needs. Recent progress in robotics and low-power embedded systems has made it possible to add mobility to small, light, low-cost sensors to be used in teams or swarms. Augmenting static sensor networks with mobile nodes addresses many design challenges that exist in traditional static sensor networks. This paper addresses the problem of topology control in mobile wireless networks. Limitations in communication, computation and energy capabilities push towards the adoption of distributed, energy-efficient solutions to perform self-deployment and relocation of the nodes. We develop a unified, distributed algorithm that has the following features. During deployment, our algorithm yields a regular tessellation of the geographical area with a given node density, called monitoring configuration. Upon the occurrence of a physical phenomenon, network nodes relocate themselves so as to properly sample and control the event, while maintaining the network connectivity. Then, as soon as the event ends, all nodes return to the monitoring configuration. To achieve these goals, we use a virtual force-based strategy which proves to be very effective even when compared to an optimal centralized solution. We assess the performance of our approach in the presence of events with different shapes, and we investigate the transient behavior of our algorithm. This allows us to evaluate the effectiveness and the response time of the proposed solution under various environmental conditions.

关键词： distributed algorithm mobile network sensor relocation wireless sensor network

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Fractional-order systems without equilibria:The first example of hyperchaos and its application to synchronization

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Chinese Physics B 2015年第8期24卷 224-232页

作者： Donato Cafagna Giuseppe Grassi dipartimento Ingegneria Innovazione Università del Salento

A challenging topic in nonlinear dynamics concerns the study of fractional-order systems without equilibrium *** particular, no paper has been published to date regarding the presence of hyperchaos in these systems. This paper aims to bridge the gap by introducing a new example of fractional-order hyperchaotic system without equilibrium points. The conducted analysis shows that hyperchaos exists in the proposed system when its order is as low as 3.84. Moreover, an interesting application of hyperchaotic synchronization to the considered fractional-order system is provided.

关键词： fractional-order systems equilibrium points hyperchaotic systems synchronization

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Role of blood AFP mRNA and tumor grade in the preoperative prognostic evaluation of patients with hepatoceiluiar carcinoma

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World Journal of Gastroenterology 2005年第44期11卷 6920-6925页

作者： Umberto Cillo Alessandro Vitale Filippo Navaglia Daniela Basso Umberto Montin Marco Bassanello Francesco D'Amico Francesco Antonio Ciarleglio Alberto Brolese Giacomo Zanus Vito De Pascale Mario Plebani Davide Francesco D'Amico Clinica Chirurgica Ⅰ dipartimento di Medicina di Laboratono dipartimento Assistenziale di Chirurgia Generale ed Emergenze Chirurgiche dipartimento di Medicina di Laboratorio Clinica Chirurgica I

AIM： To explore the potential prognostic role of preoperative tumor grade and blood AFP mRNA in a cohort of patients with hepatocellular carcinoma （HCC） eligible for radical therapies according to a well-defined treatment algorithm not including nodule size and number as absolute selection criteria. METHODS： Fifty patients with a diagnosis of HCC were prospectively enrolled in the study. Inclusion criteria were：（1） histological assessment of tumor grade by means of percutaneous biopsies; （2） determination of AFP mRNA status in the blood; （3） patient＇s eligibility for radical therapies. RESULTS： At preoperative evaluation, 54% of the study group had a well-differentiated HCC, 42% had AFP mRNA in the blood, 40% had a tumor larger than 5 cm and 56% had more than one nodule. Surgery （resection or liver transplantation） was performed in 29 patients, while 21 had percutaneous ablation procedures. After a median follow-up of 28 too, 12-, 24-, and 36-mo survival rates were 78%, 58%, and 51%, respectively. Surgical therapy, performance status and three tumor-related variables （AFP mRNA, HCC grade and gross vascular invasion） resulted as significant survival predictors at univariate analysis. Nodule size and number did not perform as significant prognosticators. Multivariate study selected only surgical therapy and a biologically early HCC profile （AFP mRNA negative and well-differentiated tumor without gross vascular invasion） as independent survival variables. CONCLUSION： The preoperative determination of tumor grade and blood AFP mRNA status may potentially refine the prognostic evaluation of HCC patients and improve the selection process for radical therapies.

关键词： Hepatocellular carcinoma Prognosis Treatment policy Biomarker Tumor biology

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