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Serum chromogranin-A in hepatocellular carcinoma: Diagnostic utility and limits

World Journal of Gastroenterology 2005年第13期11卷 1987-1990页

作者： Aldo Spadaro Antonino Ajello Carmela Morace Agata Zirilli Graziella D'arrigo Carmelo Luigiano Francesco Martino Anna Bene Domenico Migliorato Santi Turiano Oscar Ferraù Maria Antonietta Freni dipartimento Clinico Sperimentale di Medicina e Farmacologia dipartimento di Statistica dipartimento di Scienze Radiologiche Unità Operativa di Gastroenterologia

AIM: The utility of serum alpha-fetoprotein (α-FP) for the detection of hepatocellular carcinoma (HCC) is questionable. High serum levels of chromogranin-A (CgA) have recently been reported in HCC. Impaired hepatic, renal, and heart functions influence circulating CgA. The aim of this study was to assess sensitivity and specificity of serum CgA as a marker of HCC in patients with liver cirrhosis (LC). METHODS: Serum CgA levels were measured by RIA in 339 patients of which 54 HCC, 132 LC, 45 chronic hepatitis (CH), 27 chronic heart failure (CHF), 36 chronic renal failure (CRF), 45 chronic inflammatory bowel disease (IBD) as disease controls and in 75 healthy controls. Patients with liver disease or IBD and concomitant renal and/or heart failure were excluded. Pearson correlation, non-parametric combination test and confidence interval analysis were used for statistical analysis. RESULTS: Serum CgA above normal values (100 ng/mL) were found in 83% of HCC patients, in 48% of LC patients, in 20% of CH patients, in 33% of IBD patients, in 92% of CRF patients, in 100% of CHF patients, and in none of the healthy controls. The mean CgA values in HCC (769±1046), in LC (249±369), in CH (87±94), in CRF (1390±1401), in CHF (577±539), in IBD (146±287) were significantly higher than those in healthy controls (48±18). HCC patients had higher CgA values (P200 ng/mL in 21% of the HCC patients and in none of the LC patients. No significant correlation was found between a-FP and CgA in patients with HCC and in patients with cirrhosis. CONCLUSION: When HCC is suspected and a-FP

关键词： Chromogranin-A Hepatocellular carcinoma Liver cirrhosis Chronic hepatitis Diagnosis

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Clustering of quorum sensing colloidal particles

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National Science Open 2024年第4期3卷 7-16页

作者： Yuxin Zhou Yunyun Li Fabio Marchesoni MOE Key Laboratory of Advanced Micro-Structured Materials and Shanghai Key Laboratory of Special Artificial Microstructure Materials and Technology School of Physics Science and EngineeringTongji UniversityShanghai 200092China dipartimento di Fisica Universitàdi CamerinoCamerino I-62032Italy

We propose a simple model of colloidal suspension,whereby individual particles change their diffusivity from high(hot)to low(cold),as the local concentration of their closest peers grows larger than a certain *** a non-reciprocal interactive mechanism is known in biology as quorum *** tuning the parameters of the adopted quorum sensing protocol,the suspension is numerically shown to go through a variety of two-phase(hot and cold)*** is an archetypal model with potential applications in robotics and social studies.

关键词： cluster quorum sensing non-reciprocal phase separation colloidal particles

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On the Large-Scale Structure of the Universe as given by the Voronoi Diagrams

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Chinese Journal of Astronomy and Astrophysics 2006年第4期6卷 387-395页

作者： L. Zaninetti dipartimento di Fisica Generale

The size distributions of 2D and 3D Voronoi cells and of cells of Vp（2, 3）,--2D cut of 3D Voronoi diagram--are explored, with the slngle-parameter （re-scaled） gamma distribution playing a central role in the analytical fitting. Observational evidence for a cellular universe is briefly reviewed. A simulated Vp（2, 3） map with galaxies lying on the cell boundaries is constructed to compare, as regards general appearance, with the observed CfA map of galaxies and voids, the parameters of the simulation being so chosen as to reproduce the largest observed void size.

