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Wireless sequential dual light delivery for programmed PDT in vivo

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Light(Science & Applications) 2024年第6期13卷 1047-1061页

作者： Jiayi Liu Bowen Sun Wenkai Li Han-Joon Kim Shu Uin Gan John S.Ho Juwita Norasmara Bte Rahmat Yong Zhang department of Oncology The Second Xiangya HospitalCentral South UniversityChangshaHunan410011China department of Biomedical engineering College of Design and EngineeringNational University of SingaporeSingapore117585Singapore department of Mechanical engineering College of Design and EngineeringNational University of SingaporeSingapore117576Singapore department of Electrical and Computer engineering College of Design and EngineeringNational University of SingaporeSingapore117583Singapore department of Medical IT Convergence engineering Kumoh National Institute of TechnologyGumi39253Republic of Korea department of Surgery Yong Loo Lin School of MedicineNational University of SingaporeSingapore119228Singapore The N.1 Institute for Health National University of SingaporeSingapore117456Singapore Institute for Health Innovation and Technology National University of SingaporeSingapore119276Singapore department of Biomedical engineering College of EngineeringCity University of Hong KongKowloonHong Kong SARChina

Using photodynamic therapy(PDT)to treat deep-seated cancers is limited due to inefficient delivery of photosensitizers and low tissue penetration of *** nanocarriers are widely used for photosensitizer delivery,while the self-quenching of the encapsulated photosensitizers would impair the PDT ***,the generated short-lived reactive oxygen spieces(ROS)can hardly diffuse out of nanocarriers,resulting in low PDT ***,a smart nanocarrier system which can be degraded by light,followed by photosensitizer activation can potentially overcome these limitations and enhance the PDT efficacy.A light-sensitive polymer nanocarrier encapsulating photosensitizer(RB-M)was *** implantable wireless dual wavelength microLED device which delivers the two light wavelengths sequentially was developed to programmatically control the release and activation of the loaded *** transmitter coils with matching resonant frequencies allow activation of the connected LEDs to emit different wavelengths *** irradiation time,dose,and RB-M concentration were determined using an agent-based digital simulation *** vitro and in vivo validation experiments in an orthotopic rat liver hepatocellular carcinoma disease model confirmed that the nanocarrier rupture and sequential low dose light irradiation strategy resulted in successful PDT at reduced photosensitizer and irradiation dose,which is a clinically significant event that enhances treatment safety.

关键词： PDT overcome hardly

Next generation multiple access for IMT towards 2030 and beyond

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Science China(Information Sciences) 2024年第6期67卷 448-450页

作者： Zhiguo DING Robert SCHOBER Pingzhi FAN H.Vincent POOR department of Computer and Information engineering Khalifa University department of Electrical and Electronic engineering University of Manchester Institute for digital Communications Friedrich Alexander-University Erlangen-Nurnberg (FAU) CSNMT International Cooperation Research Center (MoST) Southwest Jiaotong University department of Electrical and Computer engineering Princeton University

Multiple access techniques are fundamental to the design of wireless communication systems,since many crucial components of such systems depend on the choice of the multiple access technique[1].For example,the use of ...

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Structural optimization design of semi-rigid base asphalt pavement using modulus matching criterion and multi-indicator range analysis

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Journal of Traffic and Transportation engineering(English Edition) 2024年第1期11卷 131-159页

作者： Zhihao Yang Linbing Wang Dongwei Cao Yinghao Miao Hailu Yang China Airport Planning&design Institute Co. Ltd.Beijing 101312China department of Road and Urban Railway engineering Beijing University of TechnologyBeijing 100124China National Center for Materials Service Safety University of Science and Technology BeijingBeijing 100083China School of Environmental CivilAgricultural and Mechanical EngineeringUniversity of GeorgiaAthensGA 30602USA China-Road Transportation verification&Inspection Hi-Tech Co. Ltd.Beijing 100088China

Damage to semi-rigid base asphalt pavement is related to improper matching of the pavement structure *** study mainly focused on the modulus matching of structural layers and the development of a pavement structure optimization ***,the modulus loss of existing pavement structures was analysed,and a three-dimensional finite element model was established based on the existing ***,the influence of the modulus of each structural layer on the mechanical response indicators and fatigue life was *** on the results,a pavement structure design method using the smoothness of the stress-strain curve as the modulus matching criterion of the structural layers was *** it was found that a strain convex point was present and that the stress mutation between the structural layers was significant when the modulus matching of the pavement structure was ***,the evaluation indicators were divided into two groups,namely,mechanical indicators and fatigue life *** it was proposed an optimized pavement structure design method based on modulus matching and multi-indicator range ***,the optimal modulus combination of pavement structure was determined by this *** research systematically studied the influence of the modulus of each structural layer on the mechanical response and fatigue life of the pavement,and proposed the concept and specific executive criteria of modulus matching for the first ***,it also provided an effective optimization method for pavement structure design.

