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Clear mortality gap caused by graft macrosteatosis in Chinese patients after cadaveric liver transplantation

Hepatobiliary Surgery and Nutrition 2020年第6期9卷 739-758页

作者： Zhengtao Liu Wenchao Wang Li Zhuang Jingfeng Liu Shuping Que Dan Zhu Linfang Dong Jian Yu Lin Zhou Shusen Zheng Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryFirst Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina NHC Key Laboratory of Combined Multi-Organ Transplantation Key Laboratory of the Diagnosis and Treatment of Organ TransplantationCAMSFirst Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina Key Laboratory of Organ Transplantation of Zhejiang Province First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina Shulan(Hangzhou)Hospital Affiliated to Zhejiang Shuren University Shulan International Medical College HangzhouChina Science for Life Laboratory KTH-Royal Institute of TechnologySE-17121StockholmSweden dingxiang clinics HangzhouChina

Background:Liver transplantation(LT)is one of the most effective surgical treatment for patients with end-stage liver *** is a contributor for inferior graft *** its impact and safety on transplantation was less assessed in Chinese ***:Graft steatosis and related information involved in recipients,donors and surgical procedures were retrospectively collected from 239 ***:Donor macrosteatosis(MaS)caused about 2.14 and 2.80 folds of increment on patient and graft ***-response analysis revealed prominent risk of grafts on overall patient/organ mortality when MaS content exceeded 10%(P<0.05).Noteworthy,deaths were only observed in MaS group when concurrent with extremely higher post-transplant alanine aminotransferase(ALT,64%).However,microsteatosis(MiS)grafts didn’t affect outcomes after *** a cohort of Chinese patients,MaS had comprehensive effects on post-transplant outcomes with relatively lower safety threshold at 10%.Mortality gap caused by MaS grafts was observed in patients with severer ischemia reperfusion ***:Our study revealled the graft MaS affected the post-transplant outcomes in lower risk cutoff in Chinese *** study is worthy to validate these results and investigate inner mechanism under the phenomenon.

关键词： Steatosis prognosis liver transplantation(LT) dose-response analysis

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Recent Progress and Future Direction for the Application of Multiomics Data in Clinical Liver Transplantation

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Journal of Clinical and Translational Hepatology 2022年第2期10卷 363-373页

作者： Zhengtao Liu Jun Xu Shuping Que Lei Geng Lin Zhou Adil Mardinoglu Shusen Zheng Shulan International Medical College Zhejiang Shuren UniversityHangzhouZhejiangChina Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryFirst Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiangChina NHC Key Laboratory of Combined Multi-organ Transplantation Key Laboratory of the diagnosis and treatment of organ TransplantationCAMSFirst Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiangChina Key Laboratory of Organ Transplantation Zhejiang ProvinceFirst Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiangChina dingxiang clinics HangzhouZhejiangChina Science for Life Laboratory KTH-Royal Institute of TechnologyStockholmSweden Centre for Host-Microbiome Interactions Faculty of DentistryOral&Craniofacial SciencesKing’s College LondonLondonUK

Omics data address key issues in liver transplantation(LT)as the most effective therapeutic means for end-stage liver *** purpose of this study was to review the current application and future direction for omics in *** reviewed the use of multiomics to elucidate the pathogenesis leading to LT and *** directions with respect to the use of omics in LT are also described based on perspectives of surgeons with experience in *** molecules were identified and summarized based on omics,with a focus on post-transplant liver fibrosis,early allograft dysfunction,tumor recurrence,and graft *** emphasized the importance omics for clinicians who perform LTs and prioritized the directions that should be *** also outlined the ideal workflow for omics in *** step with advances in technology,the quality of omics data can be guaranteed using an improved algorithm at a lower *** should be addressed on the translational value of omics for better therapeutic effects in patients undergoing LT.

关键词： Multiomic analysis Transcriptomics Proteomics Metabolomics Liver transplantation EAD

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