关键词： surveys -- galaxies clusters general -- (cosmology:) large-scale structure of Universe

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Sensor Deployment and Relocation:A Unified Scheme

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Journal of Computer Science & Technology 2008年第3期23卷 400-412页

作者： Michele Garetto Marco Gribaudo Carla-Fabiana Chiasserini Emilio Leonardi dipartimento di Informatica Università di TorinoTorinoItaly dipartimento di Elettronica Politecnico di TorinoTorinoItaly

Sensor networks are envisioned to revolutionize our daily life by ubiquitously monitoring our environment and/or adjusting it to suit our needs. Recent progress in robotics and low-power embedded systems has made it possible to add mobility to small, light, low-cost sensors to be used in teams or swarms. Augmenting static sensor networks with mobile nodes addresses many design challenges that exist in traditional static sensor networks. This paper addresses the problem of topology control in mobile wireless networks. Limitations in communication, computation and energy capabilities push towards the adoption of distributed, energy-efficient solutions to perform self-deployment and relocation of the nodes. We develop a unified, distributed algorithm that has the following features. During deployment, our algorithm yields a regular tessellation of the geographical area with a given node density, called monitoring configuration. Upon the occurrence of a physical phenomenon, network nodes relocate themselves so as to properly sample and control the event, while maintaining the network connectivity. Then, as soon as the event ends, all nodes return to the monitoring configuration. To achieve these goals, we use a virtual force-based strategy which proves to be very effective even when compared to an optimal centralized solution. We assess the performance of our approach in the presence of events with different shapes, and we investigate the transient behavior of our algorithm. This allows us to evaluate the effectiveness and the response time of the proposed solution under various environmental conditions.

关键词： distributed algorithm mobile network sensor relocation wireless sensor network

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Evolutionary Safe Padé Approximation Scheme for Dynamical Study of Nonlinear Cervical Human Papilloma Virus Infection Model

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2275-2296页

作者： Javaid Ali Armando Ciancio Kashif Ali Khan Nauman Raza Haci Mehmet Baskonus Muhammad Luqman Zafar-Ullah Khan Department of Mathematics Govt.Graduate College TownshipLahore54770Pakistan Universitàdegli Studi di Messina Dipartimento di Scienze BiomedicheOdontoiatriche e delle Immagini Morfologiche e FunzionaliMessina98122Italy Department of Mathematics University of Engineering and TechnologyLahore54890Pakistan Department of Mathematics University of the PunjabLahore54590Pakistan Mathematics Research Center Near East University TRNCMersin 10Nicosia99138Turkey Department of Mathematics and Science Education Faculty of EducationHarran UniversitySanliurfa63190Turkey Department of Dermatology Rashid Latif Medical CollegeLahore54600Pakistan

This study proposes a structure-preserving evolutionary framework to find a semi-analytical approximate solution for a nonlinear cervical cancer epidemic(CCE)*** underlying CCE model lacks a closed-form exact *** solutions obtained through traditional finite difference schemes do not ensure the preservation of the model’s necessary properties,such as positivity,boundedness,and ***,the development of structure-preserving semi-analytical approaches is always *** research introduces an intelligently supervised computational paradigm to solve the underlying CCE model’s physical properties by formulating an equivalent unconstrained optimization ***-free safe Padérational functions approximate the mathematical shape of state variables,while the model’s physical requirements are treated as problem *** primary model of the governing differential equations is imposed to minimize the error between approximate *** evolutionary algorithm,the Genetic Algorithm with Multi-Parent Crossover(GA-MPC),executes the optimization *** resulting method is the Evolutionary Safe PadéApproximation(ESPA)*** proof of unconditional convergence of the ESPA scheme on the CCE model is supported by numerical *** performance of the ESPA scheme on the CCE model is thoroughly investigated by considering various orders of non-singular Padéapproximants.