关键词： Stress-strain curve Modulus matching Structural optimization design Multi-indicator range analysis Fatigue life

Monothetic and conductive network and mechanical stress releasing layer on micron-silicon anode enabling high-energy solid-state battery

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Rare Metals 2024年第3期43卷 1017-1029页

作者： Xiang Han Min Xu Lan-Hui Gu Chao-Fei Lan Min-Feng Chen Jun-Jie Lu Bi-Fu Sheng Peng Wang Song-Yan Chen Ji-Zhang Chen College of Materials Science and engineering Co-Innovation Center of Efficient Processing and Utilization of Forestry ResourcesNanjing Forestry UniversityNanjing210037China department of Physics Xiamen UniversityXiamen361005China Western digital Corporation MilpitasCA95035USA

Silicon has ultrahigh capacity,dendrite-free alloy lithiation mechanism and low cost and has been regarded as a promising anode candidate for solid-state *** to the low infiltration of solid-state electrolyte(SSE),not the unstable solid-electrolyte interphase(SEI),but the huge stress during lithiation-and delithiation-induced particle fracture and conductivity lost tend to be the main *** this study,starting with micron-Si,a novel monothetic carbon conductive framework and a MgO coating layer are designed,which serve as electron pathway across the whole electrode and stress releasing layer,*** addition,the in situ reaction between Si and SSE helps to form a LiF-rich and mechanically stable SEI *** a result,the mechanical stability and charge transfer kinetics of the uniquely designed Si anode are significantly ***,high initial Coulombic efficiency,high capacity and durable cycling stability can be achieved by applying the Si@MgO@C anode in *** example,high specific capacity of 3224.6 mAh·g^(-1)and long cycling durability of 200 cycles are *** work provides a new concept for designing alloy-type anode that combines surface coating on particle and electrode structure design.

关键词： Lithium-ion battery(LIB) Solid-state electrolyte(SSE) Silicon anode Stress relief Coating

A Survey on an Emerging Safety Challenge for Autonomous Vehicles:Safety of the Intended Functionality

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engineering 2024年第2期33卷 17-34页

作者： Hong Wang Wenbo Shao Chen Sun Kai Yang Dongpu Cao Jun Li Tsinghua Intelligent Vehicle design and Safety Research Institute School of Vehicle and MobilityTsinghua UniversityBeijing 100084China CogDrive Lab Department of Mechanical and Mechatronics EngineeringUniversity of WaterlooWaterlooON N2L3G1Canada College of Mechanical and Vehicle engineering Chongqing UniversityChongqing 400044China

As the complexity of autonomous vehicles(AVs)continues to increase and artificial intelligence algorithms are becoming increasingly ubiquitous,a novel safety concern known as the safety of the intended functionality(SOTIF)has emerged,presenting significant challenges to the widespread deployment of *** focuses on issues arising from the functional insufficiencies of the AVs’intended functionality or its implementation,apart from conventional safety *** the systems engineering standpoint,this study offers a comprehensive exploration of the SOTIF landscape by reviewing academic research,practical activities,challenges,and perspectives across the development,verification,validation,and operation *** research encompasses system-level SOTIF studies and algorithm-related SOTIF issues and ***,it encapsulates practical SOTIF activities undertaken by corporations,government entities,and academic institutions spanning international and Chinese contexts,focusing on the overarching methodologies and practices in different ***,the paper presents future challenges and outlook pertaining to the development,verification,validation,and operation phases,motivating stakeholders to address the remaining obstacles and challenges.

关键词： Safety of the intended functionality Autonomous vehicles Artificial intelligence Uncertainty verification Validation

Microfluidic bubble-generator enables digital light processing 3D printing of porous structures

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Aggregate 2024年第1期5卷 280-291页

作者： Philipp Weber Ling Cai Francisco Javier Aguilar Rojas Carlos Ezio Garciamendez-Mijares Maria Celeste Tirelli Francesco Nalin Jakub Jaroszewicz Wojciech Swi eszkowski Marco Costantini Yu Shrike Zhang Division of engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolCambridgeMassachusettsUSA Institute of Physical Chemistry—Polish Academy of Sciences KasprzakaPoland Biomaterials Group Materials Design DivisionFaculty of Materials Science and EngineeringWarsaw University of TechnologyWoloskaPoland

Three-dimensional(3D)printing is an emerging technique that has shown promising success in engineering human tissues in recent *** development of vatphotopolymerization printing modalities has significantly enhanced the complexity level for 3D printing of various functional structures and ***,the development of microfluidic chip systems is an emerging research sector with promising medical *** work demonstrates the coupling of a digital light processing(DLP)printing procedure with a microfluidic chip system to produce size-tunable,3D-printable porosities with narrow pore size distributions within a gelatin methacryloyl(GelMA)hydrogel *** is found that the generation of size-tunable gas bubbles trapped within an aqueous GelMA hydrogel-precursor can be controlled with high ***,the porosities are printed in two-dimensional(2D)as well as in 3D using the DLP *** addition,the cytocompatibility of the printed porous scaffolds is investigated using fibroblasts,where high cell viabilities as well as cell proliferation,spreading,and migration are *** is anticipated that the strategy is widely applicable in a range of application areas such as tissue engineering and regenerative medicine,among others.

