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Molecular analysis of pancreatic cystic neoplasm in routine clinical practice

World Journal of Gastrointestinal endoscopy 2021年第2期13卷 56-71页

作者： Raquel Herranz Pérez Felipe de la Morena López Pedro L Majano Rodríguez Francisca Molina Jiménez Lorena Vega Piris Cecilio Santander Vaquero Department of Gastroenterology and Hepatology Hospital Universitario de La PrincesaInstituto de Investigación Sanitaria PrincesaCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y DigestivasMadrid 28006Spain Molecular Biology Laboratory Department of Gastroenterology and HepatologyHospital Universitario de La PrincesaInstituto de Investigación Sanitaria PrincesaCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y DigestivasMadrid 28006Spain Methodological Support unit Department of Statistical AnalysisHospital Universitario de La PrincesaInstituto de Investigación Sanitaria PrincesaCP MadridMadrid 28006Spain Department of Gastroenterology and Hepatology Hospital Universitario de La PrincesaInstituto de Investigación Sanitaria PrincesaMadrid 28006Spain

BACKGROUND Cystic pancreatic lesions consist of a wide variety of lesions that are becoming increasingly diagnosed with the growing use of imaging *** these,mucinous cysts are especially relevant due to their risk of ***,morphological findings are often suboptimal for their *** ultrasound fine-needle aspiration(EUS-FNA)with molecular analysis has been suggested to improve the diagnosis of pancreatic *** To determine the impact of molecular analysis on the detection of mucinous cysts and *** An 18-month prospective observational study of consecutive patients with pancreatic cystic lesions and an indication for EUS-FNA following European clinical practice guidelines was *** cysts included those>15 mm with unclear diagnosis,and a change in follow-up or with concerning features in which results might change clinical ***-FNA with cytological,biochemical and glucose and molecular analyses with next-generation sequencing were performed in 36 pancreatic *** cysts were classified as mucinous and non-mucinous by the combination of morphological,cytological and biochemical analyses when surgery was not *** was defined as cytology positive for malignancy,high-grade dysplasia or invasive carcinoma on surgical specimen,clinical or morphological progression,metastasis or death related to neoplastic complications during the 6-mo follow-up ***-generation sequencing results were compared for cyst type and *** Of the 36 lesions included,28(82.4%)were classified as mucinous and 6(17.6%)as ***,5(13.9%)lesions were classified as *** amount of deoxyribonucleic acid obtained was sufficient for molecular analysis in 25(69.4%)pancreatic *** amount of intracystic deoxyribonucleic acid was not statistically related to the cyst fluid volume obtained from the *** of KRAS and/or GNAS showed 83.33%[95%confidence

关键词： Pancreatic cysts Molecular analysis Next-generation sequencing Mucinous cyst Pancreatic cyst fluid Pancreatic cancer

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Therapeutic upper gastrointestinal tract endoscopy in Paediatric Gastroenterology

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World Journal of Gastrointestinal endoscopy 2015年第3期7卷 169-182页

作者： Imdadur Rahman Praful Patel Philip Boger Shahnawaz Rasheed Mike Thomson Nadeem Ahmad Afzal Department of Gastroenterology University Hospital Southampton SO16 6YD Southampton United Kingdom Department of Paediatrics University Hospital Southampton SO16 6YD Southampton United Kingdom Department of surgery the Royal Marsden Hospital SW3 6JJ London United Kingdom Department of Paediatric Gastroenterology the Children's Hospital Sheffield Western Bank S10 2TH Sheffield United Kingdom

Since the first report of use of endoscopy in children in the 1970 s, there has seen an exponential growthin published experience and innovation in the field. In this review article we focus on modern age therapeutic endoscopy practice, explaining use of traditional as well as new and innovative techniques, for diagnosis and treatment of diseases in the paediatric upper gastrointestinal tract.