关键词： Nonlinear cervical cancer epidemic non-singular Padéapproximants approximate solutions computational biology

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Fractional-order systems without equilibria:The first example of hyperchaos and its application to synchronization

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Chinese Physics B 2015年第8期24卷 224-232页

作者： Donato Cafagna Giuseppe Grassi dipartimento Ingegneria Innovazione Università del Salento

A challenging topic in nonlinear dynamics concerns the study of fractional-order systems without equilibrium *** particular, no paper has been published to date regarding the presence of hyperchaos in these systems. This paper aims to bridge the gap by introducing a new example of fractional-order hyperchaotic system without equilibrium points. The conducted analysis shows that hyperchaos exists in the proposed system when its order is as low as 3.84. Moreover, an interesting application of hyperchaotic synchronization to the considered fractional-order system is provided.

关键词： fractional-order systems equilibrium points hyperchaotic systems synchronization

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Role of blood AFP mRNA and tumor grade in the preoperative prognostic evaluation of patients with hepatoceiluiar carcinoma

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World Journal of Gastroenterology 2005年第44期11卷 6920-6925页

作者： Umberto Cillo Alessandro Vitale Filippo Navaglia Daniela Basso Umberto Montin Marco Bassanello Francesco D'Amico Francesco Antonio Ciarleglio Alberto Brolese Giacomo Zanus Vito De Pascale Mario Plebani Davide Francesco D'Amico Clinica Chirurgica Ⅰ dipartimento di Medicina di Laboratono dipartimento Assistenziale di Chirurgia Generale ed Emergenze Chirurgiche dipartimento di Medicina di Laboratorio Clinica Chirurgica I

AIM： To explore the potential prognostic role of preoperative tumor grade and blood AFP mRNA in a cohort of patients with hepatocellular carcinoma （HCC） eligible for radical therapies according to a well-defined treatment algorithm not including nodule size and number as absolute selection criteria. METHODS： Fifty patients with a diagnosis of HCC were prospectively enrolled in the study. Inclusion criteria were：（1） histological assessment of tumor grade by means of percutaneous biopsies; （2） determination of AFP mRNA status in the blood; （3） patient＇s eligibility for radical therapies. RESULTS： At preoperative evaluation, 54% of the study group had a well-differentiated HCC, 42% had AFP mRNA in the blood, 40% had a tumor larger than 5 cm and 56% had more than one nodule. Surgery （resection or liver transplantation） was performed in 29 patients, while 21 had percutaneous ablation procedures. After a median follow-up of 28 too, 12-, 24-, and 36-mo survival rates were 78%, 58%, and 51%, respectively. Surgical therapy, performance status and three tumor-related variables （AFP mRNA, HCC grade and gross vascular invasion） resulted as significant survival predictors at univariate analysis. Nodule size and number did not perform as significant prognosticators. Multivariate study selected only surgical therapy and a biologically early HCC profile （AFP mRNA negative and well-differentiated tumor without gross vascular invasion） as independent survival variables. CONCLUSION： The preoperative determination of tumor grade and blood AFP mRNA status may potentially refine the prognostic evaluation of HCC patients and improve the selection process for radical therapies.

关键词： Hepatocellular carcinoma Prognosis Treatment policy Biomarker Tumor biology

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Radiative decays D*(s)→ D(s)γ in covariant confined quark model

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Chinese Physics C 2024年第2期48卷 45-56页

作者： C.T.Tran M.A.Ivanov P.Santorelli Q.C.Vo Department of Physics HCMC University of Technology and EducationVo Van Ngan 1700000 Ho Chi Minh CityVietnam Bogoliubov Laboratory of Theoretical Physics Joint Institute for Nuclear Research141980 DubnaRussia dipartimento di Fisica"E.Pancini" Universitàdi Napoli Federico ⅡComplesso Universitario di Monte S.AngeloVia CintiaEdificio 680126 NapoliItaly Istituto Nazionale di Fisica Nucleare Sezione di Napoli80126 NapoliItaly University of Science 700000 Ho Chi Minh CityVietnam