关键词： 3D printing biofabrication bubble digital light processing microfluidics porous

A Survey on Belief Propagation Decoding of Polar Codes

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China Communications 2021年第8期18卷 133-168页

作者： Ahmet Cagrı Arlı Orhan Gazi digital design and verification engineering department Electra ICAnkaraTurkiye Electronic and Communication engineering Cankaya UniversityAnkaraTurkiye

The increasing data traffic rate of wireless communication systems forces the development of new technologies *** high data rate,extremely low latency and improvement on quality of service are the main subjects of next generation 5G wireless communication systems which will be in the people’s life in the years of *** the newest and first mathematically proven forward error correction code,polar code is one of the best candidates among error correction methods that can be employed for 5G wireless *** aim of this tutorial is to show that belief propagation decoding of polar codes can be a promising forward error correction technique in upcoming 5G ***,we survey the novel approaches to the belief propagation based decoding of polar codes and continue with the studies about the simplification of these ***,early detection and termination methods and concept of scheduling are going to be presented throughout the ***,polar construction algorithms,error types in belief propagation based decoders and hardware implementations are going to be ***,this tutorial proves that the BP based decoding of polar codes has a great potential to be a part of communication standards.

关键词： polar codes belief propagation 5G

Forecasting measured responses of structures using temporal deep learning and dual attention

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Frontiers of Structural and Civil engineering 2024年第6期18卷 832-850页

作者： Viet-Hung DANG Trong-Phu NGUYEN Thi-Lien PHAM Huan X.NGUYEN department of Structural Mechanics Hanoi University of Civil EngineeringHanoi 11600Vietnam Faculty of Applied Science University of Economics-Technology for IndustriesHanoi 11600Vietnam London digital Twin Research Centre Faculty of Science and TechnologyMiddlesex UniversityLondon NW44BTUK International School Vietnam National UniversityHanoi 11600Vietnam

The objective of this study is to develop a novel and efficient model for forecasting the nonlinear behavior of structures in response to time-varying random *** key idea is to design a deep learning architecture to leverage the relationships,between external excitations and structure's vibration signals,and between historical values and future values,within multiple time-series *** proposed method consists of two main steps:the first step applies a global attention mechanism to combine multiple-measured time series and time-varying excitation into a weighted time series before feeding it to a temporal architecture;the second step utilizes a self-attention mechanism followed by a fully connected layer to predict multi-step future *** viability of the proposed method is demonstrated via two case studies involving synthetic data from a three-dimensional(3D)reinforced concrete structure and experimental data from an 18-story steel ***,comparison and robustness studies are carried out,showing that the proposed method outperforms conventional methods and maintains high performance in the presence of noise with an amplitude of less than 10%.

关键词： structural dynamic time-varying excitation deep learning signal processing response forecasting

Tensile strength and failure behavior of rock-mortar interfaces: Direct and indirect measurements

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Journal of Rock Mechanics and Geotechnical engineering 2024年第1期16卷 41-55页

作者： Ghasem Shams Patrice Rivard Omid Moradian Civil engineering and Building engineering department Universitéde SherbrookeSherbrookeQuébecCanada department of Earth Sciences Swiss Federal Institute of Technology(ETH)ZurichSwitzerland department of Civil and Environmental engineering Colorado School of MinesGoldenCOUSA

The tensile strength at the rock-concrete interface is one of the crucial factors controlling the failure mechanisms of structures,such as concrete gravity *** the critical importance of the failure mechanism and tensile strength of rock-concrete interfaces,understanding of these factors remains very *** study investigated the tensile strength and fracturing processes at rock-mortar interfaces subjected to direct and indirect tensile *** image correlation(DIC)and acoustic emission(AE)techniques were used to monitor the failure mechanisms of specimens subjected to direct tension and indirect loading(Brazilian tests).The results indicated that the direct tensile strength of the rock-mortar specimens was lower than their indirect tensile strength,with a direct/indirect tensile strength ratio of 65%.DIC strain field data and moment tensor inversions(MTI)of AE events indicated that a significant number of shear microcracks occurred in the specimens subjected to the Brazilian *** presence of these shear microcracks,which require more energy to break,resulted in a higher tensile strength during the Brazilian *** contrast,microcracks were predominantly tensile in specimens subjected to direct tension,leading to a lower tensile *** monitoring of the cracking processes in the rock-mortar interfaces revealed that they show AE precursors before failure under the Brazilian test,whereas they show a minimal number of AE events before failure under direct *** to different microcracking mechanisms,specimens tested under Brazilian tests showed lower roughness with flatter fracture surfaces than those tested under direct tension with jagged and rough fracture *** results of this study shed light on better understanding the micromechanics of damage in the rock-concrete interfaces for a safer design of engineering structures.

关键词： Rock-mortar Rock-concrete Moment tensor inversion(MTI) Acoustic emission(AE) digital image correlation(DIC) Tensile strength Direct tensile test Brazilian test