关键词： Child Pediatrics endoscopy Gastroscopy Intestinal polyps Hemorrhage Caustics Gastrostomy Mitomycin Gastroesophageal reflux

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Primary intestinal lymphangiectasia diagnosed by capsule endoscopy and double balloon enteroscopy

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World Journal of Gastrointestinal endoscopy 2011年第11期3卷 235-240页

作者： Tak Geun Oh Joo Won Chung Hee Man Kim Seok-Joo Han Jin Sung Lee Jung Yeob Park Si Young Song Division of Gastroenterology Department of Internal MedicineYonsei Institute of GastroenterologyYonsei University College of MedicineSeoul 120-752South Korea epartment of Pediatric surgery Yonsei University College of MedicineSeoul 120-752South Korea Department of Pediatrics Yonsei University College of MedicineSeoul 120-752South Korea Division of Gastroenterology Department of Internal MedicineBrain Korea 21 Project for Medical Science and Severance Biomedical Science InstituteYonsei University College of MedicineSeoul 120-752South Korea

Primary intestinal lymphangiectasia(PIL)is a rare disorder characterized by dilated intestinal lymphatics and the development of protein-losing *** with PIL develop hypoalbuminemia,hypocalcemia,lymphopenia and hypogammaglobulinemia,and present with bilateral lower limb edema,fatigue,abdominal pain and *** reveals diffusely elongated,circumferential and polypoid mucosae covered with whitish enlarged villi,all of which indicate intestinal *** is conf irmed by characteristic tissue pathology,which includes dilated intestinal lymphatics with diffusely swollen mucosa and enlarged *** prevalence of PIL has increased since the introduction of capsule *** etiology and prevalence of PIL remain *** studies have reported that several genes and regulatory molecules for lymphangiogenesis are related to *** report the case of a patient with PIL involving the entire small bowel that was confirmed by capsule endoscopy and double-balloon enteroscopy-guided tissue pathology who carried a deletion on chromosome *** relationship between this deletion on chromosome 4 and PIL remains to be investigated.

关键词： Capsule endoscopy Double balloon enteroscopy Chromosome deletion Chromosome 4q25 Primary intestinal lymphangiectasia

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Medium-term surgical outcomes and health-related quality of life after laparoscopic vs open colorectal cancer resection: SF-36 health survey questionnaire

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World Journal of Gastrointestinal endoscopy 2023年第3期15卷 163-176页

作者： Chao-Ming Hung Kuo-Chuan Hung Hon-Yi Shi Shih-Bin Su Hui-Ming Lee Meng-Che Hsieh Cheng-Hao Tseng Shung-Eing Lin Chih-Cheng Chen Chao-Ming Tseng Ying-Nan Tsai Chi-Zen Chen Jung-Fa Tsai Chong-Chi Chiu Department of General surgery E-Da Cancer HospitalI-Shou UniversityKaohsiung 82445TaiwanChina School of Medicine College of MedicineI-Shou UniversityKaohsiung 82445TaiwanChina Department of Anesthesiology Chi Mei Medical CenterTainan 71004TaiwanChina Department of Hospital and Health Care Administration College of Recreation and Health ManagementChia Nan University of Pharmacy and ScienceTainan 71710TaiwanChina Department of Healthcare Administration and Medical Informatics Kaohsiung Medical UniversityKaohsiung 80708TaiwanChina Department of Business Management National Sun Yat-Sen UniversityKaohsiung 80424TaiwanChina Department of Medical Research Kaohsiung Medical University HospitalKaohsiung 80756TaiwanChina Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung 40402TaiwanChina Department of Occupational Medicine Chi Mei Medical CenterLiouying 73657TaiwanChina Department of Occupational Medicine Chi Mei Medical CenterTainan 71004TaiwanChina Department of Leisure Recreation and Tourism ManagementSouthern Taiwan University of Science and TechnologyTainan 71005TaiwanChina College of Medicine I-Shou UniversityKaohsiung 82445TaiwanChina Department of Hematology-Oncology E-Da Cancer HospitalI-Shou UniversityKaohsiung 82445TaiwanChina Department of Gastroenterology and Hepatology E-Da Cancer HospitalI-Shou UniversityKaohsiung 82445TaiwanChina Department of Gastroenterology and Hepatology E-Da HospitalI-Shou UniversityKaohsiung 82445TaiwanChina Department of Colon and Rectal surgery E-Da Cancer HospitalI-Shou UniversityKaohsiung 82445TaiwanChina Department of Gastroenterology and Hepatology E-Da Dachang HospitalI-Shou UniversityKaohsiung 80794TaiwanChina Department of Medical Education and Research E-Da Cancer HospitalI-Shou UniversityKaohsiung 82445TaiwanChina Department of General surgery Chi Mei Medical CenterLiouying 73657TaiwanChina