Radiative decays D((s))*→D((s))γare revisited in light of new experimental data from the BaBar and BESⅢ*** radiative couplings gD*Dγencoding nonperturbative QCD effects are calculated in the framework of the covariant confined quark model developed by *** compare our results with other theoretical studies and experimental *** couplings(in GeV-1)|g(D*+D+γ)|=0.45(9)and|g(D*0D0γ)|=1.72(34)calculated in our model agree with the corresponding experimental data|g(D*+D+γ)|=0.47(7)and|g(D*0D0γ)|=1.77(16).The most interesting case is the decay Ds*→Dsγ,for which a recent prediction based on light-cone sum rules at next-to-leading order|gDs*Dsγ|=0.60(19)deviates from the first(and only to date)lattice QCD result|gDs*Dsγ|=0.11(2)at nearly3σ.Our calculation yields|gDs*Dsγ|=0.29(6),which falls somehow between the two mentioned results,although it is larger than those predicted in other studies using quark models or QCD sum rules.

关键词： covariant quark model radiative decay charmed meson

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Finite Sample Properties of Virtual Reference Feedback Tuning Control

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Journal of Systems Science & Complexity 2018年第3期31卷 664-676页

作者： WANG Jianhong dipartimento di Elettronica Informazione Politecnico di Milano

In this paper, finite sample properties of virtual reference feedback tuning control are considered, by using the theory of finite sample properties from system identification. To design a controller in closed loop system structure, the idea of virtual reference feedback tuning is proposed to avoid the identification process corresponding to the plant model. After constructing one identification cost without any knowledge of plant model, the author derives one bound on the difference between the expected identification cost and its sample identification cost under the condition that the number of data points is finite. Also the correlation between the plant input and external noise is considered in the derivation of this bound. Furthermore, the author continues to derive one probability bound to quantify this difference by using some probability inequalities and control theory.

关键词： Asymptotic theory finite sample properties, virtual reference feedback control.

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Impact of chronic exposure to bevacizumab on EpCAM-based detection of circulating tumor cells

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Chinese Journal of Cancer Research 2015年第5期27卷 491-496页

作者： Chiara Nicolazzo Isabella Massimi Lavinia V.Lotti Simone Vespa Cristina Raimondi Fabio Maria Pulcinelli Angela Gradilone Paola Gazzaniga dipartimento di Medicina Molecolare Sapienza Università di Roma dipartimento di Medicina Sperimentale Sapienza Università di Roma

Background： Circulating tumor cells （CTCs） are often undetected through the immunomagnetic epithelial cell adhesion molecule （EpCAM）-based CellSearch~ System in breast and colorectal cancer （CRC） patients treated with bevacizumab （BEV）, where low CTC numbers have been reported even in patients with evidence of progression of disease. To date, the reasons for this discrepancy have not been clarified. This study was carried out to investigate the molecular and phenotypic changes in CRC cells after chronic exposure to BEV in vitro. Methods： The human CRC cell line WiDr was exposed to a clinically relevant dose of BEV for 3 months in vitro. The expression of epithelial and mesenchymal markers and EpCAM isoforms was determined by western blotting and immunofluorescence. To evaluate the impact of EpCAM variant isoforms expression on CTC enumeration by CellSearch, untreated and treated colon cancer cells were spiked into 7.5 mL of blood from a healthy donor and enumerated by CellSearch. Results： Chronic exposure of CRC cell line to BEV induced decreased expression of EpCAM 40 kDa isoform and increased expression EpCAM 42 kDa isoform, together with a decreased expression of cytokeratins （CK）, while no evidence of epithelial to mesenchymal transition （EMT） in treated cells was observed. The recovery rate of cells through CellSearch was gradually reduced in course of treatment with BEV, being 84% , 70% and 40% at l, 2 and 3 months, respectively. Conclusions： We hypothesize that BEV may prevent CellSearch from capturing CTCs through altering EpCAM isoforms.

关键词： Circulating tumor cells (CTCs) epithelial cell adhesion molecule (EpCAM) isoform bevacizumab(BEV) colorectal cancer (CRC)

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