BACKGROUND Previous studies that compared the postoperative health-related quality of life(HRQoL)outcomes after receiving laparoscopic resection(LR)or open resection(OR)in patients with colorectal cancer(CRC)have different *** To explore the medium-term effect of postoperative HRQoL in such *** This study randomized 567 patients undergoing non-metastatic CRC surgery managed by one surgeon to the LR or OR *** was assessed during the preoperative period and 3,6,and 12 mo postoperative using a modified version of the 36-Item Short Form(SF-36)Health Survey questionnaire,emphasizing eight specific *** This cohort randomly assigned 541 patients to receive LR(n=296)or OR(n=245)surgical *** episodes of postoperative urinary tract infection(Psurgery-related complications,course of recovery,and especially some health domains of HRQoL at least within 6 mo *** should undergo LR if there is no contraindication.

关键词： Health-related quality of life Medium-term result Laparoscopic Open surgery Non-metastatic colorectal cancer

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A typical presentation of a rare cause of obscure gastrointestinal bleeding

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World Journal of Gastrointestinal endoscopy 2011年第2期3卷 40-45页

作者： Stefan Reuter Dominik Bettenworth Sren Torge Mees Jrg Neumann Torsten Beyna Wolfram Domschke Johannes Wessling Hansjrg Ullerich Department of Internal Medicine D University Hospital Münster Albert-Schweitzer Str. 33 Münster 48149 Germany Department of Internal Medicine B University Hospital Münster Albert-Schweitzer Str. 33 Münster 48149 Germany Department of General and Visceral surgery University Hospital Münster Albert-Schweitzer Str. 33 Münster 48149 Germany Gerhard Domagk Institute of Pathology University Hospital Münster Albert-Schweitzer Str. 33 Münster 48149 Germany Department of Radiology University Hospital Münster Albert-Schweitzer Str. 33 Münster 48149 Germany

A 52-year-old white woman had suffered from intermittent gastrointestinal (GI) bleeding for one year. Upper GI endoscopy, colonoscopy and peroral doubleballoon enteroscopy (DBE) did not detect any bleeding sour ce, suggesting obscure GI bleeding. However, in video capsule endoscopy a jejunal ulceration without blee ding signs was suspected and this was endoscopically conf irmed by another peroral DBE. After transfusion of packed red blood cells, the patient was discharged from our hospital in good general *** weeks later she was readmitted because of another episode of acute bleeding. Multi-detector row computed tomography with 3D reconstruction was performed revealing a jejunal tumor causing lower gastrointestinal bleeding. The patient underwent exploratory laparotomy with partial jejunal resection and end-to-end jejunostomy for reconstruction. Histological examination of the specimen confirmed the diagnosis of a low risk gastrointestinal stromal tumor (GIST). Nine days after surgery the patient was discharged in good health. No signs of gastrointestinal rebleeding occurred in a followup of eight months. We herein describe the comp lex presentation and course of this patient with GIST and also review the current approach to treatm ent.

关键词： Gastrointestinal stromal tumor Gastrointestinal neoplasms Gastrointestinal hemorrhage Computed tomography

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